Statistics and Probability Commons^™

Theranostic Applications Of Sirna Bioconjugates In Cancer Detection And Treatment, Sunil S. Shah

Seton Hall University Dissertations and Theses (ETDs)

Abstract

The emerging field of RNA nanotechnology has led to rapid advances in the applications of RNA in chemical biology, medicinal chemistry, and biotechnology. At the forefront of its utility is the ability to self-assemble multiple siRNAs into nanostructure formulations capable of targeting selected oncogenes and potentiating the gene therapy of malignant tumors. Self-assembled siRNA integrates multiple siRNAs within a single molecular platform for silencing multiple oncogenic mRNA targets with high precision and efficacy to potentially induce cancer cell apoptosis through the RNA interference (RNAi) pathway. Furthermore, the conjugation of siRNA self-assemblies with bio-active probes results in multi-functional theranostic (therapy+diagnostic) …

Characterizing The Northern Hemisphere Circumpolar Vortex Through Space And Time, Nazla Bushra

LSU Doctoral Dissertations

This hemispheric-scale, steering atmospheric circulation represented by the circumpolar vortices (CPVs) are the middle- and upper-tropospheric wind belts circumnavigating the poles. Variability in the CPV area, shape, and position are important topics in geoenvironmental sciences because of the many links to environmental features. However, a means of characterizing the CPV has remained elusive. The goal of this research is to (i) identify the Northern Hemisphere CPV (NHCPV) and its morphometric characteristics, (ii) understand the daily characteristics of NHCPV area and circularity over time, (iii) identify and analyze spatiotemporal variability in the NHCPV’s centroid, and (iv) analyze how CPV features relate …

Bayesian Methods In Operational Testing: Enhancing Testing Through Combining Information, Victoria R C Sieck

Mathematics & Statistics ETDs

When developing a system, considering system performance from a user perspective can be done through operational testing|assessing the ability of representative users to accomplish tasks with the system in operationally representative environments. This critical process can be expensive and time-consuming. We show how to leverage an existing design of experiments (DOE) process to construct a Bayesian adaptive design. This method allows for interim analyses using predictive probabilities to stop testing early for success or futility. Furthermore, operational environments are directly used in product evaluation. Representative simulations demonstrate reductions in necessary test events. Next, priors are built using developmental testing data. …

A Highly Predictive Microrna Panel For Determining Delayed Cerebral Vasospasm Risk Following Aneurysmal Subarachnoid Hemorrhage, Wang-Xia Wang, Joe E. Springer, Kevin Xie, David W. Fardo, Kevin W. Hatton

Sanders-Brown Center on Aging Faculty Publications

Approximately one-third of aneurysmal subarachnoid hemorrhage (aSAH) patients develop delayed cerebral vasospasm (DCV) 3–10 days after aneurysm rupture resulting in additional, permanent neurologic disability. Currently, no validated biomarker is available to determine the risk of DCV in aSAH patients. MicroRNAs (miRNAs) have been implicated in virtually all human diseases, including aSAH, and are found in extracellular biofluids including plasma and cerebrospinal fluid (CSF). We used a custom designed TaqMan Low Density Array miRNA panel to examine the levels of 47 selected brain and vasculature injury related miRNAs in CSF and plasma specimens collected from 31 patients with or without DCV …

Is Gallaudet Diverse? Creating An R Package To Measure Institutional Diversity, Emelia Beldon

Undergraduate University Honors Capstones

One of the biggest trends in social science is the study of racial and ethnic diversity measures. Numerous scholarly articles and journals detail how important it is to encourage a racially and ethnically diverse community in higher education. However, the question remains: how do we accurately measure racial and ethnic diversity? Furthermore, how do we present the diversity in terms of statistics for best use? With this project, I answer these questions. I created an R software package, diversityGV, to measure institutional racial and ethnic diversity using the Generalized Variance mathematical approach. I then used diversityGV with a dataset from …

We’Re Here To Get You There: A Statistical Analysis Of Bridgewater State University’S Transit System, Abigail Adams

Honors Program Theses and Projects

Bridgewater State University first established its on-campus transportation service in January of 1984. While it began only running as an on-campus service for students throughout the day, the service grew to expand by offering an off-campus connection to the neighboring city of Brockton and absorbed the night service system from the campus safety team. As BSU Transit continues to grow, the organization is seeking ways to improve their overall service and better prepare their fleet and driver pool to accommodate this growth. The purpose of this research is to analyze trends among the data collected by BSU Transit and assist …

