Analysis Of Research And Development Trends Of New Drugs,
2024
Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China
University of Chinese Academy of Sciences, Beijing 100049, China
Analysis Of Research And Development Trends Of New Drugs, Ping Xu, Li Xu, Ruo-Nan Yang, Wei Li, Kaixian Chen
Bulletin of Chinese Academy of Sciences (Chinese Version)
As an important component in the pharmaceutical innovation, research and development (R&D) of new drugs stands at the forefront of a new round of life science and technology revolution and bioeconomic reform, which is of strategic significance to leading scientific and technological innovation, driving economic development, and improving people’s health and well-being. At present, continuous innovation in cutting-edge technologies, cross-domain integration of disciplines, and digital depth enablement drive active innovation in the field of new drug R&D. Both domestically and internationally, innovative small molecule drugs, antibody drugs, immune cell therapy, gene therapy and nucleic acid drugs are receiving intensive market …
New Frontier In Race For Deep Space Exploration: Lunar Water Resources,
2024
College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China
New Frontier In Race For Deep Space Exploration: Lunar Water Resources, Yong Wei, Honglei Lin, Fei He, Hui Zhang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Deep space exploration has become the commanding heights of science and technology competition. Since the beginning of the 21st century, China has successfully completed the lunar exploration missions of “orbiting, landing, and returning” in just twenty years, and upgraded to a new roadmap of “survey, construction, and utilization”. Meanwhile, lunar exploration worldwide has shown a trend towards normalization and commercialization. The research on lunar water resources has sparked widespread interest and intense competition among countries and space agencies, marking a new focus in human’s deep space exploration. The exploration of lunar water can help reveal crucial processes in the formation …
Multiple Input System Of Disruptive Technologies,
2024
Chinese Academy of Engineering Innovation Strategy, Beijing 100088, China
Multiple Input System Of Disruptive Technologies, Mimi Zhan, Xianke Peng, Xiaoyang Cao, Xiaomian Hu
Bulletin of Chinese Academy of Sciences (Chinese Version)
As the great power to drive human society’s development and the industrial transformation, disruptive technologies have attracted the attention of countries around the world. The major economies worldwide have made relevant strategic plans to develop disruptive technologies for preempting the zenith of technological innovation. As the effective approach to gather various resources, the multiple input system of disruptive technologies has become a place of strategic importance and related studies have also been paid more and more attention. The multiple input system of disruptive technologies is investigated firstly from the perspective of innovation mechanism in this study. Based on the innovation …
Synthetic Biology Enablement: From Academic Development To Industrial Transformation,
2024
Shanghai Information Center for Life Sciences, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China
University of Chinese Academy of Sciences, Beijing 100049, China
Synthetic Biology Enablement: From Academic Development To Industrial Transformation, Yan Xiong, Xueqing Ma, Daming Chen, Xiao Liu, Guoping Zhao
Bulletin of Chinese Academy of Sciences (Chinese Version)
Synthetic biology revolutionizes the comprehension of life systems from an engineering perspective, employing a “bottomup” approach in life science research. It adopts an iterative research paradigm of “design-build-test-learn” in life science research and creates engineered new life systems grounded in genomics and systems biology. This provides a new pathway of “from creation to understanding” for life sciences, departing from the traditional reductionist research strategy of “study the whole to understand the parts” and opening up a new culture of “building to understand” the essence of life. Additionally, synthetic biology elevates existing biotechnologies previously based on “simulating natural processes” and “genetic …
Advances In Data-Driven Life Sciences Research,
2024
Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Beijing Institute for Stem Cell and Regenerative Medicine, Chinese Academy of Sciences, Beijing 100101, China
Advances In Data-Driven Life Sciences Research, Haiping Jiang, Chunchun Gao, Wenhao Liu, Yungui Yang, Xin Li
Bulletin of Chinese Academy of Sciences (Chinese Version)
The field of life sciences is rapidly evolving, driven by advancements in experimental techniques and vast biological big data which gradually arise and play an increasingly important role in life science research. First of all, biological big data has diversity and complexity, including genomic data, epigenomic data, proteomic data and other types. These data provide researchers with more comprehensive information and help reveal the laws behind life phenomena. Second, new data-driven developments and applications in life sciences cover many fields such as gene editing, precision medicine, drug development, etc., providing unprecedented possibilities for human health and quality of life. However, …
Promoting Construction Of China’S Modern Industrial System By “ Multi-Tracking” Research And Innovation Model,
