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Articles 9931 - 9960 of 30047
Full-Text Articles in Mechanical Engineering
Prototyping A Conductive Polymer Steering Pad For Rail Freight Service, Anthony A. Villarreal, Constantine Tarawneh, Miguel Ontiveros, James Aranda, Robert Jones
Prototyping A Conductive Polymer Steering Pad For Rail Freight Service, Anthony A. Villarreal, Constantine Tarawneh, Miguel Ontiveros, James Aranda, Robert Jones
Mechanical Engineering Faculty Publications
The AdapterPlus™ steering pad is a polymer component on a railcar that helps to reduce stresses on the axle as a railcar rounds a curve. One railway application requires a minimum of 240 mA to be passed through the steering pad to the rail, which activates air valves that control automated cargo gates. Currently, two copper studs are inserted into the pad to provide a conductive path. However, after continuous cyclic loading caused by normal service operation, the copper studs deform, wear, and eventually lose contact between the two surfaces rendering the pad nonconductive. One proposed solution to this problem …
Observations Of Shear Stress Effects On Staphylococcus Aureus Biofilm Formation, Erica Sherman, Kenneth W. Bayles, Derek Moormeir, Jennifer Endres, Timothy Wei
Observations Of Shear Stress Effects On Staphylococcus Aureus Biofilm Formation, Erica Sherman, Kenneth W. Bayles, Derek Moormeir, Jennifer Endres, Timothy Wei
Department of Mechanical and Materials Engineering: Faculty Publications
Staphylococcus aureus bacteria form biofilms and distinctive microcolony or “tower” structures that facilitate their ability to tolerate antibiotic treatment and to spread within the human body. The formation of microcolonies, which break off, get carried downstream, and serve to initiate biofilms in other parts of the body, is of particular interest here. It is known that flow conditions play a role in the development, dispersion, and propagation of biofilms in general. The influence of flow on microcolony formation and, ultimately, what factors lead to microcolony development are, however, not well understood. The hypothesis being examined is that microcolony structures form …
Stress Corrosion Cracking Resistance Of Cold-Sprayed Al 6061 Deposits Using A Newly Developed Test Fixture, Mala M. Sharma, Jeremy Schreiber, Timothy Eden, Victor Champagne
Stress Corrosion Cracking Resistance Of Cold-Sprayed Al 6061 Deposits Using A Newly Developed Test Fixture, Mala M. Sharma, Jeremy Schreiber, Timothy Eden, Victor Champagne
Faculty Journal Articles
The stress corrosion cracking (SCC) response of Al 6061 bulk deposits produced by high-pressure cold spray (HPCS) was investigated and compared to commercial wrought Al 6061-T6 material. Representative tensile coupons were stressed to 25%, 65% and 85% of their respective yield strength and exposed to ASTM B117 salt fog for 90 days. After exposure, the samples were mechanically tested to failure, and subsequently investigated for stress corrosion cracking via optical and scanning electron microscopy with energy-dispersive X-ray spectroscopy (EDS). The results were compared to the wrought Al 6061-T6 properties and correlated with the observed microstructures. Wrought samples showed the initiation …
Design Of A Canine Inspired Quadruped Robot As A Platform For Synthetic Neural Network Control, Cody Warren Scharzenberger
Design Of A Canine Inspired Quadruped Robot As A Platform For Synthetic Neural Network Control, Cody Warren Scharzenberger
Dissertations and Theses
Legged locomotion is a feat ubiquitous throughout the animal kingdom, but modern robots still fall far short of similar achievements. This paper presents the design of a canine-inspired quadruped robot named DoggyDeux as a platform for synthetic neural network (SNN) research that may be one avenue for robots to attain animal-like agility and adaptability. DoggyDeux features a fully 3D printed frame, 24 braided pneumatic actuators (BPAs) that drive four 3-DOF limbs in antagonistic extensor-flexor pairs, and an electrical system that allows it to respond to commands from a SNN comprised of central pattern generators (CPGs). Compared to the previous version …
Post-Polymerization Modification Of Kapton Using Electron Beam Irradiation, Luis A. Hernandez
Post-Polymerization Modification Of Kapton Using Electron Beam Irradiation, Luis A. Hernandez
Mechanical Engineering ETDs
