Open Access. Powered by Scholars. Published by Universities.®

Biology Commons™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 631 - 660 of 39062

Full-Text Articles in Biology

Recent Advances In The Pharmacological Properties Of Scutellarin: Mechanistic Insights And Therapeutic Potential, Hind A. Satar, Emad Yousif, Ahmed Ahmed, Muna Bufaroosha Feb 2026

Recent Advances In The Pharmacological Properties Of Scutellarin: Mechanistic Insights And Therapeutic Potential, Hind A. Satar, Emad Yousif, Ahmed Ahmed, Muna Bufaroosha

AUIQ Complementary Biological System

Scutellarin, a flavonoid glycoside primarily derived from Scutellaria baicalensis, has garnered increasing scientific interest for its multifaceted pharmacological properties. This review summarizes recent advances in our understanding of scutellarin's therapeutic effects, including its antioxidant, anti-inflammatory, neuroprotective, cardioprotective and anticancer activities. Emphasis is placed on elucidating its molecular mechanisms of action, such as modulation of the NF-κB, Nrf2, and PI3K/Akt pathways, and its role in regulating oxidative stress, inflammation, and apoptosis. Additionally, we discuss formulation innovations, including nanoparticle and liposomal delivery systems, aimed at overcoming scutellarin's poor oral bioavailability and enhancing therapeutic performance. Key limitations in current research …


On-Orbit Correction Of Ecostress Radiances By Comparison With Iasi Hyperspectral Sounders, David S. Wethey, Sarah A. Woodin, Jorge Vazquez-Cuervo Feb 2026

On-Orbit Correction Of Ecostress Radiances By Comparison With Iasi Hyperspectral Sounders, David S. Wethey, Sarah A. Woodin, Jorge Vazquez-Cuervo

Faculty Publications

Radiance data from ECOSTRESS (ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station), which is the first of a planned virtual constellation of wide-swath ultra-high-resolution thermal satellites, were used to test the concept of on-orbit cross-calibration based on the Global Space-based Inter-Calibration System (GSICS) with the Infrared Atmospheric Sounding Interferometer (IASI) as the reference. Validation of the results was performed using comparisons of corrected ECOSTRESS radiances with strictly independent data from IASI and the Cross-Track Infrared Sounder (CrIS) and with RTTOV radiative transfer simulations of clear-sky observations in iQuam (the NOAA in situ sea surface temperature quality monitor database). ECOSTRESS has …


Molecular Detection Of Genes Encoded For Biofilm Formation In Bacteria Isolated From The Oral Cavity Of Patients, Tebarek Al-Taei, Ali A. Al-Hisnawi Feb 2026

Molecular Detection Of Genes Encoded For Biofilm Formation In Bacteria Isolated From The Oral Cavity Of Patients, Tebarek Al-Taei, Ali A. Al-Hisnawi

Karbala International Journal of Modern Science

Background: A biofilm is a collection of the microbial cells attached to the surface that are encased in a matrix of extracellular polymers. Biofilm formation creates a physical and chemical barrier that prevents antibiotics from reaching bacterial cells, resulting in treatment failure and reinfection. The present study aimed to investigate the biofilm formation in bacteria isolated from the oral cavity of patients.

Methods: In this study, 150 bacterial isolates were obtained from tooth and gum surface swabs of male and female patients of different ages who visited specialized centers and dental clinics in Babylon City after they were clinically diagnosed …


Investigation Of Biofilm Formation And Osmotic Stress Tolerance Of Nonmotile E. Coli Mg1655 In Simulated Microgravity, Tyler Jenkins Feb 2026

Investigation Of Biofilm Formation And Osmotic Stress Tolerance Of Nonmotile E. Coli Mg1655 In Simulated Microgravity, Tyler Jenkins

Student Research Symposium (SRS)

Simulated microgravity presents multiple physiological stressors for astronauts, including bone demineralization, muscle loss, and weakening of the immune system (Chavez et al., 2024). Bacteria serve as viable model organisms to study physiological changes because of their abundance in the human digestive system and skin. Motility in bacteria plays a significant role in cell survival, but few studies have been conducted on microgravity’s effect on motility phenotypes. While motile strains like K12 have been studied extensively under microgravity conditions (Topolski et al., 2022; Chavez et al., 2024), the effects of simulated microgravity on non-motile strains are largely unknown. To better understand …


