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Impact Of Oral Meloxicam On Circulating Physiological Biomarkers Of Stress And Inflammation In Beef Steers After Long Distance Transportation, Nicholas K. Van Engen, Matthew L. Stock, Terry Engelken, Rhonda Vann, Larry W. Wulf, Locke A. Karriker, Jeff Lakritz, Walter H. Hsu, Barry Bradford, Abigail Carpenter, Darrel Busby, Chong Wang, Johann F. Coetzee 2014 Iowa State University

Impact Of Oral Meloxicam On Circulating Physiological Biomarkers Of Stress And Inflammation In Beef Steers After Long Distance Transportation, Nicholas K. Van Engen, Matthew L. Stock, Terry Engelken, Rhonda Vann, Larry W. Wulf, Locke A. Karriker, Jeff Lakritz, Walter H. Hsu, Barry Bradford, Abigail Carpenter, Darrel Busby, Chong Wang, Johann F. Coetzee

Animal Industry Report

We hypothesized that meloxicam administration to beef steers before shipping may be effective at reducing the impact of transportation on stress biomarkers. Circulating physiological biomarkers of stress were analyzed in a transportation trial between a meloxicam treatment group and a placebo treatment group. There were significant differences in stress biomarkers between treatment groups following transport. This suggests that there may be practical benefits for the use of long-acting non-steroidal anti-inflammatory drugs (NSAIDs), specifically meloxicam, to mitigate the negative effect of transport on cattle physiology.


Introduction Infectious Disease Modeling, Cristina Lanzas 2013 University of Tennessee, Knoxville

Introduction Infectious Disease Modeling, Cristina Lanzas

Cristina Lanzas

No abstract provided.


Porcine E. Coli: Virulence-Associated Genes, Resistance Genes And Adhesion And Probiotic Activity Tested By A New Screening Method, Peter Schierack, Stefan Rödiger, Christoph Kuhl, Rico Hiemann, Dirk Roggenbuck, Ganwu Li, Jörg Weinreich, Enrico Berger, Lisa K. Nolan, Bryon A. Nicholson, Antje Römer, Ulrike Frömmel, Lothar H. Wieler, Christian Schröder 2013 Iowa State University

Porcine E. Coli: Virulence-Associated Genes, Resistance Genes And Adhesion And Probiotic Activity Tested By A New Screening Method, Peter Schierack, Stefan Rödiger, Christoph Kuhl, Rico Hiemann, Dirk Roggenbuck, Ganwu Li, Jörg Weinreich, Enrico Berger, Lisa K. Nolan, Bryon A. Nicholson, Antje Römer, Ulrike Frömmel, Lothar H. Wieler, Christian Schröder

Veterinary Microbiology and Preventive Medicine Publications and Papers

We established an automated screening method to characterize adhesion of Escherichia colito intestinal porcine epithelial cells (IPEC-J2) and their probiotic activity against infection by enteropathogenic E. coli (EPEC). 104 intestinal E. coli isolates from domestic pigs were tested by PCR for the occurrence of virulence-associated genes, genes coding for resistances to antimicrobial agents and metals, and for phylogenetic origin by PCR. Adhesion rates and probiotic activity were examined for correlation with the presence of these genes. Finally, data were compared with those from 93 E. coli isolates from wild boars.

Isolates from domestic pigs carried a broad variety of ...


Complete Genome Sequence Of The Avian Pathogenic Escherichia Coli Strain Apec O78, Paul M. Mangiamele, Bryon A. Nicholson, Yvonne Wannemuehler, Torsten Seemann, Catherine M. Logue, Ganwu Li, Kelly A. Tivendale, Lisa K. Nolan 2013 Iowa State University

Complete Genome Sequence Of The Avian Pathogenic Escherichia Coli Strain Apec O78, Paul M. Mangiamele, Bryon A. Nicholson, Yvonne Wannemuehler, Torsten Seemann, Catherine M. Logue, Ganwu Li, Kelly A. Tivendale, Lisa K. Nolan

Veterinary Microbiology and Preventive Medicine Publications and Papers

Colibacillosis, caused by avian pathogenic Escherichia coli (APEC), is a significant disease, causing extensive animal and financial losses globally. Because of the significance of this disease, more knowledge is needed regarding APEC's mechanisms of virulence. Here, we present the fully closed genome sequence of a typical avian pathogenic E. coli strain belonging to the serogroup O78.