2024
The Institute for International Affairs, Qianhai, The Chinese University of Hong Kong, Shenzhen, Shenzhen 518172, China
Promoting Construction Of China’S Modern Industrial System By “ Multi-Tracking” Research And Innovation Model, Yongnian Zheng, Lanmeng Xu
Bulletin of Chinese Academy of Sciences (Chinese Version)
The core of the competition between large nations during the fourth industrial revolution is centered on economic resilience, which is based on the industrial system of each nation. The key takeaway from the historical experience of industrial development in the United Kingdom and the United States is that the building of a modern industrial system must prioritize the balanced development of industries rather than concentrating solely on the financial and service sectors and ignoring the manufacturing sector, which leads to industrial hollowing-out. China ought to build a modern industrial system that possesses the five characteristics, including industry comprehensiveness, large capacity, …
Policy Practices And Countermeasures Analysis On Deep Integration Of Technological Innovation And Industrial Innovation,
2024
China Science and Technology Assessment and Achievement Management Research Association, Beijing 100081, China
Policy Practices And Countermeasures Analysis On Deep Integration Of Technological Innovation And Industrial Innovation, Defang He, Tao Chen, Hui Liu, Fangjuan Yang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Technological innovation serves as the strategic foundation for driving high-quality development and building a modern industrial system. To compete for global leadership in science, technology, and industrial advancement, major economies worldwide are reshaping their policy frameworks to accelerate the development of cutting-edge technologies and future industries. This study analyzes the intrinsic mechanisms and policy evolution of the integration between technological innovation and industrial innovation. By examining domestic and international case studies—such as integrated circuits, mRNA vaccines, new energy vehicles, and photovoltaics—it reveals how strategic guidance and policy coordination facilitate the convergence of innovation chains and industrial chains. Furthermore, the study …
Research And Suggestions On Top-Down Design Methodology Of High-End Cnc Machine Tools,
2024
Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education, Tianjin University, Tianjin 300354, China
Research And Suggestions On Top-Down Design Methodology Of High-End Cnc Machine Tools, Weiguo Gao, Dawei Zhang, Bingye Liu
Bulletin of Chinese Academy of Sciences (Chinese Version)
The strategic significance of top-down design theory, method and technical system of high-end CNC machine tools is expounded, so as to realize the independent research and development of high-end CNC machine tools, satisfy the requirements of high-end users in key fields and maintain the independence and control of the core technologies. The top-down design methods and some key scientific problems are proposed, including static-dynamic stiffness design, geometric accuracy design, thermal balance design, and assembly process accuracy design, based on the spatial position and attitude error, relative dynamic flexibility of the working space, through the design, processing and assembly process. The …
Development Of China’S Ultra-Precision Equipment Industry And Support Of Patient Capital,
2024
China Development Bank, Beijing 100031, China
Development Of China’S Ultra-Precision Equipment Industry And Support Of Patient Capital, Hong Jiang
Bulletin of Chinese Academy of Sciences (Chinese Version)
As a core field of high-end manufacturing, China’s ultra-precision equipment industry has achieved rapid development driven by policy support and technological advancements. Nevertheless, it still faces challenges such as technological bottlenecks, international competition, and funding shortages. Its characteristics—long R&D cycles, high risks, and substantial capital investments—are misaligned with the risk-averse nature of traditional financial systems, urgently requiring the support of “patient capital”. Although China possesses a vast pool of long-term capital (e.g., social security funds and insurance funds), systemic gaps prevent these funds from being effectively transformed into patient capital that supports frontier technologies. This study argues that developing patient …
Ultra-Precision Equipment For 15th Five-Year Plan: Challenges And Opportunities,
2024
Ji Hua Laboratory (Guangdong Provincial Laboratory of Advanced Manufacturing Science and Technology), Foshan 528200, China
Ultra-Precision Equipment For 15th Five-Year Plan: Challenges And Opportunities, Jianlin Cao
Bulletin of Chinese Academy of Sciences (Chinese Version)
People generally refer to equipment with micron-level precision in manufacturing processes as precision equipment, while equipment meeting requirements beyond the micron level (nanometer-level) is termed ultra-precision equipment. Ultra-precision equipment serves as the foundation of advanced manufacturing today and is also a critical component of several high-tech industries, such as integrated circuits, displays, aerospace, instrumentation, and high-end machine tools. The level of ultra-precision equipment in these industries has a decisive impact on their development. Ultra-precision equipment is also the crystallization of modern scientific, technological, and engineering practices, and its development is a historically iterative process, requiring the interplay of demand-driven factors, …
