A Computational Framework For Proteome-Wide Pursuit And Prediction Of Metalloproteins Using Icp-Ms And Ms/Ms Data,
2011
Philadelphia College of Osteopathic Medicine
A Computational Framework For Proteome-Wide Pursuit And Prediction Of Metalloproteins Using Icp-Ms And Ms/Ms Data, W. Andrew Lancaster, Jeremy L. Praissman, Farris L. Poole, Aleksandar Cvetkovic, Angeli Lal Menon, Joseph W. Scott, Francis E. Jenney, Michael P. Thorgersen, Ewa Kalisiak, Junefredo V. Apon, Sunia A. Trauger, Gary Siuzdak, John A. Tainer, Michael W. W. Adams
PCOM Scholarly Works
BACKGROUND: Metal-containing proteins comprise a diverse and sizable category within the proteomes of organisms, ranging from proteins that use metals to catalyze reactions to proteins in which metals play key structural roles. Unfortunately, reliably predicting that a protein will contain a specific metal from its amino acid sequence is not currently possible. We recently developed a generally-applicable experimental technique for finding metalloproteins on a genome-wide scale. Applying this metal-directed protein purification approach (ICP-MS and MS/MS based) to the prototypical microbe Pyrococcus furiosus conclusively demonstrated the extent and diversity of the uncharacterized portion of microbial metalloproteomes since a majority of the …
The Cardiac Atlas Project--An Imaging Database For Computational Modeling And Statistical Atlases Of The Heart,
2011
Touro College
The Cardiac Atlas Project--An Imaging Database For Computational Modeling And Statistical Atlases Of The Heart, Carissa G. Fonseca, Michael Backhaus, David A. Bluemke, Randall D. Britten, Jae Do Chung, Brett R. Cowan, Alan H. Kadish
Office of the President Publications and Research
MOTIVATION: Integrative mathematical and statistical models of cardiac anatomy and physiology can play a vital role in understanding cardiac disease phenotype and planning therapeutic strategies. However, the accuracy and predictive power of such models is dependent upon the breadth and depth of noninvasive imaging datasets. The Cardiac Atlas Project (CAP) has established a large-scale database of cardiac imaging examinations and associated clinical data in order to develop a shareable, web-accessible, structural and functional atlas of the normal and pathological heart for clinical, research and educational purposes. A goal of CAP is to facilitate collaborative statistical analysis of regional heart shape …
Computational Analyses Of The Uptake And Distribution Of Carbon Monoxide (Co) In Human Subjects,
2011
University of Kentucky
Computational Analyses Of The Uptake And Distribution Of Carbon Monoxide (Co) In Human Subjects, Kinnera Chada
University of Kentucky Doctoral Dissertations
Carbon monoxide (CO) is an odorless, colorless, tasteless gas that binds to hemoglobin with high affinity. This property underlies the use of low doses of CO to determine hemoglobin mass (MHb) in the fields of clinical and sports medicine. However, hemoglobin bound to CO is unable to transport oxygen and exposure to high CO concentrations is a significant environmental and occupational health concern. These contrasting aspects of CO—clinically useful in low doses but potentially lethal in higher doses—mandates a need for a quantitative understanding of the temporal profiles of the uptake and distribution of CO …
Improving Quantitative Treatment Response Monitoring With Deformable Image Registration,
2010
University of Texas Graduate School of Biomedical Sciences at Houston
Improving Quantitative Treatment Response Monitoring With Deformable Image Registration, Blake A. Cannon
Dissertations and Theses (Open Access)
Quantitative imaging with 18F-FDG PET/CT has the potential to provide an in vivo assessment of response to radiotherapy (RT). However, comparing tissue tracer uptake in longitudinal studies is often confounded by variations in patient setup and potential treatment induced gross anatomic changes. These variations make true response monitoring for the same anatomic volume a challenge, not only for tumors, but also for normal organs-at-risk (OAR). The central hypothesis of this study is that more accurate image registration will lead to improved quantitation of tissue response to RT with 18F-FDG PET/CT. Employing an in-house developed “demons” based deformable image registration algorithm, …
Cellular Automata Rules Generator For Microbial Communities,
2010
California State University, San Bernardino
Cellular Automata Rules Generator For Microbial Communities, Melissa Marie Quintana
Theses Digitization Project
The purpose of this project is to provide a visual representation as program output so that the rules and the radius of effect can be estimated. Currently there is a need for a method that extracts the cellular automata rules which simulate the growth patterns of microbial communities found within extreme environments. Contains source code.
To Live And Die In Ca,
2010
California State University, San Bernardino
To Live And Die In Ca, Jane Frances Curnutt
Theses Digitization Project
This thesis investigates the nature of elementary cellular automata to better understand their relationship of the models they support to the biological organisms that create the mats and soil crusts found in extreme environments here on earth. Cellular automata have been used to study growth and patterns in forests, arid desert environments, predator-prey problems, and sea shells. It has also been used to study areas of diverse epidemiology and linguistics. Cellular automata have been used as the core of computer games as well. This investigation has led to develop a graphical grammar for simple cellular automata, using L-systems, a grammar …
Reordered Subsets Reconstruction Of Proton Computed Tomography,
2010
California State University, San Bernardino
Reordered Subsets Reconstruction Of Proton Computed Tomography, Wenzhe Xue
Theses Digitization Project
This project investigates the improvement of iterative reconstruction using reordered subsets. Block iterative projection and Ordered Subset reconstruction algorithms are developed to improve the performance of image reconstruction. Contains source code.
Authentication Of Biometric Features Using Texture Coding For Id Cards,
2010
Technological University Dublin
Authentication Of Biometric Features Using Texture Coding For Id Cards, Jonathan Blackledge, Eugene Coyle
Conference papers
The use of image based information exchange has grown rapidly over the years in terms of both e-to-e image storage and transmission and in terms of maintaining paper documents in electronic form. Further, with the dramatic improvements in the quality of COTS (Commercial-Off-The-Shelf) printing and scanning devices, the ability to counterfeit electronic and printed documents has become a widespread problem. Consequently, there has been an increasing demand to develop digital watermarking techniques which can be applied to both electronic and printed images (and documents) that can be authenticated, prevent unauthorized copying of their content and, in the case of printed …