Comparison Of Multilocus Sequence Analysis And Virulence Genotyping Of Escherichia Coli From Live Birds, Retail Poultry Meat, And Human Extraintestinal Infection, Jessica L. Danzeisen, Yvonne Wannemuehler, Lisa K. Nolan, Timothy J. Johnson 2013 Iowa State University

Comparison Of Multilocus Sequence Analysis And Virulence Genotyping Of Escherichia Coli From Live Birds, Retail Poultry Meat, And Human Extraintestinal Infection, Jessica L. Danzeisen, Yvonne Wannemuehler, Lisa K. Nolan, Timothy J. Johnson

Veterinary Microbiology and Preventive Medicine Publications and Papers

To examine the correlations between virulence genotyping and multilocus sequence analysis of Escherichia coli from poultry and humans, 88 isolates were examined. The isolates were selected from a population of over 1000 based on their assignment to nine different virulence genotyping clusters. Clustering based on multilocus sequence analysis mostly correlated with virulence genotyping, although multilocus sequence analysis demonstrated higher discriminatory ability and greater reliability related to inferred phylogenetic relationships. No distinct patterns in host source were observed using inferred phylogeny through multilocus sequence analysis, indicating that human, avian, and retail meat isolates are diverse, and some belong to multiple shared ...


Genome Analysis And Phylogenetic Relatedness Of Gallibacterium Anatis Strains From Poultry, Timothy J. Johnson, Jessica L. Danzeisen, Darrell W. Trampel, Lisa K. Nolan, Torsten Seemann, Ragnhild J. Bager, Anders M. Bojesen 2013 Iowa State University

Genome Analysis And Phylogenetic Relatedness Of Gallibacterium Anatis Strains From Poultry, Timothy J. Johnson, Jessica L. Danzeisen, Darrell W. Trampel, Lisa K. Nolan, Torsten Seemann, Ragnhild J. Bager, Anders M. Bojesen

Veterinary Microbiology and Preventive Medicine Publications and Papers

Peritonitis is the major disease problem of laying hens in commercial table egg and parent stock operations. Despite its importance, the etiology and pathogenesis of this disease have not been completely clarified. Although avian pathogenic Escherichia coli (APEC) isolates have been incriminated as the causative agent of laying hen peritonitis, Gallibacterium anatis are frequently isolated from peritonitis lesions. Despite recent studies suggesting a role for G. anatis in the pathogenesis of peritonitis, little is known about the organism’s virulence mechanisms, genomic composition and population dynamics. Here, we compared the genome sequences of three G. anatis isolates in an effort ...


Isolation And Characterization Of Methicillin-Resistant Staphylococcus Aureus From Pork Farms And Visiting Veterinary Students, Timothy S. Frana, Aleigh R. Beahm, Blake M. Hanson, Joann M. Kinyon, Lori L. Layman, Locke A. Karriker, Alejandro Ramirez, Tara C. Smith 2013 Iowa State University

Isolation And Characterization Of Methicillin-Resistant Staphylococcus Aureus From Pork Farms And Visiting Veterinary Students, Timothy S. Frana, Aleigh R. Beahm, Blake M. Hanson, Joann M. Kinyon, Lori L. Layman, Locke A. Karriker, Alejandro Ramirez, Tara C. Smith

Veterinary Diagnostic and Production Animal Medicine Publications and Papers

In the last decade livestock-associated methicillin-resistant S. aureus (LA-MRSA) has become a public health concern in many parts of the world. Sequence type 398 (ST398) has been the most commonly reported type of LA-MRSA. While many studies have focused on long-term exposure experienced by swine workers, this study focuses on short-term exposures experienced by veterinary students conducting diagnostic investigations. The objectives were to assess the rate of MRSA acquisition and longevity of carriage in students exposed to pork farms and characterize the recovered MRSA isolates. Student nasal swabs were collected immediately before and after farm visits. Pig nasal swabs and ...