Vigorously Promote Technological Innovation Oriented Towards Industrial Development,
2024
Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China
Vigorously Promote Technological Innovation Oriented Towards Industrial Development, Guojie Li
Bulletin of Chinese Academy of Sciences (Chinese Version)
From the perspective of scientific and technological workers, this study discusses some understanding and conceptual issues related to the deep integration of technological innovation and industrial innovation. Firstly, it points out that the shift from emphasizing “transformation of achievements” to emphasizing “deep integration of scientific and technological innovation and industrial innovation” is a sublimation in the understanding of the laws of scientific and technological development and economic growth. The connection point between scientific and technological innovation and industrial innovation is the problem to be solved, and the focus of the connection is frontier technology research to explore the feasible pathways. …
Byd: Practices And Reflections On Driving Green Development Through Integrated Innovation,
2024
BYD Company Limited, Shenzhen 518118, China
Byd: Practices And Reflections On Driving Green Development Through Integrated Innovation, Chuanfu Wang
Bulletin of Chinese Academy of Sciences (Chinese Version)
In three decades of development practice, BYD has upheld the technology-based and innovation-oriented mindset of development, and seized opportunities presented by technological revolutions and industrial transformations. From battery production, to automobile research and development (R&D) and to rail transit innovations, BYD has continuously deepened integrated development, achieving notable progress in implementing innovation-driven development strategies and cultivating new quality productive forces. This study examines BYD’s integrated innovation development practices as the primary framework, summarizing five distinctive characteristics: technological DNA, vertical integration and integrated innovation, precise strategy, talent engine, and green leadership. In light of future developmental requirements, it proposes relevant insights …
How To Scientifically Understand "New Quality Productivity",
2024
The Institute for International Affairs, Qianhai, the Chinese University of Hong Kong, Shenzhen, Shenzhen 518172, China
How To Scientifically Understand "New Quality Productivity", Yongnian Zheng
Bulletin of Chinese Academy of Sciences (Chinese Version)
New quality productivity (NQP) is a strategic concept that can be defined as all economic activities that can contribute to enhancing the technological content and value-added of products based on technological progress. Discussions on NQP will have to have a scientific sense of the industrial upgrading on the basis of technological progress, avoid restricting NQP to some specific areas of technological development, and treat NQP as technologically deterministic. Empirically speaking, the development of NQP can focus on the three core production factors of basic research, applied technology, and the financial system. In addition, it is necessary to provide an effective …
Nanozyme: Combining Power Of Natural Enzymes And Artificial Catalysis,
2024
Institutes of Science and Development, Chinese Academy of Sciences, Beijing 100190, China
Nanozyme: Combining Power Of Natural Enzymes And Artificial Catalysis, Peng Du, Lizeng Gao, Jian Jiao, Kelong Fan, Xiyun Yan
Bulletin of Chinese Academy of Sciences (Chinese Version)
Nanozymes represent a novel class of artificial enzymes and biocatalysts, possessing both the physical and chemical properties of nanomaterials along with unique enzyme-like catalytic activities, which breaks the boundary between inorganic materials and organic life. Unlike natural enzymes, traditional enzyme mimics and chemical catalysts, nanozymes exhibit catalytic activity that can be regulated by their nanoscale physical and chemical properties. They are characterized by good stability, high- and lowtemperature resistance, acid and alkali resistance, adjustable activity, and multifunctionality. As a result, nanozymes have garnered widespread attention in the fields of biomedicine, environment treatment, green agriculture, new energy resources, and have begun …
Brain Science And Brain-Inspired Intelligence In Intelligent Era,
2024
Chinese Neuroscience Society, Shanghai 200032, China; Guangdong Institute of Intelligence Science and Technology, Zhuhai 519031, China
Brain Science And Brain-Inspired Intelligence In Intelligent Era, Xu Zhang
Bulletin of Chinese Academy of Sciences (Chinese Version)
With intelligence technology as the core technology and intelligent computing power as the productive force, the intelligent era has once again pushed brain science to the forefront of world science and technology. Brain science is the science that studies the nature and rule of cognition and intelligence of human, animal, and machine. A comprehensive analysis of the structure and functional connection rule of the nervous system will eventually draw the functional connectivity map of the brain. In the past decade, neuroscience research has been committed to systematically analyzing the types of neurons and neural structural connections of the nervous system, …
