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Full-Text Articles in Medicine and Health Sciences

Glucose Gel As A Potential Alternative Treatment To Infant Formula For Neonatal Hypoglycaemia In Australia, Raenee L. Barbe, Amy K. Ekin, Pushparani Sivakumar, Kay Howard, Therese O'Sullivan Jan 2018

Glucose Gel As A Potential Alternative Treatment To Infant Formula For Neonatal Hypoglycaemia In Australia, Raenee L. Barbe, Amy K. Ekin, Pushparani Sivakumar, Kay Howard, Therese O'Sullivan

Research outputs 2014 to 2021

Infant formula is often used as a treatment for neonatal hypoglycaemia in Australia; however, there are concerns that this may jeopardise mother-baby bonding and breastfeeding. Successful use of glucose gel as an alternative treatment for hypoglycaemia has been reported. We wanted to investigate in a pilot study whether the use of glucose gel has the potential to quickly and safely restore normoglycaemia in the infants of diabetic mothers in an Australian setting. Infants with asymptomatic hypoglycaemia were treated with glucose gel (n = 36) and compared to a historical group of infants which had been treated with infant formula …


Complex Training And Countermovement Jump Performance Across Multiple Sets: Effect Of Back Squat Intensity, Nick Poulos, Anic Chaouachi, Martin Buchheit, Denis Slimani, Greg Haff, Robert Newton Jan 2018

Complex Training And Countermovement Jump Performance Across Multiple Sets: Effect Of Back Squat Intensity, Nick Poulos, Anic Chaouachi, Martin Buchheit, Denis Slimani, Greg Haff, Robert Newton

Research outputs 2014 to 2021

The purpose of this investigation was to determine the acute effects of back squats on countermovement jump performance across multiple sets using a strength-power potentiation complex training protocol. Fifteen elite volleyball players performed three unloaded countermovement jumps (CMJ) following three repetitions of the back squat performed at either 65% or 87% of 1-RM, respectively, repeated for 10 sets. A control session of three CMJs was also repeated for 10 sets. Mean jump height performance was enhanced compared to performing CMJs only irrespective of which intensity was used (65% 1-RM: +3.3 ± 2.2% [CI: 1.0 to 5.6]; 87% 1-RM: 2.6 ± …


Effect Of Water Immersion Temperature On Heart Rate Variability Following Exercise In The Heat, Hui C. Choo, Kazunori Nosaka, Jeremiah J. Peiffer, Mohammed Ihsan, Chow C. Yeo, Chris R. Abbiss Jan 2018

Effect Of Water Immersion Temperature On Heart Rate Variability Following Exercise In The Heat, Hui C. Choo, Kazunori Nosaka, Jeremiah J. Peiffer, Mohammed Ihsan, Chow C. Yeo, Chris R. Abbiss

Research outputs 2014 to 2021

This study compared the effect of passive rest (CON) and water immersion at 8.6±0.2°C (CWI9), 14.6±0.3°C (CWI15) and 35.0±0.4°C (thermoneutral water immersion [TWI]) on post-exercise heart rate variability (HRV) indices. In a climate chamber (32.8±0.4°C, 32±5% relative humidity), nine men completed 25 min of cycling at the first ventilatory threshold and repeated 30-second bouts at 90% of peak power followed by a 5-minute recovery treatment in a randomised crossover manner. All water immersion re-established the HRV indices (natural logarithm of the square root of the mean sum squared differences between RR intervals [ln rMSSD], low-frequency [lnLF] and high-frequency power densities …


An Ehealth Program For Patients Undergoing A Total Hip Arthroplasty: Protocol For A Randomized Controlled Trial, Rosemary Saunders, Karla Seaman, Catherine Ashford, Trudy Sullivan, Judith Mcdowall, Lisa Whitehead, Bev Ewens, Kathryn Pedler, Karen Gullick Jan 2018

An Ehealth Program For Patients Undergoing A Total Hip Arthroplasty: Protocol For A Randomized Controlled Trial, Rosemary Saunders, Karla Seaman, Catherine Ashford, Trudy Sullivan, Judith Mcdowall, Lisa Whitehead, Bev Ewens, Kathryn Pedler, Karen Gullick

Research outputs 2014 to 2021

Background: Total hip arthroplasty is an effective surgical procedure commonly used worldwide for patients suffering the disabling effects of osteoarthritis when medical therapy is unsuccessful. Traditionally pre- and postoperative information for patients undergoing a hip arthroplasty has been provided by paper-based methods. Electronic health (eHealth) programs to support individualized patient education on preoperative preparation, in-patient care, and home rehabilitation have the potential to increase patient engagement, enhance patient recovery, and reduce potential postoperative complications.

