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Articles 601 - 630 of 39060

Full-Text Articles in Biology

Improving Entry-Level Athletic Training Student Confidence In Emergency Care: A Pilot Study, Michele Pye, Cade Watts, John Hunt, Kimberly Pritchard Mar 2026

Improving Entry-Level Athletic Training Student Confidence In Emergency Care: A Pilot Study, Michele Pye, Cade Watts, John Hunt, Kimberly Pritchard

Clinical Practice in Athletic Training

Introduction: Immediate and emergency care is essential to athletic training education and clinical practice. Athletic training students (ATS) may have limited exposure to emergencies during their clinical experiences, which can undermine their confidence. AT educators can improve ATS confidence and clinical reasoning using a simulation-based, learner-centered SNAPPS approach. SNAPPS consists of Summarizing the history and findings, Narrowing and Analyzing the differential diagnoses, Probing peers about uncertainties or confusion, Planning management, and Selecting case-related knowledge gaps for self-directed learning. This empowers students to control the learning environment while adding realism to encounters. The purpose of this pilot study was to determine …

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Recurrent Lateral Patellar Dislocation After Mpfl Repair With Subsequent Tibial Tubercle Anteromedialization And Concomiant Mpfl Reconstruction, Jacob Hardy, Anthony Thomas Drazick, Joshua Pratt, Jeremy M. Burnham Mar 2026

Recurrent Lateral Patellar Dislocation After Mpfl Repair With Subsequent Tibial Tubercle Anteromedialization And Concomiant Mpfl Reconstruction, Jacob Hardy, Anthony Thomas Drazick, Joshua Pratt, Jeremy M. Burnham

Clinical Practice in Athletic Training

Introduction: Patellar instability is a common knee pathology, particularly among adolescents and young adults, with reported incidence rates ranging from 7 to 77 per 100,000 person-years. Following an initial patellar dislocation, recurrence rates have been reported as high as 86%, particularly in patients with underlying anatomic risk factors. Identification of the multifactorial contributors to patellar instability is critical to guide appropriate management and prevent recurrent episodes. Common pathoanatomic factors associated with recurrent instability include trochlear dysplasia, patella alta, lateralized tibial tubercle, coronal or torsional malalignment, and abnormal patellar shift. This case report describes a patient who presented with a chronic …

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Comparative Antibacterial Efficacy Of Povidone-Iodine, Citric Acid, And Starch: A Study Of Combined Activity And Interference Effects Against Clinically Relevant Bacteria, Falah Hasan Obayes Al-Khikani, Mustafa Mutar Trrad, Ali Abedulameer Alhusayni Mar 2026

Comparative Antibacterial Efficacy Of Povidone-Iodine, Citric Acid, And Starch: A Study Of Combined Activity And Interference Effects Against Clinically Relevant Bacteria, Falah Hasan Obayes Al-Khikani, Mustafa Mutar Trrad, Ali Abedulameer Alhusayni

AUIQ Complementary Biological System

Povidone-iodine and citric acid are widely used antimicrobial agents. However, data on their comparative efficacy and the functional outcomes of their combination, particularly regarding the influence of common excipients like starch, is limited. Understanding these interactions is crucial for optimizing antiseptic formulations. This study aimed to evaluate and compare the antibacterial activity of povidone-iodine, citric acid (5% and 20%), and starch (5% and 20%), both individually and in combination, against clinical isolates of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The antibacterial activity of the agents was assessed using an agar well diffusion assay. Mean inhibition zone …

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Unpacking Drivers Of Heterotrophic N2 Fixation Across Aquatic Redox Gradients: A Mathematical Model With Bioenergetic And Stoichiometric Constraints, Corday R. Selden, Rebecca A. Everett, Halvor M. Halvorson, Megan Berberich, Luca Schenone, Angela Peace, Renn Schipper, Edwin Cruz-Rivera, James Powell, Keisuke Inomura, Robinson W. Fulweiler, Amy Marcarelli, J. Thad Scott Mar 2026

