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Associations Between Infectious Bovine Keratoconjunctivitis At Weaning And Ultrasongraphically Measured Body Composition Traits In Yearling Cattle, Lucas D. Funk, James M. Reecy, Chong Wang, Richard G. Tait Jr., Annette M. O'Connor 2016 Iowa State University

Associations Between Infectious Bovine Keratoconjunctivitis At Weaning And Ultrasongraphically Measured Body Composition Traits In Yearling Cattle, Lucas D. Funk, James M. Reecy, Chong Wang, Richard G. Tait Jr., Annette M. O'Connor

Chong Wang

Objective—To assess associations between infectious bovine keratoconjunctivitis (IBK) diagnosed at weaning and production traits in yearling beef calves.

Design—Retrospective population-based cohort study.

Animals—1,882 Angus calves.

Procedures—Angus calves from 1 farm were evaluated over 7 years. The association between yearling body production traits and detection of IBK lesions at weaning was evaluated.

Results—Yearlings that had evidence of IBK at weaning had less 12th rib fat depth, ribeye area, and body weight than did cohorts without evidence of IBK. Average daily gain was greater in cattle that had IBK lesions at weaning, but this did not ...


A Live-Attenuated And An Inactivated Chimeric Porcine Circovirus (Pcv)1-2 Vaccine Are Both Effective At Inducing A Humoral Immune Response And Reducing Pcv2 Viremia And Intrauterine Infection In Female Swine Of Breeding Age, Michelle Hemann, Nathan M. Beach, Xiang-Jin Meng, Chong Wang, Patrick G. Halbur, Tanja Opriessnig 2016 Iowa State University

A Live-Attenuated And An Inactivated Chimeric Porcine Circovirus (Pcv)1-2 Vaccine Are Both Effective At Inducing A Humoral Immune Response And Reducing Pcv2 Viremia And Intrauterine Infection In Female Swine Of Breeding Age, Michelle Hemann, Nathan M. Beach, Xiang-Jin Meng, Chong Wang, Patrick G. Halbur, Tanja Opriessnig

Chong Wang

The objective of this pilot study was to determine the efficacy of inactivated (1 or 2 dose) and live-attenuated chimeric porcine circovirus (PCV)1-2 vaccines in sows using the PCV2-spiked semen model. Thirty-five sows were randomly divided into 6 groups: negative and positive controls, 1 dose inactivated PCV1-2 vaccine challenged (1-VAC-PCV2), 2 dose inactivated PCV1-2 vaccine challenged (2-VAC-PCV2), 1 dose live-attenuated PCV1-2 vaccine unchallenged (1-LIVE-VAC), and 1 dose live-attenuated PCV1-2 vaccine challenged (1-LIVE-VAC-PCV2). The inactivated PCV1-2 vaccine induced higher levels of PCV2-specific antibodies in dams. All vaccination strategies provided good protection against PCV2 viremia in dams, whereas the majority of ...


Bacterial Isolates, Antimicrobial Susceptibility Patterns, And Factors Associated With Infection And Outcome In Foals With Septic Arthritis: 83 Cases (1998–2013), Kate L. Hepworth-Warren, David M. Wong, Caroline V. Fulkerson, Chong Wang, Yaxuan Sun 2016 Iowa State University

Bacterial Isolates, Antimicrobial Susceptibility Patterns, And Factors Associated With Infection And Outcome In Foals With Septic Arthritis: 83 Cases (1998–2013), Kate L. Hepworth-Warren, David M. Wong, Caroline V. Fulkerson, Chong Wang, Yaxuan Sun

Chong Wang

Objective—To determine clinical characteristics, clinicopathologic data, and bacterial culture and antimicrobial susceptibility results associated with septic arthritis in foals ≤ 180 days old.

Design—Retrospective case series.

Animals—83 foals with septic arthritis.

