Longitudinal Data Analysis and Time Series Commons^™

Targeted Maximum Likelihood Estimation For Dynamic And Static Longitudinal Marginal Structural Working Models, Maya L. Petersen, Joshua Schwab, Susan Gruber, Nello Blaser, Michael Schomaker, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

This paper presents a novel targeted maximum likelihood estimator (TMLE) estimator for the parameters of longitudinal static and dynamic marginal structural models.We consider a longitudinal data structure consisting of baseline covariates, time-dependent intervention nodes, intermediate time-dependent covariates, and a possibly time dependent outcome. The intervention nodes at each time point can include a binary treatment as well as a right-censoring indicator. Given a class of dynamic or static interventions, a marginal structural model is used to model the mean of the intervention specific counterfactual outcome as a function of the intervention and time point.Because the true shape of ...

Joint Outcome Modeling Using Shared Frailties With Application To Temporal Streamflow Data, Lihua Li

University of Western Ontario - Electronic Thesis and Dissertation Repository

Recently there has been tremendous interest in the development of tools for joint analysis of longitudinal data and time-to-event data. This has gained emphasis particularly in clinical studies, where longitudinal measurements on a response may be recorded along with a time-to-event outcome. Joint analysis of multiple outcomes beyond longitudinal and survival have also been considered, for example, joint analysis of a variety of generalized linear models including continuous and count data, or continuous and binomial data. With joint analysis of multiple outcomes, the interest may be analysis of one outcome conditional on the others, or, more typically, analysis of all ...

Is Obesity Socially Contagious?, Ciani Jean Sparks

Statistics

The main objective of this paper is to analyze three different articles that discuss whether obesity could be socially contagious. According to the World Health Organization in 2013, obesity is the fifth leading risk for deaths around the world. This disease has dramatically increased in the last decade, which has led scientists to believe there are other factors contributing to the epidemic besides genetics. The first article I analyzed, written by Nicholas Christakis and James Fowler, provided a logistic regression model to estimate the odds of a person becoming obese. The model included the explanatory variables: age, sex, education, smoking ...

Advancing The Science Of Population Health And Aging Through Open Access Interdisciplinary Research, Parminder Raina

Looking Forward: Re-Imagining the Academic Library's Role in Teaching, Learning & Research

No abstract provided.

Methodological Issues In Design And Analysis Of Studies With Correlated Data In Health Research, Jinhui Ma

Open Access Dissertations and Theses

Correlated data with complex association structures arise from longitudinal studies and cluster randomized trials. However, some methodological challenges in the design and analysis of such studies or trials have not been overcome. In this thesis, we address three of the challenges: 1) Power analysis for population based longitudinal study investigating gene-environment interaction effects on chronic disease: For longitudinal studies with interest in investigating the gene-environment interaction in disease susceptibility and progression, rigorous statistical power estimation is crucial to ensure that such studies are scientifically useful and cost-effective since human genome epidemiology is expensive. However conventional sample size calculations for longitudinal ...

Methods For Dealing With Death And Missing Data, And For Standardizing Different Health Variables In Longitudinal Datasets: The Cardiovascular Health Study, Paula Diehr

UW Biostatistics Working Paper Series

Longitudinal studies of older adults usually need to account for deaths and missing data. The databases often include multiple health-related variables, which are hard to compare because they were measured on different scales. Here we present the unified approach to these three problems, developed and used in the Cardiovascular Health Study. Data were first transformed to a new scale that had integer/ratio properties, and on which “dead” takes the value zero. Missing data were then imputed on this new scale, using each person’s own data over time. Imputation could thus be informed by impending death. The new transformed ...

Global Quantitative Assessment Of The Colorectal Polyp Burden In, Patrick M. Lynch, Jeffrey S. Morris, William A. Ross, Miguel A. Rodriguez-Bigas, Juan Posadas, Rossa Khalaf, Diane M. Weber, Valerie O. Sepeda, Bernard Levin, Imad Shureiqi

Jeffrey S. Morris

Background: Accurate measures of the total polyp burden in familial adenomatous polyposis (FAP) are lacking. Current assessment tools include polyp quantitation in limited-field photographs and qualitative total colorectal polyp burden by video.

Objective: To develop global quantitative tools of the FAP colorectal adenoma burden.

Design: A single-arm, phase II trial.

Patients: Twenty-seven patients with FAP.

Intervention: Treatment with celecoxib for 6 months, with before-treatment and after-treatment videos posted to an intranet with an interactive site for scoring.

Main Outcome Measurements: Global adenoma counts and sizes (grouped into categories: less than 2 mm, 2-4 mm, and greater than 4 mm) were ...

Analysis Of Median Household Income Differences Between Election Day-Vbm And Eip Voters, Mark Salling, Norman Robbins

Urban Publications

Analysis of early in-person (EIP) voting in 2008 in Cuyahoga County shows that African-American, white, and Hispanic voters who used EIP voting had significantly lower incomes than members of those same groups who voted on election day or by mail. This result applies to those voting EIP on weekdays, extended weekday hours, weekends, and the three days before election day.

A Study Of Mexican Free-Tailed Bat Chirp Syllables: Bayesian Functional Mixed Modeling Of Nonstationary Time Series Data With Time-Dependent Spectra, Josue G. Martinez, Kirsten M. Bohn, Raymond J. Carroll, Jeffrey S. Morris

Jeffrey S. Morris

We describe a new approach to analyze chirp syllables of free-tailed bats from two regions of Texas in which they are predominant: Austin and College Station. Our goal is to characterize any systematic regional differences in the mating chirps and assess whether individual bats have signature chirps. The data are analyzed by modeling spectrograms of the chirps as responses in a Bayesian functional mixed model. Given the variable chirp lengths, we compute the spectrograms on a relative time scale interpretable as the relative chirp position, using a variable window overlap based on chirp length. We use 2D wavelet transforms to ...

Robust Estimation Of Autoregressive Conditional Duration Models, Rola S. El Sebai

Open Access Dissertations and Theses

In this thesis, we apply the Ordinary Least Squares (OLS) and the Generalized Least Squares (GLS) methods for the estimation of Autoregressive Conditional Duration (ACD) models, as opposed to the typical approach of using the Quasi Maximum Likelihood Estimation (QMLE).

The advantages of OLS and GLS as the underlying methods of estimation lie in their theoretical ease and computational convenience. The latter property is crucial for high frequency trading, where a transaction decision needs to be made within a minute. We show that both OLS and GLS estimates are asymptotically consistent and normally distributed. The normal approximation does not seem ...

Analysis Of Dietary Patterns Over Freshman Year Of College, Chelsea Lofland

Statistics

This analysis is an investigation of changes in Cal Poly students’ eating habits over freshman year. The motivation behind this was an interest in college students’ lifestyles; college is the first time most students live on their own and it can be an important maturation period. College is stressful, exciting, liberating, and terrifying all at the same time. This distinctive life experience, along with my desire to handle big and messy data, led me to this research question.

The response variable analyzed was food consumption and the explanatory variables were: sex, race, quarter, food group, stress, exercise, BMI, sleep quality ...