Objective: The aim of this study is to compare the addition of an eHealth program versus standard care for pre- and postoperative education on patient outcomes …


The Frequency Of Drd2 Rs1076560 And Oprm1 Rs1799971 In Substance Use Disorder Patients From The United Arab Emirates, Hiba Alblooshi, Gary Hulse, Wael Osman, Ahmed El Kashef, Mansour Shawky, Hamad Al Ghaferi, Habiba Al Safar, Kwang Guan Tay Jan 2018

The Frequency Of Drd2 Rs1076560 And Oprm1 Rs1799971 In Substance Use Disorder Patients From The United Arab Emirates, Hiba Alblooshi, Gary Hulse, Wael Osman, Ahmed El Kashef, Mansour Shawky, Hamad Al Ghaferi, Habiba Al Safar, Kwang Guan Tay

Research outputs 2014 to 2021

Background - Dopaminergic and opioid systems are involved in mediating drug reward and reinforcement of various types of substances including psychoactive compounds. Genes of both systems have been candidate for investigation for associations with substance use disorder (SUD) in various populations. This study is the first study to determine the allele frequency and the genetic association of the DRD2 rs1076560 SNP and OPRM1 rs1799971 SNP variants in clinically diagnosed patients with SUD from the United Arab Emirates (UAE).

Methods - A cross-sectional case–control cohort that consisted of 512 male subjects was studied. Two hundred and fifty patients with SUD receiving …


Nitrate-Rich Vegetables Do Not Lower Blood Pressure In Individuals With Mildly Elevated Blood Pressure: A 4-Wk Randomized Controlled Crossover Trial, Lauren C. Blekkenhorst, Joshua R. Lewis, Richard L. Prince, Amanda Devine, Nicola P. Bondonno, Catherine P. Bondonno, Lisa G. Wood, Ian B. Puddey, Natalie C. Ward, Kevin D. Croft, Richard J. Woodman, Lawrence J. Beilin, Jonathan M. Hodgson Jan 2018

Nitrate-Rich Vegetables Do Not Lower Blood Pressure In Individuals With Mildly Elevated Blood Pressure: A 4-Wk Randomized Controlled Crossover Trial, Lauren C. Blekkenhorst, Joshua R. Lewis, Richard L. Prince, Amanda Devine, Nicola P. Bondonno, Catherine P. Bondonno, Lisa G. Wood, Ian B. Puddey, Natalie C. Ward, Kevin D. Croft, Richard J. Woodman, Lawrence J. Beilin, Jonathan M. Hodgson

Research outputs 2014 to 2021

Background - Emerging evidence suggests that increasing intakes of nitrate-rich vegetables may be an effective approach to reduce blood pressure.

Objective - Our primary aim was to determine whether daily consumption of nitrate-rich vegetables over 4 wk would result in lower blood pressure.

Design - Thirty participants with prehypertension or untreated grade 1 hypertension were recruited to a randomized controlled crossover trial with 4-wk treatment periods separated by 4-wk washout periods. Participants completed 3 treatments in random order: 1) increased intake (∼200 g/d) of nitrate-rich vegetables [high-nitrate (HN); ∼150 mg nitrate/d], 2) increased intake (∼200 g/d) of nitrate-poor …


Association Of Wrist Circumference And Waist-To-Height Ratio With Cardiometabolic Risk Factors Among Type Ii Diabetics In A Ghanaian Population, Christian Obirikorang, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Emmanuel Toboh, Evans Adu Asamoah, Bright Amakwaa, Emmanuella Nsenbah Batu, Peter Brenya Jan 2018

Association Of Wrist Circumference And Waist-To-Height Ratio With Cardiometabolic Risk Factors Among Type Ii Diabetics In A Ghanaian Population, Christian Obirikorang, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Emmanuel Toboh, Evans Adu Asamoah, Bright Amakwaa, Emmanuella Nsenbah Batu, Peter Brenya

Research outputs 2014 to 2021

The study determined the association of wrist circumference (WrC) and waist-to-height ratio (WHtR) with cardiometabolic risk factors among diabetics in a Ghanaian population. This cross-sectional study involved 384 diabetic patients at Begoro District Hospital, Ghana. Blood pressure, anthropometrics, and biochemical indices were measured. The overall prevalence of dyslipidaemia, metabolic syndrome (MetS), and hypertension was 42.4%, 76.3%, and 39.8%, respectively. The optimum cut-off range of WrC to identify individuals at increased cardiometabolic risk was 17.5 to –17.8 cm for men and 16.0 to 16.7 cm for women while that of WHtR was 0.52 to 0.61 for men and 0.53 to 0.59 …


