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Ligand-Receptor Interactions For Supramolecular Disassembly With Applications In Screening And Drug Delivery, Diego F. Amado Torres 2014 SelectedWorks

Ligand-Receptor Interactions For Supramolecular Disassembly With Applications In Screening And Drug Delivery, Diego F. Amado Torres

Diego Amado Torres

Proteins have the capacity to bind specific sets of compounds known as ligands, these are small molecules with a recurrent theme in their molecular design that is a characteristic exploited here to (i) identify particular affinities of small molecules for proteins with the aim of using them as ligands, inhibitors, or targeting moieties in more complex systems by means of a methodology that screens small molecules based on protein affinity; (ii) decorate a self-assembling supramolecular system at different positions, making it responsive to a complementary protein with the aim of exploring differences in disassembly and sensitivity of the release of ...


Initial Characterization Of A Conserved Active Site Residue For The Cdc34 Ubiquitin Conjugating Enzyme, Arvin Akoopie 2014 University of Nevada, Las Vegas

Initial Characterization Of A Conserved Active Site Residue For The Cdc34 Ubiquitin Conjugating Enzyme, Arvin Akoopie

Theses

Ubiquitin-conjugating enzymes (E2s) covalently modify protein substrates with ubiquitins. The active site cysteine residues on E2s are essential for catalyzing the transfer of ubiquitin from the E2 active site onto the protein substrate, however there is a limited amount of information available concerning additional active site residues for E2s that may also participate in catalysis. Cdc34 is an essential E2 that has merited the lion’s share of attention for biochemical analysis of the E2 family. Previous phylogenetic analysis of Cdc34 amino acid sequences has identified an invariably conserved histidine residue close to the active site cysteine in the primary ...


Aminoglycoside-Induced Sensitization Of Cancer Cells And Development Of Carbohydrate-Containing Drugs, Michael F. Cuccarese 2014 Northeastern University

Aminoglycoside-Induced Sensitization Of Cancer Cells And Development Of Carbohydrate-Containing Drugs, Michael F. Cuccarese

Chemistry Dissertations

Modern drug discovery requires that synthesis of compounds with unique structures and properties is performed in concert with in-depth research on the biological event being targeted. The synergy of these two components of drug discovery generates the meaningful data necessary for a hypothesis-driven approach toward novel therapeutics. Herein, research is presented that pertains both to the study of biological activity, as well as the development of novel synthetic methods.

While the bactericidal effects of aminoglycosides are well understood, their therapeutic potential in human cells is emerging. Herein, a novel use of this class of compounds in cancer therapy is described ...


Technology Assisted Strategies For The Synthesis Of Bioconjugates, Sara Elizabeth Sadler 2014 Northeastern University

Technology Assisted Strategies For The Synthesis Of Bioconjugates, Sara Elizabeth Sadler

Chemistry Dissertations

Over the past few years, one-third of the top 25 best-selling pharmaceutical drugs came off patent, and this year, the pharmaceutical industry is predicted to lose an additional $20 billion, which will stimulate more growth in the generics sector. Due to the rising costs of bringing a new molecular entity (NME) to market, pharmaceutical companies are investing in technology that will enhance the drug development process by reducing time, energy, manpower, and waste in these processes. Furthermore, there is a push in the industry to produce biological conjugates, which have shown enhanced targeting to receptors in the body. This work ...


Design And Synthesis Of Carbocyanine Based Photosensitizers For Use In Dye-Sensitized Solar Cells, Tyler Dost 2014 Georgia State University

Design And Synthesis Of Carbocyanine Based Photosensitizers For Use In Dye-Sensitized Solar Cells, Tyler Dost

Georgia State Undergraduate Research Conference

No abstract provided.


Synthesis Of Thiophene Analogs As Potential Antagonists Of Chemokine Receptor Type 4 (Cxcr4), Francisco Javier Garcia Jr. 2014 Georgia State University

Synthesis Of Thiophene Analogs As Potential Antagonists Of Chemokine Receptor Type 4 (Cxcr4), Francisco Javier Garcia Jr.

Georgia State Undergraduate Research Conference

No abstract provided.


