Open Access. Powered by Scholars. Published by Universities.®

Small or Companion Animal Medicine Commons

Open Access. Powered by Scholars. Published by Universities.®

1,190 Full-Text Articles 1,702 Authors 172,397 Downloads 19 Institutions

All Articles in Small or Companion Animal Medicine

Faceted Search

1,190 full-text articles. Page 1 of 18.

The Role Of The Gut-Brain Axis In Neurodegenerative Diseases And Relevance Of The Canine Model: A Review, Yoko Ambrosini, Dana Borcherding, Anumantha Kanthasamy, Hyun Jung Kim, Albert Jergens, Karin Allenspach, Jonathan Mochel 2019 Iowa State University

The Role Of The Gut-Brain Axis In Neurodegenerative Diseases And Relevance Of The Canine Model: A Review, Yoko Ambrosini, Dana Borcherding, Anumantha Kanthasamy, Hyun Jung Kim, Albert Jergens, Karin Allenspach, Jonathan Mochel

Biomedical Sciences Publications

Identifying appropriate animal models is critical in developing translatable in vitro and in vivo systems for therapeutic development and investigating disease pathophysiology. These animal models should have direct biological and translational relevance to the underlying disease they are supposed to mimic. Aging dogs naturally develop a cognitive decline in many aspects including learning and memory, but also exhibit human-like individual variability in the aging process. Neurodegenerative processes that can be observed in both human and canine brains include the progressive accumulation of β-amyloid (Aβ) found as diffuse plaques in the prefrontal cortex, including the gyrus proreus, the hippocampus, and in ...


The Role Of Serum Histones In Canine Heat Stroke, Jenna Acutt 2019 Claremont Colleges

The Role Of Serum Histones In Canine Heat Stroke, Jenna Acutt

Scripps Senior Theses

Rising temperatures all over the world has correlated with more frequent heat stroke related injuries and death. This statistic not only applies to humans, but to canines as well, who have similar body temperature thresholds. Recent studies have demonstrated that serum histones, released after cell death from heat stroke, play a role in heat stroke related injuries and death. This proposal aims to determine the severity of the effects caused by serum histone release after heat stroke by exposing selected canine cell lines to cell lysate and purified histones H2A, H2B, H3, and H4, which have been found to be ...


Clinical Features Of Cats With Aqueous Tear Deficiency: A Retrospective Case Series Of 10 Patients (17 Eyes), Lisa K. Uhl, Akihiko Saito, Hiroko Iwashita, David J. Maggs, Jonathan P. Mochel, Lionel Sebbag 2018 Iowa State University

Clinical Features Of Cats With Aqueous Tear Deficiency: A Retrospective Case Series Of 10 Patients (17 Eyes), Lisa K. Uhl, Akihiko Saito, Hiroko Iwashita, David J. Maggs, Jonathan P. Mochel, Lionel Sebbag

Veterinary Clinical Sciences Publications

Objectives

The aim of this study was to describe the clinical findings, diagnostic test results and response to therapy of cats with Schirmer tear test 1 (STT-1) values below the reference interval.

Methods

The medical records of three institutions were searched for cats with ocular surface disease and STT-1 values/min, confirmed at two or more separate visits.

Results

Ten cats (17 eyes) were included. The mean ± SD (range) age and STT-1 values in affected eye(s) were 6.1 ± 5.7 (0.2–16) years and 2.4 ± 3.1 (0–8) mm/min, respectively. Concurrent ocular surface disease ...


Photography-Based Method For Assessing Fluorescein Clearance Test In Dogs, Arianne Pontes Oriá, Miriam Flores Rebouças, Emanoel Martins Filho, Francisco de Assis Dórea Neto, Ana Cláudia Raposo, Lionel Sebbag 2018 Federal University of Bahia

Photography-Based Method For Assessing Fluorescein Clearance Test In Dogs, Arianne Pontes Oriá, Miriam Flores Rebouças, Emanoel Martins Filho, Francisco De Assis Dórea Neto, Ana Cláudia Raposo, Lionel Sebbag

Veterinary Clinical Sciences Publications

Background: The fluorescein clearance test (FCT) provides insight into the tear film dynamics. The purpose of this study was to describe an inexpensive and practical method for assessing FCT in dogs, using photography and software analysis, and to assess the retention time of 1 vs. 2 eye drops on the canine ocular surface.