Cynicism About Change, Work Engagement, And Job Satisfaction Of Public Sector Nurses, Diep T. N. Nguyen, Stephen T. Teo, David Pick Jan 2018

Cynicism About Change, Work Engagement, And Job Satisfaction Of Public Sector Nurses, Diep T. N. Nguyen, Stephen T. Teo, David Pick

Research outputs 2014 to 2021

This paper uses the job demands‐resources theory to examine the consequences of changes on nursing work. Data were collected from 220 public sector nurses in Australia to test the model. We conducted a two‐wave data collection process where independent variables (organisational change, workload, job control, nursing administrative stressors, cynicism about organisational change, and demographic variables) were collected in Time 1. The dependent variables (nursing work engagement and job satisfaction) were collected 6 months later. Changes to nursing work were found to cause high workload and an increase of administrative stressors that leads to an increase in nurses’ change cynicism. Job …


Correlation Between Circulating Tumour Dna And Metabolic Tumour Burden In Metastatic Melanoma Patients, Ashleigh Mcevoy, Lydia Warburton, Zeyad Al-Ogaili, Leisl Celliers, Lesley Calapre, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Mel R. Ziman Dr, Elin S. Gray Jan 2018

Correlation Between Circulating Tumour Dna And Metabolic Tumour Burden In Metastatic Melanoma Patients, Ashleigh Mcevoy, Lydia Warburton, Zeyad Al-Ogaili, Leisl Celliers, Lesley Calapre, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Mel R. Ziman Dr, Elin S. Gray

Research outputs 2014 to 2021

Background: Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the patients' overall metabolic tumour burden (MTB). Methods: Thirty-two treatment naïve metastatic melanoma patients were included in the study. MTB and metabolic tumour volume (MTV) was measured by 18F-fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT). Plasma ctDNA was quantified using droplet digital PCR (ddPCR). Results: CtDNA was detected in 23 …


The Effects Of Enactment On Communicative Competence In Aphasic Casual Conversation: A Functional Linguistic Perspective, Rimke Groenewold, Elizabeth Armstrong Jan 2018

The Effects Of Enactment On Communicative Competence In Aphasic Casual Conversation: A Functional Linguistic Perspective, Rimke Groenewold, Elizabeth Armstrong

Research outputs 2014 to 2021

Background: Previous research has shown that speakers with aphasia rely on enactment more often than non-brain-damaged language users. Several studies have been conducted to explain this observed increase, demonstrating that spoken language containing enactment is easier to produce and is more engaging to the conversation partner. This paper describes the effects of the occurrence of enactment in casual conversation involving individuals with aphasia on its level of conversational assertiveness. Aims: To evaluate whether and to what extent the occurrence of enactment in speech of individuals with aphasia contributes to its conversational assertiveness. Methods & Procedures: Conversations between a speaker with …


Image Analysis Of Periapical Radiograph For Bone Mineral Density Prediction, Rini Widyaningrum, Sri Lestari, Ferry Jie Jan 2018

Image Analysis Of Periapical Radiograph For Bone Mineral Density Prediction, Rini Widyaningrum, Sri Lestari, Ferry Jie

Research outputs 2014 to 2021

Osteoporosis is a systemic skeletal disease. Parameter from any bone site in the body has possibility to be developed as a predictor of osteoporosis. The alteration in the mandible trabecular bone is visible in periapical radiographs. The aim of this study was to correlate the area parameter and the integrated density of periapical radiograph with bone mineral density. Image analysis of periapical radiograph i.e. measurement of area parameter and integrated density was done on Region of Interest (ROI) by using canny edge detection method. Result of this study showed that the area parameter has asignificant (α < 0.05) negative correlation with the bone mass density (BMD) of the lumbar spine (r = -0.371) and T-score of the lumbar spine (r = -0.383). The linear regression test showed that the area parameter only can be used to predict T-score of the lumbar spine (F=5.822, α < 0.05). The integrated density showed a significant (α < 0.05) negative correlation with T-score of hip (r = -0.332) and T-score of lumbar spine (r = -0.377). It can be concluded that the area parameter can be used as one of input parameters for computer-aided system of osteoporosis early detection by using periapical radiograph.