Procedures—Medical records at 2 teaching hospitals between 1998 and 2013 were searched to identify those for foals ≤ 180 days old with confirmed infection of ≥ 1 synovial structure. Data extracted from the records included signalment, clinicopathologic information, bacteriologic culture and antimicrobial susceptibility results, and outcome. Data were analyzed for all foals as a single population and for foals stratified into 3 age groups (≤ 7 days, 8 to ...


A Method To Quantify Infectious Airborne Pathogens At Concentrations Below The Threshold Of Quantification By Culture, Timothy D. Cutler, Chong Wang, Steven J. Hoff, Jeffrey J. Zimmerman 2016 Iowa State University

A Method To Quantify Infectious Airborne Pathogens At Concentrations Below The Threshold Of Quantification By Culture, Timothy D. Cutler, Chong Wang, Steven J. Hoff, Jeffrey J. Zimmerman

Chong Wang

In aerobiology, dose-response studies are used to estimate the risk of infection to a susceptible host presented by exposure to a specific dose of an airborne pathogen. In the research setting, host- and pathogen-specific factors that affect the dose-response continuum can be accounted for by experimental design, but the requirement to precisely determine the dose of infectious pathogen to which the host was exposed is often challenging. By definition, quantification of viable airborne pathogens is based on the culture of micro-organisms, but some airborne pathogens are transmissible at concentrations below the threshold of quantification by culture. In this paper we ...


Evaluation Of Disinfection Protocols To Reduce Virus Transmission Via Livestock Transport Vehicles Using Model Trailers And Experimental Conditions, Peter T. Schneider, Jianqiang Zhang, Alejandro Ramirez, Chong Wang, Derald J. Holtkamp 2016 Innovative Agriculture Solutions

Evaluation Of Disinfection Protocols To Reduce Virus Transmission Via Livestock Transport Vehicles Using Model Trailers And Experimental Conditions, Peter T. Schneider, Jianqiang Zhang, Alejandro Ramirez, Chong Wang, Derald J. Holtkamp

Chong Wang

Objective: To determine the efficacy of accelerated hydrogen peroxide disinfectant and combined glutaraldehyde and quaternary ammonium disinfectant after a high-pressure wash against porcine reproductive and respiratory syndrome virus (PRRSV) and transmissible gastroenteritis virus (TGEV) in experimental settings mimicking field conditions commonly experienced on livestock trailers.

Materials and methods: Aluminum model livestock trailers (1:61) were contaminated with PRRSV- and TGEV-spiked feces. Each model trailer underwent a simple washing procedure and an assigned disinfectant application. Four environmental swabs were collected per trailer at five time points and tested by PRRSV quantitative polymerase chain reaction (qPCR) and TGEV polymerase chain reaction (PCR ...


Characterization And Functional Analysis Of Interleukin-12 In Amberjack Seriola Dumarili, Megumi Matsumoto Miss, Kyosuke Araki Dr, Kazuma Hayashi Mr, Hiroaki Suetake Dr, Atsushi Yamamoto Dr 2016 Faculty of Fisheries, Kagoshima University, Japan

Characterization And Functional Analysis Of Interleukin-12 In Amberjack Seriola Dumarili, Megumi Matsumoto Miss, Kyosuke Araki Dr, Kazuma Hayashi Mr, Hiroaki Suetake Dr, Atsushi Yamamoto Dr

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Induction Of Cell-Mediated Immune Responses After Vaccination With Inactivated Oil-Emulsion Nocardia Seriolae In Amberjack Seriola Dumerili, Kyosuke Araki, Megumi Matsumoto, Kazuma Hayashi, Atsushi Yamamoto 2016 Faculty of Fisheries, Kagoshima University, Japan

Induction Of Cell-Mediated Immune Responses After Vaccination With Inactivated Oil-Emulsion Nocardia Seriolae In Amberjack Seriola Dumerili, Kyosuke Araki, Megumi Matsumoto, Kazuma Hayashi, Atsushi Yamamoto

