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Placement Of Intracoelomic Radiotransmitters And Silicone Passive Sampling Devices In Northern Leopard Frogs (Lithobates Pipiens), Taylor J. Yaw, Jennifer E. Swanson, Clay L. Pierce, Erin Muths, Kelly L. Smalling, Mark W. Vandever, Bianca A. Zaffarano 2017 Iowa State University

Placement Of Intracoelomic Radiotransmitters And Silicone Passive Sampling Devices In Northern Leopard Frogs (Lithobates Pipiens), Taylor J. Yaw, Jennifer E. Swanson, Clay L. Pierce, Erin Muths, Kelly L. Smalling, Mark W. Vandever, Bianca A. Zaffarano

Veterinary Clinical Sciences Publications

Historically, wetland toxin exposure studies have relied on single time point samples from stationary sampling devices. Development of passive sampling devices (PSDs) that can be attached to individual animals within wetland habitats has greatly improved in recent years, presenting an innovative sampling technology that can potentially yield individual-specific, quantifiable data about chemical exposure. In this study, silicone based PSDs were attached to the ventral skin of 20 northern leopard frogs (Lithobates pipiens) with polypropylene sutures after radiotransmitters had been surgically implanted into the coleomic cavity. After a short recovery period, frogs were released back into the wetland habitat where they ...


Grace Peterson Research Colloquium, Emma Pfeiffer 2017 DePaul University

Grace Peterson Research Colloquium, Emma Pfeiffer

Grace Peterson Nursing Research Colloquium

Mental illness is commonly under-diagnosed, misdiagnosed, or untreated, particularly in the elderly population. An expected population increase for those 65 years and older, increased in health care expenses coupled with the moral and ethical obligation of health care providers to promote quality of life at all ages makes investigation to alternative treatments in this population is worth investigating. The purpose of this literature review is to synthesize existing studies to clarify the following questions: What are the effects of pet therapy on those experiencing signs and symptoms of depression and anxiety? Why is pet therapy still lagging in validated studies ...


Tear Fluid Collection In Dogs And Cats Using Ophthalmic Sponges, Lionel Sebbag, Danielle M. Harrington, Jonathan P. Mochel 2017 Iowa State University

Tear Fluid Collection In Dogs And Cats Using Ophthalmic Sponges, Lionel Sebbag, Danielle M. Harrington, Jonathan P. Mochel

Veterinary Clinical Sciences Publications

Objective - To compare the use of two ophthalmic sponges for tear collection in dogs and cats. Animals studied - Ten healthy dogs and 10 healthy cats.

Procedures - A strip (4x10 mm) of either cellulose or polyvinyl acetal (PVA) sponge was inserted into the ventral fornix of each eye for either 15, 30 or 60 seconds. The wetted strip was placed into a 0.2-mL tube that was first punctured at its bottom. Tears were eluted through the drainage hole into a 1.5-mL tube via centrifugation. Tear volume absorbed (VA) and tear volume recovered (VR) were calculated as the difference of ...


Spotlight On The Perioperative Use Of Maropitant Citrate, Bonnie L. Hay Kraus 2017 Iowa State University

Spotlight On The Perioperative Use Of Maropitant Citrate, Bonnie L. Hay Kraus

Veterinary Clinical Sciences Publications

Neurokinin-1 (NK-1) receptors are present in both the central nervous system and peripheral tissues. Substance P (SP) is the major ligand and is involved in multiple processes including pain transmission, vasodilation, modulation of the inflammatory response, as well as the sensory neuronal transmission involved in stress, anxiety, and emesis. The involvement of NK-1 and SP in the vomiting reflex has led to the development of NK-1 antagonists to prevent and treat vomiting in human and veterinary medicine. Maropitant is a potent, selective neurokinin (NK-1) receptor antagonist that blocks the pharmacologic action of SP in the central nervous system. Maropitant is ...


Patterns And Predictors Of Antimicrobial Resistance Among Staphylococcus Spp. From Canine Clinical Cases Presented At A Veterinary Academic Hospital In South Africa, Agricola Odoi 2017 University of Tennessee, Knoxville

Patterns And Predictors Of Antimicrobial Resistance Among Staphylococcus Spp. From Canine Clinical Cases Presented At A Veterinary Academic Hospital In South Africa, Agricola Odoi

Agricola Odoi

Background
Antimicrobial resistance in staphylococci, often associated with treatment failure, is increasingly reported in veterinary medicine. The aim of this study was to investigate patterns and predictors of antimicrobial resistance among Staphylococcus spp. isolates from canine samples submitted to the bacteriology laboratory at the University of Pretoria academic veterinary hospital between 2007 and 2012. Retrospective data of 334 Staphylococcus isolates were used to calculate the proportion of samples resistant to 15 antimicrobial agents. The Cochran-Armitage trend test was used to investigate temporal trends and logistic regression models were used to investigate predictors of antimicrobial resistance in Staphylococcus aureus and Staphylococcus ...