Recreational Soccer As Sport Medicine For Middle-Aged And Older Adults: A Systematic Review, Hao Luo, Robert U. Newton, Fadi Ma'ayah, Daniel A. Galvao, Dennis R. Taaffe Jan 2018

Recreational Soccer As Sport Medicine For Middle-Aged And Older Adults: A Systematic Review, Hao Luo, Robert U. Newton, Fadi Ma'ayah, Daniel A. Galvao, Dennis R. Taaffe

Research outputs 2014 to 2021

Background Strategies to prevent or attenuate the age-related decline in physical and physiological function and reduce chronic disease risk factors are of clinical importance.

Objective To examine the health benefits of recreational soccer in middle-aged and older adults.

Design Systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Data sources All available records up until 9 June 2017 in PubMed, Web of Science, SPORTDiscus, MEDLINE, Embase, CINAHL Plus, PsycINFO and Cochrane Library databases.

Eligibility criteria for selecting studies All randomised trials with or without a control group (randomised controlled trials or randomised uncontrolled trials) …


Cognitive Impairment And Risk Of All-Cause And Cardiovascular Disease Mortality Over 20-Year Follow-Up: Results From The Blsa, Ji An, Haibin Li, Zhe Tang, Deqiang Zheng, Jin Guo, Yue Liu, Wei Feng, Xia Li, Anxin Wang, Xiangtong Liu, Lixin Tao, Chengbei Hou, Feng Zhang, Xinghua Yang, Qi Gao, Wei Wang, Xiuhua Guo, Yanxia Luo Jan 2018

Cognitive Impairment And Risk Of All-Cause And Cardiovascular Disease Mortality Over 20-Year Follow-Up: Results From The Blsa, Ji An, Haibin Li, Zhe Tang, Deqiang Zheng, Jin Guo, Yue Liu, Wei Feng, Xia Li, Anxin Wang, Xiangtong Liu, Lixin Tao, Chengbei Hou, Feng Zhang, Xinghua Yang, Qi Gao, Wei Wang, Xiuhua Guo, Yanxia Luo

Research outputs 2014 to 2021

Background-Cognitive impairment may increase the risk of all-cause and cardiovascular disease (CVD) mortality. This study examined the association between cognitive function and risk of all-cause and CVD mortality among the elderly in Beijing, China. Methods and Results-A total of 1996 participants aged ≥55 years at baseline were enrolled from the BLSA (Beijing Longitudinal Study of Aging). Cognitive function was assessed using the Mini-Mental State Examination (MMSE), and participants were categorized as:


The Potential Synergistic Behaviour Of Inter- And Intra-Genus Probiotic Combinations In The Pattern And Rate Of Short Chain Fatty Acids Formation During Fibre Fermentation, Warnakulasuriya M. A. D. B. Fernando, Steve H. Flint, K. K. D. S. Ranaweera, Arthur Bamunuarachchi, Stuart K. Johnson, Charles S. Brennan Jan 2018

The Potential Synergistic Behaviour Of Inter- And Intra-Genus Probiotic Combinations In The Pattern And Rate Of Short Chain Fatty Acids Formation During Fibre Fermentation, Warnakulasuriya M. A. D. B. Fernando, Steve H. Flint, K. K. D. S. Ranaweera, Arthur Bamunuarachchi, Stuart K. Johnson, Charles S. Brennan

Research outputs 2014 to 2021

This study compared the rate of short chain fatty acid (SCFA) production by different probiotic combinations of Lactobacillus and Bifidobacterium to determine any synergistic effects. Six different fibre fractions were fermented with nine combinations of Lactobacillus rhamnosus (LR), Lactobacillus acidophilus (LA), Bifidobacterium longum (BL) and Bifidobacterium breve (BB) for 0, 6, 24 and 48 h. SCFAs were quantified by gas chromatography. Inter-genus combinations of bacteria produced more SCFA, especially BB + BL + LR, compared to intra-genus that yielded the lowest SCFA production. Acetate was the most abundant, while propionate and butyrate were the most utilised. The SCFA formation was …


Acute Dehydration Impairs Endurance Without Modulating Neuromuscular Function, Oliver R. Barley, Dale W. Chapman, Anthony J. Blazevich, Chris R. Abbiss Jan 2018

Acute Dehydration Impairs Endurance Without Modulating Neuromuscular Function, Oliver R. Barley, Dale W. Chapman, Anthony J. Blazevich, Chris R. Abbiss

Research outputs 2014 to 2021

Introduction/Purpose: This study examined the influence of acute dehydration on neuromuscular function.