Development Of An Ied Response Model For Testing Of The Snapping Shrimp Resource Allocation Algorithm, Joanna Morris Feb 2026

Development Of An Ied Response Model For Testing Of The Snapping Shrimp Resource Allocation Algorithm, Joanna Morris

Student Research Symposium (SRS)

"Models must be capable of demonstrating adaptability across multiple case studies to confirm their reliability and versatility. The Snapping Shrimp Resource Allocation Algorithm, which has been successfully applied in a wildfire response scenario, models efficient, decentralized coordination inspired by the behavior of snapping shrimp. Building on this foundation, the current work explores the potential application of the Snapping Shrimp Resource Allocation algorithm to improvised explosive device response where rapid, autonomous coordination could significantly enhance safety and operational efficiency. Improvised explosive devices remain a persistent issue in modern conflict, requiring strategies for response that are cost-effective, scalable, and capable of adapting …


Structural And Mechanical Properties Facilitate Shock Wave Damping By Helmet-Like Orbital Hoods In Snapping Shrimp, Mia Kazel, Rebekah E. Cammack, Alexandra C.N. Kingston, Ahmed A. Alshareef, Tarek Shazly, Daniel Isaac Speiser Feb 2026

Structural And Mechanical Properties Facilitate Shock Wave Damping By Helmet-Like Orbital Hoods In Snapping Shrimp, Mia Kazel, Rebekah E. Cammack, Alexandra C.N. Kingston, Ahmed A. Alshareef, Tarek Shazly, Daniel Isaac Speiser

Faculty Publications

Snapping shrimp damp the shock waves they produce and use as weapons with a helmet-like structure termed the orbital hood. Here, we ask how structural and material properties contribute to shock wave damping by orbital hoods in Alpheus heterochaelis. Using tensile mechanical testing, we find orbital hoods are approximately half as stiff as carapace and have twice the capacity for viscous energy dissipation. Microstructural features probably contribute to tissue-specific mechanical properties: the endocuticles of orbital hoods have almost twice as many lamellae as those of carapaces despite being half as thick, suggesting a mechanism for enhanced material mobility underlying …


Discovery Of Horsfieldia Macrothyrsa Bioactives With Cytotoxic Effects On Breast Cancer Cells Through In Vitro And Docking Analyses, Megawati Megawati, Akhmad Darmawan, Agus Budiawan Naro Putra, Kartika Dyah Palupi, Marissa Angelina, Ahmad Randy, Siska Andrina Kusumastuti, Faris Hermawan, Sumi Hudiyono Feb 2026

Discovery Of Horsfieldia Macrothyrsa Bioactives With Cytotoxic Effects On Breast Cancer Cells Through In Vitro And Docking Analyses, Megawati Megawati, Akhmad Darmawan, Agus Budiawan Naro Putra, Kartika Dyah Palupi, Marissa Angelina, Ahmad Randy, Siska Andrina Kusumastuti, Faris Hermawan, Sumi Hudiyono

Karbala International Journal of Modern Science

This study investigated the phytochemical constituents and biological activities of Horsfieldia macrothyrsa leaves to identify their bioactive compounds. Methanol extracts were fractionated using n-hexane and ethyl acetate, followed by silica gel column chromatography with a stepwise polarity gradient. From 100 g of powdered leaves, three major    compounds were successfully isolated from the ethyl acetate fraction: 1-(2,4,6-trihydroxyphenyl)dodecan-1-one (1), sesamin (2), and β-sitosterol (3). Their chemical structures were confirmed using UV, IR, LC–MS/MS, and NMR  spectroscopy. Biological activities of the fractions and isolates were evaluated through DPPH antioxidant assays, α-glucosidase inhibition for antidiabetic activity, MTT …


Bull Shark (Carcharhinus Leucas) Jaw, Roman Devlin, Jade A. Mells, Rileigh Gonzalez, Nicholas D. Burchett, David W. Kerstetter Feb 2026

Bull Shark (Carcharhinus Leucas) Jaw, Roman Devlin, Jade A. Mells, Rileigh Gonzalez, Nicholas D. Burchett, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.


