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Small or Companion Animal Medicine Commons

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Photography-Based Method For Assessing Fluorescein Clearance Test In Dogs, Arianne Pontes Oriá, Miriam Flores Rebouças, Emanoel Martins Filho, Francisco de Assis Dórea Neto, Ana Cláudia Raposo, Lionel Sebbag 2018 Federal University of Bahia

Photography-Based Method For Assessing Fluorescein Clearance Test In Dogs, Arianne Pontes Oriá, Miriam Flores Rebouças, Emanoel Martins Filho, Francisco De Assis Dórea Neto, Ana Cláudia Raposo, Lionel Sebbag

Veterinary Clinical Sciences Publications

Background: The fluorescein clearance test (FCT) provides insight into the tear film dynamics. The purpose of this study was to describe an inexpensive and practical method for assessing FCT in dogs, using photography and software analysis, and to assess the retention time of 1 vs. 2 eye drops on the canine ocular surface.

Methods: (i) In vivo - Eight healthy German Shepherd dogs were recruited. Following topical anesthesia with 0.5% proxymetacaine, each eye sequentially received (1 week apart) either 1 drop (35 μL) or 2 drops (70 μL) of 0.5% fluorescein. A Schirmer strip was inserted in the ventral ...


Relationship Of The Mucosal Microbiota To Gastrointestinal Inflammation And Small Cell Intestinal Lymphoma In Cats, Kayode Garraway, Chad M. Johannes, Angela Bryan, John Peauroi, Giacomo Rossi, Min Zhang, Chong Wang, Karin Allenspach, Albert E. Jergens 2018 Iowa State University

Relationship Of The Mucosal Microbiota To Gastrointestinal Inflammation And Small Cell Intestinal Lymphoma In Cats, Kayode Garraway, Chad M. Johannes, Angela Bryan, John Peauroi, Giacomo Rossi, Min Zhang, Chong Wang, Karin Allenspach, Albert E. Jergens

Veterinary Diagnostic and Production Animal Medicine Publications

Background: The gastrointestinal (GI) microbiota in healthy cats is altered in IBD. Little research has been performed to identify whether specific bacterial groups are associated with small cell GI lymphoma (LSA).

Hypothesis: Mucosal bacteria, including Enterobacteriaceae and Fusobacterium spp., are abundant in intestinal biopsies of cats with small cell GI LSA compared to cats with IBD.

Animals: Fourteen cats with IBD and 14 cats with small cell GI LSA.

Methods: Retrospective case control study. A search of the medical records was performed to identify cats diagnosed with IBD and with GI LSA. Bacterial groups identified by FISH in GI biopsies ...


Impact Of Flow Rate, Collection Devices, And Extraction Methods On Tear Concentrations Following Oral Administration Of Doxycycline In Dogs And Cats, Lionel Sebbag, Lucas Showman, Emily M. McDowell, Ann Perera, Jonathan P. Mochel 2018 Iowa State University

Impact Of Flow Rate, Collection Devices, And Extraction Methods On Tear Concentrations Following Oral Administration Of Doxycycline In Dogs And Cats, Lionel Sebbag, Lucas Showman, Emily M. Mcdowell, Ann Perera, Jonathan P. Mochel

Veterinary Diagnostic and Production Animal Medicine Publications

Purpose: Compare the precision of doxycycline quantification in tear fluid collected with either Schirmer strips or polyvinyl acetal (PVA) sponges following oral drug administration.

Methods: Three dogs and 3 cats were administered doxycycline orally at a dose of 4.2–5 mg/kg every 12 h for 6 consecutive days. At day 5 and 6, blood and tear fluid were sampled to capture doxycycline trough and maximal concentrations. Tear fluid was collected 3 times (spaced 10 min apart) at each session with the absorbent material placed in the lower conjunctival fornix until the 20-mm mark was reached (Schirmer strip, one ...


Myringotomy As A Diagnostic And Therapeutic Tool In A Case Of Otitis Media In A Guinea Pig (Cavia Porcellus), H. M. Householder, Darren J. Berger, James O. Noxon, Bianca A. Zaffarano 2018 Iowa State University

Myringotomy As A Diagnostic And Therapeutic Tool In A Case Of Otitis Media In A Guinea Pig (Cavia Porcellus), H. M. Householder, Darren J. Berger, James O. Noxon, Bianca A. Zaffarano

Veterinary Clinical Sciences Publications

A 1.5 year old male adult guinea pig (Cavia porcellus) presented with acute vestibular disease, consisting of a right head tilt, circling, and ataxia. The head tilt was non-responsive to initial empirical antimicrobial therapy for presumptive otitis media. Video otoscopy and a myringotomy were performed under general anesthesia. A large amount of purulent debris was flushed from the middle ear and submitted for culture. Treatment with appropriate systemic and topical antibiotics was pursued for 4 weeks. Near complete resolution of clinical signs was achieved by the end of treatment with only a minor residual head tilt. This is the ...