Methods: On separate days, combat sports athletes experienced in acute dehydration practices (n = 14) completed a 3 h passive heating intervention (40∘C, 63% relative humidity) to induce dehydration (DHY) or a thermoneutral euhydration control (25∘C, 50% relative humidity: CON). In the ensuing 3 h ad libitum fluid and food intake was allowed, after which participants performed fatiguing exercise consisting of repeated unilateral knee extensions at 85% of their maximal voluntary isometric contraction (MVIC) torque until task failure. Both before and after the fatiguing protocol participants performed …


Robotic Arm Rehabilitation In Chronic Stroke Patients With Aphasia May Promote Speech And Language Recovery (But Effect Is Not Enhanced By Supplementary Tdcs), Adam Buchwald, Carolyn Falconer, Avrielle Rykman-Peltz, Mar Cortes, Alvaro Pascual-Leone, Gary W. Thickbroom, Hermano Igo Krebs, Felipe Fregni, Linda M. Gerber, Clara Oromendia, Johanna Chang, Bruce T. Volpe, Dylan J. Edwards Jan 2018

Robotic Arm Rehabilitation In Chronic Stroke Patients With Aphasia May Promote Speech And Language Recovery (But Effect Is Not Enhanced By Supplementary Tdcs), Adam Buchwald, Carolyn Falconer, Avrielle Rykman-Peltz, Mar Cortes, Alvaro Pascual-Leone, Gary W. Thickbroom, Hermano Igo Krebs, Felipe Fregni, Linda M. Gerber, Clara Oromendia, Johanna Chang, Bruce T. Volpe, Dylan J. Edwards

Research outputs 2014 to 2021

Objective: This study aimed to determine the extent to which robotic arm rehabilitation for chronic stroke may promote recovery of speech and language function in individuals with aphasia.

Methods: We prospectively enrolled 17 individuals from a hemiparesis rehabilitation study pairing intensive robot assisted therapy with sham or active tDCS and evaluated their speech (N = 17) and language (N = 9) performance before and after a 12-week (36 session) treatment regimen. Performance changes were evaluated with paired t-tests comparing pre- and post-test measures. There was no speech therapy included in the treatment protocol.

Results: Overall, the individuals …


Manipulation Of Human Verticality Using High-Definition Transcranial Direct Current Stimulation, Taiza E.G. Santos, Diandra B. Favoretto, Iman Ghodratti Toostani, Diego C. Nascimento, Brunna P. Rimoli, Eduardo Bergonzoni, Tenysson Will Lemos, Dennis Q. Truong, Alexandre C.B. Delbem, Bahador Makkiabadi, Renato Moraes, Francisco Louzada, Marom Bikson, Joao P. Leite, Dylan J. Edwards Jan 2018

Manipulation Of Human Verticality Using High-Definition Transcranial Direct Current Stimulation, Taiza E.G. Santos, Diandra B. Favoretto, Iman Ghodratti Toostani, Diego C. Nascimento, Brunna P. Rimoli, Eduardo Bergonzoni, Tenysson Will Lemos, Dennis Q. Truong, Alexandre C.B. Delbem, Bahador Makkiabadi, Renato Moraes, Francisco Louzada, Marom Bikson, Joao P. Leite, Dylan J. Edwards

Research outputs 2014 to 2021

Background: Using conventional tDCS over the temporo-parietal junction (TPJ) we previously reported that it is possible to manipulate subjective visual vertical (SVV) and postural control. We also demonstrated that high-definition tDCS (HD-tDCS) can achieve substantially greater cortical stimulation focality than conventional tDCS. However, it is critical to establish dose-response effects using well-defined protocols with relevance to clinically meaningful applications.

Objective: To conduct three pilot studies investigating polarity and intensity-dependent effects of HD-tDCS over the right TPJ on behavioral and physiological outcome measures in healthy subjects. We additionally aimed to establish the feasibility, safety, and tolerability of this stimulation protocol.

Methods: …


Corrigendum: Identification Of The Cftr C.1666a > G Mutation In Hereditary Inclusion Body Myopathy Using Next-Generation Sequencing Analysis, Yan Lu, Yu-Wei Da, Yong-Biao Zhang, Xin-Gang Li, Min Wang, Li Di, Mi Pang, Lin Lei Jan 2018

Corrigendum: Identification Of The Cftr C.1666a > G Mutation In Hereditary Inclusion Body Myopathy Using Next-Generation Sequencing Analysis, Yan Lu, Yu-Wei Da, Yong-Biao Zhang, Xin-Gang Li, Min Wang, Li Di, Mi Pang, Lin Lei

Research outputs 2014 to 2021

A Corrigendum on Identification of the CFTR c.1666A>G Mutation in Hereditary Inclusion Body Myopathy Using Next-Generation Sequencing Analysis

by Lu, Y., Da, Y.-W., Zhang, Y.-B., Li, X.-G., Wang, M., Di, L., et al. (2018). Front. Neurosci. 12:329. doi: 10.3389/fnins.2018.00329

An error was found in the first and second sentence of the original article's abstract.