Optimizing The Purification Of Wild Type And Mutant Recombinant Phospholipase D: Approaches To Developing A C. Pseudotuberculosis Vaccine, Utsav M. Patwardhan 2013 Occidental College

Optimizing The Purification Of Wild Type And Mutant Recombinant Phospholipase D: Approaches To Developing A C. Pseudotuberculosis Vaccine, Utsav M. Patwardhan

Biochemistry Student Honors Theses

No abstract provided.


Investigating Effects Of Between- And Within- Host Variability On Escherichia Coli O157 Shedding Pattern And Transmission, Shi Chen, Mike Sanderson, Cristina Lanzas 2013 University of Tennessee, Knoxville

Investigating Effects Of Between- And Within- Host Variability On Escherichia Coli O157 Shedding Pattern And Transmission, Shi Chen, Mike Sanderson, Cristina Lanzas

Cristina Lanzas

Healthy cattle and their environment are the reservoir for the human pathogen Escherichia coli O157. In E. coli O157 epidemiology, supershedders have been loosely defined as cattle that shed high concentrations of E. coli O157 (≥104 colony-forming cells (CFU)/g of feces) at a single (or multiple) cross-section in time. Due to the variability in the pathogen shedding level among animals (between-host variability), as well as fluctuations in the level shed by a single animal (within-host variability), it is difficult to interpret fecal bacteria distributions, as well as to parse the relative contribution of between- and within-host variability to the ...


Epidemiology, Geographical Distribution, And Economic Consequences Of Swine Zoonoses: A Narrative Review, Salah Uddin Khan, Kalina R. Atanasova, Whitney S. Krueger, Alejandro Ramirez, Gregory C. Gray 2013 Iowa State University

Epidemiology, Geographical Distribution, And Economic Consequences Of Swine Zoonoses: A Narrative Review, Salah Uddin Khan, Kalina R. Atanasova, Whitney S. Krueger, Alejandro Ramirez, Gregory C. Gray

Veterinary Diagnostic and Production Animal Medicine Publications and Papers

We sought to review the epidemiology, international geographical distribution, and economic consequences of selected swine zoonoses. We performed literature searches in two stages. First, we identified the zoonotic pathogens associated with swine. Second, we identified specific swine-associated zoonotic pathogen reports for those pathogens from January 1980 to October 2012. Swine-associated emerging diseases were more prevalent in the countries of North America, South America, and Europe. Multiple factors were associated with the increase of swine zoonoses in humans including: the density of pigs, poor water sources and environmental conditions for swine husbandry, the transmissibility of the pathogen, occupational exposure to pigs ...


Determination Of Farm-Specific Lawsonia Intracellularis Seroprevalence In Central Kentucky Thoroughbreds And The Identification Of Factors Contributing To Equine Proliferative Enteropathy, Allen E. Page 2013 University of Kentucky

Determination Of Farm-Specific Lawsonia Intracellularis Seroprevalence In Central Kentucky Thoroughbreds And The Identification Of Factors Contributing To Equine Proliferative Enteropathy, Allen E. Page

Theses and Dissertations--Veterinary Science

Lawsonia intracellularis and the disease it causes in horses, equine proliferative enteropathy (EPE), is an emerging pathogen of increasing importance to the horse industry from both an economic and welfare standpoint. Long recognized as an economically important disease of swine, the hallmark of EPE is a protein-losing enteropathy, where affected horses suffer weight loss and some ultimately succumb to the disease despite aggressive treatment. There are currently no known EPE preventative measures and the epidemiology of the disease remains poorly defined. While EPE is a sporadic disease affecting less than 25% of exposed horses, some farms experience clinical cases year ...


