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Articles 2191 - 2220 of 39062

Full-Text Articles in Biology

Movement And Activity Of Burbot, (Mizay; Lota Lota) In A Spring-Fed Minnesota Lake, Abigail M. Fountain Jan 2025

Movement And Activity Of Burbot, (Mizay; Lota Lota) In A Spring-Fed Minnesota Lake, Abigail M. Fountain

Biology Graduate Theses

Burbot (Mizay; Lota lota) are a relatively unmanaged freshwater fish, important in many local Indigenous cultures, but often overlooked or maltreated in research, conservation, and fishing practices. As such, relatively little research has been conducted on Burbot, despite ecological significance as an indicator species. A recent resurgence in popularity as a target species, however, has prompted new research to inform management policies. The objectives of this study were to summarize Burbot movement by identifying patterns in swimming activity and identify possible predictors of the movement observed. This study investigated the movements of 39 individuals implanted with acoustic transmitters in Bad …

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Analysis Of Mutations In Bmpr2 Gene Associated With Hypertension, Elaine Vanterpool, Keury C. Ruiz Jan 2025

Analysis Of Mutations In Bmpr2 Gene Associated With Hypertension, Elaine Vanterpool, Keury C. Ruiz

Student Posters

Mutations in the BMPR2 gene are primarily recognized for their role in the development of blood vessels, however, they have also been associated with the pathogenesis of high blood pressure, specifically in regards to altered vascular function and the endothelial cell signal. Early detection and targeted treatment, as well as lifestyle changes, are pivotal in reducing the risk of serious complications associated with high blood pressure. Recent genetic research and personalized medicine have demonstrated the potential to enhance the prevention, diagnosis, and treatment of high blood pressure, particularly through the identification of genetic mutations in the BMPR2 gene.

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Analyzing The Inhibition Of Chemical Compounds On Protease In P. Aeruginosa, Elaine Vanterpool Jan 2025

Analyzing The Inhibition Of Chemical Compounds On Protease In P. Aeruginosa, Elaine Vanterpool

Student Posters

Pseudomonas aeruginosa is a gram-negative, bacillus-shaped opportunistic pathogen, notorious for invading immunocompromised individual leading to secondary infections. These opportunistic microbes typically are implicated mild to more severe infections including burn or wound infections to more serious systemic infections. The bacterium Ps. aeruginosa utilizes a variety of virulence factors to enhance the pathogenicity of the organism. Virulence factors secreted by Ps. aeruginosa include its pili, adhesins, capsule, exotoxin A, and lipopolysaccharide (LPS). The proteases produced by Ps. aeruginosa are powerful virulence factors that can lead to tissue destruction and immune invasion. It is imperative that we find ways of regulating the …

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Gata1 Gene Variants Associated With Myeloproliferative Syndrome And Its Impact On Hematopoiesis, Elaine Vanterpool, Marliza Mendez Del Orbe Jan 2025

Gata1 Gene Variants Associated With Myeloproliferative Syndrome And Its Impact On Hematopoiesis, Elaine Vanterpool, Marliza Mendez Del Orbe

Student Posters

Myeloproliferative syndrome (MPS) are rare blood cancers that originate from an abnormal mutation in a stem cell within the bone marrow, leading to excessive production of red blood cells, white blood cells, or platelets. These disorders affect approximately 20,000 individuals annually in the United States, with around 295,000 people currently living with the condition. The purpose of this study is to identify and assess the pathogenicity of GATA1 gene variants associated with MPS.

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An Analysis Of Ftl Variants Associated With Cataracts Disease, Elaine Vanterpool, Joram Kisaka Jan 2025

An Analysis Of Ftl Variants Associated With Cataracts Disease, Elaine Vanterpool, Joram Kisaka

Student Posters

Cataract is an eye disease that clouds the eye's natural lens, which is used to focus light on the retina. This eye disease causes symptoms such as blurry vision, double vision, sensitivity to light, and difficulty seeing at night. Cataracts are tied to the gene called Ferritin Light Chain (FLT), which is found in both prokaryotes and eukaryotes and plays a role in encoding the light subunits of the ferritin protein. The purpose of this research study was to identify the Ferritin Light Chain mutations that cause cataracts.