A Study On Differing Generational Values And Expectations In Corporate America, Abigail Grella

Honors Program Theses and Projects

This paper examines the most common factors that lead to voluntary employee turnover, and the implications employee turnover has on an organization. Additionally, this paper will consider the varying values and workplace expectations of different demographic groups such as Millennials, Generation X, Generation Y, and Baby Boomers and how such factors could influence voluntary turnover. A study is conducted from survey results gathered across a large span of generations that are currently employed. Using statistical analysis employing t-tests and a Mood’s Median test, the results show that different generations have differently weighing values for specific organizational offerings. The results show …

Guidelines For Regression Analysis In Sas And R: A Case Study, Sarah Milligan

Honors Program Theses and Projects

When a player is a free agent, an individual who is able to sign to any team, one wonders what their best option is. Will signing with Team A or Team B provide them with the largest salary? What factors will affect their salary the most? Does last year’s statistics have a strong impact on next year’s salary? These questions can be answered by performing a regression analysis on previous years data. The primary focus of this project is to determine the most important variables related to an NBA salary. Likewise, the statistical programs SAS and R will be compared …

Neural Oscillatory Activity Serving Sensorimotor Control Is Regulated By The Mitochondrial Redox Environment In Health And Disease, Rachel Spooner

Theses & Dissertations

Despite effective regimens of combination antiretroviral therapy, individuals with HIV are still at higher risk for developing forms of cognitive impairment, with one of the most common behavioral abnormalities to manifest being motor dysfunction. This is an important consideration, as deficits in motor control likely contribute to higher-order cognitive impairments, which together, lead to functional dependencies in the ever-growing aging population of HIV-infected adults. While the neuroanatomical bases of motor dysfunction have recently been illuminated in people living with HIV (PLWH), there remains an open question regarding the molecular processes supporting the circuit-level neuronal dynamics that potentially serve these behavioral …

Markov Model Composition Of Balinese Reyong Norot Improvisations, Taylor Flanagan, Robert Rovetti

Honors Thesis

Markov models are mathematical structures that model the transition between possible states based on the probability of moving from one state to any other. Thus, given a distribution of starting points, the model produces a chain of states that are visited in sequence. Such models have been used extensively to generate music based on probabilities, as sequences of states can represent sequences of notes and rhythms. While music generation is a common application of Markov models, most existing work attempts to reconstruct the musical style of classical Western composers. In this thesis, we produce a series of Markov chains that …

Time Series Forecasting Of Covid-19 Deaths In Massachusetts, Andrew Disher

Honors Program Theses and Projects

The aim of this study was to use data provided by the Department of Public Health in the state of Massachusetts on its online dashboard to produce a time series model to accurately forecast the number of new confirmed deaths that have resulted from the spread of CoViD-19. Multiple different time series models were created, which can be classified as either an Auto-Regressive Integrated Moving Average (ARIMA) model or a Regression Model with ARIMA Errors. Two ARIMA models were created to provide a baseline forecasting performance for comparison with the Regression Model with ARIMA Errors, which used the number of …

Cardiovascular Complications Of Systemic Lupus Erythematosus: Impact Of Risk Factors And Therapeutic Efficacy--A Tertiary Centre Experience In An Appalachian State, Elise Danielle Mcveigh, Amna Batool, Arnold J. Stromberg, Ahmed K. Abdel-Latif, Nayef Mohammed Kazzaz

Statistics Faculty Publications

OBJECTIVES: Cardiovascular complications became a notable cause of morbidity and mortality in patients with lupus as therapeutic advancements became more efficient at managing other complications. The Appalachian community in Kentucky has a higher prevalence of traditional cardiovascular risk factors, predisposing them to cardiovascular events. Namely, the mean body mass index of the members of the Kentucky Appalachian community was reported at 33 kg/m² and 94.3% of male members of this community use tobacco. We sought to identify risk factors that predispose patients with lupus to cardiovascular morbidities and examine the effect of immunomodulatory drugs.

METHODS: We identified 20 UKHS …

Application Of Randomness In Finance, Jose Sanchez, Daanial Ahmad, Satyanand Singh

Publications and Research

Brownian Motion which is also considered to be a Wiener process and can be thought of as a random walk. In our project we had briefly discussed the fluctuations of financial indices and related it to Brownian Motion and the modeling of Stock prices.