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Shiga Toxin-Producing Escherichia Coli Infection: Temporal And Quantitative Relationships Among Colonization, Toxin Production, And Systemic Disease, Nancy A. Cornick, Ilze Matise, James E. Samuel, Brad T. Bosworth, Harley W. Moon 2016 Iowa State University

Shiga Toxin-Producing Escherichia Coli Infection: Temporal And Quantitative Relationships Among Colonization, Toxin Production, And Systemic Disease, Nancy A. Cornick, Ilze Matise, James E. Samuel, Brad T. Bosworth, Harley W. Moon

Nancy Cornick

Edema disease, a naturally occurring disease of swine caused by Shiga toxin-producing Escherichia coli (STEC), was used as a model for the sequence of events that occur in the pathogenesis of STEC infection. The mean time from production of levels of Shiga toxin 2e (Stx2e) detectable in the feces (day 1) to the onset of clinical disease (neurologic disturbances or death) was 5 days (range, 3–9). Bacterial colonization and titers of Stx2e in the ileum peaked at 4 days after inoculation in pigs without signs of clinical disease and at 6 days after inoculation in clinically affected pigs. Animals ...


Grazing Management Effects On Sediment, Phosphorus, And Pathogen Loading Of Streams In Cool-Season Grass Pastures, Kirk A. Schwarte, James R. Russell, John Kovar, Daniel G. Morrical, Steve Ensley, Kyoung-Jin Yoon, Nancy A. Cornick, Yong Il Cho 2016 Iowa State University

Grazing Management Effects On Sediment, Phosphorus, And Pathogen Loading Of Streams In Cool-Season Grass Pastures, Kirk A. Schwarte, James R. Russell, John Kovar, Daniel G. Morrical, Steve Ensley, Kyoung-Jin Yoon, Nancy A. Cornick, Yong Il Cho

Nancy Cornick

Erosion and runoff from pastures may lead to degradation of surface water. A 2-yr grazing study was conducted to quantify the effects of grazing management on sediment, phosphorus (P), and pathogen loading of streams in cool-season grass pastures. Six adjoining 12.1-ha pastures bisected by a stream in central Iowa were divided into three treatments: continuous stocking with unrestricted stream access (CSU), continuous stocking with restricted stream access (CSR), and rotational stocking (RS). Rainfall simulations on stream banks resulted in greater (P < 0.10) proportions of applied precipitation and amounts of sediment and P transported in runoff from bare sites than from vegetated sites across grazing treatments. Similar differences were observed comparing vegetated sites in CSU and RS pastures with vegetated sites in CSR pastures. Bovine enterovirus was shed by an average of 24.3% of cows during the study period and was collected in the runoff of 8.3 and 16.7% of runoff simulations on bare sites in CSU pastures in June and October of 2008, respectively, and from 8.3% of runoff simulations on vegetated sites in CSU pastures in April 2009. Fecal pathogens (bovine coronavirus [BCV], bovine rotavirus group A, andEscherichia coli O157:H7) shed or detected in runoff were almost nonexistent; only BCV was detected in feces ...


Dietary Inclusion Of Colicin E1 Is Effective In Preventing Postweaning Diarrhea Caused By F18-Positive Escherichia Coli In Pigs, Sara A. Cutler, Steven M. Lonergan, Nancy A. Cornick, Anna K. Johnson, Chad H. Stahl 2016 Iowa State University

Dietary Inclusion Of Colicin E1 Is Effective In Preventing Postweaning Diarrhea Caused By F18-Positive Escherichia Coli In Pigs, Sara A. Cutler, Steven M. Lonergan, Nancy A. Cornick, Anna K. Johnson, Chad H. Stahl

Nancy Cornick

With worldwide concern over the use of antibiotics in animal agriculture and their contribution to the spread of antibiotic resistance, alternatives to conventional antibiotics are needed. Previous research in our laboratories has shown that colicin E1 is effective against some Escherichia coli strains responsible for postweaning diarrhea (PWD) in vitro. In this study we examined the efficacy of the dietary inclusion of colicin E1 in preventing experimentally induced PWD caused by F18-positive enterotoxigenic E. coli in young pigs. Twenty-four weaned pigs (23 days of age), identified by genotyping to be susceptible to F18-positive E. coliinfections, were individually housed and ...