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An Examination Of Lacc1 Variants Linked To Rheumatoid Arthritis, Elaine Vanterpool, Rochelle Gunter Jan 2025

An Examination Of Lacc1 Variants Linked To Rheumatoid Arthritis, Elaine Vanterpool, Rochelle Gunter

Student Posters

Rheumatoid arthritis is an inflammatory disease with an annual diagnosis rate of 70 cases per 100,000 people. This is a disease that is usually identified by the abnormal entry of immune cells, such as B lymphocytes, T lymphocytes, and innate lymphoid cells, into the synovial tissues of the joints. When these immune cells infiltrate the joints, they can become too active, thereby contributing to the chronic inflammatory response characteristic of the disease. The objective of this study is to identify and evaluate the pathogenic potential of LACC1 variants implicated in the pathogenesis of arthritis. Simple ClinVar identified LACC1 as a …

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The Duality Of The Bard1 Gene, Elaine Vanterpool, Khadra Burden Jan 2025

The Duality Of The Bard1 Gene, Elaine Vanterpool, Khadra Burden

Student Posters

Breast cancer is the 2nd most diagnosed cancer in women in the United States (Mayo Clinic). Cancer is the overproduction of cells. In other words, cancer-infected cells continue to grow and may cause large growths called tumors. Although there have been innumerable strides in breast cancer research, the exact cause for breast cancer is not yet known (Mayo Clinic). It is believed that factors such as family history of the disease, early menstruation age, and obesity can increase an individual’s chances of having breast cancer. One of the well-known genes associated with breast cancer is BRCA1. A much less researched …

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An Analysis Of Androgen Receptor (Ar) Variants In Breast Cancer, Elaine Vanterpool, Jordae Smith Jan 2025

An Analysis Of Androgen Receptor (Ar) Variants In Breast Cancer, Elaine Vanterpool, Jordae Smith

Student Posters

The androgen receptor (AR) is a steroid-hormone activated transcription factor that regulates gene expression in response to testosterone and dihydrotestosterone (DHT). While AR has been extensively studied in prostate cancer, emerging research suggests its role in breast cancer, particularly in estrogen receptor-positive (ER-positive) and triple-negative breast cancer (TNBC). This study investigates AR variants associated with breast cancer, assessing their pathogenicity and potential impact on prognosis and treatment.

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Study Of Myl3 Mutation Variants And Their Association With Cardiac Amyloidosis, Elaine Vanterpool, Kyla Tucker Jan 2025

Study Of Myl3 Mutation Variants And Their Association With Cardiac Amyloidosis, Elaine Vanterpool, Kyla Tucker

Student Posters

Cardiac Amyloidosis is a rare serious, pathological, clinical progressive disease that is caused by the buildup of amyloid fibrils deposited at the cardiac level. The excess amyloid fibrils deposited in the myocardium leads to this critical condition. Cardiac amyloidosis is best treated when diagnosed in its initial stages. The purpose of this study was to identify and assess the clinical significance and pathogenicity of the Myosin light chain 3 (MYL3) its variants, and the potential link to cardiac amyloidosis. For this study, Simple ClinVar was utilized to identify MYL3 as one of the genes correlated with Cardiac Amyloidosis and variants. …

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Silver Nanoparticles And Natural Compounds Can Modulate Proteolytic Activities Of Escherichia Coli, Elaine Vanterpool Jan 2025

Silver Nanoparticles And Natural Compounds Can Modulate Proteolytic Activities Of Escherichia Coli, Elaine Vanterpool

Student Posters

Escherichia coli (E. coli) is a gram-negative, facultative anaerobic bacterium that naturally resides in the human gastrointestinal tract as a commensal microorganism. While non-pathogenic strains contribute to digestion and vitamin production, certain pathogenic strains can cause a wide range of diseases, from mild gastrointestinal discomfort to severe illness. A key factor in its pathogenicity is the production of protease enzymes that break down proteins which play a crucial role in bacterial survival and virulence. This study aimed to investigate the effectiveness of different antibacterial compounds in inhibiting the function of both secreted and cell-associated E. coli protease activity.

