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Supplement: A Field Trial Of 2 Point Of Care Glucometers In Healthy Calves, Joseph Smith, Lisa Ebner, Haley Cremerius, Channing Cantrell, Windy Soto-Gonzalez, Rebecca Rahn, Jon P. Mochel, Jeff Olivarez, Amanda Kreuder 2021 UTK

Supplement: A Field Trial Of 2 Point Of Care Glucometers In Healthy Calves, Joseph Smith, Lisa Ebner, Haley Cremerius, Channing Cantrell, Windy Soto-Gonzalez, Rebecca Rahn, Jon P. Mochel, Jeff Olivarez, Amanda Kreuder

Faculty Publications and Other Works -- Large Animal Clinical Sciences

No abstract provided.


Pharmacokinetics Of Tulathromycin In Pregnant Ewes (Ovis Aries) Challenged With Campylobacter Jejuni, Michael Yaeger, Jonathan P. Mochel, Zuowei Wu, Paul Plummer, Orhan Sahin, Joseph Smith, Melda Ocal, Ashenafi Beyi, Changyun Xu, Qijing Zhang, Ronald W. Griffith 2021 Iowa State University

Pharmacokinetics Of Tulathromycin In Pregnant Ewes (Ovis Aries) Challenged With Campylobacter Jejuni, Michael Yaeger, Jonathan P. Mochel, Zuowei Wu, Paul Plummer, Orhan Sahin, Joseph Smith, Melda Ocal, Ashenafi Beyi, Changyun Xu, Qijing Zhang, Ronald W. Griffith

Faculty Publications and Other Works -- Large Animal Clinical Sciences

The purpose of this study was to evaluate the pharmacokinetics of tulathromycin in the plasma and maternal and fetal tissues of pregnant ewes when administered within 24 hours of a single, IV Campylobacter jejuni (C. jejuni) challenge. Twelve, pregnant ewes between 72–92 days of gestation were challenged IV with C. jejuni IA3902 and then treated with 1.1 ml/45.36 kg of tulathromycin subcutaneously 18 hours post-challenge. Ewes were bled at predetermined time points and euthanized either at a predetermined time point or following the observation of vaginal bleeding or abortion. Following euthanasia, tissues were collected for bacterial ...


Equine Influenza Virus And Vaccines, Fatai S. Oladunni, Saheed Oluwasina Oseni, Luis Martinez-Sobrido, Thomas M. Chambers 2021 Texas Biomedical Research Institute

Equine Influenza Virus And Vaccines, Fatai S. Oladunni, Saheed Oluwasina Oseni, Luis Martinez-Sobrido, Thomas M. Chambers

Veterinary Science Faculty Publications

Equine influenza virus (EIV) is a constantly evolving viral pathogen that is responsible for yearly outbreaks of respiratory disease in horses termed equine influenza (EI). There is currently no evidence of circulation of the original H7N7 strain of EIV worldwide; however, the EIV H3N8 strain, which was first isolated in the early 1960s, remains a major threat to most of the world’s horse populations. It can also infect dogs. The ability of EIV to constantly accumulate mutations in its antibody-binding sites enables it to evade host protective immunity, making it a successful viral pathogen. Clinical and virological protection against ...


Steroidogenic Enzyme And Steroid Receptor Expression In The Equine Accessory Sex Glands, Robyn E. Ellerbrock, Giorgia Podico, Kirsten E. Scoggin, Barry A. Ball, Mariano Carossino, Igor F. Canisso 2021 University of Illinois Urbana-Champaign

Steroidogenic Enzyme And Steroid Receptor Expression In The Equine Accessory Sex Glands, Robyn E. Ellerbrock, Giorgia Podico, Kirsten E. Scoggin, Barry A. Ball, Mariano Carossino, Igor F. Canisso

Maxwell H. Gluck Equine Research Center Faculty Publications

The expression pattern and distribution of sex steroid receptors and steroidogenic enzymes during development of the equine accessory sex glands has not previously been described. We hypothesized that equine steroidogenic enzyme and sex steroid receptor expression is dependent on reproductive status. Accessory sex glands were harvested from mature stallions, pre-pubertal colts, geldings, and fetuses. Expression of mRNA for estrogen receptor 1 (ESR1), estrogen receptor 2 (ESR2), androgen receptor (AR), 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3βHSD), P450,17α hydroxylase, 17–20 lyase (CYP17), and aromatase (CYP19) were quantified by RT-PCR, and protein localization of AR, ER-α, ER-β, and 3βHSD were investigated by ...


