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402 full-text articles. Page 1 of 8.

Pharmacokinetics Of Tulathromycin In Pregnant Ewes (Ovis Aries) Challenged With Campylobacter Jejuni, Michael Yaeger, Jonathan P. Mochel, Zuowei Wu, Paul Plummer, Orhan Sahin, Joseph Smith, Melda Ocal, Ashenafi Beyi, Changyun Xu, Qijing Zhang, Ronald W. Griffith 2021 Iowa State University

Pharmacokinetics Of Tulathromycin In Pregnant Ewes (Ovis Aries) Challenged With Campylobacter Jejuni, Michael Yaeger, Jonathan P. Mochel, Zuowei Wu, Paul Plummer, Orhan Sahin, Joseph Smith, Melda Ocal, Ashenafi Beyi, Changyun Xu, Qijing Zhang, Ronald W. Griffith

Faculty Publications and Other Works -- Large Animal Clinical Sciences

The purpose of this study was to evaluate the pharmacokinetics of tulathromycin in the plasma and maternal and fetal tissues of pregnant ewes when administered within 24 hours of a single, IV Campylobacter jejuni (C. jejuni) challenge. Twelve, pregnant ewes between 72–92 days of gestation were challenged IV with C. jejuni IA3902 and then treated with 1.1 ml/45.36 kg of tulathromycin subcutaneously 18 hours post-challenge. Ewes were bled at predetermined time points and euthanized either at a predetermined time point or following the observation of vaginal bleeding or abortion. Following euthanasia, tissues were collected for bacterial ...


Retrospective Evaluation Of A Dose-Dependent Effect Of Angiotensin-Converting Enzyme Inhibitors On Long-Term Outcome In Dogs With Cardiac Disease, Jessica L. Ward, Yen-Yu Chou, Lingnan Yuan, Karin S. Dorman, Jonathan P. Mochel 2021 Iowa State University

Retrospective Evaluation Of A Dose-Dependent Effect Of Angiotensin-Converting Enzyme Inhibitors On Long-Term Outcome In Dogs With Cardiac Disease, Jessica L. Ward, Yen-Yu Chou, Lingnan Yuan, Karin S. Dorman, Jonathan P. Mochel

Veterinary Clinical Sciences Publications

Background: Angiotensin-converting enzyme inhibitors (ACEIs) are commonly prescribed in dogs, but the ideal dosage is unknown.

Hypothesis/Objectives: In dogs with cardiac disease, a dose-response relationship exists for ACEIs with respect to long-term outcome.

Animals: One hundred forty-four dogs with cardiac disease, 63 with current or prior congestive heart failure.

Methods: Retrospective medical record review. Cox proportional hazards models were used to determine variables associated with 2-year survival or survival from first-onset congestive heart failure (CHF).

Results: Median initial ACEI dosage was 0.84 (interquartile range [IQR], 0.56-0.98) mg/kg/day, and 108/144 (75%) of dogs received ...


Nonlinear Mixed-Effect Pharmacokinetic Modeling And Distribution Of Doxycycline In Healthy Female Donkeys After Multiple Intragastric Dosing–Preliminary Investigation, Ronan J.J. Chapuis, Joseph Smith, Hilari M. French, Felix Ngosa Toka, Erik W. Peterson, Erika L. Little 2021 Ross University School of Veterinary Medicine

Nonlinear Mixed-Effect Pharmacokinetic Modeling And Distribution Of Doxycycline In Healthy Female Donkeys After Multiple Intragastric Dosing–Preliminary Investigation, Ronan J.J. Chapuis, Joseph Smith, Hilari M. French, Felix Ngosa Toka, Erik W. Peterson, Erika L. Little

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Doxycycline (DXC) is a broad-spectrum antibacterial antimicrobial administered to horses for the treatment of bacterial infections which may also affect donkeys. Donkeys have a different metabolism than horses, leading to differences in the pharmacokinetics of drugs compared to horses. This study aimed to describe the population pharmacokinetics of DXC in donkeys. Five doses of DXC hyclate (10 mg/kg) were administered via a nasogastric tube, q12 h, to eight non-fasted, healthy, adult jennies. Serum, urine, synovial fluid and endometrium were collected for 72 h following the first administration. Doxycycline concentration was measured by competitive enzyme immunoassay. Serum concentrations versus time ...