Development Of A Safe And Efficient Near-Infrared Diagnostic Method For Alzheimer's Disease, Joseph Tawney 2014 Georgia State University

Development Of A Safe And Efficient Near-Infrared Diagnostic Method For Alzheimer's Disease, Joseph Tawney

Georgia State Undergraduate Research Conference

No abstract provided.


Peo-Based Hybrid Hydrogels With Hairy Nanoparticles As Polyfunctional Crosslinker, Jessica A. Ellett Ms. 2014 University of North Georgia

Peo-Based Hybrid Hydrogels With Hairy Nanoparticles As Polyfunctional Crosslinker, Jessica A. Ellett Ms.

University of North Georgia Annual Research Conference

PEO-Based Hybrid Hydrogels with Hairy Nanoparticles as Polyfunctional Crosslinker

Jessica A. Ellett, Roger A. E. Wright, and Bin Zhao

Department of Chemistry, University of Tennessee, Knoxville, TN 37996

Hydrogels, consisting of a crosslinked 3-dimensional (3D) polymeric network swollen with water, are used in multiple applications such as drug delivery, chemical sensing, and tissue engineering. Synthetic hydrogels, however, tend to be brittle and lack toughness. It has been shown that both high network uniformity and the incorporation of nanoparticles can enhance the mechanical properties of hydrogels. This work is aimed at fabricating hybrid hydrogels with advanced mechanical properties using thiol-terminated polymer ...


Application Of Magnetic “Fishing” And Mass Spectrometry For Function-Based Assays Of Biomolecular Interactions, Meghan J. McFadden 2014 McMaster University

Application Of Magnetic “Fishing” And Mass Spectrometry For Function-Based Assays Of Biomolecular Interactions, Meghan J. Mcfadden

Open Access Dissertations and Theses

The human interactome presents a goldmine of potentially powerful therapeutic targets, yet very few small molecule modulators of protein-protein interactions (PPI) have been identified. PPI pose a particular challenge for drug discovery, and one of the major obstacles to fully exploiting these interactions is a lack of appropriate technologies to screen for modulating compounds. This thesis aims to address the need for function- based approaches that target PPI by using magnetic beads (MB) and mass spectrometry (MS) to develop efficient assays to monitor these interactions and their modulation by small molecules. The work begins with the validation of a novel ...


The Wet Adhesion Of Polyvinylamine To Cellulose, John-Louis DiFlavio 2014 McMaster University

The Wet Adhesion Of Polyvinylamine To Cellulose, John-Louis Diflavio

Open Access Dissertations and Theses

A systematic investigation of Polyvinylamine (PVAm) as a strength-enhancing polymer for wet paper was undertaken through the development of a new test method that simulates the influence of polymers on fibre-fibre bonding in paper. Pairs of wet regenerated cellulose membranes were laminated using the paper strength-enhancing polymer as the lamination adhesive. The resulting laminates served as a physical model for fibre-fibre bonds in paper and the wet laminate strength was determined by ninety degree peeling experiments. Key experimental parameters and sources of error were identified.

The mechanism of PVAm paper wet strength enhancement was explored by the wet cellulose delamination ...


Direct Infusion Lipidomics: Profiling The Lipidome Of A Composite Tailings Reclamation Site, Paul A. Hodgson 2014 McMaster University

Direct Infusion Lipidomics: Profiling The Lipidome Of A Composite Tailings Reclamation Site, Paul A. Hodgson

Open Access Dissertations and Theses

The comprehensive analysis of intact lipids (called lipidomics) can provide information about the presence of microbial communities in an ecosystem and assist in understanding the biogeochemistry in that system. In previous work we had developed a method to determine the profiles of eight phospholipid classes in a soil microorganism by direct-infusion electrospray mass spectroscopy using tandem mass spectrometry. The work done in this study encompasses first the optimization of previous methodology for use with water and sediment samples containing low concentration of phospholipids and large amounts of organic contaminants and secondly the application of this method to the analysis of ...