Escherichia Coli Isolates That Carry Vat, Fyua, Chua, And Yfcv Efficiently Colonize The Urinary Tract, Rachel R. Spurbeck, Paul C. Dinh Jr., Seth T. Walk, Ann E. Stapleton, Thomas M. Hooton, Lisa K. Nolan, Kwang Sik Kim, James R. Johnson, Harry L. T. Mobley 2012 Iowa State University

Escherichia Coli Isolates That Carry Vat, Fyua, Chua, And Yfcv Efficiently Colonize The Urinary Tract, Rachel R. Spurbeck, Paul C. Dinh Jr., Seth T. Walk, Ann E. Stapleton, Thomas M. Hooton, Lisa K. Nolan, Kwang Sik Kim, James R. Johnson, Harry L. T. Mobley

Veterinary Microbiology and Preventive Medicine Publications and Papers

Extraintestinal Escherichia coli (ExPEC), a heterogeneous group of pathogens, encompasses avian, neonatal meningitis, and uropathogenic E. coli strains. While several virulence factors are associated with ExPEC, there is no core set of virulence factors that can be used to definitively differentiate these pathotypes. Here we describe a multiplex of four virulence factor-encoding genes, yfcV, vat,fyuA, and chuA, highly associated with uropathogenic E. coli strains that can distinguish three groups of E. coli: diarrheagenic and animal-associated E. colistrains, human commensal and avian pathogenic E. coli strains, and uropathogenic and neonatal meningitis E. coli strains. Furthermore, human intestinal isolates that encode ...


Strong Concordance Between Transcriptomic Patterns Of Spleen And Peripheral Blood Leukocytes In Response To Avian Pathogenic Escherichia Coli Infection, Erin E. Sandford, Megan Orr, Xianyao Li, Huaijun Zhou, Timothy J. Johnson, Subhashinie Kariyawasam, Peng Liu, Lisa K. Nolan, Susan J. Lamont 2012 Iowa State University

Strong Concordance Between Transcriptomic Patterns Of Spleen And Peripheral Blood Leukocytes In Response To Avian Pathogenic Escherichia Coli Infection, Erin E. Sandford, Megan Orr, Xianyao Li, Huaijun Zhou, Timothy J. Johnson, Subhashinie Kariyawasam, Peng Liu, Lisa K. Nolan, Susan J. Lamont

Veterinary Microbiology and Preventive Medicine Publications and Papers

Avian pathogenic Escherichia coli (APEC) causes morbidity in chickens and exhibits zoonotic potential. Understanding host transcriptional responses to infection aids the understanding of protective mechanisms and serves to inform future colibacillosis control strategies. Transcriptomes of spleen and peripheral blood leukocytes (PBLs) of the same individual birds in response to APEC infection were compared to identify common response patterns and connecting pathways. More than 100 genes in three contrasts examining pathology and infection status were significantly differentially expressed in both tissues and similarly regulated. Tissue-specific differences in catalytic activity, however, appear between birds with mild and severe pathology responses. Early expression ...


Socioeconomic Determinants Of Geographic Disparities In Campylobacteriosis Risk: A Comparison Of Global And Local Modeling Approaches, Jennifer Weisent, Barton Rohrbach, John Dunn, Agricola Odoi 2012 University of Tennessee, Knoxville

Socioeconomic Determinants Of Geographic Disparities In Campylobacteriosis Risk: A Comparison Of Global And Local Modeling Approaches, Jennifer Weisent, Barton Rohrbach, John Dunn, Agricola Odoi

Agricola Odoi

Background: Socioeconomic factors play a complex role in determining the risk of campylobacteriosis. Understanding the spatial interplay between these factors and disease risk can guide disease control programs. Historically, Poisson and negative binomial models have been used to investigate determinants of geographic disparities in risk. Spatial regression models, which allow modeling of spatial effects, have been used to improve these modeling efforts. Geographically weighted regression (GWR) takes this a step further by estimating local regression coefficients, thereby allowing estimations of associations that vary in space. These recent approaches increase our understanding of how geography influences the associations between determinants and ...