Effect Of Tear Collection On Lacrimal Total Protein Content In Dogs And Cats: A Comparison Between Schirmer Strips And Ophthalmic Sponges, Lionel Sebbag, Emily M. McDowell, Patrick M. Hepner, Jonathan P. Mochel 2018 Iowa State University

Effect Of Tear Collection On Lacrimal Total Protein Content In Dogs And Cats: A Comparison Between Schirmer Strips And Ophthalmic Sponges, Lionel Sebbag, Emily M. Mcdowell, Patrick M. Hepner, Jonathan P. Mochel

Veterinary Clinical Sciences Publications

Background Quantification of lacrimal total protein content (TPC) is an important tool for clinical scientists to understand disease pathogenesis, identify potential biomarkers and assess response to therapy, among other applications. However, TPC is not only affected by disease state but also by the method used for tear collection. Thus, the purpose of this study is to determine the impact on TPC of two methods of tear collection in dogs and cats: Schirmer strips and polyvinyl acetal (PVA) sponges.

Methods (i) In vivo - Ten healthy dogs and 10 healthy cats were examined. Each animal underwent two sessions, separated by 10 min ...


Ovaries And Testes, Oh My!, Jessica Burka, Samantha Garcia, Kenneth Kent, Elizabeth Potalivo, Jessica Schrader 2018 Daemen College

Ovaries And Testes, Oh My!, Jessica Burka, Samantha Garcia, Kenneth Kent, Elizabeth Potalivo, Jessica Schrader

Academic Festival Posters

This poster presentation will discuss the pros and cons of spaying or neutering household pets. Many animals are euthanized annually due to overpopulation issues, so pet owners have been urged to neuter/spay their household pets to limit overpopulation. Recent research suggests that early neutering may have negative consequences for companion animals. The goal of the presentation is to educate the public about the benefits and risks associated with pet reproductive procedures.


Development And Implementation Of A Novel Immune Thrombocytopenia Bleeding Score For Dogs, Kelly M. Makielski, Marjory B. Brooks, Chong Wang, Jonah N. Cullen, Annette M. O'Connor, Dana N. Levine 2018 Iowa State University

Development And Implementation Of A Novel Immune Thrombocytopenia Bleeding Score For Dogs, Kelly M. Makielski, Marjory B. Brooks, Chong Wang, Jonah N. Cullen, Annette M. O'Connor, Dana N. Levine

Veterinary Diagnostic and Production Animal Medicine Publications

Background

A method of quantifying clinical bleeding in dogs with immune thrombocytopenia (ITP) is needed because ITP patients have variable bleeding tendencies that inconsistently correlate with platelet count. A scoring system will facilitate patient comparisons and allow stratification based on bleeding severity in clinical trials.

Hypothesis/Objectives

To develop and evaluate a bleeding assessment tool for dogs, and a training course for improving its consistent implementation.

Animals

Client‐owned dogs (n = 61) with platelet counts <50,000/μL; 34 classified as primary ITP, 17 as secondary ITP, and 10 as non‐ITP.

Methods

A novel bleeding assessment tool, DOGiBAT, comprising bleeding grades from 0 (none) to 2 (severe) at 9 anatomic sites, was developed. Clinicians and technicians ...


Intestinal Stem Cells To Advance Drug Development, Precision, And Regenerative Medicine: A Paradigm Shift In Translational Research, Jonathan P. Mochel, Albert E. Jergens, Dawn Kingsbury, Hyun Jung Kim, Martín G. Martín, Karin Allenspach 2018 Iowa State University

Intestinal Stem Cells To Advance Drug Development, Precision, And Regenerative Medicine: A Paradigm Shift In Translational Research, Jonathan P. Mochel, Albert E. Jergens, Dawn Kingsbury, Hyun Jung Kim, Martín G. Martín, Karin Allenspach

Biomedical Sciences Publications

Recent advances in our understanding of the intestinal stem cell niche and the role of key signaling pathways on cell growth and maintenance have allowed the development of fully differentiated epithelial cells in 3D organoids. Stem cell-derived organoids carry significant levels of proteins that are natively expressed in the gut and have important roles in drug transport and metabolism. They are, therefore, particularly relevant to study the gastrointestinal (GI) absorption of oral medications. In addition, organoids have the potential to serve as a robust preclinical model for demonstrating the effectiveness of new drugs more rapidly, with more certainty, and at ...