Assessing Climate Adaptation Among Canada Lynx (Lynx Canadensis) Populations At The Trailing Edge, Tanya Lama, Blair P. Bentley, Warren E. Johnson, Lisa M. Komoroske, Stephen Destefano, Jennifer Vashon, Kaela Beaulerc, Jason M. Kamilar, Giulio Formenti, Andrea Batista, Andrew G. Spencer, Olivier Fedrigo, Erich D. Jarvis, Jeff S. Bowman, Paul Wilson, John F. Organ Feb 2026

Assessing Climate Adaptation Among Canada Lynx (Lynx Canadensis) Populations At The Trailing Edge, Tanya Lama, Blair P. Bentley, Warren E. Johnson, Lisa M. Komoroske, Stephen Destefano, Jennifer Vashon, Kaela Beaulerc, Jason M. Kamilar, Giulio Formenti, Andrea Batista, Andrew G. Spencer, Olivier Fedrigo, Erich D. Jarvis, Jeff S. Bowman, Paul Wilson, John F. Organ

Biological Sciences: Faculty Publications

Species must acclimate, shift their distributions, or adapt in place in response to anthropogenic climate change. Populations at low-latitude trailing edges of species distributions typically experience thermal conditions closest to the upper limit of their thermoregulatory capacity. Landscape and functional genomic approaches provide quantitative measures of risk and adaptive capacity which can inform and prioritize conservation actions. Using low-coverage whole genomes from Canada lynx (Lynx canadensis), we characterized population genomic structure and identified putatively adaptive loci using genotype-environment association analyses across the eastern extent of their distribution. We detected genetic breaks across two previously identified biogeographical barriers, the St. Lawrence …


Intense Solar Radiation Constrains Plant Species Richness In Global Grasslands, Marie Spohn, Carlos Alberto Arnillas, Jonathan D. Bakker, Elizabeth T. Borer, Kari Anne Bråthen, Marc W. Cadotte, Erika I. Hersch-Green, Et Al. Feb 2026

Intense Solar Radiation Constrains Plant Species Richness In Global Grasslands, Marie Spohn, Carlos Alberto Arnillas, Jonathan D. Bakker, Elizabeth T. Borer, Kari Anne Bråthen, Marc W. Cadotte, Erika I. Hersch-Green, Et Al.

Michigan Tech Publications

The search for predictors of plant diversity has challenged scientists for decades. Here we identify intense photosynthetically active radiation (PAR) as a major factor constraining plant species richness in global grasslands. We show that the strength of the negative relationship between species richness and PAR increases with increasing elevation and that species richness is more strongly correlated with intense PAR than with UV-B radiation, climate variables, and atmospheric nitrogen deposition. In addition to species richness, plant biomass was also negatively correlated with PAR at higher elevations, indicating that intense PAR also constrains plant biomass in montane grasslands. Furthermore, we show …


Microplastic Contamination In Longfin Squid (Doryteuthis Pealeii) From The Florida Gulf Coast: Evidence Of Marine Based Pollution, Jordan Kleinschmidt Dilena Feb 2026

Microplastic Contamination In Longfin Squid (Doryteuthis Pealeii) From The Florida Gulf Coast: Evidence Of Marine Based Pollution, Jordan Kleinschmidt Dilena

USF Tampa Graduate Theses and Dissertations

Microplastic contamination is a pervasive global issue, yet its impact on ecologically significant cephalopod populations remains poorly understood. This study quantified microplastic prevalence and distribution in longfin squid (Doryteuthis pealeii), a key trophic link in the Gulf of Mexico. Following hydrogen peroxide digestion of digestive tract and mantle tissues, microplastics were isolated via vacuum filtration and characterized using microscopy. Fourier-transform infrared (FTIR) spectroscopy confirmed polymer identities. Microplastic contamination was exceptionally high, with 96.4% of individuals containing particles (mean = 36.6 ± 20.0 particles per individual, range = 0–94, n = 110 squid). From 4,072 total particles analyzed, fragments dominated (98.3%), …


New Host And Distributional Records For Helminth Parasites (Monogenoidea, Trematoda, Cestoda, Nematoda) Of Arkansas Reptiles (Testudines, Ophidia), C. T. Mcallister, C. R. Bursey, T. J. Fayton, S. E. Trauth, H. W. Robison Feb 2026