Unpacking Drivers Of Heterotrophic N2 Fixation Across Aquatic Redox Gradients: A Mathematical Model With Bioenergetic And Stoichiometric Constraints, Corday R. Selden, Rebecca A. Everett, Halvor M. Halvorson, Megan Berberich, Luca Schenone, Angela Peace, Renn Schipper, Edwin Cruz-Rivera, James Powell, Keisuke Inomura, Robinson W. Fulweiler, Amy Marcarelli, J. Thad Scott

Michigan Tech Publications

N2 fixation by aquatic organoheterotrophs supplies bioavailable nitrogen to the biosphere and thereby supports ecosystem production; yet the factors which drive this activity are poorly understood. Here, we present a generalized chemostat model to investigate stoichiometric and energetic constraints on free-living heterotrophic diazotrophs across gradients in redox state, resource quantity/quality, and resource stoichiometry. The model couples nutrient uptake and allocation functions to predict elemental fluxes with an energy dissipation model to calculate growth efficiency. After constraining model parameters with relevant culturing (e.g., Azotobacter) and environmental literature, we assessed model sensitivity to these parameters using Latin Hypercube Sampling and the statistical …

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Assessment Of Aluminum-Based Drinking Water Treatment Residuals From Multiple Utilities In The United States As Green Sorbents For Pfas, Parisa Javidan, Roxana Rahmati, Zhiming Zhang, Anshuman Satpathy, Steven Larson, Rupali Datta, Dibyendu Sarkar Mar 2026

Assessment Of Aluminum-Based Drinking Water Treatment Residuals From Multiple Utilities In The United States As Green Sorbents For Pfas, Parisa Javidan, Roxana Rahmati, Zhiming Zhang, Anshuman Satpathy, Steven Larson, Rupali Datta, Dibyendu Sarkar

Michigan Tech Publications

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants causing human health concerns. In this study, five aluminum-based drinking water treatment residuals (Al-WTRs) were evaluated as green adsorbents for the removal of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) from water. Al-WTRs are nonhazardous solid wastes generated during the coagulation process of water treatment using aluminum salts or polymers. Although high PFAS adsorption capacity of Al-WTRs generated in one facility in the US has been reported, no study exists assessing PFAS adsorption capabilities of WTRs generated in multiple facilities using various types of aluminum coagulants. Batch adsorption experiments of PFOA …

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Stemflow Dynamics In The Jamari National Forest (Brazilian Amazon): Ii. Solute Concentrations And Flux Dynamics, Jeferson Alberto De Lima, John T. Van Stan Ii, Karolina Lewińska, Agnieszka Dradrach, Jakub Ceglarek, Kelly Cristina Tonello Mar 2026

Stemflow Dynamics In The Jamari National Forest (Brazilian Amazon): Ii. Solute Concentrations And Flux Dynamics, Jeferson Alberto De Lima, John T. Van Stan Ii, Karolina Lewińska, Agnieszka Dradrach, Jakub Ceglarek, Kelly Cristina Tonello

Biological, Geological, and Environmental Faculty Publications

Trees can redirect large volumes of rainwater to the base of their stems. This stemflow not only redistributes water but also channels canopy-derived solutes to the forest floor. Building on research showing canopy geometry and bark properties govern stemflow volumes, we examined how those same traits modulate the biogeochemical side of this flux. Over a 12-month period in Jamari National Forest (Brazil), we quantified stemflow volume and solute chemistry for 19 trees grouped by diameter at breast height (D: < 10, 10-20 and > 20 cm), crown area (CA: < 30, 30-60 and > 60 m(2)) and bark texture (smooth, fissured and rough). Small-stemmed, smooth-barked trees produced the greatest stemflow …

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Alfred Russel Wallace Notes 39. What About Wallace's 'Agnosticism'...?, Charles H. Smith Mar 2026

Alfred Russel Wallace Notes 39. What About Wallace's 'Agnosticism'...?, Charles H. Smith

Faculty/Staff Personal Papers

Alfred Russel Wallace (1823−1913) seems to have distinguished his earlier years of agnosticism from his later period as a spiritualist, but a closer look at the situation suggests he actually remained an agnostic all the way through to the end of his life. The confusion is occasioned by a lack of terminology that can be applied to his position, which most closely resembles a Spinozian manner of thinking.