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Analysis Of Kcnj2 Variants Associated With Wolff-Parkinson-White Syndrome, Elaine Vanterpool, Kerenlaime Bautista Jan 2025

Analysis Of Kcnj2 Variants Associated With Wolff-Parkinson-White Syndrome, Elaine Vanterpool, Kerenlaime Bautista

Student Posters

Wolff-Parkinson-White (WPW) syndrome is a cardiac disorder characterized by an accessory electrical pathway, leading to tachycardia and arrhythmias. It is diagnosed via electrocardiogram (ECG), showing a shortened PR interval and delta wave. WPW is typically managed with medications, catheter ablation, or surgery. Although primarily caused by anatomical anomalies, emerging research suggests genetic factors, including ion channel mutations, may contribute to the condition. The KCNJ2 gene encodes an inward-rectifier potassium channel critical for cardiac excitability. Mutations in KCNJ2 are linked to Andersen-Tawil syndrome, a disorder featuring arrhythmias and muscle weakness, raising questions about its role in WPW. This study investigates whether …

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An Analysis Of Htt Involvement In Huntington’S Disease, Elaine Vanterpool, Micah Andrews Jan 2025

An Analysis Of Htt Involvement In Huntington’S Disease, Elaine Vanterpool, Micah Andrews

Student Posters

Huntington's disease is a neurodegenerative disorder characterized by loss of striatal neurons. These striatal neurons are essential in cognition, motor function, decision-making, motivation, reinforcement, and reward perception. Affected individuals may show symptoms such as isolation, lack of motivation, depression, mood swings, and personality changes. This study’s purpose is to analyze and highlight the variants of the HTT gene in the pathogenesis of Huntington’s disease.

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An Analysis Of Dnajc13 Variants Associated With Parkinson’S Disease, Elaine Vanterpool, Rhadames M. Batista-Mendez Jan 2025

An Analysis Of Dnajc13 Variants Associated With Parkinson’S Disease, Elaine Vanterpool, Rhadames M. Batista-Mendez

Student Posters

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons, leading to motor impairments such as tremors, rigidity, and postural instability. Affecting millions worldwide, PD has been linked to both genetic and environmental factors. This study aims to identify and assess the pathogenicity of DNAJC13 variants associated with Parkinson's disease.

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An Analysis Of Dguok Variants Associated With Mitochondrial Dna Depletion Syndrome, Elaine Vanterpool, Ethan Harris Jan 2025

An Analysis Of Dguok Variants Associated With Mitochondrial Dna Depletion Syndrome, Elaine Vanterpool, Ethan Harris

Student Posters

Mitochondrial DNA Depletion Syndrome(MDDS) is a clinically heterogeneous group of autosomal recessive mitochondrial disorders that reduces the number of mitochondrial DNA (mtDNA) in the affected cells. This disease is characterized by the disruption of hepatocytes, skeletal muscle, and cerebral function. This study's purpose is to identify and assess the pathogenicity of DGUOK variants associated with MDDS.

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Analysis Of Dmd Variants Associated With Duchenne Muscular Dystrophy, Elaine Vanterpool, K’Sia Byass Jan 2025

Analysis Of Dmd Variants Associated With Duchenne Muscular Dystrophy, Elaine Vanterpool, K’Sia Byass

Student Posters

Duchenne Muscular Dystrophy is an X-linked recessive disorder that causes muscle weakness. This disease is characterized by frequent falls, difficulty walking, running, jumping, or scoliosis. Duchenne Muscular Dystrophy 1 in every 5000 boys worldwide causes a gene tic mutation that prevents the production of dystrophin. This study aims to identify and assess the pathogenicity of DMD variants associated with Duchenne Muscular Dystrophy. Genetic mutations responsible for Duchenne Muscular Dystrophy have been reported. Studies regarding DMD and its specific role in causing Duchenne Muscular Dystrophy have been reported to be accurate and effective. X-linked inheritance patterns are applied to this disease's …