In the present study, the feasibility of chemical modification of electron-irradiated Kapton is investigated. Characterization techniques determined the changes between a pristine, electron irradiated, and a chemically treated, i.e., fluorinated, sample of Kapton. Kapton is a common material in space application as it serves as the exterior surface for space vehicles. Highly aged Kapton have significant material property changes, making them prone to electro-static discharge (ESD) damage. Understanding how Kapton material behaves under space conditions and the possibility of improving its structure and properties is of utmost important. To this end, changes to the physical properties of the material were …
Modeling Thermal And Mechanical Cancellation Of Residual Stress From Hybrid Additive Manufacturing By Laser Peening, Guru Madireddy, Chao Li, Jingfu Liu, Michael P. Sealy
Modeling Thermal And Mechanical Cancellation Of Residual Stress From Hybrid Additive Manufacturing By Laser Peening, Guru Madireddy, Chao Li, Jingfu Liu, Michael P. Sealy
Department of Mechanical and Materials Engineering: Faculty Publications
Additive manufacturing (AM) of metals often results in parts with unfavorable mechanical properties. Laser peening (LP) is a high strain rate mechanical surface treatment that hammers a workpiece and induces favorable mechanical properties. Peening strain hardens a surface and imparts compressive residual stresses improving the mechanical properties of a material. This work investigates the role of LP on layer-by-layer processing of 3D printed metals using finite element analysis. The objective is to understand temporal and spatial residual stress development after thermal and mechanical cancellation caused by cyclically coupling printing and peening. Results indicate layer peening frequency is a critical process …
Interactions Of Bacteria With Monolithic Lateral Silicon Nanospikes Inside A Microfluidic Channel, Lei Li, Feng Tian, Hao Chang, Jie Zhang, Cheng Wang, Wei Rao, Huan Hu
Interactions Of Bacteria With Monolithic Lateral Silicon Nanospikes Inside A Microfluidic Channel, Lei Li, Feng Tian, Hao Chang, Jie Zhang, Cheng Wang, Wei Rao, Huan Hu
Mechanical and Aerospace Engineering Faculty Research & Creative Works
This paper presents a new strategy of integrating lateral silicon nanospikes using metal-assisted chemical etching (MacEtch) on the sidewall of micropillars for on-chip bacterial study. Silicon nanospikes have been reported to be able to kill bacteria without using chemicals and offer a new route to kill bacteria and can prevent the overuse of antibiotics to reduce bacteria. We demonstrated a new methodology to fabricate a chip with integrated silicon nanospikes onto the sidewalls of micropillars inside the microfluidic channel and attested its interactions with the representative gram-negative bacteria Escherichia coli. The results of colony-forming unit (CFU) calculation showed that 80% …
City Of New Smyrna Beach Solar Feasibility Assessment - City Hall Annex, Florida Solar Energy Center, Charles Withers, Jr.
City Of New Smyrna Beach Solar Feasibility Assessment - City Hall Annex, Florida Solar Energy Center, Charles Withers, Jr.
FSEC Energy Research Center®
This review and solar assessment is organized by component with brief description of intended details, challenges and recommendations.
Building: City of New Smyrna Beach, City Hall Annex (Renovation of a portion of the Historic First Baptist Church of New Smyrna Beach) Year of Construction: 1920's[1] Building Use: Renovation will create spaces for City workers and a new City Council Chambers Conditioned area: 1st floor = 7856 ft2 2nd floor = 3,967 ft2 Total = 11,823 ft2[2]
[1] New Smyrna Beach Property Appraiser's website states 1920, historic marker states circa 1929. [2] New Smyrna …
Method For Fabrication Of A Soft-Matter Printed Circuit Board, Carmel Majidi, Tong Lu, Eric J. Markvicka
Method For Fabrication Of A Soft-Matter Printed Circuit Board, Carmel Majidi, Tong Lu, Eric J. Markvicka
Department of Mechanical and Materials Engineering: Faculty Publications
A fabrication process for soft - matter printed circuit boards is disclosed in which traces of liquid - phase Ga - In eutectic ( eGaIn ) are patterned with UV laser micromachining ( UVLM ) . The terminals of the elastomer - sealed LM circuit connect to the surface mounted chips through vertically aligned columns of eGaIn - coated ferromagnetic micro spheres that are embedded within an interfacial elastomer layer .