First Molecular Detection Of Hepatitis E Virus Genome In Camel And Pig Faecal Samples In Ethiopia, Fufa Dawo Bari, Haimanot Belete Wodaje, Umar Said, Hika Waktole, Melaku Sombo, Samson Leta, Tesfaye Rufael Chibsa, Paul J. Plummer 2021 Addis Ababa University

First Molecular Detection Of Hepatitis E Virus Genome In Camel And Pig Faecal Samples In Ethiopia, Fufa Dawo Bari, Haimanot Belete Wodaje, Umar Said, Hika Waktole, Melaku Sombo, Samson Leta, Tesfaye Rufael Chibsa, Paul J. Plummer

Veterinary Diagnostic and Production Animal Medicine Publications

Background: Hepatitis E is an enteric and zoonotic disease caused by hepatitis E virus (HEV) that is mainly transmitted via the faecal-oral route through contaminated food or the environment. The virus is an emerging infectious agent causing acute human infection worldwide. A high seroprevalence of the disease was reported in pregnant women in Addis Ababa, Ethiopia, raising significant public health concern. The presence of HEV specific antibodies were also reported in dromedary camels in the country; however, the infectious virus and/or the viral genome have not been demonstrated to date in animal samples.

Methods: To address this gap, a ...


Nonlinear Mixed-Effect Pharmacokinetic Modeling And Distribution Of Doxycycline In Healthy Female Donkeys After Multiple Intragastric Dosing–Preliminary Investigation, Ronan J.J. Chapuis, Joseph Smith, Hilari M. French, Felix Ngosa Toka, Erik W. Peterson, Erika L. Little 2021 Ross University School of Veterinary Medicine

Nonlinear Mixed-Effect Pharmacokinetic Modeling And Distribution Of Doxycycline In Healthy Female Donkeys After Multiple Intragastric Dosing–Preliminary Investigation, Ronan J.J. Chapuis, Joseph Smith, Hilari M. French, Felix Ngosa Toka, Erik W. Peterson, Erika L. Little

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Doxycycline (DXC) is a broad-spectrum antibacterial antimicrobial administered to horses for the treatment of bacterial infections which may also affect donkeys. Donkeys have a different metabolism than horses, leading to differences in the pharmacokinetics of drugs compared to horses. This study aimed to describe the population pharmacokinetics of DXC in donkeys. Five doses of DXC hyclate (10 mg/kg) were administered via a nasogastric tube, q12 h, to eight non-fasted, healthy, adult jennies. Serum, urine, synovial fluid and endometrium were collected for 72 h following the first administration. Doxycycline concentration was measured by competitive enzyme immunoassay. Serum concentrations versus time ...


Identification Of A Ruminant Origin Group B Rotavirus Associated With Diarrhea Outbreaks In Foals, Tirth Uprety, Chithra C. Sreenivasan, Ben M. Hause, Ganwu Li, Solomon O. Odemuyiwa, Stephen Locke, Jocelynn Morgan, Li Zeng, William F. Gilsenan, Nathan Slovis, Laurie Metcalfe, Craig N. Carter, Peter J. Timoney, David W. Horohov, Dan Wang, Erdal Erol, Emma Adam, Feng Li 2021 University of Kentucky