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Investigating Alk, Phox2b, And Brca2 Gene In Relation To Neuroblastoma, Elaine Vanterpool, Joshua Henry Jan 2025

Investigating Alk, Phox2b, And Brca2 Gene In Relation To Neuroblastoma, Elaine Vanterpool, Joshua Henry

Student Posters

One of the biggest mysteries of cancer today is Neuroblastoma. Neuroblastomas are malignancies originating from the early nerve cells of the sympathetic nervous system, often known as neuroblasts. Neuroblasts can occur anywhere throughout the sympathetic nervous system. About one-third of infants are diagnosed with neuroblastoma by the time they turn one year old and the disease frequently starts in infancy. By the age of five, almost 75% have a diagnosis. Neuroblastomas are present in some newborns, but they are not identified until later, when the child or infant starts exhibiting symptoms. Adult cases of NB are quite rare. The majority …

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Novel Infection By Mucor Hiemalis Kills Caenorhabditis Hosts Through Intestinal Perforation, Jay Ni Jan 2025

Novel Infection By Mucor Hiemalis Kills Caenorhabditis Hosts Through Intestinal Perforation, Jay Ni

West Chester University Graduate Theses, Dissertations, and Final Projects

The nematode Caenorhabditis elegans has emerged as a popular model system to investigate cell biology and host-pathogen interactions. Presently, C. elegans is studied as a natural host of intracellular pathogens such as microsporidia and Orsay virus along with extracellular bacterial and fungal pathogens. The use of C. elegans as a model in host-pathogen research is limited by the number of naturally occurring pathogens to the organism. Through a sampling project to identify new pathogens of C. elegans, we identified the fungus Mucor hiemalis as a pathogen of Caenorhabditis species. We observed the fungus in the intestinal lumen of wild-caught …

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Silver Nanoparticles And Vanillin Can Inhibit Collagenase Activities Of Serratia Marcescens, Elaine Vanterpool Jan 2025

Silver Nanoparticles And Vanillin Can Inhibit Collagenase Activities Of Serratia Marcescens, Elaine Vanterpool

Student Posters

Serratia marcescens is a gram-negative, disease-causing agent that belongs to the Enterobacteriaceae family. This rod-shaped microbe causes many infectious diseases such as urinary and respiratory infections, wound infections, and peritonitis, which can result in fatal bacteremia. Protease is a virulence factor of S. marcescens that enhances its pathogenicity by breaking down proteins via cleavage of peptide bonds. The purpose of this research is to identify testing agents that reduce the protease mediated pathogenicity of S. marcescens

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An Analysis Of Diabetes Associated With Appl1 Variants D94n And R46w, Elaine Vanterpool, Gaielle Price Jan 2025

An Analysis Of Diabetes Associated With Appl1 Variants D94n And R46w, Elaine Vanterpool, Gaielle Price

Student Posters

Diabetes is a long-term metabolic illness with high blood glucose (blood sugar) levels. Over time, this condition can cause major harm to the heart, blood vessels, eyes, kidneys, and nerves. Around 830 million people in the world with diabetes reside in low- and middle-income environments (World Health Organization). This study aims to identify and assess the pathogenicity of APPL1 variants associated with diabetes.

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Implications Of Pik3ca On Breast And Ovarian Cancer, Elaine Vanterpool, Kaylani Krigger Jan 2025

Implications Of Pik3ca On Breast And Ovarian Cancer, Elaine Vanterpool, Kaylani Krigger

Student Posters

Breast and ovarian cancer are two of the most prevalent diseases affecting women. Ovarian cancer is a disease defined by the presence of tumors in the ovaries. Breast cancer is the uncontrollable cell growth of breast tissue leading to tumor formation. BRCA 1/2, PALB2, TP53, and PTEN are common gene mutations found present in breast and ovarian cancer. The PIK3CA gene mutation is less frequent, however, its mutations are almost exclusively tied to breast and ovarian cancer. Forty percent (40%) of breast cancers and thirty percent (30%) of ovarian cancers have a mutation in the PIK3CA/AKT signaling pathway (Chen et …