Multinuclear Nmr Spectroscopy Methods For The Study Of Structure And Dynamics In Solid-State Electrolytes For Lithium Ion Batteries, Tara L. Spencer Noakes 2014 McMaster University

Multinuclear Nmr Spectroscopy Methods For The Study Of Structure And Dynamics In Solid-State Electrolytes For Lithium Ion Batteries, Tara L. Spencer Noakes

Open Access Dissertations and Theses

This thesis evaluates several solid-state NMR spectroscopy approaches to studying lithium ion dynamics in solid-state electrolytes. With the goal of reducing the risks associated with current liquid electrolytes, solid-state electrolytes provide non-flammable materials that are also stable against attack by cathode and anode materials. Solid-state NMR spectroscopy offers a versatile method to determine structural details and can also provide information about ion mobility in solid-state electrolytes. Challenges involved in the study of solid-state electrolytes include the difficulty in distinguishing between 6,7Li resonances due to the small chemical shift range of diamagnetic lithium species. The NMR methods selected in ...


Mechanistic Aspects Of The Complexation, Chalcogen Abstraction And Sigma Bond Insertion Reactions By Transient Silylenes And Germylenes In Solution, Svetlana S. Kostina 2014 McMaster University

Mechanistic Aspects Of The Complexation, Chalcogen Abstraction And Sigma Bond Insertion Reactions By Transient Silylenes And Germylenes In Solution, Svetlana S. Kostina

Open Access Dissertations and Theses

The complexation reactions of silylenes (SiMe2, SiPh2 and SiMes2) and germylenes (GeMe2, GePh2 and GeMes2) with a series of O-, S-, N- and P-donors have been studied in hexanes solution. The equilibrium constants for complexation of SiMes2 and GeMes2 with 7 Lewis bases were determined, and demonstrate that the silylene is more Lewis acidic than the germylene by ca. 1 kcal mol-1. Diethyl ether reacted with the six tetrellylenes with equilibrium constants that decrease in the order SiPh2 > SiMe2 > GePh2 > GeMe2 > SiMes2 > GeMes2, establishing a ...


Zn(L-Proline)2: A Highly Efficient Catalyst For The Multicomponent Synthesis Dihydropyrano[2,3-C]Pyrazole Derivatives., John E. Blevins 2014 Indiana University – Purdue University Fort Wayne

Zn(L-Proline)2: A Highly Efficient Catalyst For The Multicomponent Synthesis Dihydropyrano[2,3-C]Pyrazole Derivatives., John E. Blevins

IPFW Student Research and Creative Endeavor Symposium

Dihydropyrano[2, 3-c]pyrazoles have been described as important compounds possessing anticancer, antimicrobial, anti-inflammatory, insecticidal, and molluscicidal activities. It is therefore of interest to develop a method for the synthesis of these compounds without the use of toxic solvents or catalysts and also keep the procedure and work up as simple as possible. Recently zinc has been gaining attention in the field of catalysis in addition to the classical coordination chemistry applications. Nano ZnO in various morphologies and sizes were described to be effective catalysts due to their high surface areas in different organic reactions such as Knoevenagel condensations, synthesis ...


Analyzing The Efficiency Of Inserting Gp10 Into A Planar Bilayer Membrane Dopped With A Carboxylated Lipid, Hallel Paraiso 2014 Indiana University – Purdue University Fort Wayne

Analyzing The Efficiency Of Inserting Gp10 Into A Planar Bilayer Membrane Dopped With A Carboxylated Lipid, Hallel Paraiso

IPFW Student Research and Creative Endeavor Symposium

The phi29 connector, GP10, is a channel protein from the bacteriophage phi29, a virus that can infect bacteria. The protein provides a channel that allows the phi29 genomic DNA to go through it during the infection process in-vivo. It has been successfully demonstrated that the connector can be inserted into a planar lipid bilayer membrane in-vitro, and thus the channel protein could potentially be used as a single-molecule platform to detect individual molecules (both small molecules and macromolecules), to monitor chemical and biochemical reactions in real time, and to perform DNA/RNA sequencing. Understanding the process of inserting the protein ...