The Burden Of Hospitalized Sports-Related Injuries In Children: An Australian Population-Based Study, 2005–2013, Francisco J. Schneuer, Jane C. Bell, Susan E. Adams, Julie Brown, Caroline Finch, Natasha Nassar Jan 2018

The Burden Of Hospitalized Sports-Related Injuries In Children: An Australian Population-Based Study, 2005–2013, Francisco J. Schneuer, Jane C. Bell, Susan E. Adams, Julie Brown, Caroline Finch, Natasha Nassar

Research outputs 2014 to 2021

Background

There is concern about recent increase and severity of sports-related injuries in children. Despite the benefits of sports participation, injuries may carry long-term health consequences. We aimed to evaluate the prevalence, characteristics and types of hospitalized sports-related injuries in children.

Methods

Population-based study of all acute sports-related injuries requiring hospitalization in children 5 to 15 years of age in New South Wales (NSW), Australia, 2005–2013. Health information was obtained from the NSW Admitted Patient Data Collection, a census of all hospital admissions from public and private hospitals. Children with a recorded ICD10-AM injury code (S00-T79) and sport-related activity code …


Increased Risk For Obesity And Diabetes With Neurodegeneration In Developing Countries, I. J. Martins Jan 2018

Increased Risk For Obesity And Diabetes With Neurodegeneration In Developing Countries, I. J. Martins

Research outputs 2014 to 2021

The incidence of global obesity and Type 2 diabetes has increased and is predicted to rise to 30% of the global population. Diet and lifestyle factors are incapable to resolve the increased incidence for obesity and diabetes in various populations of the world. Developing countries have come to the forefront because of the higher diabetic epidemic. The urbanization may possibly provide an explanation for the global diabetic epidemic. In Western countries the metabolic syndrome and non alcoholic fatty liver disease (NAFLD) have reached 30 % of the population and now at present NAFLD afflicts 20% of developing populations. Western diets …


Insulin Therapy And Autoimmune Disease With Relevance To Non Alcoholic Fatty Liver Disease, Ian James Martins Jan 2018

Insulin Therapy And Autoimmune Disease With Relevance To Non Alcoholic Fatty Liver Disease, Ian James Martins

Research outputs 2014 to 2021

The diabetes epidemic is now expected by the year 2050 to become a global pandemic with approx. 592 million affected in both the developed and developing world. The treatment of diabetes by insulin therapy has been the focus for many diabetics with the improvement and prevention of various diseases such as cardiovascular disease, kidney disease and neurodegeneration. The global nonalcoholic fatty liver disease (NAFLD) epidemic has now become of major concern to diabetes with critical interest in insulin therapy to reverse and stabilize autoimmune disease with relevance to NAFLD and the diabetes pandemic. Dietary components that activate anti-aging genes improve …


Early Diagnosis And Nutritional Treatment Stabilizes Neuropsychiatric Disorders, Ian James Martins Jan 2018

Early Diagnosis And Nutritional Treatment Stabilizes Neuropsychiatric Disorders, Ian James Martins

Research outputs 2014 to 2021

The reliable diagnostic identification of neuropsychiatric disorders such as schizophrenia, bipolar disease, and depression has been associated with some biological markers (genomics, proteomics, metabolomics) but to date, these markers do not have the sensitivity/specificity of a diagnostic test. Biomarker tests that are relevant to global chronic disease are now applicable to neuropsychiatric diseases to prevent autoimmune disease, endoplasmic reticulum stress associated mitophagy with relevance to neuron apoptosis. Metabolic abnormalities has been linked to neuropsychiatric disorder with the careful nutritional assessment of patients reported in many published studies. Early interventions with genomic medicine now assist in the prevention of autoimmune disease …


A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline In Preclinical Alzheimer’S Disease, Tenielle Porter, Samantha C. Burnham, Greg Savage, Yen Ying Lim, Paul Maruff, Lidija Milicic, Madeline Peretti, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, Kevin Taddei, David Groth, Guiseppe Verdile, Victor L. Villemagne, Simon M. Laws Jan 2018