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Differential Effects Of Neighborhood Ambient Pm2.5 Exposure And Social Vulnerability On Cancer-Related Systemic Inflammation By Race In A Large Health Care System Population From 2000 To 2020, Benjamin A. Rybicki, Zihan Lin, Amber L. Pearson Mar 2026

Differential Effects Of Neighborhood Ambient Pm2.5 Exposure And Social Vulnerability On Cancer-Related Systemic Inflammation By Race In A Large Health Care System Population From 2000 To 2020, Benjamin A. Rybicki, Zihan Lin, Amber L. Pearson

Biological, Geological, and Environmental Faculty Publications

BackgroundThe environment can impact cancer risk both directly, such as through the air we breathe, and indirectly, through the neighborhoods we live in. These risk factors often work in concert but can have disparate effects.MethodsTo understand how air pollution, as measured by ambient particulate matter 2.5 (PM2.5) levels and neighborhood disadvantage based on a geographically assigned social vulnerability index (SVI), may act together to impact cancer risk, we used 2000-2020 statewide cohort data from a large health system based in metropolitan Detroit, MI, USA (n = 245,438). Systemic inflammation was used as a surrogate indicator of cancer risk among study …

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College Of Natural Sciences 2025 Year-End Publication, College Of Natural Sciences Mar 2026

College Of Natural Sciences 2025 Year-End Publication, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 2 Dean's Message 
Page 3 Department Highlights 
Page 4 One Day for State 
Page 5 Ice cores reveal volcanic eruptions in 13th century 
Page 5 How do our cells interpret stress 
Page 6-7 Faculty Excellence
Page 8 New chemical biology consortium will accelerate cancer research
Page 9 SDSU to combat crop disease, biofilms in new NSF-back project 
Page 9 Science as Art Competition 
Page 10-11 Student Excellence  
Page 12 SDSU researcher developing natural alternative to synthetic dyes
Page 12 Browning Retired
Page 13 Quantum technologies through NSF-backed project
Page 13 NASA Funds CNS Development of Model
Page 14 GGS …

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Fisheries Occasional Publication No. 150 - Response To 2024 External Review Of Integrated Stock Assessments For Key Wa Demersal Indicator Stocks, Rubie Evans-Powell, S. A. Hesp, Ainslie Denham, Emily A. Fisher, Rachel Marks, Fabian I. Trinnie, Brett Crisafulli Mar 2026

Fisheries Occasional Publication No. 150 - Response To 2024 External Review Of Integrated Stock Assessments For Key Wa Demersal Indicator Stocks, Rubie Evans-Powell, S. A. Hesp, Ainslie Denham, Emily A. Fisher, Rachel Marks, Fabian I. Trinnie, Brett Crisafulli

Fisheries Occasional Publications

In Western Australia (WA), stock assessments for key demersal species, including snapper and red emperor, have traditionally used bespoke integrated models developed in-house by the Department of Primary Industries and Regional Development (DPIRD). In line with other Australian jurisdictions, DPIRD is transitioning to Stock Synthesis (SS) as its primary platform for integrated stock assessments of WA finfish. To support this transition, DPIRD commissioned an independent expert review of recent integrated models applied to three demersal stocks. This publication responds to recommendations from Professor André Punt (University of Washington and CSIRO) in his 2024 review, which examined assessments for Pilbara red …

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Dna Barcoding And Metabarcoding Reveal Labeling Accuracy And Species Substitution In Squid And Surimi From Los Angeles Markets, Demian A. Willette, Margarita L. Joaquin Mar 2026

Dna Barcoding And Metabarcoding Reveal Labeling Accuracy And Species Substitution In Squid And Surimi From Los Angeles Markets, Demian A. Willette, Margarita L. Joaquin

Biology Faculty Works

Accurate species identification of seafood remains a persistent challenge in local and global marketplaces. This is particularly true for processed products that obscure diagnostic features. Here, we conduct a dual-molecular investigation into frozen squid and imitation crab products sold at American, Asian, and Hispanic grocery stores in Los Angeles, California, to assess label integrity under current U.S. Food & Drug Administration (FDA) guidance. Forty-eight squid samples from 13 retailers underwent DNA barcoding and yielded high percentage matches to 10 species across six genera. Despite broad labeling as ‘squid’, all samples matched FDA Acceptable Market Names with a 0 % mislabeling …

