Food Science Commons^™

Living Heritage, Resilience And Ethically Informed Infrastructures In Malawi, Martha B. Lerski, Frank Puluputu Mwale

Publications and Research

Rooted in a rural community’s needs, this paper explores how historically, and ethically informed infrastructures can support community engagement towards identification, documentation, and dissemination of local, traditional, and indigenous knowledge relating to climate change. The paper examines climate adaptation and sustainability issues through the lenses of community organizing and Library & Information Science best practices. It draws on a growing body of literature identifying a role for expanded epistemological and subject discipline perspectives. While the impacts of climate on material culture are increasingly recognized, intangible, and biocultural heritage have not received as much attention. Living heritage traditions and knowledge systems …

The Dynamic Responses Of The Mouse Gut Microbiome To Dietary Supplementation With Various Anthocyanin-Rich Foods In The Context Of A Western Diet, Abby D. Benninghoff

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Background/Objectives: Chronic inflammation and Western-style diets elevate colorectal cancer (CRC) risk, particularly in individuals with colitis, a feature of inflammatory bowel disease (IBD). Diets rich in polyphenol-containing functional foods, such as cocoa, may reduce gut inflammation and modulate the gut microbiome. This study examined the effects of cocoa polyphenol (CP) supplementation on inflammation and microbiome composition before, during, and after colitis in mice fed either a healthy or Western diet. We hypothesized that CPs would attenuate inflammation and promote distinct micro-biome shifts, especially in the context of a Western diet. Methods: A 2×2 factorial design tested the effects of basal …

Utilization Of Watermelon Rind Waste Powder For Developing Bakery Products, Babar Khan, Asadullah Marri, Nida Shaikh, Asif Irshad

Journal of Bioresource Management

Watermelon rind waste powder (WRWP) is a rich source of dietary fiber and bioactive compounds; hence it could be used to develop functional foods such as bakery products. The present study aimed to utilize WRWP in bakery products development. The treatments included: T₁ = Cake without WRWP, T₂ = Cake with 10 % WRWP, T₃= Cake with 20 % WRWP, T₄= Biscuit without WRWP, T₅ = Biscuit with 10 % WRWP, T₆ = Biscuit with 20 % WRWP. The physicochemical and nutritional properties of watermelon rind waste powder were also determined. The …

Descriptive Sensory Analysis Of Gluten-Containing And Gluten-Free Chocolate Chip Cookies Available In The Marketplace, Eniola Ola, Victoria J. Hogan, Han-Seok Seo

Food Science Faculty Publications and Presentations

Limited research has systematically compared the detailed sensory profiles of commercially available gluten-containing (C) and gluten-free (F) cookies using trained panelists. This study aimed to develop a comprehensive sensory lexicon for C and F chocolate chip cookies and identify key sensory attributes that differentiate them. Seven professionally trained panelists created a lexicon of 33 attributes spanning aroma, flavor, basic taste, texture, and residual property. Using this lexicon, a descriptive analysis was conducted on 12 C and 12 F cookie samples. Multivariate analysis of variance revealed significant differences between the two groups across the 33 sensory attributes (p < 0.05). A mixed model analysis showed that C cookies had higher intensities of chocolate-related and sweet aroma complex notes, while F cookies exhibited stronger nutty, artificial, and off-note flavors. In terms of texture, F cookies were higher in toothpack and powdery mouthcoat, while C cookies displayed more melt-in-mouth characteristics. Principal component analysis and agglomerative hierarchical clustering revealed three distinct clusters of test samples within both crispy and chewy cookie types, with some F cookies closely aligning with C profiles. These findings, along with the developed lexicon, provide a valuable foundation for enhancing the sensory appeal and quality of gluten-free chocolate chip cookies.

