Veterinary Pathology and Pathobiology Commons

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Recent Articles in Veterinary Pathology and Pathobiology

Perinatal Lamb Model Of Respiratory Syncytial Virus (Rsv) Infection, Rachel J. Derscheid, Mark R. Ackermann Iowa State University

Perinatal Lamb Model Of Respiratory Syncytial Virus (Rsv) Infection, Rachel J. Derscheid, Mark R. Ackermann

Veterinary Pathology Publications and Papers

Respiratory syncytial virus (RSV) is the most frequent cause of bronchiolitis in infants and children worldwide. Many animal models are used to study RSV, but most studies investigate disease in adult animals which does not address the unique physiology and immunology that makes infants more susceptible. The perinatal (preterm and term) lamb is a useful model of infant RSV disease as lambs have similar pulmonary structure including airway branching, Clara and type II cells, submucosal glands and Duox/lactoperoxidase (LPO) oxidative system, and prenatal alveologenesis. Lambs can be born preterm (90% gestation) and survive for experimentation although both preterm and ...