The Effects Of Reward-Based Training On The Behavioral Assessment Of The Domestic Dog, Shelby Vandergraff, Shelby K. Vandergraff 2017 Murray State University

The Effects Of Reward-Based Training On The Behavioral Assessment Of The Domestic Dog, Shelby Vandergraff, Shelby K. Vandergraff

Murray State Theses and Dissertations

Contrary to popular belief, pet overpopulation is caused more by owners failing to keep their dog than with accidental or intentional breeding (Moulton et al., 1991). Factors related to relinquishment have been researched, and concluded that behavioral problems are the most reoccurring reasons observed (Bailey, 1992; Miller at al., 1996; Patronek et al., 1996; Serpell, 1966; Salman et al., 1998, 2000; Scarlett et al, 1999; New et al., 2000; Shore et al., 2003, 2005; Mondelli 2004, Blackwell et al., 2008). When animals are relinquished to the shelter, the likelihood of the animal being euthanized increases. The purpose of this research ...


Systematic Review Protocol: The Effects Of Glucocorticoids On Selected Hemodynamic And Biochemical Parameters In Dogs And Cats, Jessica Ward, Allison Masters, Annette O'Connor 2017 Iowa State University

Systematic Review Protocol: The Effects Of Glucocorticoids On Selected Hemodynamic And Biochemical Parameters In Dogs And Cats, Jessica Ward, Allison Masters, Annette O'Connor

Veterinary Diagnostic and Production Animal Medicine Reports

Objective: The objective of this scoping review is to define the scope of literature pertaining to the effects of glucocorticoids in dogs or cats on selected parameters that may affect cardiac function or fluid balance (blood glucose, blood pressure, sodium and potassium levels, echocardiographic or invasive hemodynamic indices, or indicators of volume status). It is our intention that after evaluating the available literature, we will then make a determination of the potential to conduct a systematic review and meta-analysis of the relevant literature for specific interventions.


Metastatic Intraocular Hemangiopericytoma In A Dog, Jonathan D. Pucket, Rachel A. Allbaugh, Mary L. Higginbotham, Amy J. Rankin, Leandro Teixeira 2017 Oklahoma State University

Metastatic Intraocular Hemangiopericytoma In A Dog, Jonathan D. Pucket, Rachel A. Allbaugh, Mary L. Higginbotham, Amy J. Rankin, Leandro Teixeira

Veterinary Clinical Sciences Publications

A 10-year-old Labrador Retriever who had been undergoing therapy for a recurrent hemangiopericytoma of the right flank presented to the Kansas State University Ophthalmology service for evaluation of a painful left eye. Examination revealed secondary glaucoma and irreversible blindness of the affected eye and multifocal chorioretinal lesions in the fellow eye. Therapeutic and diagnostic enucleation of the left eye was performed and histopathologic examination demonstrated the presence of a presumed metastatic spindle cell sarcoma. Further immunohistochemical staining confirmed the intraocular neoplasia to be metastatic spread from the previously removed flank mass. Rapid progression in size and number of chorioretinal lesions ...


Randomized, Controlled Trial Evaluating The Effect Of Multi-Strain Probiotic On The Mucosal Microbiota In Canine Idiopathic Inflammatory Bowel Disease, Robin White, Todd Atherly, Blake Guard, Giacomo Rossi, Chong Wang, Curtis Mosher, Craig Webb, Steve Hill, Mark Ackermann, Peter Sciabarra, Karin Allenspach, Jan Suchodolski, Albert E. Jergens 2017 Iowa State University

Randomized, Controlled Trial Evaluating The Effect Of Multi-Strain Probiotic On The Mucosal Microbiota In Canine Idiopathic Inflammatory Bowel Disease, Robin White, Todd Atherly, Blake Guard, Giacomo Rossi, Chong Wang, Curtis Mosher, Craig Webb, Steve Hill, Mark Ackermann, Peter Sciabarra, Karin Allenspach, Jan Suchodolski, Albert E. Jergens