Variable Accuracy, Precision, And Consistency Of Compounded Famciclovir Formulated For Management Of Feline Herpesvirus-1 In Cats, Louise M. O'Leary, Rachel A. Allbaugh, Dwayne Schrunk, Thomas E. Olson, Lionel Sebbag 2021 Iowa State University

Variable Accuracy, Precision, And Consistency Of Compounded Famciclovir Formulated For Management Of Feline Herpesvirus-1 In Cats, Louise M. O'Leary, Rachel A. Allbaugh, Dwayne Schrunk, Thomas E. Olson, Lionel Sebbag

Veterinary Clinical Sciences Publications

Objective: To evaluate compounded famciclovir suspensions for accuracy, precision, and consistency in drug content.

Procedures: Two compounded famciclovir concentrations were evaluated (250 and 400 mg/mL, 30 preparations total from nine 503A compounding pharmacies) with U.S. Food and Drug Administration (FDA)-approved famciclovir tablets as control. Drug quantification via high-performance liquid chromatography (with famciclovir reference standard and pramipexole internal standard) was performed at 0, 14, and 28 days with concentrations of 90%–110% of labeled dose considered acceptable (US Pharmacopoeia standards).

Results: FDA-approved tablets from three different manufacturers were found to be accurate and precise with acceptable drug content ...


Comparison Of Canine And Human Physiological Factors: Understanding Interspecies Differences That Impact Drug Pharmacokinetics, Marilyn N. Martinez, Jonathan P. Mochel, Sibylle Neuhoff, Devendra Pade 2021 United States Food and Drug Administration

Comparison Of Canine And Human Physiological Factors: Understanding Interspecies Differences That Impact Drug Pharmacokinetics, Marilyn N. Martinez, Jonathan P. Mochel, Sibylle Neuhoff, Devendra Pade

Biomedical Sciences Publications

This review is a summary of factors affecting the drug pharmacokinetics (PK) of dogs versus humans. Identifying these interspecies differences can facilitate canine-human PK extrapolations while providing mechanistic insights into species-specific drug in vivo behavior. Such a cross-cutting perspective can be particularly useful when developing therapeutics targeting diseases shared between the two species such as cancer, diabetes, cognitive dysfunction, and inflammatory bowel disease. Furthermore, recognizing these differences also supports a reverse PK extrapolations from humans to dogs. To appreciate the canine-human differences that can affect drug absorption, distribution, metabolism, and elimination, this review provides a comparison of the physiology, drug ...


Case Report: Successful Management Of Refractory Keratomycosis In An Alpaca Using Penetrating Keratoplasty And Combination Antifungal Therapy (Caspofungin 0.5% And Terbinafine 1%), Braidee C. Foote, Joseph Smith, Anna Catherine Bowden, Rachel A. Allbaugh, Lionel Sebbag 2021 UTK

Case Report: Successful Management Of Refractory Keratomycosis In An Alpaca Using Penetrating Keratoplasty And Combination Antifungal Therapy (Caspofungin 0.5% And Terbinafine 1%), Braidee C. Foote, Joseph Smith, Anna Catherine Bowden, Rachel A. Allbaugh, Lionel Sebbag

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Fungal keratitis is a common disease in certain parts of the world and affects several species, including equids, camelids, and homo sapiens, leading to blindness or loss of the eye if the infection is not adequately controlled. Reports of clinical use of antifungals caspofungin and terbinafine are limited across both veterinary and human medical literature. The alpaca presented in this case demonstrates that deep keratomycosis can be caused by Scopulariopsis brevicaulis and Fusarium verticillioides, two previously unreported fungi to cause keratomycosis in camelids. This report demonstrates successful management with a combination of surgery and topical ophthalmic treatment with caspofungin 0 ...


Letter To The Editor Regarding “Efficacy Of Adding Ramipril (Vasotop) To The Combination Of Furosemide (Lasix) And Pimobendan (Vetmedin) In Dogs With Mitral Valve Degeneration: The Valve Trial”, Clarke Atkins, Bruce Keene, Teresa C. DeFrancesco, Sandra Tou, Valérie Chetboul, Étienne Côté, Stephen Ettinger, Philip R. Fox, Robert L. Hamlin, Jonathan P. Mochel, Jean‐Louis Pouchelon, Rebecca L. Stepien 2021 North Carolina State University