Confidence Intervals Of Covid-19 Vaccine Efficacy Rates, Frank Wang

Numeracy

This tutorial uses publicly available data from drug makers and the Food and Drug Administration to guide learners to estimate the confidence intervals of COVID-19 vaccine efficacy rates with a Bayesian framework. Under the classical approach, there is no probability associated with a parameter, and the meaning of confidence intervals can be misconstrued by inexperienced students. With Bayesian statistics, one can find the posterior probability distribution of an unknown parameter, and state the probability of vaccine efficacy rate, which makes the communication of uncertainty more flexible. We use a hypothetical example and a real baseball example to guide readers to …

Species In Vernal Pools: Anova, Lisa Manne

Open Educational Resources

A one-way analysis of variance exercise using data on species diversities from vernal pools.Data are from vernal pools in Willowbrook Park (adjacent to College of Staten Island's campus) in spring.

The typical ANOVA gives a straightforward result (significant anova, easily-interpreted Tukey-Kramer analysis). This data set requires more nuanced interpretation, as the ANOVA is marginally significant, and Tukey-Kramer yields one significant pairwise comparison between groups. Relative lack of variation within groups explains this apparent enigma.

Motor Control-Based Assessment Of Therapy Effects In Individuals Post-Stroke: Implications For Prediction Of Response And Subject-Specific Modifications, Ashley Rice

Doctoral Dissertations

Producing a coordinated motion such as walking is, at its root, the result of healthy communication pathways between the central nervous system and the musculoskeletal system. The central nervous system produces an electrical signal responsible for the excitation of a muscle, and the musculoskeletal system contains the necessary equipment for producing a movement-driving force to achieve a desired motion. Motor control refers to the ability an individual has to produce a desired motion, and the complexity of motor control is a mathematical concept stemming from how the electrical signals from the central nervous system translate to muscle activations. Exercising a …

Applications Of Evidence Theory To High-Consequence Systems Safety, Christina Marie Deffenbaugh

Mathematics & Statistics ETDs

Issues linked to abnormal environments (like high-consequence systems safety, e.g., nuclear weapon components, bridges, apartment buildings, etc.) may have insufficient information to use either classical statistical methods or Bayesian approaches for calculating associated probabilistic risks, so there is often a requirement for another method that can deal with a low-information situation to obtain a risk assessment. Belief/plausibility measures of uncertainty from A. P. Dempster and G. Shafer’s Evidence Theory is one such method. This thesis has two goals. First, a brief discussion on belief/plausibility measures as an application of Evidence Theory will familiarize the audience with its history and how …

The Hybridizing Ions Treatment (Hit) Method Development And Computational Study On Sars-Cov-2 E Protein., Shengjie Sun

Open Access Theses & Dissertations

Fast and accurate calculations of the electrostatic features for highly charged biomolecules such as DNA, RNA, highly charged proteins, are crucial but challenging tasks. Traditional implicit solvent methods calculate the electrostatic features fast, but they are not able to balance the high net charges in the biomolecules effectively. Explicit solvent methods add unbalanced ions to neutralize the highly charged biomolecules in molecular dynamic simulations, which require more expensive computing resources. Here we developed a novel method, the Hybridizing Ions Treatment (HIT) method, which hybridizes the implicit solvent method with the explicit method to realistically calculate the electrostatic potential for highly …

Statistical Analysis Of 2017-18 Premier League Match Statistics Using A Regression Analysis In R, Bergen Campbell

Undergraduate Theses and Capstone Projects

This thesis analyzes the correlation between a team’s statistics and the success of their performances, and develops a predictive model that can be used to forecast final season results for that team. Data from the 2017-2018 Premier League season is to be gathered and broken down within R to highlight what factors and variables are largely contributing to the success or downfall of a team. A multiple linear regression model and stepwise selection process is then used to include any factors that are significant in predicting in match results.

The predictions about the 17-18 season results based on the model …

Retail Trading And Stock Volatility: The Case Of Robinhood, Cooper Jones

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

We examine the relation between Robinhood usership and stock market volatility. We show that daily fluctuations in Robinhood usership, which is used to proxy retail trading, significantly influence various measures of volatility. These results might suggest that Robinhood users contribute to noise trading as they are generally individuals trading on name recognition, media coverage, popularity, and familiarity of products, rather than on fundamental values. In our empirical approach, we find that the percentage increase in Robinhood usership Granger causes increases in daily stock volatility.