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Full-Text Articles in Statistics and Probability

Theranostic Applications Of Sirna Bioconjugates In Cancer Detection And Treatment, Sunil S. Shah May 2021

Theranostic Applications Of Sirna Bioconjugates In Cancer Detection And Treatment, Sunil S. Shah

Seton Hall University Dissertations and Theses (ETDs)

Abstract

The emerging field of RNA nanotechnology has led to rapid advances in the applications of RNA in chemical biology, medicinal chemistry, and biotechnology. At the forefront of its utility is the ability to self-assemble multiple siRNAs into nanostructure formulations capable of targeting selected oncogenes and potentiating the gene therapy of malignant tumors. Self-assembled siRNA integrates multiple siRNAs within a single molecular platform for silencing multiple oncogenic mRNA targets with high precision and efficacy to potentially induce cancer cell apoptosis through the RNA interference (RNAi) pathway. Furthermore, the conjugation of siRNA self-assemblies with bio-active probes results in multi-functional theranostic (therapy ...


Understanding The Effect Of Adaptive Mutations On The Three-Dimensional Structure Of Rna, Justin Cook May 2021

Understanding The Effect Of Adaptive Mutations On The Three-Dimensional Structure Of Rna, Justin Cook

Undergraduate Research and Scholarship Symposium

Single-nucleotide polymorphisms (SNPs) are variations in the genome where one base pair can differ between individuals.1 SNPs occur throughout the genome and can correlate to a disease-state if they occur in a functional region of DNA.1According to the central dogma of molecular biology, any variation in the DNA sequence will have a direct effect on the RNA sequence and will potentially alter the identity or conformation of a protein product. A single RNA molecule, due to intramolecular base pairing, can acquire a plethora of 3-D conformations that are described by its structural ensemble. One SNP, rs12477830, which ...


Cardiovascular Complications Of Systemic Lupus Erythematosus: Impact Of Risk Factors And Therapeutic Efficacy--A Tertiary Centre Experience In An Appalachian State, Elise Danielle Mcveigh, Amna Batool, Arnold J. Stromberg, Ahmed K. Abdel-Latif, Nayef Mohammed Kazzaz May 2021

Cardiovascular Complications Of Systemic Lupus Erythematosus: Impact Of Risk Factors And Therapeutic Efficacy--A Tertiary Centre Experience In An Appalachian State, Elise Danielle Mcveigh, Amna Batool, Arnold J. Stromberg, Ahmed K. Abdel-Latif, Nayef Mohammed Kazzaz

Statistics Faculty Publications

OBJECTIVES: Cardiovascular complications became a notable cause of morbidity and mortality in patients with lupus as therapeutic advancements became more efficient at managing other complications. The Appalachian community in Kentucky has a higher prevalence of traditional cardiovascular risk factors, predisposing them to cardiovascular events. Namely, the mean body mass index of the members of the Kentucky Appalachian community was reported at 33 kg/m2 and 94.3% of male members of this community use tobacco. We sought to identify risk factors that predispose patients with lupus to cardiovascular morbidities and examine the effect of immunomodulatory drugs.

METHODS: We identified ...


Application Of Randomness In Finance, Jose Sanchez, Daanial Ahmad, Satyanand Singh May 2021

Application Of Randomness In Finance, Jose Sanchez, Daanial Ahmad, Satyanand Singh

Publications and Research

Brownian Motion which is also considered to be a Wiener process and can be thought of as a random walk. In our project we had briefly discussed the fluctuations of financial indices and related it to Brownian Motion and the modeling of Stock prices.


Confidence Intervals Of Covid-19 Vaccine Efficacy Rates, Frank Wang May 2021

Confidence Intervals Of Covid-19 Vaccine Efficacy Rates, Frank Wang

Numeracy

This tutorial uses publicly available data from drug makers and the Food and Drug Administration to guide learners to estimate the confidence intervals of COVID-19 vaccine efficacy rates with a Bayesian framework. Under the classical approach, there is no probability associated with a parameter, and the meaning of confidence intervals can be misconstrued by inexperienced students. With Bayesian statistics, one can find the posterior probability distribution of an unknown parameter, and state the probability of vaccine efficacy rate, which makes the communication of uncertainty more flexible. We use a hypothetical example and a real baseball example to guide readers to ...


