The Test-Retest Reliability Of Erp Components As Assessed By The Brief Neurometric Battery, 2018 The College of William and Mary
The Test-Retest Reliability Of Erp Components As Assessed By The Brief Neurometric Battery, James D. Cole, Paul Kieffaber
Undergraduate Honors Theses
Electroencephalography (EEG) has been a crucial component of neuropsychological research for nearly a century. Recent applications of the EEG recordings in a clinical setting have demonstrated a range of diagnostic and prognostic uses. Certain changes in event-related potentials (ERP) have been linked to the effects of different neurological conditions and can be accurately used to determine the severity of those conditions. However, in order to assess the stability of these ERP recordings over an extended period of time, one must first establish their statistical test-retest reliability. Using a novel Brief Neurometric Battery we assessed seven different ERP components in twenty ...
Systematic Review And Meta-Analysis: Tuberculosis, Tnfα Inhibitors, And Crohn's Disease, 2018 University of Central Florida
Systematic Review And Meta-Analysis: Tuberculosis, Tnfα Inhibitors, And Crohn's Disease, Brent L. Cao
Honors Undergraduate Theses
Inflammation is often a protective reaction against harmful foreign agents. However, in many disease conditions, the mechanisms behind the inflammatory response are poorly understood. Often times, the inflammation causes adverse effects, such as joint pain, abdominal pain, fever, fatigue, and loss of appetite. Thus, many treatments aim to inhibit the inflammatory response in order to control adverse symptoms. Such treatments include TNFα inhibitors. However, a major risk associated with drugs inhibiting tumor necrosis factor alpha (TNFα) is serious infection, including tuberculosis (TB).
Anti-TNFα therapy is used to treat patients with Crohn’s disease, for which the risk of tuberculosis may ...
Multi-State Modeling Of Hospital Frequent Users, 2018 University of Windsor
Multi-State Modeling Of Hospital Frequent Users, Yu Liang
The top 1% of frequent users account for 34% of public health system expenditures in Ontario, while the top 5% account for 66%. In this paper, we explore the efficacy of an intervention aimed at reducing hospital utilization for a group of patients defined as frequent users, by using Multi-state modeling. We employ time-homogeneous, time-inhomogeneous, parametric and semi-parametric Markov processes to study the transitions of the patients between hospital, ER and outside during a follow up period of one year. The results do not indicate any strong evidence that the intervention was beneficial.
Real-Time Dengue Forecasting In Thailand: A Comparison Of Penalized Regression Approaches Using Internet Search Data, 2018 University of Massachusetts Amherst
Real-Time Dengue Forecasting In Thailand: A Comparison Of Penalized Regression Approaches Using Internet Search Data, Caroline Kusiak
Dengue fever affects over 390 million people annually worldwide and is of particu- lar concern in Southeast Asia where it is one of the leading causes of hospitalization. Modeling trends in dengue occurrence can provide valuable information to Public Health officials, however many challenges arise depending on the data available. In Thailand, reporting of dengue cases is often delayed by more than 6 weeks, and a small fraction of cases may not be reported until over 11 months after they occurred. This study shows that incorporating data on Google Search trends can improve dis- ease predictions in settings with severely ...
The Impact Of Truncating Data On The Predictive Ability For Single-Step Genomic Best Linear Unbiased Prediction, 2018 University of Nebraska–Lincoln
The Impact Of Truncating Data On The Predictive Ability For Single-Step Genomic Best Linear Unbiased Prediction, Jeremy T. Howard, Thomas A. Rathje, Caitlyn E. Bruns, Danielle F. Wilson-Wells, Stephen D. Kachman, Matthew L. Spangler
Faculty Papers and Publications in Animal Science
Simulated and swine industry data sets were utilized to assess the impact of removing older data on the predictive ability of selection candidate estimated breeding values (EBV) when using single-step genomic best linear unbiased prediction (ssGBLUP). Simulated data included thirty replicates designed to mimic the structure of swine data sets. For the simulated data, varying amounts of data were truncated based on the number of ancestral generations back from the selection candidates. The swine data sets consisted of phenotypic and genotypic records for three traits across two breeds on animals born from 2003 to 2017. Phenotypes and genotypes were iteratively ...
Some Dimension Reduction Strategies For The Analysis Of Survey Data, 2017 University of Kentucky
Some Dimension Reduction Strategies For The Analysis Of Survey Data, Jiaying Weng, Derek S. Young
Statistics Faculty Publications
In the era of big data, researchers interested in developing statistical models are challenged with how to achieve parsimony. Usually, some sort of dimension reduction strategy is employed. Classic strategies are often in the form of traditional inference procedures, such as hypothesis testing; however, the increase in computing capabilities has led to the development of more sophisticated methods. In particular, sufficient dimension reduction has emerged as an area of broad and current interest. While these types of dimension reduction strategies have been employed for numerous data problems, they are scantly discussed in the context of analyzing survey data. This paper ...