Feline Dry Eye Syndrome Of Presumed Neurogenic Origin: A Case Report, Lionel Sebbag, Patricia A. Pesavento, Sebastian E. Carrasco, Christopher M. Reilly, David J. Maggs 2018 Iowa State University

Feline Dry Eye Syndrome Of Presumed Neurogenic Origin: A Case Report, Lionel Sebbag, Patricia A. Pesavento, Sebastian E. Carrasco, Christopher M. Reilly, David J. Maggs

Veterinary Clinical Sciences Publications

Case summary A 14-year-old female spayed Abyssinian cat, which about 1 year previously underwent thoracic limb amputation, radiotherapy and chemotherapy for an incompletely excised vaccine-related fibrosarcoma, was presented for evaluation of corneal opacity in the left eye (OS). The ocular surface of both eyes (OU) had a lackluster appearance and there was a stromal corneal ulcer OS. Results of corneal aesthesiometry, Schirmer tear test-1 (STT-1) and tear film breakup time revealed corneal hypoesthesia, and quantitative and qualitative tear film deficiency OU. Noxious olfactory stimulation caused increased lacrimation relative to standard STT-1 values suggesting an intact nasolacrimal reflex. Various lacrimostimulants were ...


Concurrent Renal Amyloidosis And Thymoma Resulting In A Fatal Ventricular Thrombus In A Dog, Jennifer M. Loewen, Rachel E. Cianciolo, Liwen Zhang, Michael Yaeger, Jessica L. Ward, Jodi D. Smith, Dana N. LeVine 2018 Iowa State University

Concurrent Renal Amyloidosis And Thymoma Resulting In A Fatal Ventricular Thrombus In A Dog, Jennifer M. Loewen, Rachel E. Cianciolo, Liwen Zhang, Michael Yaeger, Jessica L. Ward, Jodi D. Smith, Dana N. Levine

Veterinary Clinical Sciences Publications

Thymoma‐associated nephropathies have been reported in people but not in dogs. In this report, we describe a dog with thymoma and concurrent renal amyloidosis. A 7‐year‐old castrated male Weimaraner was presented for progressive anorexia, lethargy, and tachypnea. The dog was diagnosed with azotemia, marked proteinuria, and a thymoma that was surgically removed. Postoperatively, the dog developed a large left ventricular thrombus and was euthanized. Necropsy confirmed the presence of a left ventricular thrombus and histopathology revealed renal amyloidosis. We speculate that the renal amyloidosis occurred secondary to the thymoma, with amyloidosis in turn leading to nephrotic syndrome ...


Placement Of Intracoelomic Radiotransmitters And Silicone Passive Sampling Devices In Northern Leopard Frogs (Lithobates Pipiens), Taylor J. Yaw, Jennifer E. Swanson, Clay L. Pierce, Erin Muths, Kelly L. Smalling, Mark W. Vandever, Bianca A. Zaffarano 2017 Iowa State University

Placement Of Intracoelomic Radiotransmitters And Silicone Passive Sampling Devices In Northern Leopard Frogs (Lithobates Pipiens), Taylor J. Yaw, Jennifer E. Swanson, Clay L. Pierce, Erin Muths, Kelly L. Smalling, Mark W. Vandever, Bianca A. Zaffarano

Veterinary Clinical Sciences Publications

Historically, wetland toxin exposure studies have relied on single time point samples from stationary sampling devices. Development of passive sampling devices (PSDs) that can be attached to individual animals within wetland habitats has greatly improved in recent years, presenting an innovative sampling technology that can potentially yield individual-specific, quantifiable data about chemical exposure. In this study, silicone based PSDs were attached to the ventral skin of 20 northern leopard frogs (Lithobates pipiens) with polypropylene sutures after radiotransmitters had been surgically implanted into the coleomic cavity. After a short recovery period, frogs were released back into the wetland habitat where they ...


Grace Peterson Research Colloquium, Emma Pfeiffer 2017 DePaul University

Grace Peterson Research Colloquium, Emma Pfeiffer

Grace Peterson Nursing Research Colloquium

Mental illness is commonly under-diagnosed, misdiagnosed, or untreated, particularly in the elderly population. An expected population increase for those 65 years and older, increased in health care expenses coupled with the moral and ethical obligation of health care providers to promote quality of life at all ages makes investigation to alternative treatments in this population is worth investigating. The purpose of this literature review is to synthesize existing studies to clarify the following questions: What are the effects of pet therapy on those experiencing signs and symptoms of depression and anxiety? Why is pet therapy still lagging in validated studies ...