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Improving Biocompatibility And Structural Integrity Of Decellularized Biomaterials, Elaine Vanterpool Jan 2025

Improving Biocompatibility And Structural Integrity Of Decellularized Biomaterials, Elaine Vanterpool

Student Posters

Tissue engineering is a revolutionary approach to regenerative medicine. Within the field of tissue engineering, biomaterials such as the great saphenous vein or synthetic materials such as PET, are used in tissue generation for grafts and wound healing in many other uses. This is promising and has the potential to save many lives, but many glaring issues prevent the use of these scaffolds in a clinical setting. Some of these include body rejection, lack of hemocompatibility, and weak structural integrity.

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The Role Of Nkx2-5 Variants Associated With Congenital Heart Disease, Elaine Vanterpool, Jayda Russell Jan 2025

The Role Of Nkx2-5 Variants Associated With Congenital Heart Disease, Elaine Vanterpool, Jayda Russell

Student Posters

About 1% of live births worldwide are affected by congenital heart disease (CHD), a group of structural heart defects that exist from birth. Finding and evaluating the effects of NKX2-5 variations linked to CHD is the goal of this study. From basic heart defects like atrial septal defects (ASD) to more intricate malformations, congenital heart disease (CHD) encompasses a variety of structural heart abnormalities. Its development is influenced by both environmental and genetic factors. NKX2-5 is a protein coding gene that encodes a home box- containing a transcription factor. This gene plays a role in the early development of the …

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The Analysis Of Variants Of The Atm Gene In Breast Cancer, Elaine Vanterpool, Kyah Miller Jan 2025

The Analysis Of Variants Of The Atm Gene In Breast Cancer, Elaine Vanterpool, Kyah Miller

Student Posters

Breast Cancer is defined as abnormal cell growth within the breast tissue, resulting in a tumor. Those affected by this disease often experience lumping in the breasts, changes in breast size and shape, nipple retraction, skin dimpling, and redness and irritation of the breast. This disease most commonly affects women, but men can be affected as well. Although subject to variation due to race and ethnicity, approximately 13% of women will be diagnosed with breast cancer throughout their lifetime. With further study and new treatment methods, the mortality rate is steadily decreasing. The purpose of this research is to analyze …

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Analysis Of Wwox Gene Associated With Cancer, Elaine Vanterpool, Jovaughn Redley Jan 2025

Analysis Of Wwox Gene Associated With Cancer, Elaine Vanterpool, Jovaughn Redley

Student Posters

Cancer is a disease caused by abnormal cell growth and uncontrollable spread throughout one’s body. According to the World Health Organization, about 1 in 5 people develop cancer: 1 in 9 in males and 1 in 12 in females (WHO). WWOX was the gene studied, and it has been reported to be involved in cancer progression. Specifically with Gastric cancer, an increase in invasion and migration of Gastric Cancer cells was caused by the WWOX gene. Simple ClinVar was used to identify WWOX as a gene and the three missense variants associated with the WWOX gene; Pro47Thr, Asp58Asn, and His46Tyr. …

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An Analysis Of Pdgfra Variants Associated With Fibroids, Elaine Vanterpool, Nadja Hunt Jan 2025

An Analysis Of Pdgfra Variants Associated With Fibroids, Elaine Vanterpool, Nadja Hunt

Student Posters

Originally research was to be conducted on the effects of gene mutations associated with endometriosis, but there was not a substantial amount of information in the database for an adequate study. Instead, research was done on the genes associated with Fibroids. Fibroids are commonly characterized as benign tumors that typically form in the wall of the uterus. Fibroid symptoms usually include heavy menstrual bleeding, prolonged periods, and pelvic pain. In some cases, there are no symptoms. Statistically, fibroids affect 20–30% of women ages 30–50. This study’s purpose is to identify and analyze the pathogenicity of PDGFRA (platelet-derived growth factor receptor …

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Estimating The Amount Of Carbon Dioxide Gas Removed From The Atmosphere By The Bryant Park Tree Population, Edimarlyn Gonzalez Jan 2025

Estimating The Amount Of Carbon Dioxide Gas Removed From The Atmosphere By The Bryant Park Tree Population, Edimarlyn Gonzalez

Open Educational Resources

No abstract provided.