Identification Of A Ruminant Origin Group B Rotavirus Associated With Diarrhea Outbreaks In Foals, Tirth Uprety, Chithra C. Sreenivasan, Ben M. Hause, Ganwu Li, Solomon O. Odemuyiwa, Stephen Locke, Jocelynn Morgan, Li Zeng, William F. Gilsenan, Nathan Slovis, Laurie Metcalfe, Craig N. Carter, Peter J. Timoney, David W. Horohov, Dan Wang, Erdal Erol, Emma Adam, Feng Li

Maxwell H. Gluck Equine Research Center Faculty Publications

Equine rotavirus group A (ERVA) is one of the most common causes of foal diarrhea. Starting in February 2021, there was an increase in the frequency of severe watery to hemorrhagic diarrhea cases in neonatal foals in Central Kentucky. Diagnostic investigation of fecal samples failed to detect evidence of diarrhea-causing pathogens including ERVA. Based on Illumina-based metagenomic sequencing, we identified a novel equine rotavirus group B (ERVB) in fecal specimens from the affected foals in the absence of any other known enteric pathogens. Interestingly, the protein sequence of all 11 segments had greater than 96% identity with group B ...


Transcriptomic Analysis Of Equine Chorioallantois Reveals Immune Networks And Molecular Mechanisms Involved In Nocardioform Placentitis, Hossam El-Sheikh Ali, Shavahn C. Loux, Laura Kennedy, Kirsten E. Scoggin, Pouya Dini, Carleigh E. Fedorka, Ted S. Kalbfleisch, Alejandro Esteller-Vico, David W. Horohov, Erdal Erol, Craig N. Carter, Jackie L. Smith, Barry A. Ball 2021 University of Kentucky

Transcriptomic Analysis Of Equine Chorioallantois Reveals Immune Networks And Molecular Mechanisms Involved In Nocardioform Placentitis, Hossam El-Sheikh Ali, Shavahn C. Loux, Laura Kennedy, Kirsten E. Scoggin, Pouya Dini, Carleigh E. Fedorka, Ted S. Kalbfleisch, Alejandro Esteller-Vico, David W. Horohov, Erdal Erol, Craig N. Carter, Jackie L. Smith, Barry A. Ball

Maxwell H. Gluck Equine Research Center Faculty Publications

Nocardioform placentitis (NP) continues to result in episodic outbreaks of abortion and preterm birth in mares and remains a poorly understood disease. The objective of this study was to characterize the transcriptome of the chorioallantois (CA) of mares with NP. The CA were collected from mares with confirmed NP based upon histopathology, microbiological culture and PCR for Amycolatopsis spp. Samples were collected from the margin of the NP lesion (NPL, n = 4) and grossly normal region (NPN, n = 4). Additionally, CA samples were collected from normal postpartum mares (Control; CRL, n = 4). Transcriptome analysis identified 2892 differentially expressed genes (DEGs ...


Investigating The Relationship Of Porcine Reproductive And Respiratory Syndrome Virus Rna Detection Between Adult/Sow Farm And Wean-To-Market Age Categories, Yiqun Jiang, Qing Li, Giovani Trevisan, Daniel C. L. Linhares, Cameron A. MacKenzie 2021 Iowa State University

Investigating The Relationship Of Porcine Reproductive And Respiratory Syndrome Virus Rna Detection Between Adult/Sow Farm And Wean-To-Market Age Categories, Yiqun Jiang, Qing Li, Giovani Trevisan, Daniel C. L. Linhares, Cameron A. Mackenzie

Veterinary Diagnostic and Production Animal Medicine Publications

Porcine reproductive and respiratory syndrome (PRRS) is a disease caused by the PRRS virus (PRRSV) that has spread globally in the last 30 years and causes huge economic losses every year. This research aims to 1) investigate the relationship between the PRRSV detection in two age categories (wean-to-market and adult/sow farm), and 2) examine the extent to which the wean-to-market PRRSV positive rate forecasts the adult/sow farm PRRSV positive rate. The data we used are the PRRSV RNA detection results between 2007 and 2019 integrated by the US Swine Disease Reporting System project that represent 95% of all ...


