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Small or Companion Animal Medicine Commons

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Current Controversies In Feline Nutrition, Maryanne Murphy, Joe Bartges, Claudia Kirk, Angela Lusby, Beth Hamper, Donna Raditic 2014 University of Tennessee, Knoxville

Current Controversies In Feline Nutrition, Maryanne Murphy, Joe Bartges, Claudia Kirk, Angela Lusby, Beth Hamper, Donna Raditic

Donna M Raditic

No abstract provided.


The Unique Nutritional Requirements Of The Cat: A Strict Carnivore, Beth Hamper, Joe Bartges, Claudia Kirk, Angela Lusby, Maryanne Murphy, Donna Raditic 2014 University of Tennessee, Knoxville

The Unique Nutritional Requirements Of The Cat: A Strict Carnivore, Beth Hamper, Joe Bartges, Claudia Kirk, Angela Lusby, Maryanne Murphy, Donna Raditic

Donna M Raditic

No abstract provided.


Use Of Xylazine/Ketamine Or Medetomidine Combined With Either Ketamine, Ketamine/Butorphanol, Or Ketamine/Telazol For Immobilization Of White-Tailed Deer (Odocoileus Virginianus), Lisa Muller, David Osborn, Edward Ramsay, Thomas Doherty, Brad Miller, Robert Warren, Karl Miller 2014 University of Tennessee - Knoxville

Use Of Xylazine/Ketamine Or Medetomidine Combined With Either Ketamine, Ketamine/Butorphanol, Or Ketamine/Telazol For Immobilization Of White-Tailed Deer (Odocoileus Virginianus), Lisa Muller, David Osborn, Edward Ramsay, Thomas Doherty, Brad Miller, Robert Warren, Karl Miller

Lisa I Muller

We immobilized 18 captive, adult, female white-tailed deer (Odocoileus virginianus) with a combination of either 1) xylazine/ketamine (XK; 1.6+0.1 mg kg 1 xylazine and 7.8+0.3 mg kg 1 ketamine antagonized with 2.1+0.1 mg kg 1 tolazoline), 2) Medetomidine/Ketamine (MK; 0.075+0.01 mg kg 1 medetomidine and 2.1+0.2 mg kg 1 ketamine antagonized with 0.37+0.0 mg kg 1 atipamezole), 3) Medetomidine/Ketamine/Butorphanol (MKB; 0.072+0.01 mg kg 1 medetomidine, 2.1+0.2 mg kg 1 ketamine and 0 ...


Survey Of Canine Monogenetic Diseases With Established Molecular Bases, Brent J. Pepin, Samantha J. Hau, Erin N. Bradley, Janessa R. Thompson, Timothy H. Helms, Amie M. Johnson, Marisa Rotolo, Miranda M. Uriell, Matthew T. Brewer, Steve A. Carlson 2014 Iowa State University

Survey Of Canine Monogenetic Diseases With Established Molecular Bases, Brent J. Pepin, Samantha J. Hau, Erin N. Bradley, Janessa R. Thompson, Timothy H. Helms, Amie M. Johnson, Marisa Rotolo, Miranda M. Uriell, Matthew T. Brewer, Steve A. Carlson

Biomedical Sciences Publications

The development of a dog breed often involves selection, which intentionally propagates valued genetic traits. Unfortunately, untoward traits can be collaterally propagated during this process. For the purpose of identifying trends in canine genetic diseases, we examined 36 randomly chosen canine pathologies involving single gene mutations. For each disease we provide a brief summary of breed predilection, clinical signs, the underlying genetic mutation, and the availability of a commercial diagnostic test. The following trends were noted in this non-exhaustive list of diseases. First, these genetic diseases primarily involve the ophthalmic (28%) and nervous systems (28%). Second, no single breed was ...


Anticholinergic Drugs In Dogs, Bonnie L. Hay Kraus 2014 Iowa State University

Anticholinergic Drugs In Dogs, Bonnie L. Hay Kraus

Veterinary Clinical Sciences Publications

Can I use anticholinergic drugs with dexmedetomidine in dogs?


Characterization Of Mandible And Femur Canine Mesenchymal Stem Cells: A Pilot Study, Juan M. Bugueno 2014 University of Pennsylvania

Characterization Of Mandible And Femur Canine Mesenchymal Stem Cells: A Pilot Study, Juan M. Bugueno

Dental Theses

Mesenchymal stem cells (MSCs) are emerging donor grafts for bone regeneration in dentistry. MSCs are phenotypically and functionally skeletal site- specific based on extensive studies using human and rodent MSCs but there is paucity of information on canine MSCs (cMSCs) and their regenerative applications in veterinary dentistry. We hypothesized that cMSCs are functionally skeletal-site specific and that mandible cMSCs (M-cMSCs) are highly osteogenic relative to femur cMSCs (F-cMSCs). Trabecular bone samples were obtained from mandible and femur of 2 healthy beagle dogs (ages: 3 weeks, females). Primary M-cMSCs and F-cMSCs were established in culture. Using early passage cells, colony-forming units ...


