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242 full-text articles. Page 1 of 9.

Update To The Study Protocol For An Implementation-Effectiveness Trial Comparing Two Education Strategies For Improving The Uptake Of Noninvasive Ventilation In Patients With Severe Copd Exacerbation, Mihaela S. Stefan, Penelope S. Pekow, Christopher M. Shea, Ashley M. Hughes, Nicholas S. Hill, Jay S. Steingrub, Mary Jo S. Farmer, Dean R. Hess, Karen L. Riska, Taylar A. Clark, Peter K. Lindenauer 2021 University of Massachusetts Medical School

Update To The Study Protocol For An Implementation-Effectiveness Trial Comparing Two Education Strategies For Improving The Uptake Of Noninvasive Ventilation In Patients With Severe Copd Exacerbation, Mihaela S. Stefan, Penelope S. Pekow, Christopher M. Shea, Ashley M. Hughes, Nicholas S. Hill, Jay S. Steingrub, Mary Jo S. Farmer, Dean R. Hess, Karen L. Riska, Taylar A. Clark, Peter K. Lindenauer

COVID-19 Publications by UMass Chan Authors

BACKGROUND: There is strong evidence that noninvasive ventilation (NIV) improves the outcomes of patients hospitalized with severe COPD exacerbation, and NIV is recommended as the first-line therapy for these patients. Yet, several studies have demonstrated substantial variation in NIV use across hospitals, leading to preventable morbidity and mortality. In addition, prior studies suggested that efforts to increase NIV use in COPD need to account for the complex and interdisciplinary nature of NIV delivery and the need for team coordination. Therefore, our initial project aimed to compare two educational strategies: online education (OLE) and interprofessional education (IPE), which targets complex team-based ...


Systematic Review Of Polyherbal Combinations Used In Metabolic Syndrome, Amber Hanif Palla, Faridah Amin, Bilqees Fatima, Arooj Shafiq, Najeeb Ur Rehman, Ikram Ul Haq, Anwar-Ul-Hassan Gilani 2021 Aga Khan University

Systematic Review Of Polyherbal Combinations Used In Metabolic Syndrome, Amber Hanif Palla, Faridah Amin, Bilqees Fatima, Arooj Shafiq, Najeeb Ur Rehman, Ikram Ul Haq, Anwar-Ul-Hassan Gilani

Department of Biological & Biomedical Sciences

Background: Metabolic syndrome (MetS) is a multifactorial disease, whose main stay of prevention and management is life-style modification which is difficult to attain. Combination of herbs have proven more efficacious in multi-targeted diseases, as compared to individual herbs owing to the "effect enhancing and side-effect neutralizing" properties of herbs, which forms the basis of polyherbal therapies This led us to review literature on the efficacy of herbal combinations in MetS.
Methods: Electronic search of literature was conducted by using Cinnahl, Pubmed central, Cochrane and Web of Science, whereas, Google scholar was used as secondary search tool. The key words used ...


Using Increased Trust In Medical Researchers To Increase Minority Recruitment: The Recruit Cluster Randomized Clinical Trial, Barbara C. Tilley, Arch G. Mainous 3rd, Rossybelle P. Amorrortu, M. Diane McKee, Daniel W. Smith, Ruosha Li, Stacia M. DeSantis, Sally W. Vernon, Gary Koch, Marvella E. Ford, Vanessa Diaz, Jennifer Alvidrez 2021 University of Texas

Using Increased Trust In Medical Researchers To Increase Minority Recruitment: The Recruit Cluster Randomized Clinical Trial, Barbara C. Tilley, Arch G. Mainous 3rd, Rossybelle P. Amorrortu, M. Diane Mckee, Daniel W. Smith, Ruosha Li, Stacia M. Desantis, Sally W. Vernon, Gary Koch, Marvella E. Ford, Vanessa Diaz, Jennifer Alvidrez

Open Access Publications by UMass Chan Authors

While extensive literature exists on barriers and strategies to increase minority participation in clinical trials, progress is limited. Few strategies were evaluated in randomized trials. We studied the impact of RECRUIT, a trust-based, cluster randomized minority recruitment trial layered on top of four traditional NIH-funded parent trials (BMT CTN, CABANA, PACES, STEADY-PD III; fifty specialty sites). RECRUIT was conducted from July 2013 through April 2017. Intervention sites implemented trust-based approaches customized to individual sites, promoting relationships between physician-investigators and minority-serving physicians and their minority patients. Control sites implemented only parent trials' recruitment procedures. Adjusting for within-site clustering, we detected no ...


