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Mechanistic Mathematical Models: An Underused Platform For Hpv Research, Marc Ryser, Patti Gravitt, Evan R. Myers 2017 George Washington University

Mechanistic Mathematical Models: An Underused Platform For Hpv Research, Marc Ryser, Patti Gravitt, Evan R. Myers

Global Health Faculty Publications

Health economic modeling has become an invaluable methodology for the design and evaluation of clinical and public health interventions against the human papillomavirus (HPV) and associated diseases. At the same time, relatively little attention has been paid to a different yet complementary class of models, namely that of mechanistic mathematical models. The primary focus of mechanistic mathematical models is to better understand the intricate biologic mechanisms and dynamics of disease. Inspired by a long and successful history of mechanistic modeling in other biomedical fields, we highlight several areas of HPV research where mechanistic models have the potential to advance the ...


Uncovering Functional Relationships In Leukemia, Reginald McGee 2017 Mathematical Biosciences Institute

Uncovering Functional Relationships In Leukemia, Reginald Mcgee

Biology and Medicine Through Mathematics Conference

No abstract provided.


Firing Rate Heterogeneity And Consequences For Coding In Feedforward Circuits, Cheng Ly, Gary Marsat 2017 Virginia Commonwealth University

Firing Rate Heterogeneity And Consequences For Coding In Feedforward Circuits, Cheng Ly, Gary Marsat

Biology and Medicine Through Mathematics Conference

No abstract provided.


On The Analysis Of The Sir Epidemic Model For Small Networks: An Application In Hospital Settings, Martin Lopez-Garcia 2017 University of Leeds

On The Analysis Of The Sir Epidemic Model For Small Networks: An Application In Hospital Settings, Martin Lopez-Garcia

Biology and Medicine Through Mathematics Conference

No abstract provided.


Methods For Parameter Estimation Of A Stochastic Seir Model, Kaitlyn Martinez 2017 Colorado School of Mines

Methods For Parameter Estimation Of A Stochastic Seir Model, Kaitlyn Martinez

Biology and Medicine Through Mathematics Conference

No abstract provided.


Shape Features Underlying The Perception Of Liquids, Jan Jaap R. van Assen, Pascal Barla, Roland W. Fleming 2017 Department of Psychology, Justus-Liebig-University Giessen

Shape Features Underlying The Perception Of Liquids, Jan Jaap R. Van Assen, Pascal Barla, Roland W. Fleming

MODVIS Workshop

No abstract provided.


The Acquisition And Analysis Of Electroencephalogram Data For The Classification Of Benign Partial Epilepsy Of Childhood With Centrotemporal Spikes, Jessica A. Scarborough 2017 University of San Francisco

The Acquisition And Analysis Of Electroencephalogram Data For The Classification Of Benign Partial Epilepsy Of Childhood With Centrotemporal Spikes, Jessica A. Scarborough

Master's Theses

In this thesis, I will expand upon each step in the process of acquiring and analyzing electroencephalogram (EEG) for the classification of benign childhood epilepsy with centrotemporal spikes. Despite huge advancements in the field of health informatics—natural language processing, machine learning, predictive modeling—there are significant barriers to the access of clinical data. These barriers include information blocking, privacy policy concerns, and a lack of stakeholder support. We will see that these roadblocks are all responsible for stunting biomedical research in some way, including my own experiences in acquiring the data for the second chapter of this thesis.

This ...


Using Mathematical Models Of Biological Processes In Genome-Wide Association Studies Of Psychiatric Disorders, Amy Cochran 2017 University of Michigan-Ann Arbor

Using Mathematical Models Of Biological Processes In Genome-Wide Association Studies Of Psychiatric Disorders, Amy Cochran

Biology and Medicine Through Mathematics Conference

No abstract provided.


A Generalized Linear Model For Marital Disruption In Namibia, Lillian Pazvakawambwa 2017 University of Namibia, Department of Statistics and Population Studies

A Generalized Linear Model For Marital Disruption In Namibia, Lillian Pazvakawambwa

Andrews Research Conference

Marital disruption has attracted wide attention among researchers. In recent years, the world has experienced reductions in marriage rates, along with significant increases in cohabiting unions, divorce and separation, leading to rising conjugal and family instability. While some have seen this as a sign of social and moral disruption with a potential to shatter the family institution and the foundations of society itself, others have embraced these trends as signaling increased individual liberty and the loosening of suffocating social mores. There is limited research on the factors influencing marital disruption in Namibia. This paper used the Namibia Demographic and Health ...


Can Cone Signals In The Wild Be Predicted From The Past?, David H. Foster, Iván Marín-Franch 2017 University of Manchester, UK

Can Cone Signals In The Wild Be Predicted From The Past?, David H. Foster, Iván Marín-Franch

MODVIS Workshop

In the natural world, the past is usually a good guide to the future. If light from the sun and sky is blue earlier in the day and yellow now, then it is likely to be more yellow later, as the sun's elevation decreases. But is the light reflected from a scene into the eye as predictable as the light incident upon the scene, especially when lighting changes are not just spectral but include changes in local shadows and mutual reflections? The aim of this work was to test the predictability of cone photoreceptor signals in the wild over ...