New Host And Distributional Records For Helminth Parasites (Monogenoidea, Trematoda, Cestoda, Nematoda) Of Arkansas Reptiles (Testudines, Ophidia), C. T. Mcallister, C. R. Bursey, T. J. Fayton, S. E. Trauth, H. W. Robison

Journal of the Arkansas Academy of Science

Over the last decade or more, our collaborative research has provided noteworthy information on the helminth parasites of reptiles of Arkansas. Because several species still need to be surveyed from the state, some for the first time, there has been a general void of information on their parasites. We therefore examined 10 reptiles, including seven species/subspecies of turtles, as well as three species/subspecies of snakes for helminth parasites. Found were 24 taxa of parasites, including two monogeneans, 14 digeneans, one tapeworm, and seven nematodes. We document several new host and distributional records for these parasites from some reptiles of the …


Gene Regulatory Programs Of Nk Cells Show That Ncam1 (Cd56) And Kirs Are Controlled By Genetically Polymorphic Distal Regulatory Elements, Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma, Caprice D. Eisele, Nitin Chakravarti, Dean A. Lee, Aharon G. Freud, Bethany L. Mundy-Bosse, Patrick L. Collins Feb 2026

Gene Regulatory Programs Of Nk Cells Show That Ncam1 (Cd56) And Kirs Are Controlled By Genetically Polymorphic Distal Regulatory Elements, Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma, Caprice D. Eisele, Nitin Chakravarti, Dean A. Lee, Aharon G. Freud, Bethany L. Mundy-Bosse, Patrick L. Collins

Kimmel Cancer Center Faculty Papers

Owing to their immunoprotective properties, natural killer (NK) cells are critical for the innate immune response to pathogens, as well as a new wave of cancer immunotherapy that harnesses natural cytotoxicity. We sought to study the genetic and epigenetic drivers behind human-specific NK cell receptors, so that we can better understand the underlying cellular function. Here, we present a transcriptomic, proteomic (CITE-seq), and chromatin (single nuclei ATAC-seq) profiling of human peripheral NK cell subsets, which was then compared with genomic databases. Through integrative multi-omics, we demonstrate that CD56bright versus CD56dim NK cell subsets have differential distal regulatory element …


Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment For Solid Tumors, Stephen O'Rourke, Nuo Xu, Hongjun Wang, Hexin Chen Feb 2026

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment For Solid Tumors, Stephen O'Rourke, Nuo Xu, Hongjun Wang, Hexin Chen

Faculty Publications

The emergence of effective immunotherapies has drastically revolutionized clinical management of many cancer types. Among them, chimeric antigen receptor (CAR)-T cell therapy (CTT), as a groundbreaking approach, has been considered as a “living drug,” displaying unprecedented clinical outcomes with hematological malignancies, including B cell leukemia and lymphomas, and multiple myeloma. Despite the high remission rates and improved survival achieved with hematological cancers, the effectiveness of CTT in solid tumors remains largely unsatisfactory. The efficacy of CTT in solid tumors is significantly challenged by multiple factors, including tumor-antigen heterogeneity, limited T cell trafficking and infiltration, a highly immunosuppressive tumor microenvironment, and …


How To Measure, Analyze, And Interpret Age-Related Changes In Caenorhabditis Elegans: Lessons For Mechanistic And Evolutionary Theories Of Aging, Zuzana Kocsisova, Brian M. Egan, Andrea Scharf, Xavier Anderson, Franziska Pohl, Aaron Anderson, Kerry Kornfeld Feb 2026

How To Measure, Analyze, And Interpret Age-Related Changes In Caenorhabditis Elegans: Lessons For Mechanistic And Evolutionary Theories Of Aging, Zuzana Kocsisova, Brian M. Egan, Andrea Scharf, Xavier Anderson, Franziska Pohl, Aaron Anderson, Kerry Kornfeld

Biological Sciences Faculty Research & Creative Works

Aging is characterized by progressive degenerative changes in tissue organization and function, some of which increase the probability of mortality. Major goals of aging research are to elucidate the series of events that cause degenerative changes, and to identify environmental, pharmacological, and genetic factors that influence these changes; this information might lead to new strategies to extend health span and lifespan. Mechanistic studies of aging depend on accurate and precise descriptions of age-related changes, since these descriptions define the aging phenotype. Here, we review studies that describe age-related changes in C. elegans, including measurements of integrated functions such as behavior …