Letter To The Editor Regarding “Efficacy Of Adding Ramipril (Vasotop) To The Combination Of Furosemide (Lasix) And Pimobendan (Vetmedin) In Dogs With Mitral Valve Degeneration: The Valve Trial”, Clarke Atkins, Bruce Keene, Teresa C. Defrancesco, Sandra Tou, Valérie Chetboul, Étienne Côté, Stephen Ettinger, Philip R. Fox, Robert L. Hamlin, Jonathan P. Mochel, Jean‐Louis Pouchelon, Rebecca L. Stepien

Biomedical Sciences Publications

The manuscript entitled Efficacy of adding ramipril (VAsotop) to the combination of furosemide (Lasix) and pimobendan (VEtmedin) in dogs with mitral valve degeneration: The VALVE trial1 reports a study which sought to answer the question “could pimobendan be all that is needed beyond loop diuretics to manage congestive heart failure (CHF) in myxomatous mitral valve disease (MMVD)?” This was done by prospectively comparing the efficacy of pimobendan + ramipril + furosemide (triple treatment) to pimobendan + furosemide (double treatment) to treat new‐onset CHF caused by MMVD.


Changes In Circulating Lymphocytes And Lymphoid Tissue Associated With Vaccination Of Colostrum Deprived Calves, Shollie M. Falkenberg, Rohana P. Dassanayake, Mitchell V. Palmer, Simone Silveira, James A. Roth, Eric Gauger, Troy J. Kaiser, Christian Guidarini, John D. Neill, Julia F. Ridpath 2020 United States Department of Agriculture

Changes In Circulating Lymphocytes And Lymphoid Tissue Associated With Vaccination Of Colostrum Deprived Calves, Shollie M. Falkenberg, Rohana P. Dassanayake, Mitchell V. Palmer, Simone Silveira, James A. Roth, Eric Gauger, Troy J. Kaiser, Christian Guidarini, John D. Neill, Julia F. Ridpath

Veterinary Microbiology and Preventive Medicine Publications

The objective of this study was to compare immunological responses and lymphoid depletion in young, colostrum deprived calves following administration of vaccines containing modified-live bovine viral diarrhea virus (BVDV). A group of calves exposed to a typical virulence non-cytopathic (ncp) BVDV-2 field strain (ncp exposed) was included to compare responses of calves receiving vaccine to responses generated against a field strain (mimicking a natural infection). A negative control group administered a placebo was used in all comparisons. All vaccines used in the study were administered per manufacturer recommendations while ncp BVDV exposed calves received 5 ml intranasally (2.5 ml ...


Afoxolaner As A Treatment For A Novel Sarcoptes Scabiei Infestation In A Juvenile Potbelly Pig, Joe S. Smith, Darren J. Berger, Sarah E. Hoff, Jeba R. J. Jesudoss Chelladurai, Katy A. Martin, Matthew T. Brewer 2020 Iowa State University

Afoxolaner As A Treatment For A Novel Sarcoptes Scabiei Infestation In A Juvenile Potbelly Pig, Joe S. Smith, Darren J. Berger, Sarah E. Hoff, Jeba R. J. Jesudoss Chelladurai, Katy A. Martin, Matthew T. Brewer

Veterinary Pathology Publications and Papers

A 2 months old female Vietnamese potbellied pig presented to a veterinary teaching hospital with a referring complaint of pruritus. A human caretaker of the pig had recently been diagnosed with a Sarcoptes spp. dermatitis. Microscopic examination of the skin scrape samples and BLAST analysis confirmed the species of the mite as most closely related to Sarcoptes scabiei var. canis (AY493391). The pig was treated with afoxolaner as previous treatment with ivermectin was not efficacious. Recheck examinations and follow up revealed the pig to be non-pruritic and resolving. Afoxolaner may be a therapeutic option when treating Sarcoptes spp. infections in ...


Repurposing The Open Access Malaria Box Reveals Compounds With Activity Against Tritrichomonas Foetus Trophozoites, Katy A. Martin, Jeba R.J. Jesudoss Chelladurai, Christopher Bader, Elizabeth Carreiro, Katelyn Long, Kylie Thompson, Matthew T. Brewer 2020 Iowa State University

Repurposing The Open Access Malaria Box Reveals Compounds With Activity Against Tritrichomonas Foetus Trophozoites, Katy A. Martin, Jeba R.J. Jesudoss Chelladurai, Christopher Bader, Elizabeth Carreiro, Katelyn Long, Kylie Thompson, Matthew T. Brewer

Veterinary Pathology Publications and Papers

The protozoan parasite Tritrichomonas foetus causes early embryonic death in cattle which results in severe economic loss. In the United States, there are no drugs are approved for treatment of this pathogen. In this study, we evaluated in vitro anti-protozoal effects of compounds from an open access chemical library against T. foetus trophozoites. An initial high-throughput screen identified 16 compounds of interest. Further investigation revealed 12 compounds that inhibited parasite growth and 4 compounds with lethal effects. For lethal compounds, dose-response curves were constructed and the LD50 was calculated for laboratory and field strains of T. foetus. Our experiments revealed ...