Midlife And Late-Life Vascular Risk Factors And White Matter Microstructural Integrity: The Atherosclerosis Risk In Communities Neurocognitive Study., Melinda C Power, Jonathan V Tingle, Robert I Reid, Juebin Huang, A Richey Sharrett, Josef Coresh, Michael Griswold, Kejal Kantarci, Clifford R Jack, David Knopman, Rebecca F Gottesman, Thomas H Mosley 2017 George Washington University

Midlife And Late-Life Vascular Risk Factors And White Matter Microstructural Integrity: The Atherosclerosis Risk In Communities Neurocognitive Study., Melinda C Power, Jonathan V Tingle, Robert I Reid, Juebin Huang, A Richey Sharrett, Josef Coresh, Michael Griswold, Kejal Kantarci, Clifford R Jack, David Knopman, Rebecca F Gottesman, Thomas H Mosley

Epidemiology and Biostatistics Faculty Publications

BACKGROUND: Diffusion tensor imaging measures of white matter (WM) microstructural integrity appear to provide earlier indication of WM injury than WM hyperintensities; however, risk factors for poor WM microstructural integrity have not been established. Our study quantifies the association between vascular risk factors in midlife and late life with measures of late-life WM microstructural integrity.

METHODS AND RESULTS: We used data from 1851 participants in ARIC (Atherosclerosis Risk in Communities Study) who completed 3-T magnetic resonance imaging, including diffusion tensor imaging, as part of the ARIC Neurocognitive Study (ARIC-NCS). We quantified the association among lipids, glucose, and blood pressure from ...


Cohort Profile: Seek, Test, Treat And Retain United States Criminal Justice Cohort., Redonna Chandler, Michael S Gordon, Bridget Kruszka, Lauren N Strand, Frederick L Altice, Irene Kuo, +several additional authors 2017 George Washington University

Cohort Profile: Seek, Test, Treat And Retain United States Criminal Justice Cohort., Redonna Chandler, Michael S Gordon, Bridget Kruszka, Lauren N Strand, Frederick L Altice, Irene Kuo, +Several Additional Authors

Epidemiology and Biostatistics Faculty Publications

BACKGROUND: The STTR treatment cascade provides a framework for research aimed at improving the delivery of services, care and outcomes of PLWH. The development of effective approaches to increase HIV diagnoses and engage PLWH in subsequent steps of the treatment cascade could lead to earlier and sustained ART treatment resulting in viral suppression. There is an unmet need for research applying the treatment cascade to improve outcomes for those with criminal justice involvement.

METHODS: The Seek, Test, Treat, and Retain (STTR) criminal justice (CJ) cohort combines data from 11 studies across the HIV treatment cascade that focused on persons involved ...


Cox Processes For Visual Object Counting, Yongming Ma 2017 Portland State University

Cox Processes For Visual Object Counting, Yongming Ma

Student Research Symposium

We present a model that utilizes Cox processes and CNN classifiers in order to count the number of instances of an object in an image. Poisson processes are well suited to events that occur randomly in space, like the location of objects in an image, as well as to the task of counting. Mixed Poisson processes also offer increased flexibility, however they do not easily scale with image size: they typically require O(n3) computation time and O(n2) storage, where n is the number of pixels. To mitigate this problem, we employ Kronecker algebra which takes advantage of the ...


Do You Know What Your Phone Is Doing To You? - Analysis On Usage Data Over An Entire Semester, Jawa El-Shanti 2017 Chapman University

Do You Know What Your Phone Is Doing To You? - Analysis On Usage Data Over An Entire Semester, Jawa El-Shanti

Student Research Day Abstracts and Posters

Like many teens today, I am a victim of cell phone addiction. Over the course of the spring 2017 semester I recorded my phone usage with the aim to quantify the degree of my addiction. I am using an iPhone application called Moment, which records the amount of time I spend on each application, the number of times I pick up my phone, and when I first and last used my phone during the day. I decided to keep track of the applications I want to minimize my time on which include Snapchat, Instagram, Netflix, YouTube and Messages. I am ...


Gilmore Girls And Instagram: A Statistical Look At The Popularity Of The Television Show Through The Lens Of An Instagram Page, Brittany Simmons 2017 Chapman University

Gilmore Girls And Instagram: A Statistical Look At The Popularity Of The Television Show Through The Lens Of An Instagram Page, Brittany Simmons

Student Research Day Abstracts and Posters

After going on the Warner Brothers Tour in December of 2015, I created a Gilmore Girls Instagram account. This account, which started off as a way for me to create edits of the show and post my photos from the tour turned into something bigger than I ever could have imagined. In just over a year I have over 55,000 followers. I post content including revival news, merchandise, and edits of the show that have been featured in Entertainment Weekly, Bustle, E! News, People Magazine, Yahoo News, & GilmoreNews.