How Vision Governs The Collective Behaviour Of Dense Cycling Pelotons, J. Belden, Mohammad M. Mansoor, A. Hellum, S. R. Rahman, A. Meyer, C. Pease, J. Pacheco, S. Koziol, Tadd T. Truscott
How Vision Governs The Collective Behaviour Of Dense Cycling Pelotons, J. Belden, Mohammad M. Mansoor, A. Hellum, S. R. Rahman, A. Meyer, C. Pease, J. Pacheco, S. Koziol, Tadd T. Truscott
Mechanical and Aerospace Engineering Faculty Publications
In densely packed groups demonstrating collective behaviour, such as bird flocks, fish schools or packs of bicycle racers (cycling pelotons), information propagates over a network, with individuals sensing and reacting to stimuli over relatively short space and time scales. What remains elusive is a robust, mechanistic understanding of how sensory system properties affect interactions, information propagation and emergent behaviour. Here, we show through direct observation how the spatio-temporal limits of the human visual sensory system govern local interactions and set the network structure in large, dense collections of cyclists. We found that cyclists align in patterns within a ± 30° …
Characterization Of Single- And Multi-Phase Shock-Accelerated Flows, Patrick John Wayne
Characterization Of Single- And Multi-Phase Shock-Accelerated Flows, Patrick John Wayne
Mechanical Engineering ETDs
Experiments conducted in the Shock Tube Facility at the University of New Mexico are focused on characterization of shock-accelerated flows. Single-phase (gaseous) initial conditions consist of a heavy gas column of sulfur hexafluoride seeded with approximately 11% acetone gas by mass. Visualization of the image plane for gaseous initial conditions is accomplished via planar laser-induced fluorescence (PLIF) with a high-powered Nd:YAG ultraviolet laser and an Apogee Alta U-42 monochrome CCD camera, with a quantum efficiency > 90%. Multi-phase (gas-solid) initial conditions consist of glass micro-beads deposited on small 1-cm diameter discs of specific surface chemistry, mounted flush with the bottom wall …
Microfluidic Gasketless Interconnect Sealed By Superhydrophobic Surfaces, Xiaoxiao Zhao
Microfluidic Gasketless Interconnect Sealed By Superhydrophobic Surfaces, Xiaoxiao Zhao
LSU Doctoral Dissertations
Lab-on-a-chip technologies are widely applied in the field of life sciences and potentially in clinical diagnostics. There is a high demand for standardized, efficient interconnects between components in modular microfluidic systems. Chip-to-chip contactless, microfluidic interconnects, that allow fluid flow between chips, were designed and evaluated. The interconnects are 'gasketless' without the need for O-ring’s or fillers. Specifically, two microfluidic chips are assembled face-to-face and the fluidic ports on each chip were accurately aligned to allow the passage of fluids, through liquid bridges spanning the gap. Formation of the liquid bridges was governed by superhydrophobic films coating the surface around the …
Pseudo-Spectral Method To Control Three-Degree-Of-Freedom Wave Energy Converters, Ossama Abdelkhalik, Giorgio Bacelli, Shangyan Zou, Rush D. Robinett Iii, David G. Wilson, Ryan G. Coe
Pseudo-Spectral Method To Control Three-Degree-Of-Freedom Wave Energy Converters, Ossama Abdelkhalik, Giorgio Bacelli, Shangyan Zou, Rush D. Robinett Iii, David G. Wilson, Ryan G. Coe
Michigan Tech Patents
The invention provides optimal control of a three-degree-of-freedom wave energy converter using a pseudo-spectral control method. The three modes are the heave, pitch and surge. A dynamic model is characterized by a coupling between the pitch and surge modes, while the heave is decoupled. The heave, however, excites the pitch motion through nonlinear parametric excitation in the pitch mode. The invention can use a Fourier series as basis functions to approximate the states and the control. For the parametric excited case, a sequential quadratic programming approach can be implemented to numerically solve for the optimal control. The numerical results show …
Investigation Of Through Thickness Microstructure And Mechanical Properties In Friction Stir Welded 7n01 Aluminum Alloy Plate, Xingxin Zhao, Zhiyong Yang, Joseph P. Domblesky, Jianmin Han, Zhiqiang Li, Xiaolong Liu
Investigation Of Through Thickness Microstructure And Mechanical Properties In Friction Stir Welded 7n01 Aluminum Alloy Plate, Xingxin Zhao, Zhiyong Yang, Joseph P. Domblesky, Jianmin Han, Zhiqiang Li, Xiaolong Liu
Mechanical Engineering Faculty Research and Publications
An on-going problem in friction stir welded (FSW) joints used in the high-speed train sector is that the microstructure and mechanical properties can significantly vary in thick sections. Because inhomogeneous properties can reduce weld efficiency and degrade service performance, it is of some interest to understand how inhomogeneous properties can develop in FSW welds made from precipitation hardening alloys such as 7N01. In the current study, butt welds were made using 12 mm thick plates and then sectioned perpendicular to the weld line. Five 2.2 mm thick slices were cut from a section and used to measure tensile properties access …
Engineering Of Bio-Mimetic Substratum Topographies For Enhanced Early Colonization Of Filamentous Algae, Ali Khoshkhoo, Andres L. Carrano, David M. Blersch, Kamran Kardel