An Eye On The Dog As The Scientist's Best Friend For Translational Research In Ophthalmology: Focus On The Ocular Surface, Lionel Sebbag, Jonathan P. Mochel 2020 Iowa State University

An Eye On The Dog As The Scientist's Best Friend For Translational Research In Ophthalmology: Focus On The Ocular Surface, Lionel Sebbag, Jonathan P. Mochel

Biomedical Sciences Publications

Preclinical animal studies provide valuable opportunities to better understand human diseases and contribute to major advances in medicine. This review provides a comprehensive overview of ocular parameters in humans and selected animals, with a focus on the ocular surface, detailing species differences in ocular surface anatomy, physiology, tear film dynamics and tear film composition. We describe major pitfalls that tremendously limit the translational potential of traditional laboratory animals (i.e., rabbits, mice, and rats) in ophthalmic research, and highlight the benefits of integrating companion dogs with clinical analogues to human diseases into preclinical pharmacology studies. This One Health approach can ...


The Use Of The Heter-Lp Algorithm To Reposition Antibiotics For Managing E. Coli Mastitis In Dairy Cattle, Somayeh Sharifi, Maryam Lotfi Shahreza, Abbas Pakdel, James M. Reecy, Nasser Ghadiri, Hadi Atashi, Mahmoud Motamedi, Esmaeil Ebrahimie 2020 Isfahan University of Technology

The Use Of The Heter-Lp Algorithm To Reposition Antibiotics For Managing E. Coli Mastitis In Dairy Cattle, Somayeh Sharifi, Maryam Lotfi Shahreza, Abbas Pakdel, James M. Reecy, Nasser Ghadiri, Hadi Atashi, Mahmoud Motamedi, Esmaeil Ebrahimie

Animal Science Publications

Mastitis, a disease with high incidence worldwide, is the most prevalent and costly disease in the dairy industry. Environmental mastitis pathogens, such as Escherichia coli (E. coli), are major etiological agents of bovine mastitis in well-managed dairy farms. However, there is still a need to develop more efficient, safe, and economical treatments for mastitis. In the current research, Heter-LP, a new system biology-based method of drug repositioning, was applied to potentially identify novel therapeutic avenues for the treatment of E. coli mastitis. On-line data repositories relevant to known diseases, drugs, and gene targets along with other specialized biological information for ...


Transport Of Artificial Virus-Like Nanocarriers (Avn) Through Intestinal Monolayer Via Microfold Cells, Tianjian Tong, Yijun Qi, Luke Bussiere, Michael J. Wannemeuhler, Cathy L. Miller, Chenxu Yu, Qun Wang 2020 Iowa State University

Transport Of Artificial Virus-Like Nanocarriers (Avn) Through Intestinal Monolayer Via Microfold Cells, Tianjian Tong, Yijun Qi, Luke Bussiere, Michael J. Wannemeuhler, Cathy L. Miller, Chenxu Yu, Qun Wang

Agricultural and Biosystems Engineering Publications

Compared with subcutaneous or intramuscular routes for vaccination, vaccine delivery via gastrointestinal mucosa has tremendous potential as it is easy to administer and pain free. Robust immune responses can be triggered successfully once vaccine carried antigen reaches the mucosal associated lymphoid sites (e.g., Peyer’s patches). However, the absence of an efficient delivery method has always been an issue for successful oral vaccine development. In our study, inspired by mammalian orthoreovirus (MRV) transport into gut mucosal lymphoid tissue via Microfold cells (M cells), artificial virus-like nanocarriers (AVN), consisting of gold nanocages functionalized with the 1 protein from mammalian reovirus ...