American Kestrel Population Trends And Vital Rates At The Continental Scale, Paige E. Howell, Abigail J. Lawson, Kristin P. Davis, Guthrie S. Zimmerman, Orin J. Robinson, Matthew A. Boggie, Mitchell J. Eaton, Fitsum Abadi, Jessi L. Brown, Julie A. Heath, John A. Smallwood, Karen Steenhof, Ted Swem, Brian W. Rolek, Christopher J.W. Mcclure, Jean Francois Therrien, Karl E. Miller, Brian A. Millsap Feb 2026

American Kestrel Population Trends And Vital Rates At The Continental Scale, Paige E. Howell, Abigail J. Lawson, Kristin P. Davis, Guthrie S. Zimmerman, Orin J. Robinson, Matthew A. Boggie, Mitchell J. Eaton, Fitsum Abadi, Jessi L. Brown, Julie A. Heath, John A. Smallwood, Karen Steenhof, Ted Swem, Brian W. Rolek, Christopher J.W. Mcclure, Jean Francois Therrien, Karl E. Miller, Brian A. Millsap

Department of Biology Faculty Scholarship and Creative Works

The American kestrel (Falco sparverius, hereafter referred to as kestrel) has declined across much of its North American range since at least the mid-1960s. Kestrel population dynamics have been explored through a multitude of local studies and two broad reviews of available data. Across large geographic extents, however, the demographic cause(s) of kestrel population declines remain(s) largely unknown. As part of a collaborative effort to elucidate the drivers of kestrel population declines, we developed a continental-scale integrated population model using band-recovery data, productivity data, and Breeding Bird Survey indices from 1986 to 2019 to estimate indices of annual population sizes, …


Genomic Comparisons And The Adaptive Basis Of Brain Size Plasticity And Chromosomal Instability In The Eurasian Common Shrew, William R. Thomas, Tanya M. Lama, Cecilia Baldoni, Laia Marín-Gual, Diana Moreno Santillán, Marta Farré, Linelle Abueg, Jennifer Balacco, Olivier Fedrigo, Giulio Formenti, Nivesh Jain, Jacquelyn Mountcastle, Tatiana Tilley, Ying Sims, Alan Tracey, Jo Wood, David A. Ray, Dominik Von Elverfeldt, John Nieland, Angelique P. Corthals, Aurora Ruiz-Herrera, Dina K.N. Dechmann, Erich Jarvis, Liliana M. Dávalos Feb 2026

Genomic Comparisons And The Adaptive Basis Of Brain Size Plasticity And Chromosomal Instability In The Eurasian Common Shrew, William R. Thomas, Tanya M. Lama, Cecilia Baldoni, Laia Marín-Gual, Diana Moreno Santillán, Marta Farré, Linelle Abueg, Jennifer Balacco, Olivier Fedrigo, Giulio Formenti, Nivesh Jain, Jacquelyn Mountcastle, Tatiana Tilley, Ying Sims, Alan Tracey, Jo Wood, David A. Ray, Dominik Von Elverfeldt, John Nieland, Angelique P. Corthals, Aurora Ruiz-Herrera, Dina K.N. Dechmann, Erich Jarvis, Liliana M. Dávalos

Biological Sciences: Faculty Publications

Sorex araneus, the Eurasian common shrew, has seasonal brain size plasticity (Dehnel's phenomenon) and many intraspecific chromosomal rearrangements. Genomic contributions to these traits, however, remain unknown. We couple a chromosome-scale genome assembly with seasonal brain transcriptomes to discover relationships between molecular evolution and both traits. While Positively Selected Genes (PSGs) enriched the Fanconi anemia DNA repair pathway (FANCI, FAAP100), which is likely involved in chromosomal rearrangements by preventing the accumulation of chromosomal aberrations, genes under positive selection or showing seasonal differential expression in the brain implicate neurogenesis (PCDHA6, SOX9, Notch signaling) and metabolic regulation (VEGFA, SPHK2) as key mechanisms underlying …