Impact Of The Covid-19 Pandemic On Clinical Research Activities: Survey Of Study Participants And Health Care Workers Participating In A Hypertension Trial In Vietnam, Hoa L. Nguyen, Oanh T. Tran, Duc A. Ha, Van H. Phan, Cuc T. Nguyen, Giang H. Nguyen, Thang T. Nguyen, German Chiriboga, Robert J. Goldberg, Jeroan J. Allison 2021 University of Massachusetts Medical School

Impact Of The Covid-19 Pandemic On Clinical Research Activities: Survey Of Study Participants And Health Care Workers Participating In A Hypertension Trial In Vietnam, Hoa L. Nguyen, Oanh T. Tran, Duc A. Ha, Van H. Phan, Cuc T. Nguyen, Giang H. Nguyen, Thang T. Nguyen, German Chiriboga, Robert J. Goldberg, Jeroan J. Allison

COVID-19 Publications by UMass Chan Authors

BACKGROUND: The COVID-19 pandemic has had a profound worldwide impact. Vietnam, a lower middle-income country with limited resources, has successfully slowed this pandemic. The objectives of this report are to explore the impact of the COVID-19 pandemic on the research activities of an ongoing hypertension trial using a storytelling intervention in Vietnam.

METHODS: Data were collected in a mixed-methods study among 86 patients and 10 health care workers participating in a clinical trial designed to improve hypertension control. Several questions related to the impact of COVID-19 on patient's daily activities and adherence to the study interventions were included in ...


Tocilizumab And Covid-19: A Meta-Analysis Of 2120 Patients With Severe Disease And Implications For Clinical Trial Methodologies, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Hinna Aftab, Zainab Pervaiz 2021 Aga Khan University

Tocilizumab And Covid-19: A Meta-Analysis Of 2120 Patients With Severe Disease And Implications For Clinical Trial Methodologies, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Hinna Aftab, Zainab Pervaiz

Department of Paediatrics and Child Health

Background/aim: Since the outbreak of the COVID-19, numerous therapies to counteract this severe disease have emerged. The benefits of Tocilizumab for severely infected COVID-19 patients and the methodologies of ongoing clinical trials are explored.
Materials and methods: A systematic search adhering to PRISMA guidelines was conducted in PubMed, Cochrane Central, medRxiv, and bioRxiv using the following keywords: “Tocilizumab,” “Actemra,” “COVID-19.” An additional subsearch was conducted on Clinicaltrials.gov to locate ongoing tocilizumab trials.
Results: A total of 13 studies were included in the meta-analysis comprising 2120 patients. The treatment group had lower mortality compared to the control group (OR ...


Randomized Controlled Trial Of Sulforaphane And Metabolite Discovery In Children With Autism Spectrum Disorder, Andrew W. Zimmerman, Kanwaljit Singh, Susan Connors, Hua Liu, Anita A. Panjwani, Li-Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye, Jed W. Fahey 2021 University of Massachusetts Medical School

Randomized Controlled Trial Of Sulforaphane And Metabolite Discovery In Children With Autism Spectrum Disorder, Andrew W. Zimmerman, Kanwaljit Singh, Susan Connors, Hua Liu, Anita A. Panjwani, Li-Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye, Jed W. Fahey

Open Access Publications by UMass Chan Authors

BACKGROUND: Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. Previous clinical trials of oral SF demonstrated positive clinical effects on behavior in young men and changes in urinary metabolomics in children with ASD.

METHODS: We conducted a 15-week randomized parallel double-blind placebo-controlled clinical trial with 15-week open-label treatment and 6-week no-treatment extensions in 57 children, ages 3-12 years, with ASD over 36 weeks. Twenty-eight were assigned SF and 29 received placebo (PL). Clinical effects, safety and tolerability of SF were measured as were biomarkers ...


Confidence Intervals Of Covid-19 Vaccine Efficacy Rates, Frank Wang 2021 LaGuardia Community College, CUNY

Confidence Intervals Of Covid-19 Vaccine Efficacy Rates, Frank Wang

Numeracy

This tutorial uses publicly available data from drug makers and the Food and Drug Administration to guide learners to estimate the confidence intervals of COVID-19 vaccine efficacy rates with a Bayesian framework. Under the classical approach, there is no probability associated with a parameter, and the meaning of confidence intervals can be misconstrued by inexperienced students. With Bayesian statistics, one can find the posterior probability distribution of an unknown parameter, and state the probability of vaccine efficacy rate, which makes the communication of uncertainty more flexible. We use a hypothetical example and a real baseball example to guide readers to ...