A Study To Assess The Correlation Between Plasma, Oral Fluid And Urine Concentrations Of Flunixin Meglumine With The Tissue Residue Depletion Profile In Finishing-Age Swine, Jessica L. Bates, Locke A. Karriker, Suzanne M. Rajewski, Zhoumeng Lin, Ronette Gehring, Mengjie Li, Jim E. Riviere, Johann F. Coetzee 2020 Iowa State University

A Study To Assess The Correlation Between Plasma, Oral Fluid And Urine Concentrations Of Flunixin Meglumine With The Tissue Residue Depletion Profile In Finishing-Age Swine, Jessica L. Bates, Locke A. Karriker, Suzanne M. Rajewski, Zhoumeng Lin, Ronette Gehring, Mengjie Li, Jim E. Riviere, Johann F. Coetzee

Veterinary Diagnostic and Production Animal Medicine Publications

Background

Flunixin meglumine (FM) was investigated for the effectiveness of plasma, oral fluid, and urine concentrations to predict tissue residue depletion profiles in finishing-age swine, along with the potential for untreated pigs to acquire tissue residues following commingled housing with FM-treated pigs. Twenty pigs were housed in groups of three treated and one untreated control. Treated pigs received one 2.2 mg/kg dose of FM intramuscularly. Before treatment and at 1, 3, 6, 12, 24, 36, and 48 h (h) after treatment, plasma samples were taken. At 1, 4, 8, 12 and 16 days (d) post-treatment, necropsy and collection ...


Considerations In The Extrapolation Drug Toxicity Between Humans And Dogs, Marilyn N. Martinez, Jonathan P. Mochel, Devendra Pade 2020 United States Food and Drug Administration

Considerations In The Extrapolation Drug Toxicity Between Humans And Dogs, Marilyn N. Martinez, Jonathan P. Mochel, Devendra Pade

Biomedical Sciences Publications

The dog is an important species used in preclinical studies in support of human drug product development. Likewise, because of the many active pharmaceutical ingredients (APIs) with therapeutic relevance to both humans and dogs, extrapolation can also occur in the reverse, from human to dog. In either situation, it is important to appreciate species-specific factors influencing drug pharmacokinetics (absorption, metabolism, disposition, and elimination) and the potential impact of disease on the applicability of these extrapolations. Furthermore, tools such as physiologically based pharmacokinetic (PBPK) models not only enable investigators to extrapolate species-specific data on systemic or organ exposure to the parent ...


Chitosan-Adjuvanted Salmonella Subunit Nanoparticle Vaccine For Poultry Delivered Through Drinking Water And Feed, Sankar Renu, Yi Han, Santosh Dhakal, Yashavanth S. Lakshmanappa, Ninoshkaly Feliciano-Ruiz, Sujata Senapati, Balaji Narasimhan, Ramesh Selvaraj, Gourapura J. Renukaradhya 2020 Ohio Agricultural Research and Development Center and The Ohio State University

Chitosan-Adjuvanted Salmonella Subunit Nanoparticle Vaccine For Poultry Delivered Through Drinking Water And Feed, Sankar Renu, Yi Han, Santosh Dhakal, Yashavanth S. Lakshmanappa, Ninoshkaly Feliciano-Ruiz, Sujata Senapati, Balaji Narasimhan, Ramesh Selvaraj, Gourapura J. Renukaradhya

Chemical and Biological Engineering Publications

Poor induction of mucosal immunity in the intestines by current Salmonella vaccines is a challenge to the poultry industry. We prepared and tested an oral deliverable Salmonella subunit vaccine containing immunogenic outer membrane proteins (OMPs) and flagellin (F) protein loaded and F-protein surface coated chitosan nanoparticles (CS NPs) (OMPs-F-CS NPs). The OMPs-F-CS NPs had mean particle size distribution of 514 nm, high positive charge and spherical in shape. In vitro and in vivo studies revealed the F-protein surface coated CS NPs were specifically targeted to chicken immune cells. The OMPs-F-CS NPs treatment of chicken immune cells upregulated TLRs, and Th1 ...


The Comparative Cytotoxicity Of Riddelliine In Primary Mouse, Rat And Chick Hepatocytes, Bryan L. Stegelmeier, William S. Resager, Steven M. Colegate 2020 USDA-Agricultural Research Service

The Comparative Cytotoxicity Of Riddelliine In Primary Mouse, Rat And Chick Hepatocytes, Bryan L. Stegelmeier, William S. Resager, Steven M. Colegate

Poisonous Plant Research (PPR)

Dehydropyrrolizidine alkaloid (DHPA) producing plants commonly poison livestock, wildlife and humans. Poisoning occurs when DHPAs are ingested as feed or food, or when they contaminate medicinal or herbal products. Direct toxicologic comparison of individual DHPAs is essential to estimate their actual health risks. This has been problematic due to varying models and difficulties in DHPA isolation or synthesis. In contrast, the macrocyclic DHPA riddelliine is readily isolated and it has been used as a benchmark to characterize different models of toxicity and carcinogenicity. Following earlier work with immortalized cell lines, the objective of this study was to characterize the effect ...