Zeta Function Regularization And Its Relationship To Number Theory, Stephen Wang May 2021

Zeta Function Regularization And Its Relationship To Number Theory, Stephen Wang

Electronic Theses and Dissertations

While the "path integral" formulation of quantum mechanics is both highly intuitive and far reaching, the path integrals themselves often fail to converge in the usual sense. Richard Feynman developed regularization as a solution, such that regularized path integrals could be calculated and analyzed within a strictly physics context. Over the past 50 years, mathematicians and physicists have retroactively introduced schemes for achieving mathematical rigor in the study and application of regularized path integrals. One such scheme was introduced in 2007 by the mathematicians Klaus Kirsten and Paul Loya. In this thesis, we reproduce the Kirsten and Loya approach to ...


Cointegration And Statistical Arbitrage Of Precious Metals, Judge Van Horn May 2021

Cointegration And Statistical Arbitrage Of Precious Metals, Judge Van Horn

Finance Undergraduate Honors Theses

When talking about financial instruments correlation is often thrown around as a measure of the relation between two securities. An often more useful or tradeable measure is cointegration. Cointegration is the measure of two securities tendency to revert to an average price over time. In other words, cointegration ignores directionality and only cares about the distance between two securities. For a mean reversion strategy such as statistical arbitrage cointegration proves to be a far more reliable statistical measure of mean reversion, and while it is more reliable than correlation it still has its own problems. One thing to consider is ...


Applying Emotional Analysis For Automated Content Moderation, John Shelnutt May 2021

Applying Emotional Analysis For Automated Content Moderation, John Shelnutt

Computer Science and Computer Engineering Undergraduate Honors Theses

The purpose of this project is to explore the effectiveness of emotional analysis as a means to automatically moderate content or flag content for manual moderation in order to reduce the workload of human moderators in moderating toxic content online. In this context, toxic content is defined as content that features excessive negativity, rudeness, or malice. This often features offensive language or slurs. The work involved in this project included creating a simple website that imitates a social media or forum with a feed of user submitted text posts, implementing an emotional analysis algorithm from a word emotions dataset, designing ...


Improving Bayesian Graph Convolutional Networks Using Markov Chain Monte Carlo Graph Sampling, Aneesh Komanduri May 2021

Improving Bayesian Graph Convolutional Networks Using Markov Chain Monte Carlo Graph Sampling, Aneesh Komanduri

Computer Science and Computer Engineering Undergraduate Honors Theses

In the modern age of social media and networks, graph representations of real-world phenomena have become incredibly crucial. Often, we are interested in understanding how entities in a graph are interconnected. Graph Neural Networks (GNNs) have proven to be a very useful tool in a variety of graph learning tasks including node classification, link prediction, and edge classification. However, in most of these tasks, the graph data we are working with may be noisy and may contain spurious edges. That is, there is a lot of uncertainty associated with the underlying graph structure. Recent approaches to modeling uncertainty have been ...


The Effect Of High Elevation Weather Stations On The Usda's Pasture, Rangeland, And Forage Insurance Program, Wyatt Matthew Feuz May 2021

The Effect Of High Elevation Weather Stations On The Usda's Pasture, Rangeland, And Forage Insurance Program, Wyatt Matthew Feuz

All Graduate Theses and Dissertations

This paper examines the effect of high elevation weather stations on the rainfall index used by the Pasture, Rangeland, and Forage insurance program. Weather station data for the state of Utah is used to identify high elevation weather stations and their location. Utilizing the corresponding rainfall index data, the effect of the high elevation weather stations is determined. This paper finds when high elevation weather stations begin reporting there is a jump up of 19.01–27.88 percentage points on average in the rainfall index for the corresponding grid locations. This indicates the rainfall index may not accurately represent ...


Use Of Linear Discriminant Analysis In Song Classification: Modeling Based On Wilco Albums, Caroline Pollard May 2021

Use Of Linear Discriminant Analysis In Song Classification: Modeling Based On Wilco Albums, Caroline Pollard

Honors Theses

The study of music recommender algorithms is a relatively new area of study. Although these algorithms serve a variety of functions, they primarily help advertise and suggest music to users on music streaming services. This thesis explores the use of linear discriminant analysis in music categorization for the purpose of serving as a cheaper and simpler content-based recommender algorithm. The use of linear discriminant analysis was tested by creating lineardiscriminant functions that classify Wilco’s songs into their respective albums, specifically A.M., Yankee Hotel Foxtrot, and Sky Blue Sky. 4 sample songs were chosen from each album, and song ...