Methods: (i) In vivo - Eight healthy German Shepherd dogs were recruited. Following topical anesthesia with 0.5% proxymetacaine, each eye sequentially received (1 week apart) either 1 drop (35 μL) or 2 drops (70 μL) of 0.5% fluorescein. A Schirmer strip was inserted in the ventral ...


Relationship Of The Mucosal Microbiota To Gastrointestinal Inflammation And Small Cell Intestinal Lymphoma In Cats, Kayode Garraway, Chad M. Johannes, Angela Bryan, John Peauroi, Giacomo Rossi, Min Zhang, Chong Wang, Karin Allenspach, Albert E. Jergens 2018 Iowa State University

Relationship Of The Mucosal Microbiota To Gastrointestinal Inflammation And Small Cell Intestinal Lymphoma In Cats, Kayode Garraway, Chad M. Johannes, Angela Bryan, John Peauroi, Giacomo Rossi, Min Zhang, Chong Wang, Karin Allenspach, Albert E. Jergens

Veterinary Diagnostic and Production Animal Medicine Publications

Background: The gastrointestinal (GI) microbiota in healthy cats is altered in IBD. Little research has been performed to identify whether specific bacterial groups are associated with small cell GI lymphoma (LSA).

Hypothesis: Mucosal bacteria, including Enterobacteriaceae and Fusobacterium spp., are abundant in intestinal biopsies of cats with small cell GI LSA compared to cats with IBD.

Animals: Fourteen cats with IBD and 14 cats with small cell GI LSA.

Methods: Retrospective case control study. A search of the medical records was performed to identify cats diagnosed with IBD and with GI LSA. Bacterial groups identified by FISH in GI biopsies ...


Impact Of Flow Rate, Collection Devices, And Extraction Methods On Tear Concentrations Following Oral Administration Of Doxycycline In Dogs And Cats, Lionel Sebbag, Lucas Showman, Emily M. McDowell, Ann Perera, Jonathan P. Mochel 2018 Iowa State University

Impact Of Flow Rate, Collection Devices, And Extraction Methods On Tear Concentrations Following Oral Administration Of Doxycycline In Dogs And Cats, Lionel Sebbag, Lucas Showman, Emily M. Mcdowell, Ann Perera, Jonathan P. Mochel

Veterinary Diagnostic and Production Animal Medicine Publications

Purpose: Compare the precision of doxycycline quantification in tear fluid collected with either Schirmer strips or polyvinyl acetal (PVA) sponges following oral drug administration.

Methods: Three dogs and 3 cats were administered doxycycline orally at a dose of 4.2–5 mg/kg every 12 h for 6 consecutive days. At day 5 and 6, blood and tear fluid were sampled to capture doxycycline trough and maximal concentrations. Tear fluid was collected 3 times (spaced 10 min apart) at each session with the absorbent material placed in the lower conjunctival fornix until the 20-mm mark was reached (Schirmer strip, one ...


Myringotomy As A Diagnostic And Therapeutic Tool In A Case Of Otitis Media In A Guinea Pig (Cavia Porcellus), H. M. Householder, Darren J. Berger, James O. Noxon, Bianca A. Zaffarano 2018 Iowa State University

Myringotomy As A Diagnostic And Therapeutic Tool In A Case Of Otitis Media In A Guinea Pig (Cavia Porcellus), H. M. Householder, Darren J. Berger, James O. Noxon, Bianca A. Zaffarano

Veterinary Clinical Sciences Publications

A 1.5 year old male adult guinea pig (Cavia porcellus) presented with acute vestibular disease, consisting of a right head tilt, circling, and ataxia. The head tilt was non-responsive to initial empirical antimicrobial therapy for presumptive otitis media. Video otoscopy and a myringotomy were performed under general anesthesia. A large amount of purulent debris was flushed from the middle ear and submitted for culture. Treatment with appropriate systemic and topical antibiotics was pursued for 4 weeks. Near complete resolution of clinical signs was achieved by the end of treatment with only a minor residual head tilt. This is the ...