Comparison Of Naturally Occurring Vs. Experimental Infection Of Staphylococcus Aureus Septicemia In Laying Hens In Two Different Age Groups, Meaghan Meyer, Elizabeth Bobeck, Yuko Sato, Mohamed El-Gazzar 2021 Iowa State University

Comparison Of Naturally Occurring Vs. Experimental Infection Of Staphylococcus Aureus Septicemia In Laying Hens In Two Different Age Groups, Meaghan Meyer, Elizabeth Bobeck, Yuko Sato, Mohamed El-Gazzar

Animal Science Publications

In April and November of 2018, multiple commercial laying hen flocks within the same company presented with a sharp increase in mortality and drop in egg production that persisted for several days. These flocks showed striking necropsy lesions consistent with systemic infection and responded to antimicrobial treatment in the feed. Staphylococcus aureus (SA) was the most frequently isolated organism from multiple tissues including comb and wattle lesions, lungs, liver, ovary, spleen, and bone marrow. Given such an uncommon presentation of SA, which is known as a secondary opportunistic pathogen, a challenge study was conducted to evaluate its role in these ...


Complete Coding Genome Sequence Of A Novel Porcine Reproductive And Respiratory Syndrome Virus 2 Restriction Fragment Length Polymorphism 1-4-4 Lineage 1c Variant Identified In Iowa, Usa, Giovani Trevisan, Ganwu Li, Cesar A.A. Moura, Katie Coleman, Pete Thomas, Jianqiang Zhang, Phillip Gauger, Michael Zeller, Daniel C.L. Linhares 2021 Iowa State University

Complete Coding Genome Sequence Of A Novel Porcine Reproductive And Respiratory Syndrome Virus 2 Restriction Fragment Length Polymorphism 1-4-4 Lineage 1c Variant Identified In Iowa, Usa, Giovani Trevisan, Ganwu Li, Cesar A.A. Moura, Katie Coleman, Pete Thomas, Jianqiang Zhang, Phillip Gauger, Michael Zeller, Daniel C.L. Linhares

Veterinary Diagnostic and Production Animal Medicine Publications

A porcine reproductive and respiratory syndrome virus 2 strain was identified in lung samples from nursery piglets associated with a 17.15% mortality rate on a swine farm in Iowa. Open reading frame 5 (ORF5) sequencing indicated that this strain is a restriction fragment length polymorphism (RFLP) 1-4-4 lineage 1C variant strain, and its complete coding genome sequence was determined.


Yeast Particle Encapsulation Of Scaffolded Terpene Compounds For Controlled Terpene Release, Ernesto R. Soto, Florentina Rus, Hanchen Li, Carli Garceau, Jeffrey Chicca, Mostafa Elfawal, David Gazzola, Martin K. Nielsen, Joseph F. Urban Jr., Raffi V. Aroian, Gary R. Ostroff 2021 University of Massachusetts

Yeast Particle Encapsulation Of Scaffolded Terpene Compounds For Controlled Terpene Release, Ernesto R. Soto, Florentina Rus, Hanchen Li, Carli Garceau, Jeffrey Chicca, Mostafa Elfawal, David Gazzola, Martin K. Nielsen, Joseph F. Urban Jr., Raffi V. Aroian, Gary R. Ostroff

Maxwell H. Gluck Equine Research Center Faculty Publications

Terpenes are naturally occurring compounds produced by plants that are of great commercial interest in the food, agricultural, cosmetic, and pharmaceutical industries due to their broad spectra of antibacterial, antifungal, anthelmintic, membrane permeation enhancement, and antioxidant biological activities. Applications of terpenes are often limited by their volatility and the need for surfactants or alcohols to produce stable, soluble (non-precipitated) products. Yeast particles (YPs) are hollow, porous microspheres that have been used for the encapsulation of terpenes (YP terpenes) by passive diffusion of terpenes through the porous YP cell walls. We here report the development of a second generation YP encapsulated ...