Genotypic And Phenotypic Traits That Distinguish Neonatal Meningitis-Associated Escherichia Coli From Fecal E. Coli Isolates Of Healthy Human Hosts, Catherine M. Logue, Curt Doetkott, Paul M. Mangiamele, Yvonne Wannemuehler, Timothy J. Johnson, Kelly A. Tivendale, Ganwu Li, Julie S. Sherwood, Lisa K. Nolan 2012 Iowa State University

Genotypic And Phenotypic Traits That Distinguish Neonatal Meningitis-Associated Escherichia Coli From Fecal E. Coli Isolates Of Healthy Human Hosts, Catherine M. Logue, Curt Doetkott, Paul M. Mangiamele, Yvonne Wannemuehler, Timothy J. Johnson, Kelly A. Tivendale, Ganwu Li, Julie S. Sherwood, Lisa K. Nolan

Veterinary Microbiology and Preventive Medicine Publications and Papers

Neonatal meningitis Escherichia coli (NMEC) is one of the top causes of neonatal meningitis worldwide. Here, 85 NMEC and 204 fecal E. coli isolates from healthy humans (HFEC) were compared for possession of traits related to virulence, antimicrobial resistance, and plasmid content. This comparison was done to identify traits that typify NMEC and distinguish it from commensal strains to refine the definition of the NMEC subpathotype, identify traits that might contribute to NMEC pathogenesis, and facilitate choices of NMEC strains for future study. A large number of E. coli strains from both groups were untypeable, with the most common serogroups ...


Deep Sequencing-Based Transcriptome Analysis Of Chicken Spleen In Response To Avian Pathogenic Escherichia Coli (Apec) Infection, Qinghua Nie, Xiquan Zhang, Erin E. Sandford, Susan J. Lamont, Lisa K. Nolan 2012 Iowa State University

Deep Sequencing-Based Transcriptome Analysis Of Chicken Spleen In Response To Avian Pathogenic Escherichia Coli (Apec) Infection, Qinghua Nie, Xiquan Zhang, Erin E. Sandford, Susan J. Lamont, Lisa K. Nolan

Veterinary Microbiology and Preventive Medicine Publications and Papers

Avian pathogenic Escherichia coli (APEC) leads to economic losses in poultry production and is also a threat to human health. The goal of this study was to characterize the chicken spleen transcriptome and to identify candidate genes for response and resistance to APEC infection using Solexa sequencing. We obtained 14422935, 14104324, and 14954692 Solexa read pairs for non-challenged (NC), challenged-mild pathology (MD), and challenged-severe pathology (SV), respectively. A total of 148197 contigs and 98461 unigenes were assembled, of which 134949 contigs and 91890 unigenes match the chicken genome. In total, 12272 annotated unigenes take part in biological processes (11664), cellular ...


Prevalence Of Avian-Pathogenic Escherichia Coli Strain O1 Genomic Islands Among Extraintestinal And Commensal E. Coli Isolates, Timothy J. Johnson, Yvonne Wannemuehler, Subhashinie Kariyawasam, James R. Johnson, Catherine M. Logue, Lisa K. Nolan 2012 Iowa State University

Prevalence Of Avian-Pathogenic Escherichia Coli Strain O1 Genomic Islands Among Extraintestinal And Commensal E. Coli Isolates, Timothy J. Johnson, Yvonne Wannemuehler, Subhashinie Kariyawasam, James R. Johnson, Catherine M. Logue, Lisa K. Nolan

Veterinary Microbiology and Preventive Medicine Publications and Papers

Escherichia coli strains that cause disease outside the intestine are known as extraintestinal pathogenic E. coli (ExPEC) and include pathogens of humans and animals. Previously, the genome of avian-pathogenic E. coli (APEC) O1:K1:H7 strain O1, from ST95, was sequenced and compared to those of several other E. coli strains, identifying 43 genomic islands. Here, the genomic islands of APEC O1 were compared to those of other sequenced E. coli strains, and the distribution of 81 genes belonging to 12 APEC O1 genomic islands among 828 human and avian ExPEC and commensal E. coli isolates was determined. Multiple islands ...