Tear Fluid Collection In Dogs And Cats Using Ophthalmic Sponges, Lionel Sebbag, Danielle M. Harrington, Jonathan P. Mochel 2017 Iowa State University

Tear Fluid Collection In Dogs And Cats Using Ophthalmic Sponges, Lionel Sebbag, Danielle M. Harrington, Jonathan P. Mochel

Veterinary Clinical Sciences Publications

Objective - To compare the use of two ophthalmic sponges for tear collection in dogs and cats. Animals studied - Ten healthy dogs and 10 healthy cats.

Procedures - A strip (4x10 mm) of either cellulose or polyvinyl acetal (PVA) sponge was inserted into the ventral fornix of each eye for either 15, 30 or 60 seconds. The wetted strip was placed into a 0.2-mL tube that was first punctured at its bottom. Tears were eluted through the drainage hole into a 1.5-mL tube via centrifugation. Tear volume absorbed (VA) and tear volume recovered (VR) were calculated as the difference of ...


Spotlight On The Perioperative Use Of Maropitant Citrate, Bonnie L. Hay Kraus 2017 Iowa State University

Spotlight On The Perioperative Use Of Maropitant Citrate, Bonnie L. Hay Kraus

Veterinary Clinical Sciences Publications

Neurokinin-1 (NK-1) receptors are present in both the central nervous system and peripheral tissues. Substance P (SP) is the major ligand and is involved in multiple processes including pain transmission, vasodilation, modulation of the inflammatory response, as well as the sensory neuronal transmission involved in stress, anxiety, and emesis. The involvement of NK-1 and SP in the vomiting reflex has led to the development of NK-1 antagonists to prevent and treat vomiting in human and veterinary medicine. Maropitant is a potent, selective neurokinin (NK-1) receptor antagonist that blocks the pharmacologic action of SP in the central nervous system. Maropitant is ...


Patterns And Predictors Of Antimicrobial Resistance Among Staphylococcus Spp. From Canine Clinical Cases Presented At A Veterinary Academic Hospital In South Africa, Agricola Odoi 2017 University of Tennessee, Knoxville

Patterns And Predictors Of Antimicrobial Resistance Among Staphylococcus Spp. From Canine Clinical Cases Presented At A Veterinary Academic Hospital In South Africa, Agricola Odoi

Agricola Odoi

Background
Antimicrobial resistance in staphylococci, often associated with treatment failure, is increasingly reported in veterinary medicine. The aim of this study was to investigate patterns and predictors of antimicrobial resistance among Staphylococcus spp. isolates from canine samples submitted to the bacteriology laboratory at the University of Pretoria academic veterinary hospital between 2007 and 2012. Retrospective data of 334 Staphylococcus isolates were used to calculate the proportion of samples resistant to 15 antimicrobial agents. The Cochran-Armitage trend test was used to investigate temporal trends and logistic regression models were used to investigate predictors of antimicrobial resistance in Staphylococcus aureus and Staphylococcus ...


Metastatic Intraocular Hemangiopericytoma In A Dog, Jonathan D. Pucket, Rachel A. Allbaugh, Mary L. Higginbotham, Amy J. Rankin, Leandro Teixeira 2017 Oklahoma State University

Metastatic Intraocular Hemangiopericytoma In A Dog, Jonathan D. Pucket, Rachel A. Allbaugh, Mary L. Higginbotham, Amy J. Rankin, Leandro Teixeira

Veterinary Clinical Sciences Publications

A 10-year-old Labrador Retriever who had been undergoing therapy for a recurrent hemangiopericytoma of the right flank presented to the Kansas State University Ophthalmology service for evaluation of a painful left eye. Examination revealed secondary glaucoma and irreversible blindness of the affected eye and multifocal chorioretinal lesions in the fellow eye. Therapeutic and diagnostic enucleation of the left eye was performed and histopathologic examination demonstrated the presence of a presumed metastatic spindle cell sarcoma. Further immunohistochemical staining confirmed the intraocular neoplasia to be metastatic spread from the previously removed flank mass. Rapid progression in size and number of chorioretinal lesions ...