Effect Of Tear Collection On Lacrimal Total Protein Content In Dogs And Cats: A Comparison Between Schirmer Strips And Ophthalmic Sponges, Lionel Sebbag, Emily M. McDowell, Patrick M. Hepner, Jonathan P. Mochel 2018 Iowa State University

Effect Of Tear Collection On Lacrimal Total Protein Content In Dogs And Cats: A Comparison Between Schirmer Strips And Ophthalmic Sponges, Lionel Sebbag, Emily M. Mcdowell, Patrick M. Hepner, Jonathan P. Mochel

Veterinary Clinical Sciences Publications

Background Quantification of lacrimal total protein content (TPC) is an important tool for clinical scientists to understand disease pathogenesis, identify potential biomarkers and assess response to therapy, among other applications. However, TPC is not only affected by disease state but also by the method used for tear collection. Thus, the purpose of this study is to determine the impact on TPC of two methods of tear collection in dogs and cats: Schirmer strips and polyvinyl acetal (PVA) sponges.

Methods (i) In vivo - Ten healthy dogs and 10 healthy cats were examined. Each animal underwent two sessions, separated by 10 min ...


Ovaries And Testes, Oh My!, Jessica Burka, Samantha Garcia, Kenneth Kent, Elizabeth Potalivo, Jessica Schrader 2018 Daemen College

Ovaries And Testes, Oh My!, Jessica Burka, Samantha Garcia, Kenneth Kent, Elizabeth Potalivo, Jessica Schrader

Academic Festival Posters

This poster presentation will discuss the pros and cons of spaying or neutering household pets. Many animals are euthanized annually due to overpopulation issues, so pet owners have been urged to neuter/spay their household pets to limit overpopulation. Recent research suggests that early neutering may have negative consequences for companion animals. The goal of the presentation is to educate the public about the benefits and risks associated with pet reproductive procedures.


Development And Implementation Of A Novel Immune Thrombocytopenia Bleeding Score For Dogs, Kelly M. Makielski, Marjory B. Brooks, Chong Wang, Jonah N. Cullen, Annette M. O'Connor, Dana N. Levine 2018 Iowa State University

Development And Implementation Of A Novel Immune Thrombocytopenia Bleeding Score For Dogs, Kelly M. Makielski, Marjory B. Brooks, Chong Wang, Jonah N. Cullen, Annette M. O'Connor, Dana N. Levine

Veterinary Diagnostic and Production Animal Medicine Publications

Background

A method of quantifying clinical bleeding in dogs with immune thrombocytopenia (ITP) is needed because ITP patients have variable bleeding tendencies that inconsistently correlate with platelet count. A scoring system will facilitate patient comparisons and allow stratification based on bleeding severity in clinical trials.

Hypothesis/Objectives

To develop and evaluate a bleeding assessment tool for dogs, and a training course for improving its consistent implementation.

Animals

Client‐owned dogs (n = 61) with platelet counts <50,000/μL; 34 classified as primary ITP, 17 as secondary ITP, and 10 as non‐ITP.

Methods

A novel bleeding assessment tool, DOGiBAT, comprising bleeding grades from 0 (none) to 2 (severe) at 9 anatomic sites, was developed. Clinicians and technicians ...


Narrative Review Of Therapies For Chronic Enteropathies In Dogs And Cats, Kelly Makielski, Jonah Cullen, Annette O'Connor, Albert E. Jergens 2018 Iowa State University

Narrative Review Of Therapies For Chronic Enteropathies In Dogs And Cats, Kelly Makielski, Jonah Cullen, Annette O'Connor, Albert E. Jergens

Veterinary Diagnostic and Production Animal Medicine Publications

Background The optimal medical treatment for chronic enteropathy (CE) in dogs and cats is controversial. Sequential treatment using diet, antimicrobials, and immunosuppressive drugs is the most common strategy used by clinicians.

Objectives To review the evidence for the effectiveness of dietary, drug, and alternative health interventions for inducing clinical remission in dogs and cats with CE.

Animals Retrospective study of dogs and cats with a diagnosis of chronic enteropathy.

Methods MEDLINE and Centre for Agriculture and Bioscience International (CABI) databases (1950 to March 2017) were searched for randomized controlled trials (RCTs), observational studies, and case series. The primary outcome was ...