Engineering Of Bio-Mimetic Substratum Topographies For Enhanced Early Colonization Of Filamentous Algae, Ali Khoshkhoo, Andres L. Carrano, David M. Blersch, Kamran Kardel
Manufacturing Engineering: Faculty Publications (2015-2023)
This work reveals a set of surface topography parameters that are significant for algal attachment to natural rock substrata. Topography analysis of rock surfaces from a stream identifies three descriptive areal parameters (Smr, Sv, and Sa) that correlate with the presence of natural periphyton community. A method was developed and validated to reverse engineer and manufacture artificial substrata with topographic complexity defined by these parameters, using computational modeling and additive manufacturing. Results from colonization experiments with filamentous algae show statistically significant increases in early biomass accrual rates on substrata with higher values of …
The Roussopoulos And Schwinger Functionals For Nuclear Systems Involving Imprecisely Known Fluxes And Parameters: Distinctions And Equivalences, Dan Gabriel Cacuci
The Roussopoulos And Schwinger Functionals For Nuclear Systems Involving Imprecisely Known Fluxes And Parameters: Distinctions And Equivalences, Dan Gabriel Cacuci
Faculty Publications
For over 60 years, the Roussopoulos and Schwinger functionals have been used in many works and textbooks under the assumption that they provide “second-order accurate” trial functions for the forward and adjoint fluxes when computing reaction rates and/or particle detector responses in source-driven nuclear systems. The Schwinger functional has been employed as a particularly useful form of the Roussopoulos functional for systems in which the forward and adjoint particle fluxes were normalized. When using these functionals, however, the expressions for the approximate fluxes were postulated arbitrarily while the system parameters were unrealistically assumed to be perfectly well known. This work …
Design Of Variable Wall Thickness Geometry And Performance Mapping Of Scroll Expanders For Distributed Power Generation, Arun Kumar Narasimhan
Design Of Variable Wall Thickness Geometry And Performance Mapping Of Scroll Expanders For Distributed Power Generation, Arun Kumar Narasimhan
USF Tampa Graduate Theses and Dissertations
Low-temperature heat sources such as industrial waste heat, solar, and geothermal are more suitable for small-scale power generation rather than utility scale. In order to maximize the electricity generated from low-temperature heat sources, an efficient expansion device for small-scale power output is necessary. This research work has focused on evaluating the use of a scroll expander and improving its geometrical design for the power output range of 1-25 kWe.
The first part of the work focusses on modeling the performance of a scroll expander using two non-dimensionless parameters, namely, specific speed and specific diameter. Performance of a scroll …
High Enthalpy Storage Thermoset Network With Giant Stress And Energy Output In Rubbery State And Associated Applications, Jizhou Fan
LSU Doctoral Dissertations
In this study, a new shape memory thermoset network with giant stress and energy output in rubbery state is synthesized and studied firstly since the low output in stress and energy in rubbery state has been a bottleneck for wide-spread applications of thermoset shape memory polymers (SMPs). Traditionally, stress or energy storage in thermoset network is through entropy reduction by mechanical deformation or programming. We here report another mechanism for energy storage, which stores energy primarily through enthalpy increase by stretched bonds during programming. As compared to entropy-driven counterparts, which usually have a stable recovery stress from tenths to several …
Teaching Top-Down Approaches To The Engineering Design Process, Joshua E. Katz, Joshua E. Katz
Teaching Top-Down Approaches To The Engineering Design Process, Joshua E. Katz, Joshua E. Katz
STAR Program Research Presentations
One of the main focuses of metacognition is to have students think about their learning. By bringing the engineering design process with educational psychology together, it can lead to a society that thinks more in-depth on various topics. The goal of the internship was to utilize and teach top-down educational and instructional objectives. Throughout the project, we followed a modified progression of the System Architecture Methodology to help other interns think in a top-down fashion. The purpose of this procedure is to create and induce new innovative and creative ideas for different projects. As teaching this methodology was tasked, research …
Energy Transformation And Conservation Investigation, Mike Jackson, Holly Haney
Energy Transformation And Conservation Investigation, Mike Jackson, Holly Haney
High School Lesson Plans
Students will use a thermoelectric generator module to analyze the relationship between thermal and electrical energies. Using data collection sensors and analysis software, students will investigate the relationship between the temperature gradient across a thermoelectric generator module and the resulting electrical potential. Students will then use their data and analysis to solve problems relating to waste thermal energy in electrical systems and communicate their work to their peers and teacher.