A Study On Combined Effect Of Monoterpenoid Essential Oils And Polyphenols From Grape Pomace On Selected Pathogenic And Probiotic Bacteria Strains, Haona Bao, Cosmas Mwendwa Muasya, Fur-Chi Chen, Agnes Kilonzo-Nthenge, Ying Wu

Food and Animal Sciences Faculty Research

In the current study, the combined effects of essential oils (EOs) and polyphenols (PPs) were investigated as potential antibiotic alternatives. Thymol and carvacrol at a ratio of 1:1 was used as the EO due to their well-proven synergistic antimicrobial effect. The PPs were an extracted and freeze-dried product from grape pomace. The treatment solutions were prepared at the EO to PP ratios of 0:10, 3:7, 5:5, 7:3, and 10:0, at total concentrations ranging from 0 to 1000 ppm. The minimum inhibition concentrations were examined on the pathogenic bacteria strains, namely Escherichia coli O157:H7, Salmonella typhimurium, and Enterococcus cloacae, and a …

Evaluating The Chemical Composition And Sensory Attributes Of Japanese And U.S. Sake, Rahul Sen, Katie Hope, Ben Bell, Scott Robert Lafontaine

Food Science Faculty Publications and Presentations

Sake, a traditional rice beverage from Japan, is brewed using four key ingredients: rice, water, a koji mold, and yeast. While sake is gaining popularity in the US market, there remains a significant knowledge gap regarding the best practices for sake production and how different methods impact the chemical and sensory aspects of American sake as well as its resemblance to traditional Japanese sake. This study compared 21 sake samples from Japan and the U.S., covering grades such as ginjo, diaginjo, junmai, and nigori. Out of total 209 features, 120 were significant aromatic compounds with esters (e.g., ethyl decanoate, hexyl …

Filtration Challenges In Non-Alcoholic And Low-Alcohol Beer Production With A Focus On Different Yeast Strains, Christian Schubert, Joerg Maxminer, Matthew Aitkens, Andrew Maust, Bernardo Pontes Guimaraes, Rahul Sen, Scott Lafontaine

Food Science Faculty Publications and Presentations

This study examines the impact of yeast selection on fermentation performance, filtration efficiency, and the stability of low-alcohol and non-alcoholic beer (NAB). Three yeast strains (LA-01, LoNa, and W-34/70) were evaluated for their effects on key NAB parameters like ABV, bitterness, color, haze readings, and filtration-linked performance. Filtration trials revealed that highly flocculating W-34/70 resulted in lower post-filtration turbidity, whereas LA-01 and LoNa (which flocculated less) required more effective filtration techniques to achieve clarity. Among the tested filter sheets, AF 31, AF 71, and AF 101 successfully reduced turbidity below 2 EBC. However, all NABs exhibited haze formation during storage, …

Research Progress In The Application Of Tea Polyphenols In Meat Processing And Preservation, Yanting Gao, Huanhuan Li, Teng Xu, Ke Zhao, Mingwei Su, Liwen Wu, Honggang Tang

Journal of Food Science and Biotechnology

Tea polyphenols are the general term for polyphenols in tea,mainly including catechins,flavonoids,and anthocyanins,which have antioxidant and antimicrobial properties.The author reviewed the structural characteristics and the antioxidant and antibacterial mechanisms of tea polyphenols.Additionally,the application of tea polyphenols in the processing and preservation of meat products is summarized,providing a theoretical basis for their use in meat products.Studies have shown that tea polyphenols can achieve anti-oxidation by scavenging free radicals,chelating metal ions,and inhibiting oxidase activity.Moreover,tea polyphenols can inhibit cell growth and proliferation by inhibiting the activities of enzymes involved in cell metabolism and damaging the cell membrane system.As natural antioxidants,tea polyphenols can significantly …

Safety Properties , Growth Characteristics , And Fermentation Performance Of Tetragenococcus Halophilus, Ranhui Lyu, Yanhua Zhong, Yang You, Runhan Yuan, Enyi Guan, Shan Duan

Journal of Food Science and Biotechnology

[Objective ] The physiological characteristics vary greatly among different strains of Tetragenococcus halophilus (T.halophilus ).By comparing some indicators of safety properties,growth characteristics,and fermentation performance of T.halophilus strains from different sources,the authors aim to establish a regular understanding of this bacterial species.[Method ] Seventeen strains of T.halophilus derived from different aquatic products and soy sauce mash were selected,and their antibiotic resistance,biogenic amine production,hemolytic activity,growth under different environmental conditions,and flavor characteristics after fermenting soybean hydrolysate were determined.Additionally,correlation analysis was conducted to identify the associations among various indicators.[Result ] In terms of safety properties,the 17 strains were generally sensitive to penicillin,vancomycin,and tetracycline,but resistant …