Feline Dry Eye Syndrome Of Presumed Neurogenic Origin: A Case Report, Lionel Sebbag, Patricia A. Pesavento, Sebastian E. Carrasco, Christopher M. Reilly, David J. Maggs 2018 Iowa State University

Feline Dry Eye Syndrome Of Presumed Neurogenic Origin: A Case Report, Lionel Sebbag, Patricia A. Pesavento, Sebastian E. Carrasco, Christopher M. Reilly, David J. Maggs

Veterinary Clinical Sciences Publications

Case summary A 14-year-old female spayed Abyssinian cat, which about 1 year previously underwent thoracic limb amputation, radiotherapy and chemotherapy for an incompletely excised vaccine-related fibrosarcoma, was presented for evaluation of corneal opacity in the left eye (OS). The ocular surface of both eyes (OU) had a lackluster appearance and there was a stromal corneal ulcer OS. Results of corneal aesthesiometry, Schirmer tear test-1 (STT-1) and tear film breakup time revealed corneal hypoesthesia, and quantitative and qualitative tear film deficiency OU. Noxious olfactory stimulation caused increased lacrimation relative to standard STT-1 values suggesting an intact nasolacrimal reflex. Various lacrimostimulants were ...


Concurrent Renal Amyloidosis And Thymoma Resulting In A Fatal Ventricular Thrombus In A Dog, Jennifer M. Loewen, Rachel E. Cianciolo, Liwen Zhang, Michael Yaeger, Jessica L. Ward, Jodi D. Smith, Dana N. LeVine 2018 Iowa State University

Concurrent Renal Amyloidosis And Thymoma Resulting In A Fatal Ventricular Thrombus In A Dog, Jennifer M. Loewen, Rachel E. Cianciolo, Liwen Zhang, Michael Yaeger, Jessica L. Ward, Jodi D. Smith, Dana N. Levine

Veterinary Clinical Sciences Publications

Thymoma‐associated nephropathies have been reported in people but not in dogs. In this report, we describe a dog with thymoma and concurrent renal amyloidosis. A 7‐year‐old castrated male Weimaraner was presented for progressive anorexia, lethargy, and tachypnea. The dog was diagnosed with azotemia, marked proteinuria, and a thymoma that was surgically removed. Postoperatively, the dog developed a large left ventricular thrombus and was euthanized. Necropsy confirmed the presence of a left ventricular thrombus and histopathology revealed renal amyloidosis. We speculate that the renal amyloidosis occurred secondary to the thymoma, with amyloidosis in turn leading to nephrotic syndrome ...


Intestinal Stem Cells To Advance Drug Development, Precision, And Regenerative Medicine: A Paradigm Shift In Translational Research, Jonathan P. Mochel, Albert E. Jergens, Dawn Kingsbury, Hyun Jung Kim, Martín G. Martín, Karin Allenspach 2018 Iowa State University

Intestinal Stem Cells To Advance Drug Development, Precision, And Regenerative Medicine: A Paradigm Shift In Translational Research, Jonathan P. Mochel, Albert E. Jergens, Dawn Kingsbury, Hyun Jung Kim, Martín G. Martín, Karin Allenspach

Biomedical Sciences Publications

Recent advances in our understanding of the intestinal stem cell niche and the role of key signaling pathways on cell growth and maintenance have allowed the development of fully differentiated epithelial cells in 3D organoids. Stem cell-derived organoids carry significant levels of proteins that are natively expressed in the gut and have important roles in drug transport and metabolism. They are, therefore, particularly relevant to study the gastrointestinal (GI) absorption of oral medications. In addition, organoids have the potential to serve as a robust preclinical model for demonstrating the effectiveness of new drugs more rapidly, with more certainty, and at ...


Long-Term Outcome And Complications Of 32 Distal Femoral Osteotomies Performed For Correction Of Mpl In Dogs Without Cranial Cruciate Disease, Nicholas Crawfis 2018 The University of Akron

Long-Term Outcome And Complications Of 32 Distal Femoral Osteotomies Performed For Correction Of Mpl In Dogs Without Cranial Cruciate Disease, Nicholas Crawfis

Williams Honors College, Honors Research Projects

Many canines suffer severe, grade I-IV, medial patella luxation causing a persistent lameness, severely reducing the quality of life for the dog (Linney et al 2011). For these patients surgical intervention is recommended to alleviate these symptoms. The procedure used to do so is a distal femoral osteotomy (DFO). This procedure allows for correction of torsion in the femur and quadriceps mechanism, and frontal plane abnormalities at the same time. The present study aims to describe the long-term outcome and related complications of 32 DFOs, without concomitant Cranial Cruciate Ligament rupture (CCLR), in a large private practice referral hospital based ...