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Least Tern Abundance, Nesting Productivity, And Dispersal Between Nesting And On- And Off-River Foraging Sites In The Missouri National Recreational River, Kyle Jorgensen Jan 2025

Least Tern Abundance, Nesting Productivity, And Dispersal Between Nesting And On- And Off-River Foraging Sites In The Missouri National Recreational River, Kyle Jorgensen

Dissertations and Theses

The Interior Least Tern (Sterna antillarum athalassos) has experienced significant conservation success, culminating in its removal from the federal endangered species list in 2021. However, the species remains state-endangered in South Dakota, and knowledge gaps persist regarding its foraging ecology and population dynamics along the Missouri National Recreational River (MNRR). This study aimed to address these gaps by quantifying Least Tern abundance, nesting productivity, and movement patterns between nesting and foraging sites during the 2024 and 2025 breeding seasons. We conducted surveys of Least Terns on riverine sandbars and off-river wetlands within a 30-km radius of the MNRR, employing both …

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Analysis Of Recreational Data On Nearby Rivers, Rachael Meyers, Tamara Johnstone-Yellin Jan 2025

Analysis Of Recreational Data On Nearby Rivers, Rachael Meyers, Tamara Johnstone-Yellin

ASPIRE 2025

In the 1980’s. DuPont of Waynesboro, VA, contaminated over 100 miles of river on the South Fork of the Shenandoah and the South River. As part of their settlement, creel surveys are completed routinely by the Department of Wildlife Resources to collect data on angler and recreational use of these rivers. This project uses the recreational data to determine; ‘where on the South Fork of the Shenandoah River is recreational access the heaviest?’ ‘what forms of recreational use are most popular, and is there a change from 2016 to 2023?’ and ‘are there differences in the demographics of recreational users …

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Size Of Age-0 Sander Vitreus Pre And Post Dreissena Polymorpha Infestation On Brainerd And Bemidji Area Lakes, Quady Bernu Jan 2025

Size Of Age-0 Sander Vitreus Pre And Post Dreissena Polymorpha Infestation On Brainerd And Bemidji Area Lakes, Quady Bernu

Journal of Earth and Life Science

Walleye Sander vitreus is the Minnesota state fish and a vital predator fish in lake ecology. Zebra mussels, Dreissena polymorpha were first found in Minnesota inland lakes in the 1980’s. These mussels have had huge impacts on water clarity as well as phytoplankton and zooplankton population levels which affect how age-0 fish feed, especially a low light feeding predator fish like walleye. A study took place on age-0 walleye size and it supported the conclusion that age-0 walleye were negatively impacted by zebra mussels in Minnesota’s large lakes. The goals of this study were to determine how the size of …

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Microsatellites Reveal The Population Genetic Structure Of Yellow Perch In Minnesota, Megan Boche Jan 2025

Microsatellites Reveal The Population Genetic Structure Of Yellow Perch In Minnesota, Megan Boche

Journal of Earth and Life Science

When analyzing a population’s genetic makeup, looking at variation of individuals and populations is a crucial factor. The management of yellow perch will be aided by this information particularly in regard to stocking or relocation. Microsatellite loci were used to analyze the genetic population structure of yellow perch Perca flavescens within and among 29 sampling areas throughout Minnesota’s basins. Seven microsatellite DNA loci were evaluated, with heterozygosities ranging from 0.41 to 0.78. The Lower Mississippi basin samples showed higher numbers of alleles per locus and greater expected heterozygosities compared to other basins, with Lake Pepin (PEP) exhibiting the highest average …

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