Recapitulation Of The Accessible Interface Of Biopsy-Derived Canine Intestinal Organoids To Study Epithelial-Luminal Interactions, Yoko M. Ambrosini, Yejin Park, Albert E. Jergens, Woojung Shin, Soyoun Min, Todd Atherly, Dana C. Borcherding, Jinah Jang, Karin Allenspach, Jonathan P. Mochel, Hyun Jung Kim 2020 University of Texas at Austin and Iowa State University

Recapitulation Of The Accessible Interface Of Biopsy-Derived Canine Intestinal Organoids To Study Epithelial-Luminal Interactions, Yoko M. Ambrosini, Yejin Park, Albert E. Jergens, Woojung Shin, Soyoun Min, Todd Atherly, Dana C. Borcherding, Jinah Jang, Karin Allenspach, Jonathan P. Mochel, Hyun Jung Kim

Biomedical Sciences Publications

Recent advances in canine intestinal organoids have expanded the option for building a better in vitro model to investigate translational science of intestinal physiology and pathology between humans and animals. However, the three-dimensional geometry and the enclosed lumen of canine intestinal organoids considerably hinder the access to the apical side of epithelium for investigating the nutrient and drug absorption, host-microbiome crosstalk, and pharmaceutical toxicity testing. Thus, the creation of a polarized epithelial interface accessible from apical or basolateral side is critical. Here, we demonstrated the generation of an intestinal epithelial monolayer using canine biopsy-derived colonic organoids (colonoids). We optimized the ...


Dynamics Of Larkspur (Delphinium Barbeyi) Pellet Consumption And Tolerance Of The Inhibitory Effects Of Larkspur Alkaloids On Muscle Function In Cattle., Benedict T. Green, Jim Pfister, Dale Gardner, Kevin Welch, Daniel Cook 2020 USDA-ARS

Dynamics Of Larkspur (Delphinium Barbeyi) Pellet Consumption And Tolerance Of The Inhibitory Effects Of Larkspur Alkaloids On Muscle Function In Cattle., Benedict T. Green, Jim Pfister, Dale Gardner, Kevin Welch, Daniel Cook

Poisonous Plant Research (PPR)

Larkspurs (Delphinium spp.) are toxic native plants on foothill and mountain rangelands in western North America, which poison cattle grazing on those rangelands. The purpose of this study was to examine in a laboratory setting, the subclinical effects of larkspur intake and toxicosis, by allowing larkspur susceptible and resistant cattle to self-select the amount of larkspur consumed in pellet form. We hypothesized that there would be differences in short term (9 – 11 day) pellet consumption between susceptible and resistant animals. Two trials were completed, each with larkspur resistant and susceptible Angus steers, and larkspur-alfalfa pellets at a 12% and 6 ...


Vaginal Microbiota Diverges In Sows With Low And High Reproductive Performance After Porcine Reproductive And Respiratory Syndrome Vaccination, L. P. Sanglard, S. Schmitz-Esser, K. A. Gray, D. C. L. Linhares, C. J. Yeoman, J. C. M. Dekkers, M. C. Niederwerder, N. V. L. Serão 2020 Iowa State University

Vaginal Microbiota Diverges In Sows With Low And High Reproductive Performance After Porcine Reproductive And Respiratory Syndrome Vaccination, L. P. Sanglard, S. Schmitz-Esser, K. A. Gray, D. C. L. Linhares, C. J. Yeoman, J. C. M. Dekkers, M. C. Niederwerder, N. V. L. Serão

Animal Science Publications

Previous studies have demonstrated evidence for a relationship between the vaginal microbiome and reproductive performance, suggesting the vaginal microbiota may serve as a tool to predict farrowing outcomes in commercial pigs. In this study, we compared the vaginal microbiome in sows with low and high farrowing performance and used it to classify animals with contrasting reproductive outcomes in commercial sows following immune challenge with porcine respiratory and reproductive syndrome (PRRS) vaccination. Eighteen microbes were differentially abundant (q-value < 0.05) between the Low and High farrowing performance groups. Among them, Campylobacter, Bacteroides, Porphyromonas, Lachnospiraceae unclassified, Prevotella, and Phascolarctobacterium were also selected in the discriminant and linear regression analyses, and could be used ...


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