Maquiladoras In Central America: An Analysis Of Workforce Schedule, Productivity And Fatigue., Jose L. Barahona
Maquiladoras In Central America: An Analysis Of Workforce Schedule, Productivity And Fatigue., Jose L. Barahona
Masters Theses & Specialist Projects
Textile factories or Maquiladoras are very abundant and predominant in Central American economies. However, they all do not have the same standardized work schedule or routines. Most of the Maquiladoras only follow schedules and regulations established by the current labor laws without taking into consideration many variables within their organization that could affect their overall performance. As a result, the purpose of the study is to analyze the current working structure of a textile Maquiladora and determine the most suitable schedule that will abide with the current working structure but also increase production levels, employee morale and decrease employee fatigue. …
Bioprinting With Human Stem Cell-Laden Alginate-Gelatin Bioink And Bioactive Glass For Tissue Engineering, Krishna C. R. Kolan, Julie A. Semon, Bradley Bromet, D. E. Day, Ming-Chuan Leu
Bioprinting With Human Stem Cell-Laden Alginate-Gelatin Bioink And Bioactive Glass For Tissue Engineering, Krishna C. R. Kolan, Julie A. Semon, Bradley Bromet, D. E. Day, Ming-Chuan Leu
Biological Sciences Faculty Research & Creative Works
Three-dimensional (3D) bioprinting technologies have shown great potential in the fabrication of 3D models for different human tissues. Stem cells are an attractive cell source in tissue engineering as they can be directed by material and environmental cues to differentiate into multiple cell types for tissue repair and regeneration. In this study, we investigate the viability of human adipose-derived mesenchymal stem cells (ASCs) in alginate-gelatin (Alg-Gel) hydrogel bioprinted with or without bioactive glass. Highly angiogenic borate bioactive glass (13-93B3) in 50 wt% is added to polycaprolactone (PCL) to fabricate scaffolds using a solvent-based extrusion 3D bioprinting technique. The fabricated scaffolds …
Investigation Of Fundamental Principles Of Rigid Body Impact Mechanics, Khalid Alluhydan
Investigation Of Fundamental Principles Of Rigid Body Impact Mechanics, Khalid Alluhydan
Mechanical Engineering Research Theses and Dissertations
In impact mechanics, the collision between two or more bodies is a common, yet a very challenging problem. Producing analytical solutions that can predict the post-collision motion of the colliding bodies require consistent modeling of the dynamics of the colliding bodies. This dissertation presents a new method for solving the two and multibody impact problems that can be used to predict the post-collision motion of the colliding bodies. Also, we solve the rigid body collision problem of planar kinematic chains with multiple contacts with external surfaces.
In the first part of this dissertation, we study planar collisions of Balls and …
Distributed State Estimation By Using Active-Passive Sensor Networks, Akhilesh Raj, S. Jagannathan, Tansel Yucelen
Distributed State Estimation By Using Active-Passive Sensor Networks, Akhilesh Raj, S. Jagannathan, Tansel Yucelen
Electrical and Computer Engineering Faculty Research & Creative Works
This paper proposes a novel adaptive observer for heterogeneous sensor networks (HSNs) to estimate state vector of an unknown target or process by using the sensed output when the input to the target/process is also not known. In an HSN, nodes are considered either active or passive depending upon their ability to sense the target output. The local information exchange among the nodes is dictated by a connected graph. By using the criterion of collective observability, a novel distributed adaptive estimation is introduced where the nodes are allowed to have different sensor modalities. Stability analysis shows uniform ultimate boundedness of …
Active-Passive Dynamic Consensus Filters For Linear Time-Invariant Multiagent Systems, J. Daniel Peterson, Tansel Yucelen, S. Jagannathan
Active-Passive Dynamic Consensus Filters For Linear Time-Invariant Multiagent Systems, J. Daniel Peterson, Tansel Yucelen, S. Jagannathan
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Active-passive dynamic consensus filters consist of a group of agents, where a subset of these agents is able to observe a quantity of interest (i.e. active agents) and the rest are subject to no observations (i.e. passive agents). Specifically, the objective of these filters is that the states of all agents are required to converge to the weighted average of the set of observations sensed by the active agents. Existing active-passive dynamic consensus filters in the classical sense assume that all agents can be modeled as having single integrator dynamics, which may not always hold in practice. Motivating from this …