Antinociceptive And Selected Physiological Effects Of Morphine And Xylazine On Tiletamine-Zolazepam Anesthesia In Llamas, Reza Seddighi, Sarah Elliot, Brian Whitlock, Christine Egger, Thomas Doherty 2014 University of Tennessee - Knoxville

Antinociceptive And Selected Physiological Effects Of Morphine And Xylazine On Tiletamine-Zolazepam Anesthesia In Llamas, Reza Seddighi, Sarah Elliot, Brian Whitlock, Christine Egger, Thomas Doherty

Reza Seddighi

OBJECTIVE: Evaluate antinociception, anesthesia, and recovery in llamas given tiletamine-zolazepam (TZ) with either morphine, xylazine, morphine and xylazine, or saline. STUDY DESIGN: Randomized crossover experimental study. ANIMALS:m Six healthy, adult intact male llamas. METHODS:m Llamas were given each of four treatments intramuscularly with a 1-week washout: TZ (2 mg kg-1 ) combined with either morphine (0.5 mg kg-1 ; M), xylazine (0.15 mg kg-1 ; X), morphine (0.5 mg kg-1 ) and xylazine (0.15mg kg-1 ) (MX), or saline (C). Llamas breathed room air during the experiment. Characteristics of anesthesia, recovery, and selected cardiopulmonary variables were recorded. Antinociception was ...


Physiologic Assessment Of Blood Glucose Homeostasis Via Combined Intravenous Glucose And Insulin Testing In Horses, Hugo Eiler, Nicholas Frank, Frank Andrews, Jack Oliver, Kellie Fecteau 2014 University of Tennessee, Knoxville

Physiologic Assessment Of Blood Glucose Homeostasis Via Combined Intravenous Glucose And Insulin Testing In Horses, Hugo Eiler, Nicholas Frank, Frank Andrews, Jack Oliver, Kellie Fecteau

Kellie Fecteau

Objective - To characterize the physiologic response to IV bolus injection of glucose and insulin for development of a combined glucose-insulin test (CGIT) in horses. Animals - 6 healthy mares and 1 mare each with pituitary adenoma and urolithiasis. Procedure - Horses were given a CGIT (glucose, 150 mg/kg; insulin, 0.1 U/kg); results were compared with a singular IV glucose tolerance test (GTT; 150 mg/kg) and a singular IV insulin sensitivity test (IST; 0.1 U/kg). Healthy horses were also given a CGIT after receiving xylazine and undergoing stress. Results - Physiologically, the CGIT resulted in a 2-phase curve ...


Inhibition Of Collagenase Breakdown Of Equine Corneas By Tetanus Antitoxin, Equine Serum And Acetylcysteine, Kellie Fecteau, J Haffner, Hugo Eiler 2014 University of Tennessee, Knoxville

Inhibition Of Collagenase Breakdown Of Equine Corneas By Tetanus Antitoxin, Equine Serum And Acetylcysteine, Kellie Fecteau, J Haffner, Hugo Eiler

Kellie Fecteau

OBJECTIVE: To determine whether tetanus antitoxin, equine serum, and acetylcysteine, which are currently used in the treatment of equine corneal ulcer, inhibit the digestion of equine corneal collagen when exposed to collagenase in vitro. ANIMALS STUDIED: Corneas from 40 adult horses. PROCEDURES: Sections of equine corneas were incubated with saline, a solution of bacterial collagenase in saline, bacterial collagenase in saline plus equine tetanus antitoxin, bacterial collagenase in saline plus equine serum, or bacterial collagenase in saline plus acetylcysteine. Each one of the collagenase inhibitors was tested at different concentrations. The degree of corneal collagen digestion was determined by concentrations ...


The Potential Of Collagenase As A New Therapy For Separation Of Human Retained Placenta: Hydrolytic Potency On Human, Equine And Bovine Placentae, Kellie Fecteau, Hugo Eiler 2014 University of Tennessee, Knoxville

The Potential Of Collagenase As A New Therapy For Separation Of Human Retained Placenta: Hydrolytic Potency On Human, Equine And Bovine Placentae, Kellie Fecteau, Hugo Eiler

Kellie Fecteau

The purpose of this study was to determine to what degree bacterial collagenase may digest human placentae compared to equine and bovine placentae. Placenta samples from human, equine and bovine were incubated with bacterial collagenase solution at various concentrations. The degree of hydrolysis and collagen breakdown was measured by the release of total proteins and hydroxyproline into the incubation media. Also, whole placentae were injected via umbilical cord arteries with collagenase solution (200 U/ml, 200 ml total volume in human and 1000 ml in equine) and hydrolysis determined chemically and subjectively. Human and equine placental collagens were the most ...