Human Body Temperature Cues Widespread Changes In Virulence Gene Expression In Uropathogenic Escherichia Coli, Carolyn A. Dehner, Isidora N. Stankovic, Madeleine Sutherland, Lou Ann Bierwert, Stylianos P. Scordilis, Daniel M. Stoebel, Christine A. White-Ziegler Feb 2026

Human Body Temperature Cues Widespread Changes In Virulence Gene Expression In Uropathogenic Escherichia Coli, Carolyn A. Dehner, Isidora N. Stankovic, Madeleine Sutherland, Lou Ann Bierwert, Stylianos P. Scordilis, Daniel M. Stoebel, Christine A. White-Ziegler

Biological Sciences: Faculty Publications

As a bacterial pathogen enters a human host, it immediately encounters a temperature upshift to 37°C. Mimicking the early hours of infection, we analyzed the transcriptome and proteome of uropathogenic Escherichia coli CFT073 initially grown at 23°C, then shifted to 37°C for 4 h. Temperature caused a change in mRNA expression for 9% of the genome (1% false discovery rate, ≥2-fold); similar impacts were observed for the proteome with a good concordance amongst the most highly temperature-regulated genes. Comparison to E. coli K-12 MC4100 shows temperature to be a more broadly used regulatory cue in the uropathogen. Multiple operons associated …


Humanity Is Evolving Its Consciousness: The Role Of Archetypal Energies As Guides During An Unfolding Weeding Out And Alignment Process, Carroy U. Ferguson Jan 2026

Humanity Is Evolving Its Consciousness: The Role Of Archetypal Energies As Guides During An Unfolding Weeding Out And Alignment Process, Carroy U. Ferguson

Psychology Faculty Publication Series

Humanity is evolving its consciousness at individual and collective levels.  Given these seemingly tumultuous times, as of this writing (January 2026), to make such a statement may sound like a strange thing to say.  However, I suggest that if you are alive today and if you are reading these words, these are the very times for which you were born—to assist Humanity as it evolves its consciousness with your unique gifts, whatever they may be.  That is, this period of our individual and collective human being-ness may be characterized as an unfolding period of weeding out and alignment with the …


A Simple And Affordable Protocol To Assess Censer Seed Dispersal: First Confirmation Of The Mechanism In The Genus Solanum, Abigail J. Motter, Christopher T. Martine, Melody P. Sain Jan 2026

A Simple And Affordable Protocol To Assess Censer Seed Dispersal: First Confirmation Of The Mechanism In The Genus Solanum, Abigail J. Motter, Christopher T. Martine, Melody P. Sain

Faculty Journal Articles

The censer seed dispersal mechanism, whereby mature fruits are retained on plants and seeds dispersed by mechanical shaking, is among the most specialized wind-aided seed dispersal strategies employed by the flowering plants. An efficient, affordable, and easily repeatable protocol for determining whether a species uses this unusual mechanism of seed dispersal is lacking. Our focal species, Solanum tudununggae, is one of just two Solanum species (in a fleshy-fruited genus of ca. 1200 species) hypothesized to use this dispersal mechanism as a means to move seeds farther from parent plants than would gravity alone.


Community Synchrony In Aquatic Macroinvertebrates Is Unrelated To Environmental Variability But Differs Among Functional Feeding Groups, Anthony J. Pignatelli, Tad Dallas Jan 2026

Community Synchrony In Aquatic Macroinvertebrates Is Unrelated To Environmental Variability But Differs Among Functional Feeding Groups, Anthony J. Pignatelli, Tad Dallas

Faculty Publications

Environments are becoming increasingly more variable, as a function of climate change. As this occurs, species may be exposed to conditions outside their preferred range. Such variability in the environment can influence community abundance as individual species respond either similarly (synchronous dynamics) or differently (asynchronous dynamics) to each other. These fluctuations in abundances are important for understanding the impact of environmental variability on species temporal fluctuations in aquatic macroinvertebrates. This group of organisms is species-rich and highly sensitive to environmental fluctuations. We analyzed 18 stream macroinvertebrate communities sampled by the National Ecological Observatory Network between 2014 and2022 to understand how …


Development Of Human Trophoblast Cell Surface Antigen-2 (Trop-2) Specific Radiopharmaceutical Tracers, Arnav Vipulkumar Patel Jan 2026