Randomised Trials At The Level Of The Individual, Jay J H. Park, Nathan Ford, Denis Xavier, Per Ashorn, Rebecca F. Grais, Zulfiqar Ahmed Bhutta, Herman Goossens, Kristian Thorlund, Maria Eugenia Socias, Edward J. Mills 2021 University of British Columbia, Vancouver, Canada

Randomised Trials At The Level Of The Individual, Jay J H. Park, Nathan Ford, Denis Xavier, Per Ashorn, Rebecca F. Grais, Zulfiqar Ahmed Bhutta, Herman Goossens, Kristian Thorlund, Maria Eugenia Socias, Edward J. Mills

Centre of Excellence in Women and Child Health

In global health research, short-term, small-scale clinical trials with fixed, two-arm trial designs that generally do not allow for major changes throughout the trial are the most common study design. Building on the introductory paper of this Series, this paper discusses data-driven approaches to clinical trial research across several adaptive trial designs, as well as the master protocol framework that can help to harmonise clinical trial research efforts in global health research. We provide a general framework for more efficient trial research, and we discuss the importance of considering different study designs in the planning stage with statistical simulations. We ...


The Role And Challenges Of Cluster Randomised Trials For Global Health, Louis Dron, Monica Taljaard, Yin Bun Cheung, Rebecca Grais, Nathan Ford, Kristian Thorlund, Fyezah Jehan, Etheldreda Nakimuli-Mpungu, Denis Xavier, Zulfiqar Ahmed Bhutta, Jay J H. Park, Edward J. Mills 2021 McMaster University, Hamilton, Canada

The Role And Challenges Of Cluster Randomised Trials For Global Health, Louis Dron, Monica Taljaard, Yin Bun Cheung, Rebecca Grais, Nathan Ford, Kristian Thorlund, Fyezah Jehan, Etheldreda Nakimuli-Mpungu, Denis Xavier, Zulfiqar Ahmed Bhutta, Jay J H. Park, Edward J. Mills

Department of Paediatrics and Child Health

Evaluating whether an intervention works when trialled in groups of individuals can pose complex challenges for clinical research. Cluster randomised controlled trials involve the random allocation of groups or clusters of individuals to receive an intervention, and they are commonly used in global health research. In this paper, we describe the potential reasons for the increasing popularity of cluster trials in low-income and middle-income countries. We also draw on key areas of global health research for an assessment of common trial planning practices, and we address their methodological shortcomings and pitfalls. Lastly, we discuss alternative approaches for population-level intervention trials ...


Stakeholder-Engaged Process For Refining The Design Of A Clinical Trial In Home Hospice, Jennifer Tjia, Margaret Clayton, German Chiriboga, Brooke Staples, Geraldine Puerto, Lynley Rappaport, Susan DeSanto-Madeya 2021 University of Massachusetts Medical School

Stakeholder-Engaged Process For Refining The Design Of A Clinical Trial In Home Hospice, Jennifer Tjia, Margaret Clayton, German Chiriboga, Brooke Staples, Geraldine Puerto, Lynley Rappaport, Susan Desanto-Madeya

Open Access Publications by UMass Chan Authors

BACKGROUND: Clinical trials in home hospice settings are important to build the evidence base for practice, but balancing the burden and benefit of clinical trial conduct for clinicians, patients, and family caregivers is challenging. A stakeholder-engaged process can help inform and refine key aspects of home hospice clinical trials. The aim of this study was to describe a stakeholder-engaged process to refine, design, and implement aspects of an educational intervention trial in home hospice, including recommendations for refining intervention content and delivery, recruitment and enrollment strategies, and content and frequency of outcome measurement.

METHODS: A panel of interprofessional (1 hospice ...


B36: Comparing The Nephrotoxic Effects Of Cisplatin In Combination With Docetaxel Or 5-Fluorouracil, Ria Lei Marie Natividad 2021 Roseman University of Health Sciences

B36: Comparing The Nephrotoxic Effects Of Cisplatin In Combination With Docetaxel Or 5-Fluorouracil, Ria Lei Marie Natividad

Annual Research Symposium

No abstract provided.