Veterinary Diagnostic and Production Animal Medicine Publications

The intestinal microbiota is increasingly linked to the pathogenesis of idiopathic inflammatory bowel disease (IBD) in dogs. While studies have reported alterations in fecal (luminal) microbial populations, only limited information is available about the mucosal microbiota of IBD dogs at diagnosis and following medical therapy. Our aim was to characterize the mucosal microbiota and determine the clinical, microbiological, and mucosal homeostatic effects of probiotic treatment in dogs with IBD. Thirty four IBD dogs were randomized to receive standard therapy (ST = diet + prednisone) with or without probiotic. Tissue sections from endoscopic biopsies were evaluated by fluorescence in situ hybridization (FISH) on ...


Canine Emotions As Seen Through Human Social Cognition, Miiamaaria V. Kujala 2017 University of Helsinki

Canine Emotions As Seen Through Human Social Cognition, Miiamaaria V. Kujala

Animal Sentience

It is not possible to demonstrate that dogs (Canis familiaris) feel emotions, but the same is true for all other species, including our own. The issue must therefore be approached indirectly, using premises similar to those used with humans. Recent methodological advances in canine research reveal what dogs experience and what they derive from the emotions perceptible in others. Dogs attend to social cues, they respond appropriately to the valence of human and dog facial expressions and vocalizations of emotion, and their limbic reward regions respond to the odor of their caretakers. They behave differently according to the emotional situation ...


Early-Onset Progressive Retinal Atrophy Associated With An Iqcb1 Variant In African Black-Footed Cats (Felis Nigripes), Annie Oh, Jacqueline W. Pearce, Barbara Gandolfi, Erica K. Creighton, William K. Suedmeyer, Michael Selig, Ann P. Bosiack, Leilani J. Castaner, Rebecca E. H. Whiting, Ellen B. Belknap, Leslie A. Lyons, N. Matthew Ellinwood, Dorian J. Garrick, Max F. Rothschild, 99 Lives Consortium 2017 University of Missouri

Early-Onset Progressive Retinal Atrophy Associated With An Iqcb1 Variant In African Black-Footed Cats (Felis Nigripes), Annie Oh, Jacqueline W. Pearce, Barbara Gandolfi, Erica K. Creighton, William K. Suedmeyer, Michael Selig, Ann P. Bosiack, Leilani J. Castaner, Rebecca E. H. Whiting, Ellen B. Belknap, Leslie A. Lyons, N. Matthew Ellinwood, Dorian J. Garrick, Max F. Rothschild, 99 Lives Consortium

Animal Science Publications

African black-footed cats (Felis nigripes) are endangered wild felids. One male and full-sibling female African black-footed cat developed vision deficits and mydriasis as early as 3 months of age. The diagnosis of early-onset progressive retinal atrophy (PRA) was supported by reduced direct and consensual pupillary light reflexes, phenotypic presence of retinal degeneration, and a non-recordable electroretinogram with negligible amplitudes in both eyes. Whole genome sequencing, conducted on two unaffected parents and one affected offspring was compared to a variant database from 51 domestic cats and a Pallas cat, revealed 50 candidate variants that segregated concordantly with the PRA phenotype. Testing ...


Precision Medicine In Cats: Novel Niemann-Pick Type C1 Diagnosed By Whole-Genome Sequencing, D. A. Mauler, B. Gandolfi, C. R. Reinero, D. P. O'Brien, J. L. Spooner, L. A. Lyons, N. Matthew Ellinwood, Max F. Rothschild, 99 Lives Consortium 2017 University of Missouri

Precision Medicine In Cats: Novel Niemann-Pick Type C1 Diagnosed By Whole-Genome Sequencing, D. A. Mauler, B. Gandolfi, C. R. Reinero, D. P. O'Brien, J. L. Spooner, L. A. Lyons, N. Matthew Ellinwood, Max F. Rothschild, 99 Lives Consortium

Animal Science Publications

State-of-the-art health care includes genome sequencing of the patient to identify genetic variants that contribute to either the cause of their malady or variants that can be targeted to improve treatment. The goal was to introduce state-of-the-art health care to cats using genomics and a precision medicine approach. To test the feasibility of a precision medicine approach in domestic cats, a single cat that presented to the University of Missouri, Veterinary Health Center with an undiagnosed neurologic disease was whole-genome sequenced. The DNA variants from the cat were compared to the DNA variant database produced by the 99 Lives Cat ...