Development Of Human Trophoblast Cell Surface Antigen-2 (Trop-2) Specific Radiopharmaceutical Tracers, Arnav Vipulkumar Patel

ETDs from 2020-2029

Trophoblast cell surface antigen 2 (Trop2) is closely related to the development and progression of triple-negative breast cancers (TNBC) and is also being investigated as a pan-cancer biomarker. Trop-2 tumorigenesis is mediated by the calcium ion signaling pathways. By accurately predicting and targeting Trop-2 for immunotherapy, precision therapy is crucial. Trop-2 is overexpressed in tumor tissues compared to normal tissues, which makes it a promising molecular target for cancer-targeted therapy. This thesis reports the development and preclinical evaluation of two novel Trop-2-specific radiopharmaceutical tracers derived from the clinically approved antibody-drug conjugate Sacituzumab Govitecan (SG): a full antibody drug conjugate-based tracer …


Modulation Of The Cgas-Sting Inflammation Pathway In Mouse Models Of Accelerated And Slowed Aging, Benjamin David Heckman Jan 2026

Modulation Of The Cgas-Sting Inflammation Pathway In Mouse Models Of Accelerated And Slowed Aging, Benjamin David Heckman

ETDs from 2020-2029

Chronic sterile inflammation (inflammaging) is a core pillar of aging, and the cGAS-STING innate immune pathway has emerged as a key driver of this process. However, how this pathway intersects with systemic endocrine signaling remains poorly understood. Here, we investigated the intersection of endocrine signaling and cGAS-STING activation using two complementary mouse models with opposing lifespan phenotypes: a short-lived, liver-specific glucagon receptor knockout (LKO) mouse and a long-lived growth hormone-releasing hormone knockout (GHRH-KO) mouse. We demonstrate that despite presenting with a metabolically healthy phenotype, female LKO mice exhibited a significantly reduced lifespan. We link this premature mortality to a sex …


Reproductive System Variation In Tropical Red Macroalgae, Taylor M. Williams Jan 2026

Reproductive System Variation In Tropical Red Macroalgae, Taylor M. Williams

ETDs from 2020-2029

The reproductive system encompasses the relative rates of sexual versus clonal reproduction and is responsible for partitioning genetic diversity within and among populations. However, the quantification of these rates remains limited in natural populations and has primarily focused on animals and angiosperms. This knowledge gap is particularly acute among tropical macroalgae. This dissertation addresses this by focusing on the cryptogenic invader Chondria tumulosa in the Papahānaumokuākea Marine National Monument and the invasive species Acanthophora spicifera across the Hawaiian Archipelago, Australia, and Guam. For Chondria we developed nine microsatellite loci and found a dominance of tetrasporophytes, high clonal rates, and strong …


Coexisting Salps Exhibit Distinct Feeding Selectivity On Microorganisms In The North Pacific Subtropical Gyre, Anne W. Thompson, Kylee Lamberson, Kelly R. Sutherland Jan 2026

Coexisting Salps Exhibit Distinct Feeding Selectivity On Microorganisms In The North Pacific Subtropical Gyre, Anne W. Thompson, Kylee Lamberson, Kelly R. Sutherland

Biology Faculty Publications and Presentations

Mortality mechanisms play an important role in how oceanic microorganisms contribute to global biogeochemical cycles. Salps are widespread pelagic tunicates known to remove phytoplankton from coastal and high-latitude waters, but their interaction with microorganisms in the vast tropical and subtropical gyres is not well quantified. Using quantitative measurements of six major marine microorganisms in the guts of six distinct but co-occurring salp species from the North Pacific Subtropical Gyre, we examined the impact and dynamics of salp feeding on marine microorganisms in a vast open ocean region. All salps preferentially removed prey greater than 1 μm in diameter, including marine …


The Global Extent Of The Grassland Biome And Implications For The Terrestrial Carbon Sink, A S. Macdougall, B Vanzant, J Sulik, S Bagchi, D Naidu, T O. Muraina, E. Hersch-Green Jan 2026

The Global Extent Of The Grassland Biome And Implications For The Terrestrial Carbon Sink, A S. Macdougall, B Vanzant, J Sulik, S Bagchi, D Naidu, T O. Muraina, E. Hersch-Green