Retail Trading And Stock Volatility: The Case Of Robinhood, Cooper Jones May 2021

Retail Trading And Stock Volatility: The Case Of Robinhood, Cooper Jones

All Graduate Plan B and other Reports

We examine the relation between Robinhood usership and stock market volatility. We show that daily fluctuations in Robinhood usership, which is used to proxy retail trading, significantly influence various measures of volatility. These results might suggest that Robinhood users contribute to noise trading as they are generally individuals trading on name recognition, media coverage, popularity, and familiarity of products, rather than on fundamental values. In our empirical approach, we find that the percentage increase in Robinhood usership Granger causes increases in daily stock volatility.


A Comparison Of The Localized Aviation Mos Program (Lamp) And Terminal Aerodrome Forecast (Taf) Accuracy For General Aviation, Douglas D. Boyd, Thomas A. Guinn Apr 2021

A Comparison Of The Localized Aviation Mos Program (Lamp) And Terminal Aerodrome Forecast (Taf) Accuracy For General Aviation, Douglas D. Boyd, Thomas A. Guinn

Journal of Aviation Technology and Engineering

Background. For general aviation (GA) pilots, operations in instrument meteorological conditions (IMC) carry an elevated risk of a fatal accident. As to whether a general aviation flight can be safely undertaken, aerodrome-specific forecasts (TAF, LAMP) provide guidance. Although LAMP forecasts are more common for GA-frequented aerodromes, nevertheless, the FAA recommends that for such aerodromes (and for which a TAF is not issued) the airman uses the TAF generated for the geographically closest airport for pre-flight weather evaluation. Herein, for non-TAF-issuing airports, the LAMP (sLAMP) predictive accuracy for visual (VFR) and instrument (IFR) flight rules flight category was determined.

Method. sLAMP ...


Epigenome-Wide Association Study Of Kidney Function Identifies Trans-Ethnic And Ethnic-Specific Loci, Charles E. Breeze, Anna Batorsky, Mi Kyeong Lee, Mindy D. Szeto, Xiaoguang Xu, Daniel L. Mccartney, Rong Jiang, Amit Patki, Holly J. Kramer, James M. Eales, Laura Raffield, Leslie Lange, Ethan Lange, Peter Durda, Yongmei Liu, Russ P. Tracy, David Van Den Berg, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Topmed Mesa Multi-Omics Working Group, Kathryn L. Evans, William E. Kraus, Donna K. Arnett Apr 2021

Epigenome-Wide Association Study Of Kidney Function Identifies Trans-Ethnic And Ethnic-Specific Loci, Charles E. Breeze, Anna Batorsky, Mi Kyeong Lee, Mindy D. Szeto, Xiaoguang Xu, Daniel L. Mccartney, Rong Jiang, Amit Patki, Holly J. Kramer, James M. Eales, Laura Raffield, Leslie Lange, Ethan Lange, Peter Durda, Yongmei Liu, Russ P. Tracy, David Van Den Berg, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Topmed Mesa Multi-Omics Working Group, Kathryn L. Evans, William E. Kraus, Donna K. Arnett

Epidemiology Faculty Publications

BACKGROUND: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic and ethnic-specific differentially methylated positions (DMPs) associated with eGFR using an agnostic, genome-wide approach.

METHODS: The study included up to 5428 participants from multi-ethnic studies for discovery and 8109 participants for replication. We tested the associations between whole blood DNAm and eGFR using beta values from Illumina 450K or EPIC arrays. Ethnicity-stratified analyses were performed using linear ...


Anatomy Of A Conspiracy Theory: Law, Politics, And Science Denialism In The Era Of Covid-19, Brie Sherwin Apr 2021

Anatomy Of A Conspiracy Theory: Law, Politics, And Science Denialism In The Era Of Covid-19, Brie Sherwin

Texas A&M Law Review

With COVID-19, we are facing the most serious public health threat of our lifetime. Now, more than ever, we need experts and sound scientific advice to guide critical decision-making during the pandemic. With conspiracy theories and other similar rhetorical weapons being used to discredit our scientific experts, we face a myriad of misinformation, mistruths, and all-out attacks on our experts, breeding distrust between the public and the policymakers leading the fight against the pandemic. As President Trump took office, scientists were routinely denigrated and isolated. Furthermore, science denialism has permeated its way up to the highest levels of government, resulting ...