Analysis Of Volatile Aroma Components Of Black Tea Samples From Different Tea Varieties In Guangxi Based On Hs-Spme-Gc-Ms Technology, Yunxiong Zhao, Hongyu Feng, Ziping Li, Baogui Liu, Yunxian Wang, Jingjing Yang, Lianfeng Luo

Journal of Food Science and Biotechnology

[Objective ] This study aims to analyze the characteristics of volatile aroma components and key aroma components of black tea samples from different tea varieties in Guangxi.[Method ] The aroma components of 12 black tea samples from Guangxi were identified by sensory quality evaluation,headspace solid-phase microextraction-gas chromatography-mass spectrometry （HS-SPME-GC-MS ）,hierarchical cluster analysis,and orthogonal partial least squares-discrimination analysis (OPLS-DA ).[Result ] The black tea samples from different tea varieties showed different aroma characteristics and mainly presented a floral fruity aroma or a sweet aroma.The black tea from ‘Wuniuzao ’ demonstrated the highest comprehensive score (91.20),being a representative of black tea with …

Construction , Structural Characterization , And Antioxidant Activity Evaluation Of Yam Polysaccharide-Selenium Nanoparticle Complexes, Yidong Xiao, Lanmei Ou, Mengmeng Zhao

Journal of Food Science and Biotechnology

[Objective ] This study explored the structural characteristics and in vitro antioxidant activity of yam polysaccharide-selenium nanoparticle (YP-SeNPs ) complexes.[Method ] Yam polysaccharide (YP) were obtained through hot water extraction and then purified by purification,diethylaminoethyl cellulose 52 (DEAE-52) column chromatography,and dialysis.With YP as a template,YP-SeNPs were prepared with different Se/YP mass ratios (1∶3,1∶1,and 4∶3) in an oxidation-reduction system comprising ascorbic acid (VC) and sodium selenite (Na 2SeO 3）.The complexes were characterized via multiple techniques,including visual observation of solution color,ultraviolet-visible absorption (UV-vis ) spectroscopy,particle size measurement,transmission electron microscopy (TEM ),scanning electron microscopy (SEM ),atomic force microscopy (AFM ),Fourier-transform infrared spectroscopy (FT-IR …

Preparation And Anti-Exercise Fatigue Effect Evaluation Of Γ-Aminobutyric Acid-Enriched Milk Fermented With Lactic Acid Bacteria, Dong Liu, Yuning Yang, Fangfei Dou, Yuxing Li, Minghai Ju

Journal of Food Science and Biotechnology

[Objective ] This study aims to prepare γ-aminobutyric acid (GABA )-enriched milk fermented with lactic acid bacteria and evaluate its anti-exercise fatigue effect.[Method ] High GABA-producing lactic acid bacteria were selected and used to ferment milk with a commercial starter culture.A mouse model of exercise fatigue was established by four weeks of exhaustive swimming training.After four weeks,the exhaustive swimming time,serum biochemical indicators,antioxidant indicators,and energy storage substance levels were measured and analyzed.[Result ] Lactobacillus plantarum (L.plantarum ) LP- 5 was selected as the strain for fermentation,and its GABA yield reached (1.340±0.003) g/L.The fermented milk showed the titratable acidity of (46.29±2.01) ºT,the …

Research Progress In Application Of Ultra-High Pressure Sterilization In The Processing Of Prepared Dishes, Haisheng Dong, Peng Zang

Journal of Food Science and Biotechnology

As a non-thermal sterilization technology,ultra-high pressure sterilization can protect the thermosensitive nutrients and maintain the texture of food,demonstrating unique technical advantages in the processing of prepared dishes.By a review of domestic and foreign literature and performance of relevant equipment,this paper introduced the principle,equipment,and parameters of ultra-high pressure sterilization.Considering the parameters of ultra-high pressure sterilization and the effects of food ingredients on the pressure tolerance of different microbial species,the factors affecting the effect of ultra-high pressure sterilization were analyzed.In addition,the effects of ultra-high pressure sterilization on the physical and chemical properties,sensory quality,enzyme activity,microorganisms count and bioactive substances of prepared dishes were …

Research Progress In Biological Activities , Mechanisms Of Action , And Applications Of Antimicrobial Peptides, Yuxin Jiao, Ruolan Shan, Xufeng Wang, Maolong Chen, Li Wen, Yunhui Cheng, Hao Wu