Room Temperature Catalytic Hydrogenation Of Olefins And Arenes Using [Co2h9][Mgbr(Thf)]5, Cameron Griffith 2014 Indiana University – Purdue University Fort Wayne

Room Temperature Catalytic Hydrogenation Of Olefins And Arenes Using [Co2h9][Mgbr(Thf)]5, Cameron Griffith

IPFW Student Research and Creative Endeavor Symposium

Research on the hydrogenation of olefins and arenes using catalysis is dominant in Europe, because of the limited availability of petroleum. Finding an efficient, inexpensive and available hydrogen-storage catalyst would permit alternative methods for catalysis and energy storing processes. Most hydrogenation research conducted currently uses precious metal catalysts. Here this research focuses on a more earth-abundant metal, cobalt. The novel binuclear cobalt hydride complex, [Co2H9][MgBr(THF)]5, was used to catalyze the hydrogenation of a series of substrates at room temperature.* The substances chosen comprise an arene, a diene and a sterically hindered olefin: naphthalene, trans ...


Isolation Of Various Endohedral Metallofullerenes With A More Efficient Lewis Acid, Khristina Rottinger 2014 Indiana University – Purdue University Fort Wayne

Isolation Of Various Endohedral Metallofullerenes With A More Efficient Lewis Acid, Khristina Rottinger

IPFW Student Research and Creative Endeavor Symposium

We strive to develop new separation strategies for isolating endohedral metallofullerenes, which contain clusters of metals, carbides, nitrides, or oxides that are trapped inside fullerene cages. We seek a non-chromatographic approach that will take advantage of differences in chemical reactivity among the 50+ different types of fullerenes and metallofullerenes. Metallofullerenes possess an electron-rich carbon cage surface that can react with electron-deficient Lewis acids. We report an improved separation method to replace the currently used aluminum chloride technique with more selective Lewis acids. Results indicate a successful and selective separation of a diverse array of metallofullerene types.


Homology Modeling And Molecular Docking For The Science Curriculum, Owen M. McDougal, Nic Cornia, Chris Mallory, Julia Thom Oxford, Tim Andersen 2014 Boise State University

Homology Modeling And Molecular Docking For The Science Curriculum, Owen M. Mcdougal, Nic Cornia, Chris Mallory, Julia Thom Oxford, Tim Andersen

Chemistry Faculty Publications and Presentations

DockoMatic 2.0 is a powerful open source software program (downloadable from sourceforge.net) that allows users to utilize a readily accessible computational tool to explore biomolecules and their interactions. This manuscript describes a practical tutorial for use in the undergraduate curriculum that introduces students to macromolecular structure creation, ligand binding calculations, and visualization of docking results. A student procedure is provided that illustrates the use of DockoMatic to create a homology model for the amino propeptide region (223 amino acids with two disulfide bonds) of collagen α1 (XI), followed by molecular docking of the commercial drug Arixtra® to the ...


Big Horned, Juniper Harrower 2014 Claremont Colleges

Big Horned, Juniper Harrower

The STEAM Journal

Tinta y tinto (Spanish for black ink and red wine)
Through a process of oxidation, reduction, and light manipulation, Juniper stains and colors paper with red wine and a rich black pigment made of the wild harvested mushroom Coprinopsis atramentaria.


Advancement Of Petroleum Diesel Alternatives Utilizing A Multifaceted And Interdepartmental Approach, Michael Morgan 2014 Utah State University

Advancement Of Petroleum Diesel Alternatives Utilizing A Multifaceted And Interdepartmental Approach, Michael Morgan

UCUR

The advancement of biologically derived alternatives to petroleum diesel fuel requires a multifaceted approach. At Utah State University we use an interdisciplinary team including the Colleges of Engineering, Agriculture & Applied Sciences, and Science in conjunction with industry partners to drive innovation in improving the science behind petroleum diesel alternatives. With increasing petroleum use, depleting reserves, increasing emissions standards, and other factors, there is need for petroleum diesel alternatives that are cost effective, offer improvement, and perform similarly to petroleum diesel. Our team has focused on the use of oleaginous microbes utilizing low value effluent and waste sources including sugars and ...


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