How Risk-Related Statistics, As Reported In News And Social Media, Are Linked To The Use Of The Public Transit System, Prashiddhi Pokhrel Apr 2021

How Risk-Related Statistics, As Reported In News And Social Media, Are Linked To The Use Of The Public Transit System, Prashiddhi Pokhrel

Thinking Matters Symposium

Due to the pandemic, people have started relying more on televisions, news, social media, and other news outlets for guidance. Moreover, with the increasing amount of news, data, and information there is also an increase in the amount of misleading statistics. People’s opinions and decisions significantly depend on the data, statistics, and information that they are exposed to, as well as their sources. For this project, we want to look at how information and its sources are affecting the decision made by the general public for the usage of the Portland Transit System. It is very important to know ...


Markov Chains And Their Applications, Fariha Mahfuz Apr 2021

Markov Chains And Their Applications, Fariha Mahfuz

Math Theses

Markov chain is a stochastic model that is used to predict future events. Markov chain is relatively simple since it only requires the information of the present state to predict the future states. In this paper we will go over the basic concepts of Markov Chain and several of its applications including Google PageRank algorithm, weather prediction and gamblers ruin.

We examine on how the Google PageRank algorithm works efficiently to provide PageRank for a Google search result. We also show how can we use Markov chain to predict weather by creating a model from real life data.


An Ensemble Of The Icluster Method To Analyze Longitudinal Lncrna Expression Data For Psoriasis Patients, Suyan Tian, Chi Wang Apr 2021

An Ensemble Of The Icluster Method To Analyze Longitudinal Lncrna Expression Data For Psoriasis Patients, Suyan Tian, Chi Wang

Internal Medicine Faculty Publications

BACKGROUND: Psoriasis is an immune-mediated, inflammatory disorder of the skin with chronic inflammation and hyper-proliferation of the epidermis. Since psoriasis has genetic components and the diseased tissue of psoriasis is very easily accessible, it is natural to use high-throughput technologies to characterize psoriasis and thus seek targeted therapies. Transcriptional profiles change correspondingly after an intervention. Unlike cross-sectional gene expression data, longitudinal gene expression data can capture the dynamic changes and thus facilitate causal inference.

METHODS: Using the iCluster method as a building block, an ensemble method was proposed and applied to a longitudinal gene expression dataset for psoriasis, with the ...


Tournament And Non-Tournament Anglers Have Little Effect On A Largemouth Bass Population Compared To Natural Mortality, Andrea Sylvia, Stephen J. Dinsmore, Michael J. Weber Apr 2021

Tournament And Non-Tournament Anglers Have Little Effect On A Largemouth Bass Population Compared To Natural Mortality, Andrea Sylvia, Stephen J. Dinsmore, Michael J. Weber

Natural Resource Ecology and Management Publications

Popularity of bass Micropterus spp. catch and release and tournament angling during the past decade has resulted in increased potential for these activities to induce population level effects. Understanding capture rates and mortality sources relative to total population mortality is essential to focus of management. We conducted monthly electrofishing, solicited nontournament angler tag returns, and censused largemouth bass Micropterus salmoides tournaments at Brushy Creek Lake, IA, USA from April 2015 to June 2018. We used a multistate mark-recapture model to evaluate the effects of air temperature, water temperature, tournament bass per angler, and tournament initial mortality on non-tournament and tournament ...


Conjunction Of Factors Impacting The 2019-2020 Flu Season In The Us, Yichen Wang Apr 2021

Conjunction Of Factors Impacting The 2019-2020 Flu Season In The Us, Yichen Wang

Undergraduate Research Symposium 2021

The 2019-2020 flu season is regarded as one of the most serious ones in decades. Previous researchers usually studied the effects of different factors on seasonal flu separately instead of their conjugate impact, so we wanted to find how multiple factors combine to affect the spread of influenza in the 2019-2020 flu season in America. We chose types of virus (A and B), environmental factors (temperature, precipitation, relative humidity), population density, and influenza vaccination status for different age groups which are statewide data containing monthly information from Sep. 2019 to May 2020. By principal component analysis, we could see the ...