Journal of Food Science and Biotechnology

The widespread abuse of traditional antibiotics has led to the emergence and development of antimicrobial peptides due to the resultant bacterial resistance.Antimicrobial peptides demonstrate high efficacy in combating infectious pathogens and possess unique antimicrobial mechanisms and biocompatibility,effectively reducing the bacterial resistance rate.The high structural adaptability endows antimicrobial peptides with multiple biological activities,enabling targeted action against diverse types of pathogens and abnormal cells.Accordingly,antimicrobial peptides exhibit a promising development prospect.Enhanced stability contributes to prolonging the in vivo half-life and improving the bioavailability of antimicrobial peptides,which holds crucial importance for improving the clinical translation value of antimicrobial peptides.The author summarizes the research progress …

Mechanisms Of The Quality Changes Of Polygonati Rhizoma Processed By Steaming-Drying Cycles, Zicong Yu, Liuping Fan

Journal of Food Science and Biotechnology

[Objective ] This study aims to investigate the effects of steaming-drying cycles on the quality changes of Polygonati rhizoma and optimize the processing technology to enhance its application value.[Method ] Slices of Polygonati rhizoma processed by 0~5 steaming-drying cycles were prepared.The drying rate and drying kinetics during the drying stage after each cycle were analyzed,and a drying model was fitted.Changes in color difference,appearance,hardness,and mass fractions of polysaccharides,reducing sugars,polyphenols,flavonoids,saponins,and calcium oxalate raphides were measured.[Result ] The number of steaming-drying cycles significantly affected the quality of Polygonati rhizoma.The drying rate decreased as the drying time increased,conforming to the Modified Page model,while the …

Determination Of Microorganisms And Analysis Of Factors Influencing Osmophilic Yeasts In Apis Cerana Honey, Mei Song, Hongxia Li, Zhaolong Liu, Dong Qiao, Na Li, Lanzhen Chen

Journal of Food Science and Biotechnology

[Objective ] This study determined the mold count,total plate count,and osmophilic yeast count in Apis cerana honey and explored the correlations of osmophilic yeasts with quality parameters and storage conditions of the honey.[Method ] A total of 105 Apis cerana honey samples were used for the determination of mold count,total plate count,and osmophilic yeast count,as well as odor,moisture,phenolic acids,and carbohydrates.The correlations between quality indexes and osmophilic yeasts and the effects of different storage conditions on osmophilic yeast count were explored.[Result ] Among the 105 samples,1,1,and 67 samples showed the mold count,total plate count,and osmophilic yeast count exceeding the national standards.All …

Photosensitizer-Loaded Glycogen For Photodynamic Therapy Of Tumor, Keke Ma, Jiurui Fang, Huijie Zhang, Jinghua Chen

Journal of Food Science and Biotechnology

[Objective ] The aim of this study is to synthesize aminated glycogen (NG) for loading of the photosensitizer TTVBA and construct a nano drug delivery system (NGT NPs ) for photodynamic therapy (PDT ) of tumors.[Method ] Positively charged NG was synthesized through modification of glycogen with diethylenetriamine (DETA ).Then,TTVBA was encapsulated by NG via electrostatic interaction to prepare NGT NPs.The prepared NGT NPs were characterized by infrared spectroscopy,dynamic light scattering (DLS ),and transmission electron microscopy (TEM ).The hemolysis assay was performed to evaluate the biocompatibility of NGT NPs.The reactive oxygen species (ROS ) generation capability of cells treated with …

Prokaryotic Expression , Purification , And Polyclonal Antibody Preparation Of Chlamydomonas Reinhardtii Channelrhodopsin 1, Jiurong Wang, Bin Xue, Zhenchuan Fan

Journal of Food Science and Biotechnology

[Objective ] This study aims to prepare a highly specific antibody against channelrhodopsin- 1 (ChR 1) from Chlamydomonas reinhardtii (C.reinhardtii ) and investigate its regulatory mechanisms in cellular phototaxis and negative phototaxis.[Method ] The recombinant expression vector pET- 28a(+)-chr1 was constructed and transformed into Escherichia coli (E.coli ) BL21 (DE3) competent cells.The expression of the fusion protein 6×His∷ChR 1 was induced with IPTG,and the obtained protein was purified by nickel-affinity chromatography.The purified protein was used to immunize New Zealand white rabbits for the production of ChR 1 antiserum.ChR 1-specific IgG antibodies were enriched from the antiserum through protein A purification.The …