A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline In Preclinical Alzheimer’S Disease, Tenielle Porter, Samantha C. Burnham, Greg Savage, Yen Ying Lim, Paul Maruff, Lidija Milicic, Madeline Peretti, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, Kevin Taddei, David Groth, Guiseppe Verdile, Victor L. Villemagne, Simon M. Laws

Research outputs 2014 to 2021

Studies of Alzheimer’s disease risk-weighted polygenic risk scores (PRSs) for cognitive performance have reported inconsistent associations. This inconsistency is particularly evident when PRSs are assessed independent of APOE genotype. As such, the development and assessment of phenotype-specific weightings to derive PRSs for cognitive decline in preclinical AD is warranted. To this end a episodic memory-weighted PRS (emPRS) was derived and assessed against decline in cognitive performance in 226 healthy cognitively normal older adults with high brain Aβ-amyloid burden participants from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. The effect size for decline in a verbal episodic memory …


Inactivation Of Endoplasmic Reticulum Stress And The Prevention Of Neurodegenerative Diseases, Ian James Martins Jan 2018

Inactivation Of Endoplasmic Reticulum Stress And The Prevention Of Neurodegenerative Diseases, Ian James Martins

Research outputs 2014 to 2021

Biotherapeutics and nutritional therapy are essential for the treatment of endoplasmic reticulum (ER) stress in diabetes and neurodegenerative diseases. Oxidative stress and nutrient excess may induce ER stress associated with activation of the unfolded protein response and connected to cell death. The heat shock gene Sirtuin 1 (Sirt 1) is important to the heat shock response with amyloid beta aggregation associated with the induction of mitophagy and ER stress in neuron cells. Genomic medicine that activates nuclear Sirt 1 is essential for the prevention of mitochondrial apoptosis and ER stress. Inhibitors such as drugs, alcohol, excess caffeine and palmitic acid …


Prevalence And Factors Associated With Underutilization Of Antenatal Care Services In Nigeria: A Comparative Study Of Rural And Urban Residences Based On The 2013 Nigeria Demographic And Health Survey, Emmanuel O. Adewuyi, Asa Auta, Vishnu Khanal, Olasunkanmi D. Bamidele, Cynthia P. Akuoko, Kazeem Adefemi, Samson J. Tapshak, Yun Zhao Jan 2018

Prevalence And Factors Associated With Underutilization Of Antenatal Care Services In Nigeria: A Comparative Study Of Rural And Urban Residences Based On The 2013 Nigeria Demographic And Health Survey, Emmanuel O. Adewuyi, Asa Auta, Vishnu Khanal, Olasunkanmi D. Bamidele, Cynthia P. Akuoko, Kazeem Adefemi, Samson J. Tapshak, Yun Zhao

Research outputs 2014 to 2021

Introduction Antenatal care (ANC) is a major public health intervention aimed at ensuring safe pregnancy outcomes. In Nigeria, the recommended minimum of four times ANC attendance is underutilized. This study investigates the prevalence and factors associated with underutilization of ANC services with a focus on the differences between rural and urban residences in Nigeria. Methods We analyzed the 2013 Nigeria Demographic and Health Survey dataset with adjustment for the sampling weight and the cluster design of the survey. The prevalence of underutilization of ANC was assessed using frequency tabulation while associated factors were examined using Chi-Square test and multivariable logistic …


The Constituent Year Effect: Relative Age Disparities In Australian Masters Track And Field Athletic Participation, Nikola Medic, Jasmine Lares, Bradley W. Young Jan 2018

The Constituent Year Effect: Relative Age Disparities In Australian Masters Track And Field Athletic Participation, Nikola Medic, Jasmine Lares, Bradley W. Young

Research outputs 2014 to 2021

The constituent year effect, a source of relative age disparities, in masters sport has been demonstrated mainly amongst North American samples. Thus, the purpose of this study was to examine whether a participation-related constituent year effect exists among athletes (n = 6492) competing in Australian Masters Athletics competitions between 2000 and 2014. The results indicated that a participation-related constituent year effect was observed as the likelihood of participating was significantly higher for masters athletes in their first and second constituent year of any five-year age category (p < 0.0001) and was lower when they were in the fourth or fifth constituent year. The results also indicated this effect is influenced by gender and age. Specifically, the effect was significant for both male (p < 0.0001) and female (p < 0.001) masters athletes; as well during the third, sixth, seventh, and eighth + decades of life (all ps < 0.001). These data demonstrate that despite masters sport being an avenue for promotion of participation and overall health, there is potential for improving how competitive organizational strategies are implemented given the recurring intermittent patterns of participation associated with five-year age brackets which are likely to compromise benefits.