Stabilization Of Homoclinic Orbits Of Two Degree-Of-Freedom Underactuated Systems, Nilay Kant, Ranjan Mukherjee, Hassan K. Khalil
Stabilization Of Homoclinic Orbits Of Two Degree-Of-Freedom Underactuated Systems, Nilay Kant, Ranjan Mukherjee, Hassan K. Khalil
Mechanical and Aerospace Engineering Faculty Research & Creative Works
A hybrid controller for stabilization of homoclinic orbits of two degree-of-freedom (DOF) underactuated systems is proposed. The controller is comprised of continuous-time inputs, impulsive brakings, and virtual impulsive inputs for resetting of the passive coordinate. Impulsive brakings of the active coordinate result in instantaneous negative changes in the mechanical energy of the system. An impulsive dynamical system framework is adopted for modeling the hybrid dynamics and a Lyapunov function is defined for stabilization of the orbit. Sufficient conditions for stabilization are presented such that the Lyapunov function decreases monotonically under the action of the continuous inputs and undergoes negative jumps …
Electronic Cvt - Controls, Alec William Hardy, Jessalyn Leora Ann Bernick, Nicholas Esteban Capdevila, Tristan Charles Perry
Electronic Cvt - Controls, Alec William Hardy, Jessalyn Leora Ann Bernick, Nicholas Esteban Capdevila, Tristan Charles Perry
Mechanical Engineering
The following document outlines the design process, manufacturing, and testing of the control system for an electronically controlled continuously variable transmission (ECVT). This control system was integrated into the custom designed and manufactured mechanical transmission system created in parallel by another senior project group. The transmission was designed for use in the Cal Poly Baja SAE vehicle. Through researching customer needs, competition requirements, previous and alternate CVT designs, and vehicle characteristics, we were able to determine the requirements and specifications for our unique system. Input, output, speed, and durability requirements guided our hardware selection. The primary components which comprised our …
Reducing The Noise Impact Of Unmanned Aerial Vehicles By Flight Control System Augmentation, Matthew B. Galles
Reducing The Noise Impact Of Unmanned Aerial Vehicles By Flight Control System Augmentation, Matthew B. Galles
Mechanical & Aerospace Engineering Theses & Dissertations
The aim of this thesis is to explore methods to reduce the noise impact of unmanned aerial vehicles operating within acoustically sensitive environments by flight control system augmentation. Two methods are investigated and include: (i) reduction of sound generated by vehicle speed control while flying along a nominal path and (ii) reduction of acoustic exposure by vehicle path control while flying at a nominal speed. Both methods require incorporation of an acoustic model into the flight control system as an additional control objective and an acoustic metric to characterize primary noise sources dependent on vehicle state. An acoustic model was …
Unsupervised-Learning Assisted Artificial Neural Network For Optimization, Varun Kote
Unsupervised-Learning Assisted Artificial Neural Network For Optimization, Varun Kote
Mechanical & Aerospace Engineering Theses & Dissertations
Innovations in computer technology made way for Computational Fluid Dynamics (CFD) into engineering, which supported the development of new designs by reducing the cost and time by lowering the dependency on experimentation. There is a further need to make the process of development more efficient. One such technology is Artificial Intelligence. In this thesis, we explore the application of Artificial Intelligence (AI) in CFD and how it can improve the process of development.
AI is used as a buzz word for the mechanism which can learn by itself and make the decision accordingly. Machine learning (ML) is a subset of …
Endogenous Force Transmission Between Epithelial Cells And A Role For Α-Catenin, Sandeep Dumbali
Endogenous Force Transmission Between Epithelial Cells And A Role For Α-Catenin, Sandeep Dumbali
Mechanical & Aerospace Engineering Theses & Dissertations
In epithelial tissues, epithelial cells adhere to each other as well as to the underlying extra-cellular matrix (ECM). E-cadherin-based intercellular junctions play an important role in tissue integrity. These junctions experience cell-generated mechanical forces via apparent adaptor proteins such as beta (β) catenin, alpha (α) catenin and vinculin. Abnormalities in these junctions may result in skin related diseases and cancers. Here, I devised methods to determine the endogenous intercellular force within cell pairs as well as in large epithelial islands. I further ascertained the factors that affect the level of inter-cellular tension.
Experiments with pairs of epithelial cells exogenously expressing …