Engineering Escherichia Coli Tolerance To Improve Succinic Acid Production, Jingyu Pan, Yongsheng Tang, Jia Liu, Cong Gao, Xiaomin Li, Wei Song, Wanqing Wei, Guipeng Hu, Jing Wu, Liming Liu, Xiulai Chen

Journal of Food Science and Biotechnology

[Objective ] This study aims to enhance the high osmotic pressure tolerance of Escherichia coli (E.coli ) for the efficient production of succinic acid.[Method ] Adaptive evolution,transcriptomic analysis,reverse metabolic engineering,and fermentation optimization were employed for improving E.coli tolerance to high osmotic pressure.[Result ] By analyzing the key factors influencing succinic acid production by fermentation,osmotic pressure was identified as the critical factor reducing succinic acid production efficiency.A mutant strain,E.coli FN-6,with tolerance to high osmotic pressure was obtained through adaptive evolution.The key gene cusC responsible for osmotic pressure tolerance was identified by transcriptomic analysis.After optimization of the expression level of cusC,the engineered …

Study On The Antioxidant Effects Of Natural Antioxidants And Their Derivatives On Anchovy (Engraulis Japonicus ) Oil, Xuyang Ding, Fujun Liu, Fawen Yin, Dayong Zhou

Journal of Food Science and Biotechnology

[Objective ] The aim of this study is to evaluate and improve the antioxidant effects of natural antioxidants and their derivatives on anchovy (Engraulis japonicus ) oil.[Method ] The 60 ℃ accelerated oxidation model was used to evaluate the antioxidant effects of phytic acid,tea polyphenols (TP),rosemary extract,ascorbyl palmitate,vitamin E,tea polyphenol palmitate (TPP),and bamboo leaf extract on anchovy oil based on the peroxide value (POV ),thiobarbituric acid reactive substances (TBARS ) value,relative intensity of free radicals,and fatty acid composition.[Result ] TPP (single antioxidant ) and TPP+TP (composite antioxidant ) demonstrated the strongest antioxidant effects on anchovy oil.[Conclusion ] Although the antioxidant …

Establishment Of Surface-Enhanced Raman Spectroscopy For Detection Of Escherichia Coli O157:H7, Panxue Wang, Cen Li, Xiang Li, Ying Liu, Guoliang Li

Journal of Food Science and Biotechnology

[Objective ] This study aims to improve the detection specificity and sensitivity for Escherichia coli (E.coli ) O157:H7.[Method ] A high ly specific and sensitive method for the detection of E.coli O157:H7 was established based on magnetic separation and signal amplification strategies combined with surface-enhanced Raman spectroscopy (SERS ).Aptamers were used as recognition elements and combined with magnetic beads and polystyrene (PS) microspheres to construct a separation probe (MB@Apt ) and a signal amplification Raman tag (4-MBN@PS@Apt ),respectively.[Result ] In the presence of E.coli O157:H7,MB@Apt and 4-MBN@PS@Apt formed a “sandwich ” structured composite (MB@Apt/ E.coli O157:H7/4-MBN@PS@Apt ),which could be rapidly …

Rapid Determination Of Vitamin B 1 In Infant Formula Milk Powder By Fluorescent Microsphere Immunochromatographic Assay, Qianqian Lu, Ting Yang, Yongwei Feng, Jialin Hu, Hua Kuang, Chuanlai Xu, Lingling Guo

Journal of Food Science and Biotechnology

[Objective ] A fluorescent immunochromatographic assay was established based on vitamin B 1 monoclonal antibody to measure the vitamin B 1 in infant formula milk powder.[Method ] The performance of vitamin B 1 monoclonal antibody was evaluated.On this basis,a highly sensitive fluorescent immunochromatographic test strip was developed.[Result ] The vitamin B 1 monoclonal antibody showed high sensitivity,affinity,and specificity.The fluorescent immunochromatographic test strip showed a visual limit of detection (vLOD ) of 10 μg/kg,a cut-off value of 200 μg/kg,and a calculated limit of detection (cLOD ) of 2.056 μg/kg.In addition,the recovery rate of this method was 97.3%~115.4%.The test results of the …