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Demography And Dispersal Influence The Relationship Between Habitat Suitability And Population Density, Cleber Ten Caten, Tad Dallas Mar 2026

Demography And Dispersal Influence The Relationship Between Habitat Suitability And Population Density, Cleber Ten Caten, Tad Dallas

Faculty Publications

A central goal of ecology is to understand spatial patterns of species densities. Habitat suitability estimates from species distribution models (SDMs) could be used to represent species density and overcome the scarcity of density data. However, there is mixed evidence that habitat suitability is a reliable descriptor of density, and it is suggested that local dynamics affect the relationship between habitat suitability and density. We simulated population dynamics for 200 virtual species considering different combinations of factors (demographic stochasticity, dispersal, and intraspecific competition) that affect population sizes and SDMs were trained using different sets of environmental predictors to evaluate when …

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Trophic Structure And Mercury Bioaccumulation In Walleye And Yellow Perch In The Upper And Lower Red Lake Basins, Marissa Pribyl Mar 2026

Trophic Structure And Mercury Bioaccumulation In Walleye And Yellow Perch In The Upper And Lower Red Lake Basins, Marissa Pribyl

Biology Graduate Theses

Mercury is a persistent global contaminant that biomagnifies through aquatic food webs, with dietary and environmental factors serving as the primary drivers of accumulation in fishes. Trophic structure and methylmercury dynamics in Walleye (ogaa; Sander vitreus) and Yellow Perch (asaawens; Perca flavescens) were investigated in the Upper and Lower Red Lake basins in Red Lake, Minnesota, during 2024-2025. Diets of Walleye and Yellow Perch were assessed through stomach dissections, and tissue samples from both species were analyzed for total mercury concentrations. Additional analyses included shiners (gigoozens; Notropis spp., Hudsonius spp.) along with a variety of freshwater fish and …

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Evolutionary Conservation Of Midline Axon Guidance Activity Between Drosophila And Tribolium Frazzled, Piyasi Ghosh, Benjamin C. Wadsworth, Logan Terry, Timothy A. Evans Mar 2026

Evolutionary Conservation Of Midline Axon Guidance Activity Between Drosophila And Tribolium Frazzled, Piyasi Ghosh, Benjamin C. Wadsworth, Logan Terry, Timothy A. Evans

Biological Sciences Faculty Publications and Presentations

The regulation of midline crossing of axons is of fundamental importance for the proper development of nervous system connectivity in bilaterian animals. A number of conserved axon guidance signaling pathways coordinate to attract or repel axons at the nervous system midline to ensure the proper regulation of midline crossing. The attractive Netrin-Frazzled/DCC (Net-Fra) signaling pathway is widely conserved among bilaterians, but it is not clear whether the mechanisms by which Net and Fra promote midline crossing are also conserved. In Drosophila, Fra can promote midline crossing via Netrin-dependent and Netrin-independent mechanisms, by acting as a canonical midline attractive receptor and …

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Atlantic Sharpnose (Rhizoprionodon Terraenovae) Chondocranium, Morgan Indyk, Sarah Hendricks, David W. Kerstetter Feb 2026

Atlantic Sharpnose (Rhizoprionodon Terraenovae) Chondocranium, Morgan Indyk, Sarah Hendricks, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

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Paternal Effects Without Paternity? Testing Non-Genetic Male Influence On Offspring Size And Brood Size In A Gynogenetic Vertebrate, The Amazon Molly (Poecilia Formosa), Ulrike Scherer, Sean Ehlman, David Bierbach, Jens Krause, Max Wolf Feb 2026

Paternal Effects Without Paternity? Testing Non-Genetic Male Influence On Offspring Size And Brood Size In A Gynogenetic Vertebrate, The Amazon Molly (Poecilia Formosa), Ulrike Scherer, Sean Ehlman, David Bierbach, Jens Krause, Max Wolf

Faculty Publications

Paternal effects, i.e., effects of fathers on the phenotype of their offspring that are not mediated by the transmission of alleles, are increasingly recognized as a potentially significant source of phenotypic variation across taxa – even in the absence of paternal care. Gynogenetic systems, which rely on sperm to trigger embryogenesis without incorporating male genetic material, provide a powerful way to experimentally isolate paternal effects from effects caused by the integration of male genetic material. Up to now, however, paternal effects remain largely unexplored in these systems. Here, we tested for non-genetic paternal effects in the gynogenetic Amazon molly ( …