Factors Affecting Powerlifting Performance: An Analysis Of Age- And Weight-Based Determinants Of Relative Strength, Christopher Latella, Daniel Van Den Hoek, Wei-Peng Teo Jan 2018

Factors Affecting Powerlifting Performance: An Analysis Of Age- And Weight-Based Determinants Of Relative Strength, Christopher Latella, Daniel Van Den Hoek, Wei-Peng Teo

Research outputs 2014 to 2021

Powerlifting (PL) is characterised by the ability to generate maximal force. However, an understanding of the factors affecting strength in PL athletes is poorly understood. Therefore, competition data were analysed from 1368 individuals during 2017. Relative strength was compared for the squat (SQ), bench press (BP) and deadlift (DL) between age groups (Sub-junior [SJ], Junior [JU], Open [OP], and Masters’ I-IV [M1-M4]), weight classes (females; 47 kg, 52 kg, 57 kg, 63 kg, 72 kg, 84 kg and + 84 kg and males; 59 kg, 66 kg, 74 kg, 83 kg, 93 kg, 105 kg, 120 kg, + 120 kg) …


Scoring Analysis Of The Men’S 2014, 2015 And 2016 World Championship Tour Of Surfing: The Importance Of Aerial Manoeuvres In Competitive Surfing, Brendon Ferrier, Jeremy Sheppard, Oliver R.L. Farley, Josh L. Secomb, Joanna Parsonage, Robert Newton, Sophia Nimphius Jan 2018

Scoring Analysis Of The Men’S 2014, 2015 And 2016 World Championship Tour Of Surfing: The Importance Of Aerial Manoeuvres In Competitive Surfing, Brendon Ferrier, Jeremy Sheppard, Oliver R.L. Farley, Josh L. Secomb, Joanna Parsonage, Robert Newton, Sophia Nimphius

Research outputs 2014 to 2021

The aim of this study was to investigate the impact of aerial manoeuvres on scoring in professional surfing. 23,631 waves were analysed for the number and types of aerial manoeuvres performed from the 2014, 2015 and 2016 Men’s World Championship Tour. Additionally, the awarded score, timing and order of the aerial was also analysed. Descriptive statistics and Two Way ANOVA’s were performed with Sidak Multiple Comparisons Post Hoc analysis. Results were a significantly higher score being awarded (P ≤ 0.0001) when including an aerial in competition across all three seasons. In 2015 surfers were awarded a significantly larger score …


Point Prevalence And Patterns Of Mental Health Comorbidity Among People Accessing Australia's First Older Adult–Specific Alcohol And Other Drug Treatment Service, Stephen Bright, Katherine Walsh, Cylie Williams Jan 2018

Point Prevalence And Patterns Of Mental Health Comorbidity Among People Accessing Australia's First Older Adult–Specific Alcohol And Other Drug Treatment Service, Stephen Bright, Katherine Walsh, Cylie Williams

Research outputs 2014 to 2021

Objective: There are good data regarding the prevalence and patterns of dual diagnosis among the general population; however, data regarding the older adult cohort are limited. We aimed to extend the knowledge of the point prevalence and patterns of dual diagnosis among older adults and the impact of dual diagnosis on the utilization of alcohol and other drug treatment services.

Method: A 12-month medical chart audit of clients discharged from an Australian older adult–specific alcohol and other drug treatment service was performed. Measures included the Alcohol Use Disorders Identification Test–Consumption, the Drug Use Disorders Identification Test–Consumption, the Kessler 10, and …


The Nexus Of Nursing Leadership And A Culture Of Safer Patient Care, Melanie Murray, Deborah R. Sundin, Vicki C. Cope Jan 2018

The Nexus Of Nursing Leadership And A Culture Of Safer Patient Care, Melanie Murray, Deborah R. Sundin, Vicki C. Cope

Research outputs 2014 to 2021

Aims and objectives: To explore the connection between +6 nursing leadership and enhanced patient safety.

Background: Critical reports from the Institute of Medicine in 1999 and Francis QC report of 2013 indicate that healthcare organisations, inclusive of nursing leadership, were remiss or inconsistent in fostering a culture of safety. The factors required to foster organisational safety culture include supportive leadership, effective communication, an orientation programme and ongoing training, appropriate staffing, open communication regarding errors, compliance to policy and procedure, and environmental safety and security. As nurses have the highest patient interaction, and leadership is discernible at all levels of nursing, …