Colloidal Carbon-Labelled Immunochromatographic Assay For Rapid Detection Of Marbofloxacin Residues In Animal-Derived Foods, Xiujin Chen, Biao An, Jian Tao, Xinhao Yin, Yao Wang, Huawei Niu, Zhaozhou Li, Min Zhang

Journal of Food Science and Biotechnology

[Objective ] A colloidal carbon-labelled immunochromatographic assay with competitive inhibition was developed for the detection of marbofloxacin (MBF ) residues in milk powder and chicken.[Method ] The anti-MBF polyclonal antibody prepared in the author 's laboratory was employed to produce the colloidal carbon-labelled immunoprobe.The effects of pH of reaction system,resuspension solution,treatment solution of sample pad,standard dilution buffer,mass concentration of colloidal carbon,mass concentration of primary antibody,mass concentration of coating antigen,and mass concentration of secondary antibody on the MBF colloidal carbon-labelled immunochromatographic assay were investigated.The sensitivity,specificity,stability,and accuracy of the method were determined.[Result ] Under optimal conditions,the cut-off value of the method was …

Construction Of Staphylococcus Aureus Detection Method Based On, Silver Nanoclusters Dna, Xiaotong Lu, Jinzhao Li, Xinjun Du

Journal of Food Science and Biotechnology

[Objective ] A simple and sensitive detection method for Staphylococcus aureus is established for the efficient detection of this pathogen in food.[Method ] Targeting Staphylococcus aureus,a simple and sensitive fluorescent detection method for Staphylococcus aureus,EXPAR-P-AgNCs,was developed based on exponential amplification reaction (EXPAR ) combined with DNA silver nanoclusters (P-AgNCs ).A recognition probe was designed to initiate EXPAR in the presence of Staphylococcus aureus,generating a large amount of target DNA(T).The binding of T to hairpin P displaced the G-rich strand from P-AgNCs,resulting in a decrease in the relative fluorescence intensity of P-AgNCs and enabling the detection of Staphylococc us aureus.[Result ] …

Physicochemical Indicators , Microbial Diversity , And Volatile Substances In The Qupi And Quxin Of High-Temperature Daqu, Dan Xie, Cheng Wu, Wenyu Zhao, Jianfeng Hu, Pingyan Cheng, Yuanlin Bi, Junlin Yang, Xiaolong You, Diqiang Wang

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the physicochemical indicators,microbial diversity,and volatile substances in the Qupi (surface ) and Quxin (core) of high-temperature Daqu.[Method ] High-throughput sequencing and headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS ) were employed to compare the microbial diversity,volatile substances,and physicochemical indicators between Qupi and Quxin of three types of Daqu.[Result ] The moisture mass fraction in Qupi of the three types of Daqu was lower than that in Quxin (P<0.05),and the moisture mass fraction was the lowest in the Qupi of white Daqu (WP) and the highest in the Quxin of yellow Daqu (YX).The acidity of Qupi and Quxin were in the order of Quxin of black Daqu (BX) > YX > Qupi of black Daqu (BP) > Quxin of white Daqu (WX) > Qupi of yellow Daqu (YP) > WP.High-throughput sequencing results showed that Firmicutes and …

Yiqi Yangyin Tongluo Prescription Targets Lncrna Vim-As1 To Regulate Foxk2/Mtor To Promote Autophagy And Inhibit Renal Tubular Epithelial Cell Apoptosis, Rucui Yu, Ruiying Wu, Tingting Chen, Jingwei Xu

Journal of Food and Drug Analysis

Diabetic nephropathy (DN) is one dominating reason for death in diabetic patients, and its incidence is high. It has been reported that Yiqi Yangyin Tongluo prescription (YYTP) can relieve inflammation, and it owns better clinical effects in the treatment of DN. However, the molecular mechanisms of YYTP in the treatment of DN still keep unclear, and deeply investigations are needed. In this study, it firstly was manifested that YYTP can repress the lncRNA VIM-antisense 1 (VIM-AS1) expression in high glucose (HG)-evoked HK-2 cells. Overexpression of VIM-AS1 roll-backed the inhibitive impacts of YYTP on cell apoptosis in HG-triggered HK-2 cells. Additionally, …