Placenta Detachment: Unexpected High Concentrations Of 5-Hydroxytryptamine (Serotonin) In Fetal Blood And Its Mitogenic Effect On Placental Cells In Bovine, Kellie Fecteau, Hugo Eiler 2014 University of Tennessee, Knoxville

Placenta Detachment: Unexpected High Concentrations Of 5-Hydroxytryptamine (Serotonin) In Fetal Blood And Its Mitogenic Effect On Placental Cells In Bovine, Kellie Fecteau, Hugo Eiler

Kellie Fecteau

The purpose of this study was twofold: (1) to determine whether there is a profile of 5-hydroxytryptamine (5-HT, serotonin) concentrations in fetal bovine blood and tissues during pregnancy, parturition and the early neonatal period and (2) to determine whether 5-HT has a 'mitogenic' effect on cultured placentome cells in bovine. Results revealed a 5-HT concentration profile in fetal blood. Overall concentrations of 5-HT in fetal blood were 6.6 times (P< 0.001) that of adult cows and 2.8 times (P< 0.001) that of blood collected during caesarean section (from umbilical veins) and from 18-72 h old calves ...


Retained Placenta, Hugo Eiler, Kellie Fecteau 2014 University of Tennessee, Knoxville

Retained Placenta, Hugo Eiler, Kellie Fecteau

Kellie Fecteau

No abstract provided.


Prevention Of Retained Placenta By Injection Of Collagenase Into Umbilical Arteries Of Calves Delivered By Cesarean Section: A Tolerance Study, Hugo Eiler, P Wan, N Valk, Kellie Fecteau 2014 University of Tennessee, Knoxville

Prevention Of Retained Placenta By Injection Of Collagenase Into Umbilical Arteries Of Calves Delivered By Cesarean Section: A Tolerance Study, Hugo Eiler, P Wan, N Valk, Kellie Fecteau

Kellie Fecteau

In the cow, cesarean section delivery is often followed by retention of fetal membranes. Hypothetically, the retention of fetal membranes could be prevented by intraplacental injections of the enzyme collagenase. However, the infusion of this potent proteolytic enzyme into a uterus traumatized by surgery can lead to uterine damage, including perforation. Thus, the objective of this research was to evaluate tolerance of intraplacental treatment of bacterial collagenase. A cesarean section was performed on 10 experimental cows undergoing induced delivery or diagnosed with dystocia. During the surgical procedure, 200,000 units of bacterial collagenase in 1 L of saline were infused ...


Effects Of Leuprolide Acetate On Selected Blood And Fecal Sex Hormones In Hispaniolan Amazon Parrots (Amazona Ventrais), Eric Klaphake, Kellie Fecteau, Martine deWit, Cheryl Greenacre, Judith Grizzle, Michael Jones, Nancy Zagaya, L. Abney, Jack Oliver 2014 University of Tennessee - Knoxville

Effects Of Leuprolide Acetate On Selected Blood And Fecal Sex Hormones In Hispaniolan Amazon Parrots (Amazona Ventrais), Eric Klaphake, Kellie Fecteau, Martine Dewit, Cheryl Greenacre, Judith Grizzle, Michael Jones, Nancy Zagaya, L. Abney, Jack Oliver

Kellie Fecteau

The luteinizing hormone-releasing hormone agonist leuprolide acetate is used commonly to anage reproductive problems in pet birds. To determine the effect of leuprolide acetate on plas a and fecal hormone levels in a psittacine species, a single 800 microg/kg dose of the 30-day depot form of leuprolide acetate was administered IM in 11 healthy, nonbreeding adult Hispaniolan Amazon parrots (Amazona ventralis), and plasma and fecal hormone levels were measured before and after leuprolide administration. At pooled baseline to 21 days postleuprolide acetate administration, sample collection day was significantly associated with plasma 17beta-estradiol and androstenedione levels and fecal 17beta-estradiol levels ...


T-61 Use In The Euthanasia Of Domestic Animals: A Survey, Andrew N. Rowan 2014 Tufts University

T-61 Use In The Euthanasia Of Domestic Animals: A Survey, Andrew N. Rowan

Andrew N. Rowan, D.Phil.

A variety of techniques have been proposed and employed for the killing of domestic animals but relatively few have survived as suitable agents for euthanasia-namely, the induction of painless, suffering-free death. Some agents, such as strychnine, curariform agents, or potassium salts cause suffering while others have other disadvantages. 'lbday, dogs and cats are commonly euthanatized with sodium pentobarbital or with T-61 which is a mixture of a central nervous system narcotic, a paralytic agent, and a local anesthetic. The use of T-61 was first reported in the United States in 1963 (Quin 1963). The substance gradually became more popular because ...