Anticholinergic Drugs In Dogs, Bonnie L. Hay Kraus 2017 Iowa State University

Anticholinergic Drugs In Dogs, Bonnie L. Hay Kraus

Bonnie Hay Kraus

Can I use anticholinergic drugs with dexmedetomidine in dogs?


Effect Of Dosing Interval On Efficacy Of Maropitant For Prevention Of Hydromorphone-Induced Vomiting And Signs Of Nausea In Dogs, Bonnie L. Hay Kraus 2017 Iowa State University

Effect Of Dosing Interval On Efficacy Of Maropitant For Prevention Of Hydromorphone-Induced Vomiting And Signs Of Nausea In Dogs, Bonnie L. Hay Kraus

Bonnie Hay Kraus

Objective—To evaluate the effect of dosing interval on the efficacy of maropitant for prevention of opioid-induced vomiting and signs of nausea in dogs.

Design—Randomized prospective clinical study.

Animals—50 client-owned dogs that underwent an elective surgical procedure.

Procedures—Dogs were randomly assigned to receive maropitant (1 mg/kg [0.45 mg/lb], SC), then hydromorphone (0.1 mg/kg [0.045 mg/lb], IM) at 0 (simultaneously; group 0; n = 10), 15 (group 15; 10), 30 (group 30; 10), 45 (group 45; 10), or 60 (group 60; 10) minutes later. Dogs were monitored for vomiting and signs of ...


Anesthesia For Cesarean Section In The Dog, Bonnie Hay Kraus 2017 Iowa State University

Anesthesia For Cesarean Section In The Dog, Bonnie Hay Kraus

Bonnie Hay Kraus

The major goal in anesthesia for cesarean section (CS) is to minimize fetal effects of anesthetic drugs in order to minimize fetal respiratory, central nervous system and cardiovascular depression and deliver live, vigorous puppies. Of equal importance is to provide adequate analgesia to the dam and prevent anesthesia-related complications such as hypotension, hypoventilation, hypoxemia, hemorrhage and hypothermia, which will increase morbidity and mortality in both mother and puppies. The physiochemical properties which allow drugs to cross the blood-brain barrier also facilitate crossing of the placenta, therefore the assumption should be made (with very few exceptions) that anes- thetics, analgesics and ...


Efficacy Of Orally Administered Maropitant Citrate In Preventing Vomiting Associated With Hydromorphone Administration In Dogs, Bonnie L. Hay Kraus 2017 Iowa State University

Efficacy Of Orally Administered Maropitant Citrate In Preventing Vomiting Associated With Hydromorphone Administration In Dogs, Bonnie L. Hay Kraus

Bonnie Hay Kraus

Objective—To evaluate the effectiveness of orally administered maropitant citrate in preventing vomiting after hydromorphone hydrochloride administration in dogs.

Design—Randomized, blinded, prospective clinical study.

Animals—40 dogs with American Society of Anesthesiologists status of I or II, > 6 months of age, and weighing between 24 and 58.2 kg (52.8 and 128.04 lb).

Procedures—Dogs were randomly selected to receive maropitant (2.0 to 4.0 mg/kg [0.9 to 1.8 mg/lb]) or placebo (lactose monohydrate) orally 2 hours prior to receiving hydromorphone (0.1 mg/kg [0.045 mg/lb], IM). A blinded ...


Spotlight On The Perioperative Use Of Maropitant Citrate, Bonnie L. Hay Kraus 2017 Iowa State University

Spotlight On The Perioperative Use Of Maropitant Citrate, Bonnie L. Hay Kraus

Bonnie Hay Kraus

Neurokinin-1 (NK-1) receptors are present in both the central nervous system and peripheral tissues. Substance P (SP) is the major ligand and is involved in multiple processes including pain transmission, vasodilation, modulation of the inflammatory response, as well as the sensory neuronal transmission involved in stress, anxiety, and emesis. The involvement of NK-1 and SP in the vomiting reflex has led to the development of NK-1 antagonists to prevent and treat vomiting in human and veterinary medicine. Maropitant is a potent, selective neurokinin (NK-1) receptor antagonist that blocks the pharmacologic action of SP in the central nervous system. Maropitant is ...


Digital Commons powered by bepress