Evaluating The Cost-Effectiveness Of Atezolizumab-Bevacizumab In Advanced Hepatocellular Carcinoma: Insights From Taiwan, Tsung-Wei Chang, Wei-Chiao Chang, Wan-Hsuan Chou, Wei-Pin Chang, Chun-Nan Kuo

Journal of Food and Drug Analysis

Following the observed significant improvements in overall survival and progression-free survival in clinical trials, the combination of atezolizumab and bevacizumab has been recommended as a first-line therapy for patients with unresectable hepatocellular carcinoma. Despite its clinical benefits, the high cost associated with this treatment poses a substantial challenge in routine practice in Taiwan. This study aims to assess the cost-effectiveness of atezolizumab plus bevacizumab in comparison to sorafenib monotherapy. This study utilized partitioned survival analysis and extrapolated survival over a 20-year horizon to conduct a cost-effectiveness analysis from the perspective of the National Health Insurance Administration. Efficacy and utility data …

Ping-Chong-Jiang-Ni Formula Effectively Inhibits Migration And Invasion Of Endometriosis 12z Cell Line Via Trip13, Jiahua Peng, Shuzhen Liu, Yunxiang Xie, Min Xiao, Chichiu Wang, Ruining Liang

Journal of Food and Drug Analysis

The Ping-Chong-Jiang-Ni Formula (PCJNF), a compound of Traditional Chinese Medicine (TCM), has demonstrated remarkable clinical effectiveness and is widely utilized in the treatment of endometriosis (EMs). Previous studies have shown that PCJNF inhibits the proliferation and induces the apoptosis of ectopic endometrial stromal cells (EESCs) by modulating the JNK signaling pathway. In our most recent study, published in January 2024, we found that PCJNF effectively alleviates EMs-associated pain by reducing inflammatory mediators, including tumor necrosis factor-alpha (TNF-α) and nerve growth factor (NGF). Furthermore, PCJNF down-

regulates the expression of transient receptor potential vanilloid 1 (TRPV1), phosphorylated TRPV1 (p-TRPV1), and protein …

In Vitro Metabolic Profiling Of Methylenedioxy-Substituted Synthetic Cathinones For Enhanced Detection In Urine Sample Analysis, Ya-Ling Yeh, Chin-Lin Hsieh, Yi-Jia Huang, Yu-Hsiang Chang, Sheng-Meng Wang

Journal of Food and Drug Analysis

Synthetic cathinones are a widely abused class of new psychoactive substances that pose significant challenges in forensic toxicology owing to their complex metabolic pathways and lack of verified reference standards. This study investigated the in vitro metabolism of nine methylenedioxy-substituted synthetic cathinones, including methylone and eight structural isomers, which were categorized into three groups: Group 1 (dimethylone, ethylone, and butylone), Group 2 (dibutylone, pentylone, and eutylone), and Group 3 (N-ethylpentylone and dipentylone). Pooled human liver microsomes, cytosol, and uridine diphosphate glucuronic acid were used to identify phase Ⅰ and Ⅱ metabolites by liquid chromatography–quadrupole time-of-flight mass spectrometry. Key pathways included …

Integrating Network Analysis And Experimental Validation To Reveal The Ferroptosis-Associated Mechanism Of Velvet Antler In The Treatment Of Chronic Atrophic Gastritis, Quan Liao, Zhenzhen Guo, Chenchun Ding, Renjie Zuo, Guoyan Liu

Journal of Food and Drug Analysis

Chronic atrophic gastritis (CAG) is precancerosis with limited treatment options. This study investigated the therapeutic effects of velvet antler (VA), a traditional natural medicine, on CAG, with a focus on ferroptosis. In vivo experiments demonstrated the efficacy of VA in alleviating CAG, and network pharmacology analysis revealed its involvement in related terms, including inflammation, oxidative stress, and cell proliferation. Analyses further confirmed the modulation of ferroptosis by VA, particularly via the Keap1-Nrf2/HO-1/GPX4 pathway. In vitro assays supported these findings, demonstrating the ability of VA to reduce methylnitronitrosoguanidine-induced inflammation, oxidative stress, and ferroptosis in GES-1. This study provides a basis for …