Comparison Of Mycoplasma Hyopneumoniae Response To Infection By Route Of Exposure, Ana Paula S. Poeta Silva, Thaire P. Marostica, Aric McDaniel, Bailey L. Arruda, Carmen Alonso, Rachel J. Derscheid, Paul Yeske, Daniel C.L. Linhares, Luis Giménez-Lirola, Locke A. Karriker, Eduardo Fano, Jeffrey J. Zimmerman, Maria J. Clavijo 2021 Iowa State University

Comparison Of Mycoplasma Hyopneumoniae Response To Infection By Route Of Exposure, Ana Paula S. Poeta Silva, Thaire P. Marostica, Aric Mcdaniel, Bailey L. Arruda, Carmen Alonso, Rachel J. Derscheid, Paul Yeske, Daniel C.L. Linhares, Luis Giménez-Lirola, Locke A. Karriker, Eduardo Fano, Jeffrey J. Zimmerman, Maria J. Clavijo

Veterinary Diagnostic and Production Animal Medicine Publications

Mycoplasma hyopneumoniae (MHP) is a concern both for pig well-being and producer economic viability. In the absence of fully protective health interventions, producers rely on controlled exposure to induce an immune response in pigs and minimize the clinical outcomes of MHP infection in pig populations. This study compared the effect of route of exposure on MHP infection, antibody response, clinical signs, and pathology. Six-week-old MHP-negative pigs (n = 78) were allocated to negative control (n = 6) or one of three MHP exposure routes: intratracheal (n = 24, feeding catheter), intranasal (n = 24, atomization device), and aerosol (n = 24, fogger). Body weight ...


Intrauterine Blood Plasma Platelet-Therapy Mitigates Persistent Breeding-Induced Endometritis, Reduces Uterine Infections, And Improves Embryo Recovery In Mares, Lorenzo G. T. M. Segabinazzi, Igor F. Canisso, Giorgia Podico, Lais L. Cunha, Guilherme Novello, Michael F. Rosser, Shavanh C. Loux, Fabio S. Lima, Marco A. Alvarenga 2021 University of Illinois Urbana Champaign

Intrauterine Blood Plasma Platelet-Therapy Mitigates Persistent Breeding-Induced Endometritis, Reduces Uterine Infections, And Improves Embryo Recovery In Mares, Lorenzo G. T. M. Segabinazzi, Igor F. Canisso, Giorgia Podico, Lais L. Cunha, Guilherme Novello, Michael F. Rosser, Shavanh C. Loux, Fabio S. Lima, Marco A. Alvarenga

Maxwell H. Gluck Equine Research Center Faculty Publications

Microorganisms, including pathogenic or opportunistic bacteria and fungi, may gain access to the uterus during breeding, and infectious endometritis plays a major role in equine subfertility. This study aimed to assess the post-breeding inflammatory response, endometrial culture, and embryo recovery of mares susceptible to persistent breeding-induced endometritis (PBIE) treated with plasma-rich (PRP) or -poor (PPP) plasma. Mares (n = 12) susceptible to PBIE had three cycles randomly assigned to receive intrauterine infusions of lactate ringer solution (LRS, control), or autologous PRP or PPP pre- (−48 and −24 h) and post-breeding (6 and 24 h). Mares were bred with fresh semen from ...


Longitudinal Piglet Sampling In Commercial Sow Farms Highlights The Challenge Of Prrsv Detection, Marcelo Nunes de Almeida, Cesar A. Corzo, Jeffrey J. Zimmerman, Daniel C. L. Linhares 2021 Iowa State University

Longitudinal Piglet Sampling In Commercial Sow Farms Highlights The Challenge Of Prrsv Detection, Marcelo Nunes De Almeida, Cesar A. Corzo, Jeffrey J. Zimmerman, Daniel C. L. Linhares

Veterinary Diagnostic and Production Animal Medicine Publications

Background: Processing fluids (PF) and family oral fluids (FOF) are population-based surveillance samples collected from 2- to 5-day-old piglets and due-to-wean piglets, respectively. Although they are described for the surveillance of PRRSV in sows and piglet populations at processing and weaning, there is limited information on their use in commercial herds. This observational study described PRRSV RNA detection over time in PF, FOF, and piglet serum collected from farrowing groups in commercial breeding farms with the objective of achieving robust, practical, and effective PRRSV surveillance protocols. Weekly PF (an aggregate sample of all litters processed in a week from each ...