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How Can We Protect Utah Vineyards From Insect Pests And Diseases?, Josh Westhora Feb 2026

How Can We Protect Utah Vineyards From Insect Pests And Diseases?, Josh Westhora

Research on Capitol Hill

The Utah Plant Pest Diagnostics Lab (UPPDL) at USU conducts surveys of Utah vineyards for plant diseases and insect pests affecting production to notify growers of their presence. Last year’s survey was conducted without funding to provide immediate support to growers. Funding for this year’s has been requested through the USDA APHIS PPQ PPA 7721 program.

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Ant Queens Divide Tasks Among Themselves To Maximize Efficiency In Multi-Queen Colonies, Ian Brush Feb 2026

Ant Queens Divide Tasks Among Themselves To Maximize Efficiency In Multi-Queen Colonies, Ian Brush

Research on Capitol Hill

Before workers arrive, founding queens must sustain the colony on their own. In single-queen colonies, one queen performs all necessary tasks. In contrast, when several queens co-found a colony, their contributions often differ: some queens invest more in egg-laying, while others devote more effort to brood care or nest maintenance.

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We Can Use Coyotes As A Model To Understand How Social Loss Alters The Brain, Rebekah Rowe Feb 2026

We Can Use Coyotes As A Model To Understand How Social Loss Alters The Brain, Rebekah Rowe

Research on Capitol Hill

While we understand some factors that increase psychological distress for grieving individuals, little is known about this biological basis.

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Ovarian Transplants Drastically Improved The Health Of Post-Menopausal Mice, Nathan Mccoy Feb 2026

Ovarian Transplants Drastically Improved The Health Of Post-Menopausal Mice, Nathan Mccoy

Research on Capitol Hill

Women generally experience health advantages compared to men before menopause. Following menopause, this advantage diminishes, and women become more susceptible to metabolic and neurodegenerative diseases, including Alzheimer’s disease.

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Controlled Epidemics: Examining The Effect Of Virus Density And Strain Competition In Gulf Fritillary (Dione Vanillae), Lizbeth Reyes Feb 2026

Controlled Epidemics: Examining The Effect Of Virus Density And Strain Competition In Gulf Fritillary (Dione Vanillae), Lizbeth Reyes

Biology: Student Scholarship & Creative Works

This study examines how different virus strains compete within a single host population of Dione vanillae butterflies, which is important in the study of disease ecology research. For this study, we conducted controlled experimental epidemics on passionflower plants (Passiflora caerulea) in the field. First, we infected caterpillars with one of two different virus strains from Butterfly Farms in North County (BFF004) and the City of San Diego (GRM060) and placed these caterpillars on P. caerulea plants in one of three treatments (control, BFF004, and GRM060; n=3 plants per treatment). Next, we allowed healthy butterflies in the local population to lay …

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Science Communication Tools: Rubrics For Generating Posters And Manuscripts That Are Authentic To The Practice Of Science, Quinn Vega Feb 2026

Science Communication Tools: Rubrics For Generating Posters And Manuscripts That Are Authentic To The Practice Of Science, Quinn Vega

Department of Biology Faculty Scholarship and Creative Works

Traditional undergraduate science courses often prioritize content mastery over authentic engagement with the scientific process. Course-based research, also referred to as course-based undergraduate research experiences (CUREs), addresses this limitation by immersing students in authentic scientific practice. In course-based research, assessment practices can also mirror the authentic scientific practice, where extensive formative feedback supports refinement of skills and understanding. Here, we present two rubrics designed to support the teaching and assessment of science communication in a way that reflects how scientists prepare to disseminate their research findings. One rubric is for creating scientific posters and another for writing short-format manuscripts. Developed …

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The Effect Of St. John’S Wort Solution On Climbing Activity Reflecting Depressive-Like Behavior In Drosophila Melanogaster To Model Seasonal Depression In Low Sunlight Exposure, Madison Simon Feb 2026