Plants, Prions And Possibilities: Current Understanding And Significance Of Prion Uptake Into Plants, Tracy A. Nichols 2016 U.S. Department of Agriculture

Plants, Prions And Possibilities: Current Understanding And Significance Of Prion Uptake Into Plants, Tracy A. Nichols

USDA National Wildlife Research Center - Staff Publications

Chronic wasting disease (CWD) is an infectious, neurodegenerative disease of deer (white-tailed and mule), elk, moose, sika deer and muntjac caused by a misfolded version of a normally occurring protein. The notion that CWD could be spread indirectly via the environment has been documented and accepted in the scientific community for quite some time. Deer and elk consume soil, inhale dust and lick objects that have infectious material on them, resulting in chronic, low dose exposure. Surface contamination of plants with urine or feces is likely an additional source of exposure via ingestion and has been modeled in the laboratory ...


Variation In Avian Pathogenic Escherichia Coli Colonization Levels In Chickens, Melissa Monson, Michael Kaiser, Susan Lamont 2016 Iowa State University

Variation In Avian Pathogenic Escherichia Coli Colonization Levels In Chickens, Melissa Monson, Michael Kaiser, Susan Lamont

Melissa Monson

Colonization levels in five tissues after avian pathogenic Escherichia coli (APEC) inoculation were investigated in chickens to generate phenotypic data for a genome wide association study (GWAS). Bacterial loads were measured in 370 birds and varied among individuals and tissues. Mean bacterial levels were significantly different between tissues (right lung > spleen > left lung and liver > blood). There were also significant correlations in bacterial load between tissues. These data suggest that colonization levels could be used as phenotypes in GWAS and could help identify markers associated with poultry resistance to APEC infections. After verification, these markers could be used for genetic ...


Meningeal Worm In Central Iowa Goat Herds, Kelly Still Brooks 2016 Iowa State University

Meningeal Worm In Central Iowa Goat Herds, Kelly Still Brooks

Animal Industry Report

Aberrant migration of the deer meningeal worm, Parelaphostrongylus tenuis, is a commonly recognized cause of neurologic disease in South American camelids but is less frequently considered in other small ruminant species. After an unusually cool and wet summer season, central Iowa goat herds serviced by Iowa State University’s Veterinary Field Services have been increasingly affected by P. tenuis, with clinical cases presenting as early as August. Most caprine cases present with progressive neurologic deficits, starting with hind-end weakness and ataxia which may lead to complete paresis and death. Both sporadic cases and herd outbreaks involving as much as 15 ...


Infection Of Commercial Laying Hens With Newcastle Disease Virus: Differing Responses Between Birds Provide Potential For Genetic Improvement Through Selection, Kaylee Rowland, Huaijun Zhou, Rodrigo Gallardo, David Bunn, Susan J. Lamont 2016 Iowa State University

Infection Of Commercial Laying Hens With Newcastle Disease Virus: Differing Responses Between Birds Provide Potential For Genetic Improvement Through Selection, Kaylee Rowland, Huaijun Zhou, Rodrigo Gallardo, David Bunn, Susan J. Lamont

Animal Industry Report

Exotic Newcastle Disease Virus (ENDV) cause extremely rapid mortality in chickens after exposure to the virus. People rely heavily on poultry to provide protein and income in many places where NDV is not effectively controlled through vaccination and biosecurity. Losses from NDV contribute to worldwide hunger and poverty. It may be possible to use genetic selection to produce chickens that have a stronger immune response in the face of NDV challenge. For genetic selection to be successful, two major elements are required: differences in immune response among chickens and genetic control of these differences. This study clearly demonstrated the existence ...


