Inhibition Of Irf5 Cellular Activity With Cell-Penetrating Peptides That Target Homodimerization,
2020
Northwell Health
Inhibition Of Irf5 Cellular Activity With Cell-Penetrating Peptides That Target Homodimerization, J. Banga, D. Srinivasan, C. Sun, C. D. Thompson, F. Milletti, K. Huang, S. Song, B. Matta, D. Li, B. J. Barnes, +17 Additional Authors
Journal Articles
No abstract provided.
Anodal Block Permits Directional Vagus Nerve Stimulation,
2020
Northwell Health
Anodal Block Permits Directional Vagus Nerve Stimulation, U. Ahmed, U. Ahmed, Y. C. Chang, M. Cracchiolo, M. F. Lopez, J. N. Tomaio, T. Datta-Chaudhuri, T. P. Zanos, L. Rieth, Y. Al-Abed, S. Zanos
Journal Articles
© 2020, The Author(s). Vagus nerve stimulation (VNS) is a bioelectronic therapy for disorders of the brain and peripheral organs, and a tool to study the physiology of autonomic circuits. Selective activation of afferent or efferent vagal fibers can maximize efficacy and minimize off-target effects of VNS. Anodal block (ABL) has been used to achieve directional fiber activation in nerve stimulation. However, evidence for directional VNS with ABL has been scarce and inconsistent, and it is unknown whether ABL permits directional fiber activation with respect to functional effects of VNS. Through a series of vagotomies, we established physiological markers for …
Evidence Supporting The Use Of Peptides And Peptidomimetics As Potential Sars-Cov-2 (Covid-19) Therapeutics,
2020
Northwell Health
Evidence Supporting The Use Of Peptides And Peptidomimetics As Potential Sars-Cov-2 (Covid-19) Therapeutics, S. Vanpatten, M. He, A. Altiti, K. F Cheng, M. H. Ghanem, Y. Al-Abed
Journal Articles
© 2020 Newlands Press. During a disease outbreak/pandemic situation such as COVID-19, researchers are in a prime position to identify and develop peptide-based therapies, which could be more rapidly and cost-effectively advanced into a clinical setting. One drawback of natural peptide drugs, however, is their proteolytic instability; peptidomimetics can help to overcome this caveat. In this review, we summarize peptide and peptide-based therapeutics that target one main entry pathway of SARS-CoV-2, which involves the host ACE2 receptor and viral spike (S) protein interaction. Furthermore, we discuss the advantages of peptidomimetics and other potential targets that have been studied using peptide-based …
Menstruation: Science And Society,
2020
Zucker School of Medicine at Hofstra/Northwell
Menstruation: Science And Society, H. O. Critchley, E. Babayev, S. E. Bulun, S. Clark, I. Garcia-Grau, P. K. Gregersen, A. Kilcoyne, J. Y. Kim, C. N. Metz, L. G. Griffith, +11 Additional Authors
Journal Articles
© 2020 The Authors Women's health concerns are generally underrepresented in basic and translational research, but reproductive health in particular has been hampered by a lack of understanding of basic uterine and menstrual physiology. Menstrual health is an integral part of overall health because between menarche and menopause, most women menstruate. Yet for tens of millions of women around the world, menstruation regularly and often catastrophically disrupts their physical, mental, and social well-being. Enhancing our understanding of the underlying phenomena involved in menstruation, abnormal uterine bleeding, and other menstruation-related disorders will move us closer to the goal of personalized care. …
Soluble Urokinase Plasminogen Activator Receptor (Supar) Levels Predict Damage Accrual In Patients With Recent-Onset Systemic Lupus Erythematosus,
2020
Zucker School of Medicine at Hofstra/Northwell
Soluble Urokinase Plasminogen Activator Receptor (Supar) Levels Predict Damage Accrual In Patients With Recent-Onset Systemic Lupus Erythematosus, H. Enocsson, L. Wirestam, C. Dahle, L. Padyukov, A. Jönsen, M. B. Urowitz, D. D. Gladman, C. Aranow, M. Mackay, C. Sjöwall, +36 Additional Authors
Journal Articles
© 2019 The Authors Objective: The soluble urokinase plasminogen activator receptor (suPAR) has potential as a prognosis and severity biomarker in several inflammatory and infectious diseases. In a previous cross-sectional study, suPAR levels were shown to reflect damage accrual in cases of systemic lupus erythematosus (SLE). Herein, we evaluated suPAR as a predictor of future organ damage in recent-onset SLE. Methods: Included were 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who met the 1997 American College of Rheumatology classification criteria with 5-years of follow-up data available. Baseline sera from patients and age- and sex-matched controls …
Immunological Significance Of Hmgb1 Post-Translational Modification And Redox Biology,
2020
Zucker School of Medicine at Hofstra/Northwell
Immunological Significance Of Hmgb1 Post-Translational Modification And Redox Biology, M. S. Kwak, H. S. Kim, B. Lee, Y. H. Kim, M. Son, J. S. Shin
Journal Articles
© Copyright © 2020 Kwak, Kim, Lee, Kim, Son and Shin. Most extracellular proteins are secreted via the classical endoplasmic reticulum (ER)/Golgi-dependent secretion pathway; however, some proteins, including a few danger-associated molecular patterns (DAMPs), are secreted via non-classical ER/Golgi-independent secretion pathways. The evolutionarily conserved high mobility group box1 (HMGB1) is a ubiquitous nuclear protein that can be released by almost all cell types. HMGB1 lacks signal peptide and utilizes diverse non-canonical secretion mechanisms for its extracellular export. Although the post-translational modifications of HMGB1 were demonstrated, the oxidation of HMGB1 and secretion mechanisms are not highlighted yet. We currently investigated that …
A Review Of Maternal Prenatal Exposures To Environmental Chemicals And Psychosocial Stressors-Implications For Research On Perinatal Outcomes In The Echo Program,
2020
Zucker School of Medicine at Hofstra/Northwell
A Review Of Maternal Prenatal Exposures To Environmental Chemicals And Psychosocial Stressors-Implications For Research On Perinatal Outcomes In The Echo Program, A. M. Padula, C. Monk, P. A. Brennan, A. Borders, E. S. Barrett, C. T. Mcevoy, S. Foss, P. K. Gregersen, B. Diamond, K. N. Botteron, +125 Additional Authors
Journal Articles
No abstract provided.