Tkt1, Located On A Novel Pathogenicity Island, Is Prevalent In Avian And Human Extraintestinal Pathogenic Escherichia Coli, Ganwu Li, Subhashinie Kariyawasam, Kelly A. Tivendale, Yvonne Wannemuehler, Christa Ewers, Lothar H. Wieler, Catherine M. Logue, Lisa K. Nolan 2012 Iowa State University

Tkt1, Located On A Novel Pathogenicity Island, Is Prevalent In Avian And Human Extraintestinal Pathogenic Escherichia Coli, Ganwu Li, Subhashinie Kariyawasam, Kelly A. Tivendale, Yvonne Wannemuehler, Christa Ewers, Lothar H. Wieler, Catherine M. Logue, Lisa K. Nolan

Veterinary Microbiology and Preventive Medicine Publications and Papers

Background: Extraintestinal pathogenic Escherichia coli are important pathogens of human and animal hosts. Some human and avian extraintestinal pathogenic E. coli are indistinguishable on the basis of diseases caused, multilocus sequence and phylogenetic typing, carriage of large virulence plasmids and traits known to be associated with extraintestinal pathogenic E. coli virulence.

Results: The gene tkt1 identified by a previous signature-tagged transposon mutagenesis study, was found on a 16-kb genomic island of avian pathogenic Escherichia coli (APEC) O1, the first pathogenic Escherichia coli strain whose genome has been completely sequenced. tkt1 was present in 39.6% (38/96) of pathogenic Escherichia ...


Recombinant Iss As A Potential Vaccine For Avian Colibacillosis, Aaron M. Lynne, Subhashinie Kariyawasam, Yvonne Wannemuehler, Timothy J. Johnson, Sara J. Johnson, Avanti S. Sinha, Dorie K. Lynne, Harley W. Moon, Dianna M. Jordan, Catherine M. Logue, Steven L. Foley 2012 Iowa State University

Recombinant Iss As A Potential Vaccine For Avian Colibacillosis, Aaron M. Lynne, Subhashinie Kariyawasam, Yvonne Wannemuehler, Timothy J. Johnson, Sara J. Johnson, Avanti S. Sinha, Dorie K. Lynne, Harley W. Moon, Dianna M. Jordan, Catherine M. Logue, Steven L. Foley

Veterinary Microbiology and Preventive Medicine Publications and Papers

Avian pathogenic Escherichia coli (APEC) cause colibacillosis, a disease which is responsible for significant losses in poultry. Control of colibacillosis is problematic due to the restricted availability of relevant antimicrobial agents and to the frequent failure of vaccines to protect against the diverse range of APEC serogroups causing disease in birds. Previously, we reported that the increased serum survival gene (iss) is strongly associated with APEC strains, but not with fecal commensal E. coli in birds, making iss and the outer membrane protein it encodes (Iss) candidate targets for colibacillosis control procedures. Preliminary studies in birds showed that their immunization ...


Swine Biological Risk Management, Alejandro Ramirez, Pam Zaabel 2012 Iowa State University

Swine Biological Risk Management, Alejandro Ramirez, Pam Zaabel

Veterinary Diagnostic and Production Animal Medicine Publications and Papers

The purpose of this document is to serve as a reference for individuals involved in the swine industry to understand steps which can be taken to mitigate the risk of disease transmission. Biological risk management (BRM) is essential to all swine operations regardless of their size or mode of operation. Disease risk can never be completely eliminated. A full awareness of all risks is critical in mitigating threats of endemic, emerging, and foreign animal diseases. This document illustrates the best available “standard operating procedures” for a wide range of management practices. This is a working document that needs to be ...


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