Do Two Distinct Chicken Lines Differ In Their Response To Newcastle Disease Virus?, Melissa S. Herrmann, Rodrigo Gallardo, David A. Bunn, Huaijun Zhou, Susan J. Lamont 2016 Iowa State University

Do Two Distinct Chicken Lines Differ In Their Response To Newcastle Disease Virus?, Melissa S. Herrmann, Rodrigo Gallardo, David A. Bunn, Huaijun Zhou, Susan J. Lamont

Animal Industry Report

The differences between relatively resistant and susceptible chicken lines can be utilized to study the genetics behind disease resistance. To assess resistance, the viral quantity in each bird was measured after challenge with Newcastle Disease Virus (NDV) at two time points. As predicted, the resistant line was able to clear the virus more quickly than the susceptible line. Further studies are needed to determine the genetics responsible for resistance.


Genetic Parameters And Effect Of Wur Genotype On Piglet Response To Co-Infection With Prrs And Pcv2b, With Or Without Vaccination For Prrs, Jenelle R. Dunkelberger, Nick V. L. Serão, Maureen Kerrigan, Joan Lunney, Bob Rowland, Jack Dekkers 2016 Iowa State University

Genetic Parameters And Effect Of Wur Genotype On Piglet Response To Co-Infection With Prrs And Pcv2b, With Or Without Vaccination For Prrs, Jenelle R. Dunkelberger, Nick V. L. Serão, Maureen Kerrigan, Joan Lunney, Bob Rowland, Jack Dekkers

Animal Industry Report

Commercial crossbred nursery piglets were either vaccinated or not using a modified live porcine reproductive and respiratory syndrome (PRRS) virus vaccine and all pigs were co-infected with PRRS virus (PRRSV) and porcine circovirus type 2b (PCV2b) 28 days later. Genetic correlations indicate that traits associated with primary exposure to PRRSV infection (PRRS viral load (VL) of vaccinated pigs prior to co-infection and PRRS VL of non-vaccinated pigs post co-infection) are genetically the same trait. The WUR single nucleotide polymorphism on chromosome 4, previously associated with reduced PRRS VL under PRRSV-only infection, was associated with significantly reduced PRRS VL following vaccination ...


Noninvasive Assessment Of Cardiac Abnormalities In Experimental Autoimmune Myocarditis By Magnetic Resonance Microscopy Imaging In The Mouse, Chandirasegaran Massilamany, Vahid Khalilzad-Sharghi, Arunakumar Gangaplara, David Steffen, Shadi F. Othman, Jay Reddy 2016 University of Nebraska-Lincoln

Noninvasive Assessment Of Cardiac Abnormalities In Experimental Autoimmune Myocarditis By Magnetic Resonance Microscopy Imaging In The Mouse, Chandirasegaran Massilamany, Vahid Khalilzad-Sharghi, Arunakumar Gangaplara, David Steffen, Shadi F. Othman, Jay Reddy

Jay Reddy Publications

Myocarditis is an inflammation of the myocardium, but only ~10% of those affected show clinical manifestations of the disease. To study the immune events of myocardial injuries, various mouse models of myocarditis have been widely used. This study involved experimental autoimmune myocarditis (EAM) induced with cardiac myosin heavy chain (Myhc)-α 334-352 in A/J mice; the affected animals develop lymphocytic myocarditis but with no apparent clinical signs. In this model, the utility of magnetic resonance microscopy (MRM) as a non-invasive modality to determine the cardiac structural and functional changes in animals immunized with Myhc-α 334-352 is shown. EAM and ...