Pseudorabies (Aujeszky's Disease) Virus Dna Detection In Swine Nasal Swab And Oral Fluid Specimens Using A Gb-Based Real-Time Quantitative Pcr, Ting-Yu Cheng, Alexandra Henao-Diaz, Korakrit Poonsuk, Alexandra Buckley, Albert van Geelen, Kelly Lager, Karen M. Harmon, Phillip Gauger, Chong Wang, Aruna Ambagala, Jeffrey J. Zimmerman, Luis Giménez-Lirola 2021 Iowa State University

Pseudorabies (Aujeszky's Disease) Virus Dna Detection In Swine Nasal Swab And Oral Fluid Specimens Using A Gb-Based Real-Time Quantitative Pcr, Ting-Yu Cheng, Alexandra Henao-Diaz, Korakrit Poonsuk, Alexandra Buckley, Albert Van Geelen, Kelly Lager, Karen M. Harmon, Phillip Gauger, Chong Wang, Aruna Ambagala, Jeffrey J. Zimmerman, Luis Giménez-Lirola

Veterinary Diagnostic and Production Animal Medicine Publications

In this study, the detection of PRV DNA in nasal swab (n = 440) and oral fluid (n = 1,545) samples collected over time from experimentally PRV vaccinated and/or PRV inoculated pigs (n = 40) was comparatively evaluated by real-time PCR. Serum samples (n = 440) were tested by PRV gB/gE blocking ELISAs (Pseudorabies Virus gB Antibody Test Kit and Pseudorabies Virus gpI Antibody Test Kit, IDEXX Laboratories, Inc., Westbrook, ME) to monitor PRV status over time. Following exposure to a gE-deleted modified live vaccine (Ingelvac® Aujeszky MLV, Boehringer Ingelheim, Ridgefield, CT) and/or a wild-type virus (3 CR Ossabaw), PRV ...


Genomics Of Response To Prrsv In Purebred And Crossbred Sows: Antibody Response And Performance Following Natural Infection Versus Vaccination, Leticia P. Sanglard, Felipe M. W. Hickmann, Yijian Huang, Kent A. Gray, Daniel C. L. Linhares, Jack C. M. Dekkers, Megan C. Niederwerder, Rohan L. Fernando, Joseph Braccini Neto, Nick V. L. Serão 2021 Iowa State University

Genomics Of Response To Prrsv In Purebred And Crossbred Sows: Antibody Response And Performance Following Natural Infection Versus Vaccination, Leticia P. Sanglard, Felipe M. W. Hickmann, Yijian Huang, Kent A. Gray, Daniel C. L. Linhares, Jack C. M. Dekkers, Megan C. Niederwerder, Rohan L. Fernando, Joseph Braccini Neto, Nick V. L. Serão

Veterinary Diagnostic and Production Animal Medicine Publications

Antibody response, measured as sample-to-positive (S/P) ratio, to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) following a PRRSV-outbreak (S/POutbreak) in a purebred nucleus and following a PRRSV-vaccination (S/PVx) in commercial crossbred herds have been proposed as genetic indicator traits for improved reproductive performance in PRRSV-infected purebred and PRRSV-vaccinated crossbred sows, respectively. In this study, we investigated the genetic relationships of S/POutbreak and S/PVx with performance at the commercial (vaccinated crossbred sows) and nucleus level (non-infected and PRRSV-infected purebred sows), respectively, and tested the effect of previously identified SNP for these indicator traits. Antibody response was ...