Identification Of Feline Tritrichomonas Foetus Surface Epitopes: Putative Targets For Development Of A Novel Diagnostic Test For Feline Trichomonosis, Emily Nissa Gould 2016 University of Tennessee - Knoxville

Identification Of Feline Tritrichomonas Foetus Surface Epitopes: Putative Targets For Development Of A Novel Diagnostic Test For Feline Trichomonosis, Emily Nissa Gould

Masters Theses

BACKGROUND: Tritrichomonas foetus (T. foetus) is a flagellated protozoa that infects the distal ileum and proximal colon of domestic cats and also induces reproductive failure in cattle. Although feline trichomonosis is recognized to have a global prevalence of up to 30%, it still poses a diagnostic and therapeutic challenge to veterinarians; thus, there is a need for both improved diagnostics and therapeutics. Despite differing organ tropism between genotypes, evidence exists for conserved virulence factors between feline and bovine T. foetus. Two epitopes (1.15 and 1.17) of the bovine T. foetus glycosylated surface antigen 1.15-1.17 have been ...


Cinv Survey, Lauren Hackbarth 2016 Iowa State University

Cinv Survey, Lauren Hackbarth

Honors Projects and Posters

Introduction: Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of chemotherapeutic treatment experienced by dogs that can lower quality of life and functionality. These symptoms are likewise found in people receiving chemotherapy; however, human oncology has well-established protocols for preventing these side effects, while veterinary medicine does not. The objective of this research is to establish a baseline regarding current standard of care to determine how veterinary specialists are managing CINV in dogs receiving chemotherapy.

Introduction: Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of chemotherapeutic treatment experienced by dogs that can lower quality of life ...


Animal-Assisted Therapy For Military Veterans With Posttraumatic Stress Disorder: An Investigation On The Positive Effects Of Attachment And Affiliation Behaviors, Sara Miele 2016 Dominican University of California

Animal-Assisted Therapy For Military Veterans With Posttraumatic Stress Disorder: An Investigation On The Positive Effects Of Attachment And Affiliation Behaviors, Sara Miele

Scholarly & Creative Works Conference 2019

Posttraumatic stress disorder (PTSD) develops in people who have experienced a traumatic event (nimh.nih.gov, 2016). Because PTSD is a chronic disorder, it is associated with impaired quality of life (Stern et al., 2013). A specific population at high risk for developing PTSD is military veterans. It is estimated over half a million military veterans suffer from PTSD (Stern et al., 2013). Although there are psychological services and treatments for veterans, many do not seek help because fear of the negative stigma associated with mental illness (Lanning & Krenek, 2013). Recently, efforts have been made to implement veteran friendly treatment ...


Alterations Of The Ileal And Colonic Mucosal Microbiota In Canine Chronic Enteropathies, Eric Cassmann, Robin White, Todd Atherly, Chong Wang, Yaxuan Sun, Samir Khoda, Curtis L. Mosher, Mark R. Ackermann, Albert Jergens 2016 Iowa State University

Alterations Of The Ileal And Colonic Mucosal Microbiota In Canine Chronic Enteropathies, Eric Cassmann, Robin White, Todd Atherly, Chong Wang, Yaxuan Sun, Samir Khoda, Curtis L. Mosher, Mark R. Ackermann, Albert Jergens

Veterinary Clinical Sciences Publications

Background

The intestinal microbiota is increasingly linked to the pathogenesis of chronic enteropathies (CE) in dogs. While imbalances in duodenal and fecal microbial communities have been associated with mucosal inflammation, relatively little is known about alterations in mucosal bacteria seen with CE involving the ileum and colon.

Aim

To investigate the composition and spatial organization of mucosal microbiota in dogs with CE and controls.

Methods

Tissue sections from endoscopic biopsies of the ileum and colon from 19 dogs with inflammatory bowel disease (IBD), 6 dogs with granulomatous colitis (GC), 12 dogs with intestinal neoplasia, and 15 controls were studied by ...


Meningeal Worm In Central Iowa Goat Herds, Kelly Still Brooks 2016 Iowa State University

Meningeal Worm In Central Iowa Goat Herds, Kelly Still Brooks

Animal Industry Report

Aberrant migration of the deer meningeal worm, Parelaphostrongylus tenuis, is a commonly recognized cause of neurologic disease in South American camelids but is less frequently considered in other small ruminant species. After an unusually cool and wet summer season, central Iowa goat herds serviced by Iowa State University’s Veterinary Field Services have been increasingly affected by P. tenuis, with clinical cases presenting as early as August. Most caprine cases present with progressive neurologic deficits, starting with hind-end weakness and ataxia which may lead to complete paresis and death. Both sporadic cases and herd outbreaks involving as much as 15 ...