A Cross-Disease Meta-Gwas Identifies Four New Susceptibility Loci Shared Between Systemic Sclerosis And Crohn’S Disease,
2020
Zucker School of Medicine at Hofstra/Northwell
A Cross-Disease Meta-Gwas Identifies Four New Susceptibility Loci Shared Between Systemic Sclerosis And Crohn’S Disease, D. González-Serna, E. Ochoa, E. López-Isac, A. Julià, F. Degenhardt, N. Ortego-Centeno, T. R. Radstake, P. K. Gregersen, A. T. Lee, A. Gabrielli, +78 Additional Authors
Journal Articles
© 2020, The Author(s). Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn’s disease (CD), some of which confer susceptibility to both diseases. In order to identify new risk loci shared between these two immune-mediated disorders, we performed a cross-disease meta-analysis including GWAS data from 5,734 SSc patients, 4,588 CD patients and 14,568 controls of European origin. We identified 4 new loci shared between SSc and CD, IL12RB2, IRF1/SLC22A5, STAT3 and an intergenic locus at 6p21.31. Pleiotropic variants within these loci showed opposite allelic effects in the two analysed diseases …
Neutrophil Extracellular Traps In Covid-19.,
2020
Northwell Health
Neutrophil Extracellular Traps In Covid-19., Y Zuo, S Yalavarthi, H Shi, K Gockman, M Zuo, Ja Madison, C Blair, A Weber, Bj Barnes, M Egeblad, Rj Woods, Y Kanthi, Js Knight
Journal Articles
No abstract provided.
Sars-Cov-2 And Interferon Blockade,
2020
Zucker School of Medicine at Hofstra/Northwell
Sars-Cov-2 And Interferon Blockade, B. Diamond, B. T. Volpe, S. Van Patten, Y. Al Abed
Journal Articles
© 2020, The Author(s). The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.
Systemic Inflammation In Traumatic Spinal Cord Injury,
2020
Zucker School of Medicine at Hofstra/Northwell
Systemic Inflammation In Traumatic Spinal Cord Injury, O. Bloom, P. E. Herman, A. M. Spungen
Journal Articles
No abstract provided.
A Pilot Study Testing A Novel 3d Printed Amphibious Lower Limb Prosthesis In A Recreational Pool Setting,
2020
Zucker School of Medicine at Hofstra/Northwell
A Pilot Study Testing A Novel 3d Printed Amphibious Lower Limb Prosthesis In A Recreational Pool Setting, T. Goldstein, A. Oreste, G. Hutnick, A. Chory, V. Chehata, J. Seldin, M. D. Gallo, O. Bloom
Journal Articles
No abstract provided.
Relative Ratios Enhance The Diagnostic Power Of Phospholipids In Distinguishing Benign And Cancerous Ovarian Masses,
2020
Northwell Health
Relative Ratios Enhance The Diagnostic Power Of Phospholipids In Distinguishing Benign And Cancerous Ovarian Masses, T. Yagi, C. E. Kuschner, M. Shoaib, R. C. Choudhary, L. B. Becker, A. T. Lee, J. Kim
Journal Articles
No abstract provided.