B36: Comparing The Nephrotoxic Effects Of Cisplatin In Combination With Docetaxel Or 5-Fluorouracil, Ria Lei Marie Natividad Apr 2021

B36: Comparing The Nephrotoxic Effects Of Cisplatin In Combination With Docetaxel Or 5-Fluorouracil, Ria Lei Marie Natividad

Annual Research Symposium

No abstract provided.


B35: Development And Validation Of A Stability Indicating Hplc Method For Quantification Of Estriol In Compounded Glycerinated Gelatin Troches, Tayler Hutto Apr 2021

B35: Development And Validation Of A Stability Indicating Hplc Method For Quantification Of Estriol In Compounded Glycerinated Gelatin Troches, Tayler Hutto

Annual Research Symposium

No abstract provided.


B30: Identifying New G Protein Coupled Receptor Kinase 6 Substrates Among Proteins Closely Linked To Prognoses Of Pancreatic Cancer, Christine Taing, Jelena Jovanovic, Nicole Khalil, Christopher So Apr 2021

B30: Identifying New G Protein Coupled Receptor Kinase 6 Substrates Among Proteins Closely Linked To Prognoses Of Pancreatic Cancer, Christine Taing, Jelena Jovanovic, Nicole Khalil, Christopher So

Annual Research Symposium

No abstract provided.


B29: Exploring The Role Of G Protein Coupled Receptor Kinases In Modulating Behaviors To Fluoxetine Using Caenorhabditis Elegans As An Experimental Model, Victoria Pang Apr 2021

B29: Exploring The Role Of G Protein Coupled Receptor Kinases In Modulating Behaviors To Fluoxetine Using Caenorhabditis Elegans As An Experimental Model, Victoria Pang

Annual Research Symposium

No abstract provided.


B28: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced Beta Arrestin 2 Expression Levels, Angelina Marcee Apr 2021

B28: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced Beta Arrestin 2 Expression Levels, Angelina Marcee

Annual Research Symposium

No abstract provided.


B27: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced G Protein Coupled Receptor Kinase 2 Expression, Samantha Bodan Apr 2021

B27: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced G Protein Coupled Receptor Kinase 2 Expression, Samantha Bodan

Annual Research Symposium

No abstract provided.


B24: Efficacy Of Scaffold Mediated Localized Chemotherapy In Cancer: A Systematic Review, Archana Gupta Apr 2021

B24: Efficacy Of Scaffold Mediated Localized Chemotherapy In Cancer: A Systematic Review, Archana Gupta

Annual Research Symposium

No abstract provided.


B21: Exposure To Vape Smoke Enhances Sperm Mitochondrial Respiration In Mature Mice., Jeremy Y. Saito Apr 2021

B21: Exposure To Vape Smoke Enhances Sperm Mitochondrial Respiration In Mature Mice., Jeremy Y. Saito

Annual Research Symposium

No abstract provided.


B14: Angiogenic Potential Of Oral Cavity Derived Mesenchymal Stem Cells And Its Secretomes: A Systematic Review, Madhura Rajendra Shekatkar Apr 2021

B14: Angiogenic Potential Of Oral Cavity Derived Mesenchymal Stem Cells And Its Secretomes: A Systematic Review, Madhura Rajendra Shekatkar

Annual Research Symposium

No abstract provided.


B2: Presence Of Immunosuppressive Drugs Affect Innate Immune Response And Monocyte Differentiation In Lung Transplant Patients, Inayat Kaur Oms Iii, Ryan Wang Oms Ii, Amy E.L. Stone Apr 2021

B2: Presence Of Immunosuppressive Drugs Affect Innate Immune Response And Monocyte Differentiation In Lung Transplant Patients, Inayat Kaur Oms Iii, Ryan Wang Oms Ii, Amy E.L. Stone

Annual Research Symposium

Lung transplant patients are administered Immunosuppressive Drugs (ISDs) to prevent transplant rejection, but this also puts them at constant risk of infection due to the decreased ability of the immune system to respond to subsequent infections by viruses, bacteria etc.

Purpose

This paper focuses on the effect of ISDs on the innate immune response. We are using different parts of viruses and bacteria and allowing them to represent the organism as a whole.

Methods

As representatives of the innate immune system, we are going to be testing monocyte, macrophage, and dendritic cell lineages. We are hypothesizing that the presence of ...