Landscape, Demographic, Entomological, And Climatic Associations With Human Disease Incidence Of West Nile Virus In The State Of Iowa, Usa, John P. Degroote, Ramathan Sugumaran, Sarah M. Brend, Brad J. Tucker, Lyric Bartholomay
Background: West Nile virus (WNV) emerged as a threat to public and veterinary health in the Midwest United States in 2001 and continues to cause significant morbidity and mortality annually. To investigate biotic and abiotic factors associated with disease incidence, cases of reported human disease caused by West Nile virus (WNV) in the state of Iowa were aggregated by census block groups in Iowa for the years 2002–2006. Spatially explicit data on landscape, demographic, and climatic conditions were collated and analyzed by census block groups. Statistical tests of differences between means and distributions of landscape, demographic, and climatic variables ...
Burden Of Atopic Dermatitis In The United States: Analysis Of Healthcare Claims Data In The Commercial, Medicare, And Medi-Cal Databases, 2017 STATinMED Research/SIMR, Inc.
Burden Of Atopic Dermatitis In The United States: Analysis Of Healthcare Claims Data In The Commercial, Medicare, And Medi-Cal Databases, Sulena Shrestha, Raymond Miao, Li Wang, Jingdong Chao, Huseyin Yuce, Wenhui Wei
Publications and Research
Comparative data on the burden of atopic dermatitis (AD) in adults relative to the general population are limited. We performed a large-scale evaluation of the burden of disease among US adults with AD relative to matched non-AD controls, encompassing comorbidities, healthcare resource utilization (HCRU), and costs, using healthcare claims data. The impact of AD disease severity on these outcomes was also evaluated.
Mechanistic Mathematical Models: An Underused Platform For Hpv Research, 2017 George Washington University
Mechanistic Mathematical Models: An Underused Platform For Hpv Research, Marc Ryser, Patti Gravitt, Evan R. Myers
Global Health Faculty Publications
Health economic modeling has become an invaluable methodology for the design and evaluation of clinical and public health interventions against the human papillomavirus (HPV) and associated diseases. At the same time, relatively little attention has been paid to a different yet complementary class of models, namely that of mechanistic mathematical models. The primary focus of mechanistic mathematical models is to better understand the intricate biologic mechanisms and dynamics of disease. Inspired by a long and successful history of mechanistic modeling in other biomedical fields, we highlight several areas of HPV research where mechanistic models have the potential to advance the ...
Variables Associated With Overweight/Obesity Among African-American Women With Hypertension And/Or Diabetes, 2017 George Washington University
Variables Associated With Overweight/Obesity Among African-American Women With Hypertension And/Or Diabetes, Monica A. Hamilton, Dnp, Rn, Acns-Bc
Doctor of Nursing Practice Projects
Obesity is the second leading cause of preventable death next to tobacco use. Although it is prevalent in all populations, it disproportionately affects AA women. Overweight/obesity increases AA women’s chances of developing chronic illnesses such as diabetes, hypertension, heart disease, and decreases their life expectancy. The purpose of this study was to explore variables associated with overweight/obese AA women with hypertension and/or diabetes.
A secondary data analysis was conducted using a descriptive-correlational design to analyze cross-sectional data obtained from the 2013 Behavioral Risk Factor Surveillance System (BRFSS). The sample consisted of AA women (n ...
Climate Change, Natural Disasters, And Suicide: A Systematic Review, 2017 George Washington
Climate Change, Natural Disasters, And Suicide: A Systematic Review, Ans Irfan, Peter Lapuma
GW Research Days 2016 - Present
Natural disasters are projected to increase due to climate change. Mental health is not a well-researched area in public health, particularly as it relates to environmental health and in the aftermath of natural disasters. The suicide rate is approximately 13 per 100,000 people in the US, nationally. This already high suicide rate warrants researching this area mental health. Understanding the relation between natural disasters and suicide rates might help alleviate human suffering and potentially save lives in the future, in post-disaster settings. This research will further the knowledge of the association between natural disasters and suicide and provide ...
Perspectives On Model Forecasts Of The 2014–2015 Ebola Epidemic In West Africa: Lessons And The Way Forward, 2017 George Washington University
Perspectives On Model Forecasts Of The 2014–2015 Ebola Epidemic In West Africa: Lessons And The Way Forward, Gerardo Chowell, Cecile Viboud, Lone Simonsen, Stefano Merler, Alessandro Vespignani
Global Health Faculty Publications
The unprecedented impact and modeling efforts associated with the 2014–2015 Ebola epidemic in West Africa provides a unique opportunity to document the performances and caveats of forecasting approaches used in near-real time for generating evidence and to guide policy. A number of international academic groups have developed and parameterized mathematical models of disease spread to forecast the trajectory of the outbreak. These modeling efforts often relied on limited epidemiological data to derive key transmission and severity parameters, which are needed to calibrate mechanistic models. Here, we provide a perspective on some of the challenges and lessons drawn from these ...