I created a dataset of qualitative and quantitative outcomes from my ...


Statistical Methods For Assessing Individual Oocyte Viability Through Gene Expression Profiles, Michael O. Bishop 2017 Utah State University

Statistical Methods For Assessing Individual Oocyte Viability Through Gene Expression Profiles, Michael O. Bishop

All Graduate Plan B and other Reports

Abstract

Statistical Methods for Assessing Individual Oocyte Viability Through Gene Expression Profiles

By

Michael O. Bishop

Utah State University, 2017

Major Professor: Dr. John R. Stevens

Department: Mathematics and Statistics

Oocytes are the precursor cells to the female gamete, or egg. While reproduction may vary from species to species, within humans and most domesticated animals, the oocyte maturation process is fairly similar. As an oocyte matures, there are various processes that take place, all of which have an effect on the viability of the individual oocyte. Barring outside damage that may come to the oocyte, one of the primary reasons ...


Comparision Of Survival Curves Between Cox Proportional Hazards, Random Forests, And Conditional Inference Forests In Survival Analysis, Brandon Weathers, Richard Cutler Dr. 2017 Utah State University

Comparision Of Survival Curves Between Cox Proportional Hazards, Random Forests, And Conditional Inference Forests In Survival Analysis, Brandon Weathers, Richard Cutler Dr.

All Graduate Plan B and other Reports

Survival analysis methods are a mainstay of the biomedical fields but are finding increasing use in other disciplines including finance and engineering. A widely used tool in survival analysis is the Cox proportional hazards regression model. For this model, all the predicted survivor curves have the same basic shape, which may not be a good approximation to reality. In contrast the Random Survival Forests does not make the proportional hazards assumption and has the flexibility to model survivor curves that are of quite different shapes for different groups of subjects. We applied both techniques to a number of publicly available ...


A Comparison Of Statistical Methods Relating Pairwise Distance To A Binary Subject-Level Covariate, Rachael Stone 2017 Utah State University

A Comparison Of Statistical Methods Relating Pairwise Distance To A Binary Subject-Level Covariate, Rachael Stone

All Graduate Plan B and other Reports

A community ecologist provided a motivating data set involving a certain animal species with two behavior groups, along with a pairwise genetic distance matrix among individuals. Many community ecologists have analyzed similar data sets with a method known as the Hopkins method, testing for an association between the subject-level covariate (behavior group) and the pairwise distance. This community ecologist wanted to know if they used the Hopkins method, would their results be meaningful? Their question inspired this thesis work, where a different data set was used for confidentiality reasons. Multiple methods (Hopkins method, ADONIS, ANOSIM, and Distance Regression) were used ...


Cancer-Specific Mortality, Cure Fraction, And Noncancer Causes Of Death Among Diffuse Large B-Cell Lymphoma Patients In The Immunochemotherapy Era., Nadia Howlader, Angela B Mariotto, Caroline Besson, Gita Suneja, Kim Robien, Naji Younes, Eric A Engels 2017 George Washington University

Cancer-Specific Mortality, Cure Fraction, And Noncancer Causes Of Death Among Diffuse Large B-Cell Lymphoma Patients In The Immunochemotherapy Era., Nadia Howlader, Angela B Mariotto, Caroline Besson, Gita Suneja, Kim Robien, Naji Younes, Eric A Engels

Epidemiology and Biostatistics Faculty Publications

BACKGROUND

Survival after the diagnosis of diffuse large B-cell lymphoma (DLBCL) has been increasing since 2002 because of improved therapies; however, long-term outcomes for these patients in the modern treatment era are still unknown.

METHODS

Using Surveillance, Epidemiology, and End Results data, this study first assessed factors associated with DLBCL-specific mortality during 2002-2012. An epidemiologic risk profile, based on clinical and demographic characteristics, was used to stratify DLBCL cases into low-, medium-, and high-risk groups. The proportions of DLBCL cases that might be considered cured in these 3 risk groups was estimated. Risks of death due to various noncancer causes ...


A Distribution Of The First Order Statistic When The Sample Size Is Random, Vincent Z. Forgo Mr 2017 East Tennessee State University

A Distribution Of The First Order Statistic When The Sample Size Is Random, Vincent Z. Forgo Mr

Electronic Theses and Dissertations

Statistical distributions also known as probability distributions are used to model a random experiment. Probability distributions consist of probability density functions (pdf) and cumulative density functions (cdf). Probability distributions are widely used in the area of engineering, actuarial science, computer science, biological science, physics, and other applicable areas of study. Statistics are used to draw conclusions about the population through probability models. Sample statistics such as the minimum, first quartile, median, third quartile, and maximum, referred to as the five-number summary, are examples of order statistics. The minimum and maximum observations are important in extreme value theory. This paper will ...


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