Free-Roaming Dogs In Developing Countries: The Benefits Of Capture, Neuter, And Return Programs, Jennifer Jackman, Andrew N. Rowan 2014 Humane Society University

Free-Roaming Dogs In Developing Countries: The Benefits Of Capture, Neuter, And Return Programs, Jennifer Jackman, Andrew N. Rowan

Andrew N. Rowan, D.Phil.

This chapter provides an overview of animal welfare and public health problems associated with free-roaming dog populations and strategies to resolve these problems. Placing CNR programs in the context of earlier dog and rabies control methods, the chapter explores CNR’s potential to overcome some of the shortcomings of earlier approaches and to improve animal welfare, reduce dog population growth, and prevent the spread of rabies and other canine-transmitted diseases. Constraints and current debates on current implementation of CNR programs are also examined.


Efficacy Of Orally Administered Maropitant Citrate In Preventing Vomiting Associated With Hydromorphone Administration In Dogs, Bonnie L. Hay Kraus 2014 Iowa State University

Efficacy Of Orally Administered Maropitant Citrate In Preventing Vomiting Associated With Hydromorphone Administration In Dogs, Bonnie L. Hay Kraus

Veterinary Clinical Sciences Publications

Objective—To evaluate the effectiveness of orally administered maropitant citrate in preventing vomiting after hydromorphone hydrochloride administration in dogs.

Design—Randomized, blinded, prospective clinical study.

Animals—40 dogs with American Society of Anesthesiologists status of I or II, > 6 months of age, and weighing between 24 and 58.2 kg (52.8 and 128.04 lb).

Procedures—Dogs were randomly selected to receive maropitant (2.0 to 4.0 mg/kg [0.9 to 1.8 mg/lb]) or placebo (lactose monohydrate) orally 2 hours prior to receiving hydromorphone (0.1 mg/kg [0.045 mg/lb], IM). A blinded ...


Effect Of A Leucine/Pyridoxine Nutraceutical On Energy Metabolism And Satiety In Lean And Obese Dogs, Maryanne Murphy 2014 University of Tennessee - Knoxville

Effect Of A Leucine/Pyridoxine Nutraceutical On Energy Metabolism And Satiety In Lean And Obese Dogs, Maryanne Murphy

Doctoral Dissertations

Obesity is the most common nutritional disorder of pet dogs (prevalence of 23–59%). This 29-week study investigated a nutraceutical containing 1 g leucine and 13 mg pyridoxine designed to maintain lean muscle mass while decreasing adiposity when compared with positive and negative controls. After determining individual maintenance calorie requirements over 3 – 4 weeks, thirty-six healthy adult Beagles were divided into obesification, weight gain prevention, or maintain ideal body weight arms.

Obesity was induced and during a weight loss phase, excess calories were removed, and obesification dogs were given nutraceutical with CAD (ObN), placebo with CAD (ObP), or a therapeutic ...


Measurement Of Intraocular Pressures In Glaucomatous And Non-Glaucomatous Kittens, Allison Ludwig 2014 Iowa State University

Measurement Of Intraocular Pressures In Glaucomatous And Non-Glaucomatous Kittens, Allison Ludwig

Symposium on Undergraduate Research and Creative Expression

Glaucoma, a group of eye conditions associated with damage to the retina and optic nerve, is commonly associated with increased pressure within the eye, or intraocular pressure (IOP). This project was focused on gaining an understanding of the differences in eyelid opening and IOP between affected and unaffected kittens in an inherited glaucoma feline breeding colony. IOP measurements were taken in the morning and evening within 48-hour windows for 10, 13, 17, 21, 28, 35, and 42 days postnatally by rebound tonometry of non-sedated, lightly restrained animals. Measurements were recorded in triplicates from each eye resulting in a total of ...


Dogs As A Model For Mucopolysaccharidosis: Measuring Learning Ability, Alyssa Swan 2014 Iowa State University

Dogs As A Model For Mucopolysaccharidosis: Measuring Learning Ability, Alyssa Swan

Symposium on Undergraduate Research and Creative Expression

The mucopolysaccharidoses (MPS) are a family of lysosomal storage disorders, each characterized by the absence of a specific enzyme necessary for the degradation of glycosaminoglycans. We will attempt to document the decline in cognitive function seen in human MPS IIIB patients using a series of mazes that measure working memory, memory acquisition, and short and long term memory in a dog model. We are currently developing the T-maze, following the approach of Sanders et al. This maze assesses learning ability using reversal learning tasks. Each reversal phase consists of 10 trials daily, during which the dog will attempt to choose ...


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