Predictive Value Of 18F-Florbetapir And 18F-Fdg Pet For Conversion From Mild Cognitive Impairment To Alzheimer Dementia,
2020
Northwell Health
Predictive Value Of 18F-Florbetapir And 18F-Fdg Pet For Conversion From Mild Cognitive Impairment To Alzheimer Dementia, G. Blazhenets, Y. Ma, A. Sörensen, F. Schiller, G. Rücker, D. Eidelberg, L. Frings, P. T. Meyer
Journal Articles
© 2020 by the Society of Nuclear Medicine and Molecular Imaging. The present study examined the predictive values of amyloid PET, 18F-FDG PET, and nonimaging predictors (alone and in combination) for development of Alzheimer dementia (AD) in a large population of patients with mild cognitive impairment (MCI). Methods: The study included 319 patients with MCI from the Alzheimer Disease Neuroimaging Initiative database. In a derivation dataset (n = 159), the following Cox proportional-hazards models were constructed, each adjusted for age and sex: amyloid PET using 18F-florbetapir (pattern expression score of an amyloid-β AD conversion-related pattern, constructed by principle-components analysis); 18F-FDG …
Hmgb1 In Systemic Lupus Erythematosus,
2020
Zucker School of Medicine at Hofstra/Northwell
Hmgb1 In Systemic Lupus Erythematosus, T. Liu, M. Son, B. Diamond
Journal Articles
No abstract provided.
Potential T Cell-Intrinsic Regulatory Roles For Irf5 Via Cytokine Modulation In T Helper Subset Differentiation And Function,
2020
Zucker School of Medicine at Hofstra/Northwell
Potential T Cell-Intrinsic Regulatory Roles For Irf5 Via Cytokine Modulation In T Helper Subset Differentiation And Function, Z. Brune, M. R. Rice, B. J. Barnes
Journal Articles
No abstract provided.
Modulating Cytokine Production Via Select Packaging And Secretion From Extracellular Vesicles,
2020
Zucker School of Medicine at Hofstra/Northwell
Modulating Cytokine Production Via Select Packaging And Secretion From Extracellular Vesicles, B. J. Barnes, C. C. Somerville
Journal Articles
No abstract provided.
Reproducible Metabolic Topographies Associated With Multiple System Atrophy: Network And Regional Analyses In Chinese And American Patient Cohorts,
2020
Northwell Health
Reproducible Metabolic Topographies Associated With Multiple System Atrophy: Network And Regional Analyses In Chinese And American Patient Cohorts, B. Shen, S. Wei, J. Ge, S. Peng, F. Liu, L. Li, S. Guo, P. Wu, D. Eidelberg, Y. Ma, +2 Additional Authors
Journal Articles
© 2020 The Authors Purpose: Multiple system atrophy (MSA) is an atypical parkinsonian syndrome and often difficult to discriminate clinically from progressive supranuclear palsy (PSP) and Parkinson's disease (PD) in early stages. Although a characteristic metabolic brain network has been reported for MSA, it is unknown whether this network can provide a clinically useful biomarker in different centers. This study was aimed to identify and cross-validate MSA-related brain network and assess its ability for differential diagnosis and clinical correlations in Chinese and American patient cohorts. Methods: We included 18F-FDG PET scans retrospectively from 128 clinically diagnosed parkinsonian patients (34 MSA, …
Nono Is A Novel Co-Factor Of Prdm1 And Regulates Inflammatory Response In Monocyte Derived-Dendritic Cells,
2020
Northwell Health
Nono Is A Novel Co-Factor Of Prdm1 And Regulates Inflammatory Response In Monocyte Derived-Dendritic Cells, K. Lee, S. H. Jang, H. Tian, S. J. Kim
Journal Articles
© Copyright © 2020 Lee, Jang, Tian and Kim. Proper expression of the transcription factor, Positive regulatory domain 1 (PRDM1), is required for maintaining homeostasis of human monocyte derived-dendritic cells (MO-DCs). The molecular mechanisms and gene targets of PRDM1 in B and T lymphocytes have been identified. However, the function of PRDM1 in dendritic cells (DCs) remains unclear. We investigate co-regulators of PRDM1 in MO-DCs identified by mass spectrometry (MS) and co-immunoprecipitation (Co-IP). Notably, non-POU domain-containing octamer-binding protein (NonO) was found to be a PRDM1 binding protein in the nucleus of MO-DCs. NonO is recruited to the PRDM1 binding site …
Ultrasound Powered Piezoelectric Neurostimulation Devices: A Commentary.,
2020
Zucker School of Medicine at Hofstra/Northwell
Ultrasound Powered Piezoelectric Neurostimulation Devices: A Commentary., T. Sun, J. Wright, T. Datta-Chaudhuri
Journal Articles
Conventional neurostimulation systems for preclinical research can be bulky and invasive due to the need for batteries or wired interfaces. Emerging as a new neural interface technique, ultrasound-powered piezoelectric neural stimulators work by converting ultrasound energy to electrical charge for neural stimulation. In addition to the benefits of wireless powering and miniaturization leading to less traumatic surgery, piezoelectric neural stimulators can also exhibit prolonged operational lifetimes for a long-term stable neural interface, and show promise for clinical translation. As one of first steps to demonstrate the value of ultrasound-powered piezoelectric neural interface, Li et al. developed a piezoelectric stimulator to …