An Inactivated Bacterium (Paraprobiotic) Expressing Bacillus Thuringiensis Cry5b As A Therapeutic For Ascaris And Parascaris Spp. Infections In Large Animals, Joseph F. Urban, Martin K. Nielsen, David Gazzola, Yue Xie, Ethiopia Beshah, Yan Hu, Hanchen Li, Florentina Rus, Kelly Flanagan, Austin Draper, Sridhar Vakalapudi, Robert W. Li, Gary R. Ostroff, Raffi V. Aroian 2021 U.S. Department of Agriculture

An Inactivated Bacterium (Paraprobiotic) Expressing Bacillus Thuringiensis Cry5b As A Therapeutic For Ascaris And Parascaris Spp. Infections In Large Animals, Joseph F. Urban, Martin K. Nielsen, David Gazzola, Yue Xie, Ethiopia Beshah, Yan Hu, Hanchen Li, Florentina Rus, Kelly Flanagan, Austin Draper, Sridhar Vakalapudi, Robert W. Li, Gary R. Ostroff, Raffi V. Aroian

Maxwell H. Gluck Equine Research Center Faculty Publications

Ascaris and Parascaris are important parasites in the family Ascarididae, large, ubiquitous intestinal-dwelling nematodes infecting all classes of vertebrates. Parasitic nematode drug resistance in veterinary medicine and drug recalcitrance in human medicine are increasing worldwide, with few if any new therapeutic classes on the horizon. Some of these parasites are zoonotic, e.g., Ascaris is passed from humans to pigs and vice versa. The development of new therapies against this family of parasites would have major implications for both human and livestock health. Here we tested the therapeutic ability of a paraprobiotic or dead probiotic that expresses the Bacillus thuringiensis ...


“Adopt-A-Tissue” Initiative Advances Efforts To Identify Tissue-Specific Histone Marks In The Mare, N. B. Kingsley, Natasha A. Hamilton, Gabriella Lindgren, Ludovic Orlando, Ernest Bailey, Samantha Brooks, Molly McCue, Ted S. Kalbfleisch, James N. MacLeod, Jessica L. Petersen, Carrie J. Finno, Rebecca R. Bellone 2021 University of California, Davis

“Adopt-A-Tissue” Initiative Advances Efforts To Identify Tissue-Specific Histone Marks In The Mare, N. B. Kingsley, Natasha A. Hamilton, Gabriella Lindgren, Ludovic Orlando, Ernest Bailey, Samantha Brooks, Molly Mccue, Ted S. Kalbfleisch, James N. Macleod, Jessica L. Petersen, Carrie J. Finno, Rebecca R. Bellone

Maxwell H. Gluck Equine Research Center Faculty Publications

No abstract provided.


Case Report: Successful Management Of Refractory Keratomycosis In An Alpaca Using Penetrating Keratoplasty And Combination Antifungal Therapy (Caspofungin 0.5% And Terbinafine 1%), Braidee C. Foote, Joseph Smith, Anna Catherine Bowden, Rachel A. Allbaugh, Lionel Sebbag 2021 UTK

Case Report: Successful Management Of Refractory Keratomycosis In An Alpaca Using Penetrating Keratoplasty And Combination Antifungal Therapy (Caspofungin 0.5% And Terbinafine 1%), Braidee C. Foote, Joseph Smith, Anna Catherine Bowden, Rachel A. Allbaugh, Lionel Sebbag

Faculty Publications and Other Works -- Large Animal Clinical Sciences

Fungal keratitis is a common disease in certain parts of the world and affects several species, including equids, camelids, and homo sapiens, leading to blindness or loss of the eye if the infection is not adequately controlled. Reports of clinical use of antifungals caspofungin and terbinafine are limited across both veterinary and human medical literature. The alpaca presented in this case demonstrates that deep keratomycosis can be caused by Scopulariopsis brevicaulis and Fusarium verticillioides, two previously unreported fungi to cause keratomycosis in camelids. This report demonstrates successful management with a combination of surgery and topical ophthalmic treatment with caspofungin 0 ...


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