Some Reflections On Developing Trend Of Gravimetry In China,
2024
State Key Laboratory of Geodesy and Earth's Dynamics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430077, China
College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
Some Reflections On Developing Trend Of Gravimetry In China, Heping Sun
Bulletin of Chinese Academy of Sciences (Chinese Version)
With the development of modern science and technology, gravimetry is growing vigorously and is increasingly becoming an interdisciplinary subject that is closely related to many others such as geology, fundamental physics, geodynamics, hydrology, oceanography, and astronomy. It is now a key subject in giving service to demands in national strategy and fundamental researches in geoscience such as fiducial surveying and mapping, resource exploration, military security, and hazard monitoring. Therefore, owning the core gravimetric techniques is one of the pivots which reflect national core competitiveness. This study first briefly overviews the history and actuality of the growth of gravimetry subject in …
Technology Innovation Is The Key To Future Space Science Missions,
2024
National Space Science Center, Chinese Academy of Sciences, Beijing 100190, China
Technology Innovation Is The Key To Future Space Science Missions, Ji Wu
Bulletin of Chinese Academy of Sciences (Chinese Version)
Space science is one of the important space activities of China together with space technology and space application. Although it is a space program aimed at scientific discovery and breakthrough, with the development of technology and the increasing number of achievements received in the past, space science missions require more and more technological innovation to achieve their goals. This study first reviews the development trend of space science missions since their birth, then analyzes the cultivation process of space science mission proposals with technological innovation and the responsibilities of the chief scientist leading such tasks, and finally analyzes and proposes …
Promoting Ecosystem Based Marine Management Through A Marine Ecological Classification And Zoning System,
2024
National Marine Data and Information Service, Tianjin 300171, China
Promoting Ecosystem Based Marine Management Through A Marine Ecological Classification And Zoning System, Wenhai Lu, Xiao Li, Meng Cui
Bulletin of Chinese Academy of Sciences (Chinese Version)
Ecosystem based ocean management is an important means of building marine ecological civilization. The current marine ecological classification and zoning in China comprehensively sorts out the types and natural geographical characteristics of marine ecosystems, divided the Chinese seas and adjacent waters into several levels of ecological spatial units according to different scales, effectively characterizes the geographical distribution features of marine biological communities and their habitats, and provides effective support for ecosystem based marine management. This study analyzed the practical significance of marine ecological classification and zoning. Based on a review of the development of marine ecological classification and zoning, this …
Winning Battle For Key And Core Technologies In Emerging Fields—Inspiration Based On 863 Program Related Projects,
2024
Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China
Winning Battle For Key And Core Technologies In Emerging Fields—Inspiration Based On 863 Program Related Projects, Guangzu Bai, Li Li, Hongfei Meng, Qiang Wang, Xiaoyang Cao, Anrong Liu, Bo Cheng, Mimi Zhan, Jing Li, Leiei Cui, Xiangwan Du
Bulletin of Chinese Academy of Sciences (Chinese Version)
Emerging technology fields have become the main battleground for strategic competition among major powers today, with key and core technologies serving as crucial approach in shaping a nation’s international competitive advantage. This study, from the perspective of national strategy, profoundly understands the significant importance of winning the key and core technology battle in emerging fields. Based on this understanding, it starts with a comparison between the implementation background of the 863 Program and the current reality. It systematically summarizes valuable experiences from projects aimed at advancing key and core technologies in emerging fields, and puts forward reflections and suggestions for …
Modernization Of Science And Technology From Perspective Of Chinese Path: Implications Of The Era, Characteristics, And Reflections,
2024
Publicity Department, Party Committee of University of Chinese Academy of Sciences, Beijing 100049, China
Modernization Of Science And Technology From Perspective Of Chinese Path: Implications Of The Era, Characteristics, And Reflections, Baoyu Jia, Yan Ying, Jiang Yu
Bulletin of Chinese Academy of Sciences (Chinese Version)
The modernization of science and technology is the key to Chinese path to modernization and plays a fundamental and strategic supporting role in building a powerful socialist modernization country. This study reviews various stages of development including sprouting and exploration, recovery and acceleration, catching up and leading, summarizes the characteristics and experience, and discusses the improvement in terms of level, concept, culture, topic selection, organization, system, governance, team, and guarantee, and then, proposes the concept of “Chinese Path to S&T Modernization”.