The Effects Of Reward-Based Training On The Behavioral Assessment Of The Domestic Dog, Shelby Vandergraff, Shelby K. Vandergraff 2017 Murray State University

The Effects Of Reward-Based Training On The Behavioral Assessment Of The Domestic Dog, Shelby Vandergraff, Shelby K. Vandergraff

Murray State Theses and Dissertations

Contrary to popular belief, pet overpopulation is caused more by owners failing to keep their dog than with accidental or intentional breeding (Moulton et al., 1991). Factors related to relinquishment have been researched, and concluded that behavioral problems are the most reoccurring reasons observed (Bailey, 1992; Miller at al., 1996; Patronek et al., 1996; Serpell, 1966; Salman et al., 1998, 2000; Scarlett et al, 1999; New et al., 2000; Shore et al., 2003, 2005; Mondelli 2004, Blackwell et al., 2008). When animals are relinquished to the shelter, the likelihood of the animal being euthanized increases. The purpose of this research ...


Canine Emotions As Seen Through Human Social Cognition, Miiamaaria V. Kujala 2017 University of Helsinki

Canine Emotions As Seen Through Human Social Cognition, Miiamaaria V. Kujala

Animal Sentience

It is not possible to demonstrate that dogs (Canis familiaris) feel emotions, but the same is true for all other species, including our own. The issue must therefore be approached indirectly, using premises similar to those used with humans. Recent methodological advances in canine research reveal what dogs experience and what they derive from the emotions perceptible in others. Dogs attend to social cues, they respond appropriately to the valence of human and dog facial expressions and vocalizations of emotion, and their limbic reward regions respond to the odor of their caretakers. They behave differently according to the emotional situation ...


Precision Medicine In Cats: Novel Niemann-Pick Type C1 Diagnosed By Whole-Genome Sequencing, D. A. Mauler, B. Gandolfi, C. R. Reinero, D. P. O'Brien, J. L. Spooner, L. A. Lyons, N. Matthew Ellinwood, Max F. Rothschild, 99 Lives Consortium 2017 University of Missouri

Precision Medicine In Cats: Novel Niemann-Pick Type C1 Diagnosed By Whole-Genome Sequencing, D. A. Mauler, B. Gandolfi, C. R. Reinero, D. P. O'Brien, J. L. Spooner, L. A. Lyons, N. Matthew Ellinwood, Max F. Rothschild, 99 Lives Consortium

Animal Science Publications

State-of-the-art health care includes genome sequencing of the patient to identify genetic variants that contribute to either the cause of their malady or variants that can be targeted to improve treatment. The goal was to introduce state-of-the-art health care to cats using genomics and a precision medicine approach. To test the feasibility of a precision medicine approach in domestic cats, a single cat that presented to the University of Missouri, Veterinary Health Center with an undiagnosed neurologic disease was whole-genome sequenced. The DNA variants from the cat were compared to the DNA variant database produced by the 99 Lives Cat ...


Early-Onset Progressive Retinal Atrophy Associated With An Iqcb1 Variant In African Black-Footed Cats (Felis Nigripes), Annie Oh, Jacqueline W. Pearce, Barbara Gandolfi, Erica K. Creighton, William K. Suedmeyer, Michael Selig, Ann P. Bosiack, Leilani J. Castaner, Rebecca E. H. Whiting, Ellen B. Belknap, Leslie A. Lyons, N. Matthew Ellinwood, Dorian J. Garrick, Max F. Rothschild, 99 Lives Consortium 2017 University of Missouri

Early-Onset Progressive Retinal Atrophy Associated With An Iqcb1 Variant In African Black-Footed Cats (Felis Nigripes), Annie Oh, Jacqueline W. Pearce, Barbara Gandolfi, Erica K. Creighton, William K. Suedmeyer, Michael Selig, Ann P. Bosiack, Leilani J. Castaner, Rebecca E. H. Whiting, Ellen B. Belknap, Leslie A. Lyons, N. Matthew Ellinwood, Dorian J. Garrick, Max F. Rothschild, 99 Lives Consortium

Animal Science Publications

African black-footed cats (Felis nigripes) are endangered wild felids. One male and full-sibling female African black-footed cat developed vision deficits and mydriasis as early as 3 months of age. The diagnosis of early-onset progressive retinal atrophy (PRA) was supported by reduced direct and consensual pupillary light reflexes, phenotypic presence of retinal degeneration, and a non-recordable electroretinogram with negligible amplitudes in both eyes. Whole genome sequencing, conducted on two unaffected parents and one affected offspring was compared to a variant database from 51 domestic cats and a Pallas cat, revealed 50 candidate variants that segregated concordantly with the PRA phenotype. Testing ...


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