Ring Test Evaluation Of The Detection Of Influenza A Virus In Swine Oral Fluids By Real-Time Reverse-Transcription Polymerase Chain Reaction And Virus Isolation, Christa K. Goodell, Jianqiang Zhang, Erin Strait, Karen Harmon, Devi Patnayak, Tracy Otterson, Marie Culhane, Jane Christopher-Hennings, Travis Clement, Pamela Leslie-Steen, Richard Hesse, Joe Anderson, Kevin Skarbek, Amy Vincent, Pravina Kitikoon, Sabrina Swenson, Melinda Jenkins-Moore, Jodi McGill, Rolf Rauh, William Nelson, Catherine O'Connell, Rohn Shah, Chong Wang, Rodger Main, Jeffery J. Zimmerman 2016 Iowa State University

Ring Test Evaluation Of The Detection Of Influenza A Virus In Swine Oral Fluids By Real-Time Reverse-Transcription Polymerase Chain Reaction And Virus Isolation, Christa K. Goodell, Jianqiang Zhang, Erin Strait, Karen Harmon, Devi Patnayak, Tracy Otterson, Marie Culhane, Jane Christopher-Hennings, Travis Clement, Pamela Leslie-Steen, Richard Hesse, Joe Anderson, Kevin Skarbek, Amy Vincent, Pravina Kitikoon, Sabrina Swenson, Melinda Jenkins-Moore, Jodi Mcgill, Rolf Rauh, William Nelson, Catherine O'Connell, Rohn Shah, Chong Wang, Rodger Main, Jeffery J. Zimmerman

Veterinary Diagnostic and Production Animal Medicine Publications

The probability of detecting influenza A virus (IAV) in oral fluid (OF) specimens was calculated for each of 13 assays based on real-time reverse-transcription polymerase chain reaction (rRT-PCR) and 7 assays based on virus isolation (VI). The OF specimens were inoculated with H1N1 or H3N2 IAV and serially diluted 10-fold (10(-1) to 10(-8)). Eight participating laboratories received 180 randomized OF samples (10 replicates × 8 dilutions × 2 IAV subtypes plus 20 IAV-negative samples) and performed the rRT-PCR and VI procedure(s) of their choice. Analysis of the results with a mixed-effect logistic-regression model identified dilution and assay as variables ...


Host-Pathogen Protein-Protein Interaction Prediction Using An In Silico Model, John C. F. Hsieh, Robert L. Jernigan, Susan J. Lamont 2016 Iowa State University

Host-Pathogen Protein-Protein Interaction Prediction Using An In Silico Model, John C. F. Hsieh, Robert L. Jernigan, Susan J. Lamont

Animal Industry Report

Newcastle Disease (ND) is caused by Newcastle Disease Virus (NDV) and is a major problem in developing countries where vaccination against NDV is not easily achievable. A step required for NDV infection is the cleavage of the NDV fusion (F) protein. Using structural information of the NDV F protein and the only known host protein binding partner, protein disulfide isomerase A3 (PDIA3), we computer modeled the interaction between the two proteins by looking at a docked structure of these two proteins. With our docked structure, we visualized one of the catalytic domains of PDIA3 being near the cleavage site of ...


Variation In Avian Pathogenic Escherichia Coli Colonization Levels In Chickens, Melissa S. Monson, Michael G. Kaiser, Susan J. Lamont 2016 Iowa State University

Variation In Avian Pathogenic Escherichia Coli Colonization Levels In Chickens, Melissa S. Monson, Michael G. Kaiser, Susan J. Lamont

Animal Industry Report

Colonization levels in five tissues after avian pathogenic Escherichia coli (APEC) inoculation were investigated in chickens to generate phenotypic data for a genome wide association study (GWAS). Bacterial loads were measured in 370 birds and varied among individuals and tissues. Mean bacterial levels were significantly different between tissues (right lung > spleen > left lung and liver > blood). There were also significant correlations in bacterial load between tissues. These data suggest that colonization levels could be used as phenotypes in GWAS and could help identify markers associated with poultry resistance to APEC infections. After verification, these markers could be used for genetic ...


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