The Effect Of St. John’S Wort Solution On Climbing Activity Reflecting Depressive-Like Behavior In Drosophila Melanogaster To Model Seasonal Depression In Low Sunlight Exposure, Madison Simon

Journal of the South Carolina Academy of Science

Although depression is a known substantial threat to public health, seasonal affective disorder (SAD) is under-researched. SAD refers to recurrent seasonal patterns of depression. This depressive disorder has few accepted treatments. The purpose of this study was to test whether St. John’s Wort (SJW), a natural supplement with researched antidepressant properties, could be a cheaper alternative with fewer limitations for treating SAD. SJW’s efficacy as a seasonal depression inhibitor was tested through a Drosophila depression-like model using climbing activity to reflect depressive behavior. It was hypothesized that as the concentration of SJW solution increases, the climbing activity of stressed Drosophila …

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Science Communication Tools: Rubrics For Generating Posters And Manuscripts That Are Authentic To The Practice Of Science, Tamarah Lynne Adair, Swati Agrawal, Yesmi P. Ahumada-Santos, Regina Alvarez, Kirk Anders, Rebekah F. Hare Feb 2026

Science Communication Tools: Rubrics For Generating Posters And Manuscripts That Are Authentic To The Practice Of Science, Tamarah Lynne Adair, Swati Agrawal, Yesmi P. Ahumada-Santos, Regina Alvarez, Kirk Anders, Rebekah F. Hare

Biology Faculty Scholarship

Traditional undergraduate science courses often prioritize content mastery over authentic engagement with the scientific process. Course-based research, also referred to as course-based undergraduate research experiences (CUREs), addresses this limitation by immersing students in authentic scientific practice. In course-based research, assessment practices can also mirror the authentic scientific practice, where extensive formative feedback supports refinement of skills and understanding. Here, we present two rubrics designed to support the teaching and assessment of science communication in a way that reflects how scientists prepare to disseminate their research findings. One rubric is for creating scientific posters and another for writing short-format manuscripts. Developed …

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Structure–Activity Modeling And Hybrid Machine Learning-Based Prediction Of Bioactivity In Pyrazole Derivatives For Drug Discovery Applications, Kader Şahi̇n, Serhat Kiliçarslan, Serdar Durdaği, Emi̇n Saripinar Feb 2026

Structure–Activity Modeling And Hybrid Machine Learning-Based Prediction Of Bioactivity In Pyrazole Derivatives For Drug Discovery Applications, Kader Şahi̇n, Serhat Kiliçarslan, Serdar Durdaği, Emi̇n Saripinar

Turkish Journal of Biology

Background/aim: Pyrazole derivatives are of growing interest due to their diverse pharmacological activities. However, their biological activity is often highly sensitive to subtle structural modifications. Existing quantitative structure–activity relationships (QSAR) approaches frequently fail to capture the conformational flexibility and nonlinear structure–activity relationships (SAR) of such heterocyclic scaffolds, creating a gap in the accurate prediction of their biological profiles. Therefore, there is a strong need for more robust and predictive computational frameworks. This study addresses this gap by integrating four-dimensional (4D)-QSAR descriptors with hybrid machine learning (ML) techniques to improve predictive accuracy and provide a more reliable tool for structure-based drug …

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Cover And Contents Feb 2026

Cover And Contents

Turkish Journal of Biology

No abstract provided.

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Selenium-Thioredoxin Axis Contributes To Ferroptosis Resistance In Pancreatic Cancer Cells, Arslan Amer, Micah Olamide Idowu, Aqsa Ahsan, Alyssa A. Abbas, Tahiyat Alothaim, Xiaohu Tang Feb 2026

Selenium-Thioredoxin Axis Contributes To Ferroptosis Resistance In Pancreatic Cancer Cells, Arslan Amer, Micah Olamide Idowu, Aqsa Ahsan, Alyssa A. Abbas, Tahiyat Alothaim, Xiaohu Tang