Models For Hsv Shedding Must Account For Two Levels Of Overdispersion, 2016 University of Washington - Seattle Campus
Models For Hsv Shedding Must Account For Two Levels Of Overdispersion, Amalia Magaret
UW Biostatistics Working Paper Series
We have frequently implemented crossover studies to evaluate new therapeutic interventions for genital herpes simplex virus infection. The outcome measured to assess the efficacy of interventions on herpes disease severity is the viral shedding rate, defined as the frequency of detection of HSV on the genital skin and mucosa. We performed a simulation study to ascertain whether our standard model, which we have used previously, was appropriately considering all the necessary features of the shedding data to provide correct inference. We simulated shedding data under our standard, validated assumptions and assessed the ability of 5 different models to reproduce the ...
Spatiotemporal Meta-Analysis: Reviewing Health Psychology Phenomena Over Space And Time., 2016 University of Connecticut
Spatiotemporal Meta-Analysis: Reviewing Health Psychology Phenomena Over Space And Time., Blair T. Johnson
This supplemental material is meant to support this article:
Johnson, B. T., Crowley, E., & Marrouch, N. Spatiotemporal meta-analysis: Reviewing health psychology phenomena over space and time. Health Psychology Review.
Specifically, it is a database of GDPs per capita for nations in the world between 1800 and 2015. It is archived here to support an online supplement to this article.
GDP per capita
Generalized Confidence Intervals And Fiducial Intervals For Some Epidemiological Measures., 2016 George Washington University
Generalized Confidence Intervals And Fiducial Intervals For Some Epidemiological Measures., Ionut Bebu, G. Luta, T. Mathew, B. K. Agan
GW Biostatistics Center
For binary outcome data from epidemiological studies, this article investigates the interval estimation of several measures of interest in the absence or presence of categorical covariates. When covariates are present, the logistic regression model as well as the log-binomial model are investigated. The measures considered include the common odds ratio (OR) from several studies, the number needed to treat (NNT), and the prevalence ratio. For each parameter, confidence intervals are constructed using the concepts of generalized pivotal quantities and fiducial quantities. Numerical results show that the confidence intervals so obtained exhibit satisfactory performance in terms of maintaining the coverage probabilities ...
Evaluating The Effects Of Standardized Patient Care Pathways On Clinical Outcomes, 2015 University of Tennessee - Knoxville
Evaluating The Effects Of Standardized Patient Care Pathways On Clinical Outcomes, Anna V. Romanova
The main focus of this study is to create a standardized approach to evaluating the impact of the patient care pathways across all major disease categories and key outcome measures in a hospital setting when randomized clinical trials are not feasible. Toward this goal I identify statistical methods, control factors, and adjustments that can correct for potential confounding in observational studies. I investigate the efficiency of existing bias correction methods under varying conditions of imbalanced samples through a Monte Carlo simulation. The simulation results are then utilized in a case study for one of the largest primary diagnosis areas, chronic ...
Teaching Of Biostatistics And Epidemiology In Medical Schools: How Do We Fare Compared With Developed Countries, 2015 National Institute of Health and Family Welfare
Teaching Of Biostatistics And Epidemiology In Medical Schools: How Do We Fare Compared With Developed Countries, Vijay Tiwari, Kuldeep Kumar, Sherin Raj
Background Biostatistics is taught in almost all medical schools at the undergraduate and the postgraduate levels as a core course and is a prerequisite to epidemiology, public health and evidence-based medicine. However, it has to be taught in a different way in medical schools as compared with how it is taught to the students studying MSc (Biostatistics) or in the Statistics Department in universities. Objectives (1) To review the experience of teaching biostatistics in medical schools in India and compares the same with abroad (2) How best the curriculum can be designed as per the need of the medical students ...
Analyzing Alcohol Behavior In San Luis Obispo, 2014 California Polytechnic State University - San Luis Obispo
Analyzing Alcohol Behavior In San Luis Obispo, Ariana Montes
No abstract provided.
Should We Love Or Hate Big Data? The Good, The Bad, And The Ugly, 2014 La Salle University
Should We Love Or Hate Big Data? The Good, The Bad, And The Ugly, Dennis Crossen M.Sc., Mba, Karti Puranam Phd, Madjid Tavana Phd
No abstract provided.
Stratified Meta-Analysis To Examine Data Biases In Lung Cancer Studies Of Refinery Workers, Sherman Selix
Yale Day of Data
Petroleum refineries employ a variety of workers who historically experienced different potentials for asbestos exposure depending on job tasks. Associations between petroleum refinery work and lung cancer related to occupational asbestos exposure have been quantified among various locations, corporations, and time periods. To combine the data from several individual refinery studies and examine an overall effect, a systematic review and stratified meta-analysis was employed. Using set search terms among four databases, 112 potential publications were identified, of which 29 qualified for meta-analysis. Risk estimates and confidence intervals were extracted from these publications to construct four separate datasets. Inverse variance weighting ...