Michigan Tech Publications

Land cover data are commonly used to model the terrestrial carbon (C) sink, yet these data have wide margins of error that significantly alter estimates of global C storage. Here we demonstrate this data vulnerability in grasslands, which are critical to C cycling but whose estimated distribution has varied by >50 million km (3.5-42% of the Earth's terrestrial surface). Comparing multiple high-resolution land cover products with expertly annotated grassland data from six continents, we show sources of mapping error and discuss C implications based on 2023 United Nations (UN) FAO estimates. Past misidentification arose from inconsistent definitions on grassland identity …


Weather Conditions Associated With Citrus Canker Incidence Caused By Aw Strain In The Lower Rio Grande Valley Of South Texas, Amit Sharma, Teresa Patricia Feria-Arroyo, George Yanev, Madhurababu Kunta Jan 2026

Weather Conditions Associated With Citrus Canker Incidence Caused By Aw Strain In The Lower Rio Grande Valley Of South Texas, Amit Sharma, Teresa Patricia Feria-Arroyo, George Yanev, Madhurababu Kunta

School of Integrative Biological & Chemical Sciences Faculty Publications

Citrus canker, caused by bacterium Xanthomonas citri subsp. citri (Xcc), affects the citrus industry by making the fruit unmarketable due to unsightly lesions on the fruit. Citrus canker caused by a relatively new AWstrain of Xcc was reported on the citrus trees in the residential areas of the Lower Rio Grande Valley (LRGV) of South Texas. Xcc AW has a limited host range, predominantly affecting limes and a few other citrus species. Previous work has reported prevailing environmental conditions that influence the incidence and spread of the citrus canker caused by the Asiatic A strain. However, no information is available …


The Interactive Relationship Between Fusobacterium Necrophorum, Bacteroides Pyogenes, And Porphyromonas Levii In Driving Inflammatory Uterine Disease, Dianjun Cao, Mehwish Ammad, Bindu Subhadra, Mrunmaya Kumar Panda, Thomas J. Inzana, Federico Cunha, Segundo Casaro, Kristi L. Jones, Rosabel Ramirez-Hernandez, John J. Bromfield, Klibs N. A. Galvão, Soo Jin Jeon Jan 2026

The Interactive Relationship Between Fusobacterium Necrophorum, Bacteroides Pyogenes, And Porphyromonas Levii In Driving Inflammatory Uterine Disease, Dianjun Cao, Mehwish Ammad, Bindu Subhadra, Mrunmaya Kumar Panda, Thomas J. Inzana, Federico Cunha, Segundo Casaro, Kristi L. Jones, Rosabel Ramirez-Hernandez, John J. Bromfield, Klibs N. A. Galvão, Soo Jin Jeon

Faculty Publications - Biological Sciences

Background

Bovine metritis is associated with uterine microbiota dysbiosis, characterized by the proliferation of Gram-negative anaerobes, including Fusobacterium necrophorum, Bacteroides pyogenes, and Porphyromonas levii. However, the mechanisms by which these opportunistic pathogens proliferate together and contribute to disease remain unclear. This study aimed to identify the interactions among these bacteria and to elucidate their role in the development of metritis.

Methods

F. necrophorum, B. pyogenes, and P. levii were isolated from the uteri of cows with metritis and cultured anaerobically in chopped meat carbohydrate broth. Bacterial growth, coaggregation, biofilm formation, endotoxin production, protease activity, adhesion to bovine endometrial epithelial (BEND) …


Longfin Mako (Isurus Paucus) Jaw, Nicholas D. Burchett, David W. Kerstetter Jan 2026

Longfin Mako (Isurus Paucus) Jaw, Nicholas D. Burchett, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.


Male Great Hammerhead (Sphyrna Mokarran) Chondrocranium, Michelle W. Bassali, Nicholas D. Burchett, Samuel Escobar, Preston Rice, David W. Kerstetter Jan 2026

Male Great Hammerhead (Sphyrna Mokarran) Chondrocranium, Michelle W. Bassali, Nicholas D. Burchett, Samuel Escobar, Preston Rice, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Male ~10ft Great Hammerhead (Sphyrna mokarran) Chondrocranium