Michigan Tech Publications

Pancreatic ductal adenocarcinoma (PDAC) shows substantial heterogeneity in cysteine dependence and ferroptosis sensitivity. We identify two PDAC subtypes distinguished by EMT status: mesenchymal-like cells are highly cysteine-dependent and rapidly undergo ferroptosis upon cystine deprivation or system xc− inhibition, whereas epithelial-type cells are ferroptosis-resistant. Selenium supplementation protects cells from erastin-induced ferroptosis, and this protection persists even when intracellular glutathione (GSH) is depleted, supporting an additional GPX4-independent protective mechanism. Sepp1 knockdown does not alter sensitivity, indicating that selenium’s protective effect is independent of Sepp1. Instead, epithelial-type cells rely on both cytosolic and mitochondrial thioredoxin reductases (TrxR1 and TrxR2) to maintain ferroptosis …

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Addressing Population Aging: Innovative Approaches To Aging Research In China, Jingyi Li, Jinghui Lei, Qun Chu, Weiqi Zhang, Moshi Song, Yaojin Peng, Guanghui Liu Feb 2026

Addressing Population Aging: Innovative Approaches To Aging Research In China, Jingyi Li, Jinghui Lei, Qun Chu, Weiqi Zhang, Moshi Song, Yaojin Peng, Guanghui Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The increasing prevalence of aging and associated diseases poses a substantial challenge worldwide. In recent years, the field of aging research has achieved numerous breakthroughs. Nevertheless, challenges still persist. This study offers a comprehensive analysis of the advancements within China’s aging research, highlighting current challenges and proposing strategy and policy recommendations. These suggestions draw from various areas, including research paradigms and key issues, efficient resource management, development of essential technological research and innovation ecosystems, international collaboration, and considerations of ethics and governance. The aim is to provide valuable insights and guidance for enhancing the quality and impact of aging research …

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Identification Of Berbamine Hydrochloride As A Novel Coagulation Factor Vii Inhibitor By Natural Product Library Screening Using Zebrafish As A Model, Jyotheeswaran Panapakam, Jillian Via, Ambarish Kumar, Ritu Adhikary, Edgar M. Elizondo, Jabila Mary, Rajeev Azad, Art Groven, Pubur Jagadeeswaran Feb 2026

Identification Of Berbamine Hydrochloride As A Novel Coagulation Factor Vii Inhibitor By Natural Product Library Screening Using Zebrafish As A Model, Jyotheeswaran Panapakam, Jillian Via, Ambarish Kumar, Ritu Adhikary, Edgar M. Elizondo, Jabila Mary, Rajeev Azad, Art Groven, Pubur Jagadeeswaran

Faculty Publications - Biological Sciences

Current antithrombotic drugs cause gastrointestinal and intracranial hemorrhage and interact with dietary components and other medications. Thus, there is a need for alternative antithrombotic drugs that have fewer side effects. We screened 547 natural products (NPs) for lethality and found 321 NPs were non-lethal to zebrafish larvae. Laser-induced venous thrombosis on larvae incubated with 321 NPs identified 76 NPs with prolonged time to occlusion of the vessel (TTO). Out of these, 43 were already identified platelet inhibitors and the remaining 33 NPs were tested using laser-induced arterial, ferric chloride-induced, and phenylhydrazine-induced thrombosis assays. Of the 33 NPs tested, 4 prolonged …

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Crispr Spacers Reveal Diverse And Abundant Thermococcales Viruses In Hydrothermal Vents, Ryan Catchpole, Justin Mclean, Emily St John, Anna-Louise Reysenbach, Mart Krupovic, Michael P. Terns Feb 2026

Crispr Spacers Reveal Diverse And Abundant Thermococcales Viruses In Hydrothermal Vents, Ryan Catchpole, Justin Mclean, Emily St John, Anna-Louise Reysenbach, Mart Krupovic, Michael P. Terns

Biology Faculty Publications and Presentations

Viruses are the most pervasive biological entities on Earth and they profoundly shape host ecology and evolution. However, for many microbial lineages, knowledge of their viromes remains limited, especially for those inhabiting remote environments, including deep-sea ecosystems. Here, we leverage one of the most extensively cultivated and genomically characterized archaeal lineages, the Thermococcales, to identify novel viral genomes. By utilizing CRISPR spacers from isolates and spacer arrays reconstructed from metagenomes, we mined mobile genetic elements (MGEs) in 1,172 publicly available and newly sequenced hydrothermal vent metagenomic datasets. Comparative genomics and identification of viral hallmark proteins revealed 620 viral genomes across …

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