B35: Development And Validation Of A Stability Indicating Hplc Method For Quantification Of Estriol In Compounded Glycerinated Gelatin Troches, Tayler Hutto 2021 Roseman University of Health Sciences

B35: Development And Validation Of A Stability Indicating Hplc Method For Quantification Of Estriol In Compounded Glycerinated Gelatin Troches, Tayler Hutto

Annual Research Symposium

No abstract provided.


B30: Identifying New G Protein Coupled Receptor Kinase 6 Substrates Among Proteins Closely Linked To Prognoses Of Pancreatic Cancer, Christine Taing, Jelena Jovanovic, Nicole Khalil, Christopher So 2021 Roseman University of Health Sciences

B30: Identifying New G Protein Coupled Receptor Kinase 6 Substrates Among Proteins Closely Linked To Prognoses Of Pancreatic Cancer, Christine Taing, Jelena Jovanovic, Nicole Khalil, Christopher So

Annual Research Symposium

No abstract provided.


B29: Exploring The Role Of G Protein Coupled Receptor Kinases In Modulating Behaviors To Fluoxetine Using Caenorhabditis Elegans As An Experimental Model, Victoria Pang 2021 Roseman University of Health Sciences

B29: Exploring The Role Of G Protein Coupled Receptor Kinases In Modulating Behaviors To Fluoxetine Using Caenorhabditis Elegans As An Experimental Model, Victoria Pang

Annual Research Symposium

No abstract provided.


B28: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced Beta Arrestin 2 Expression Levels, Angelina Marcee 2021 Roseman University of Health Sciences

B28: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced Beta Arrestin 2 Expression Levels, Angelina Marcee

Annual Research Symposium

No abstract provided.


B27: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced G Protein Coupled Receptor Kinase 2 Expression, Samantha Bodan 2021 Roseman University of Health Sciences

B27: Evaluating The Chemotherapeutic Effects Of The Fac Regimen In Mda Mb 231 Breast Cancer Cells With Reduced G Protein Coupled Receptor Kinase 2 Expression, Samantha Bodan

Annual Research Symposium

No abstract provided.


B24: Efficacy Of Scaffold Mediated Localized Chemotherapy In Cancer: A Systematic Review, Archana Gupta 2021 Roseman University of Health Sciences

B24: Efficacy Of Scaffold Mediated Localized Chemotherapy In Cancer: A Systematic Review, Archana Gupta

Annual Research Symposium

No abstract provided.


B21: Exposure To Vape Smoke Enhances Sperm Mitochondrial Respiration In Mature Mice., Jeremy Y. Saito 2021 Brigham Young University

B21: Exposure To Vape Smoke Enhances Sperm Mitochondrial Respiration In Mature Mice., Jeremy Y. Saito

Annual Research Symposium

No abstract provided.


B14: Angiogenic Potential Of Oral Cavity Derived Mesenchymal Stem Cells And Its Secretomes: A Systematic Review, Madhura Rajendra Shekatkar 2021 Dr. D. Y. Patil Vidyapeeth

B14: Angiogenic Potential Of Oral Cavity Derived Mesenchymal Stem Cells And Its Secretomes: A Systematic Review, Madhura Rajendra Shekatkar

Annual Research Symposium

No abstract provided.


B2: Presence Of Immunosuppressive Drugs Affect Innate Immune Response And Monocyte Differentiation In Lung Transplant Patients, Inayat Kaur OMS III, Ryan Wang OMS II, Amy E.L. Stone 2021 Roseman University of Health Sciences

B2: Presence Of Immunosuppressive Drugs Affect Innate Immune Response And Monocyte Differentiation In Lung Transplant Patients, Inayat Kaur Oms Iii, Ryan Wang Oms Ii, Amy E.L. Stone

Annual Research Symposium

Lung transplant patients are administered Immunosuppressive Drugs (ISDs) to prevent transplant rejection, but this also puts them at constant risk of infection due to the decreased ability of the immune system to respond to subsequent infections by viruses, bacteria etc.

Purpose

This paper focuses on the effect of ISDs on the innate immune response. We are using different parts of viruses and bacteria and allowing them to represent the organism as a whole.

Methods

As representatives of the innate immune system, we are going to be testing monocyte, macrophage, and dendritic cell lineages. We are hypothesizing that the presence of ...


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