Retinal Detachment Post-Phacoemulsification In Bichons Frises: A Retrospective Study Of 54 Dogs, Silvia G. Pryor, Ellison Bentley, Gillian J. McLellan, Elizabeth A. Giuliano, Rachel A. Allbaugh, Amy J. Rankin, Amber L. Labelle, Kevin A. Buhr 2016 University of Wisconsin-Madison

Retinal Detachment Post-Phacoemulsification In Bichons Frises: A Retrospective Study Of 54 Dogs, Silvia G. Pryor, Ellison Bentley, Gillian J. Mclellan, Elizabeth A. Giuliano, Rachel A. Allbaugh, Amy J. Rankin, Amber L. Labelle, Kevin A. Buhr

Veterinary Clinical Sciences Publications

Objective—To compare rates of retinal detachment (RD) post phacoemulsification in American Bichons Frises with and without prophylactic retinopexy.

Procedures—Medical records of 54 Bichons Frises undergoing phacoemulsification with or without prophylactic retinopexy between 2003–2013 in one or both eyes were reviewed from five Midwestern university veterinary teaching hospitals. Inclusion criteria were pre-operative ERG, at least 6 months of follow up post phacoemulsification, and absence of pre-existing RD as determined by ophthalmic examination and/or ultrasound. Statistical analyses used chi-squared and Wilcoxon rank-sum tests and Wilson confidence intervals with the p value

Results—Phacoemulsification was performed without retinopexy in ...


Development Of A Novel In Vivo Corneal Fibrosis Model In The Dog, K. M. Gronkiewicz, Elizabeth A. Giuliano, K. Kuroki, F. Bunyak, Ajay Sharma, L. B. C. Teixeira, C. W. Hamm, R. R. Mohan 2016 College of Veterinary Medicine, Columbia

Development Of A Novel In Vivo Corneal Fibrosis Model In The Dog, K. M. Gronkiewicz, Elizabeth A. Giuliano, K. Kuroki, F. Bunyak, Ajay Sharma, L. B. C. Teixeira, C. W. Hamm, R. R. Mohan

Pharmacy Faculty Articles and Research

The aim of this study was to develop a novel in vivo corneal model of fibrosis in dogs utilizing alkali burn and determine the ability of suberanilohydroxamic acid (SAHA) to inhibit corneal fibrosis using this large animal model. To accomplish this, we used seven research Beagle dogs. An axial corneal alkali burn in dogs was created using 1 N NaOH topically. Six dogs were randomly and equally assigned into 2 groups: A) vehicle (DMSO, 2 μL/mL); B) anti-fibrotic treatment (50 μM SAHA). The degree of corneal opacity, ocular health, and anti-fibrotic effects of SAHA were determined utilizing the Fantes ...


Molecular Mechanisms Of Suberoylanilide Hydroxamic Acid In The Inhibition Of Tgf-Β1-Mediated Canine Corneal Fibrosis, Kristina M. Gronkiewicz, Elizabeth A. Giuliano, Ajay Sharma, Rajiv R. Mohan 2016 University of Missouri, Columbia

Molecular Mechanisms Of Suberoylanilide Hydroxamic Acid In The Inhibition Of Tgf-Β1-Mediated Canine Corneal Fibrosis, Kristina M. Gronkiewicz, Elizabeth A. Giuliano, Ajay Sharma, Rajiv R. Mohan

Pharmacy Faculty Articles and Research

Objective—To investigate molecular mechanisms mediating anti-fibrotic effect of SAHA in the canine cornea using an in vitro model. We hypothesized that SAHA attenuates corneal fibrosis by modulating Smad-dependent and, to a lesser extent, Smad-independent signaling pathways activated by TGF-β1, as well as matrix metalloproteinase (MMP) activity.

Methods—Cultured canine corneal fibroblasts (CCF) were incubated in the presence/absence of TGF-β1 (5ng/ml) and SAHA (2.5μM) for 24hrs. Western blot analysis was used to quantify non-phosphorylated and phosphorylated isoforms of Smad2/3, p38 MAP kinase (MAPK), ERK1/2 and JNK1. Real-time PCR and zymography were utilized to quantify MMP1 ...


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