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Relation Of Serum Estrogen Metabolites With Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy., Hannah Oh, Zeina G Khodr, Mark E Sherman, Maya Palakal, Ruth M Pfeiffer, Laura Linville, Berta M Geller, Pamela M Vacek, Donald L Weaver, Rachael E Chicoine, Roni T Falk, Hisani N Horne, Daphne Papathomas, Deesha A Patel, Jackie Xiang, Xia Xu, Timothy Veenstra, Stephen M Hewitt, John A Shepherd, Louise A Brinton, Jonine D Figueroa, Gretchen L Gierach 2019 Cedarville University

Relation Of Serum Estrogen Metabolites With Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy., Hannah Oh, Zeina G Khodr, Mark E Sherman, Maya Palakal, Ruth M Pfeiffer, Laura Linville, Berta M Geller, Pamela M Vacek, Donald L Weaver, Rachael E Chicoine, Roni T Falk, Hisani N Horne, Daphne Papathomas, Deesha A Patel, Jackie Xiang, Xia Xu, Timothy Veenstra, Stephen M Hewitt, John A Shepherd, Louise A Brinton, Jonine D Figueroa, Gretchen L Gierach

Timothy Veenstra, Ph.D.

Higher levels of circulating estrogens and estrogen metabolites (EMs) have been associated with higher breast cancer risk. In breast tissues, reduced levels of terminal duct lobular unit (TDLU) involution, as reflected by higher numbers of TDLUs and acini per TDLU, have also been linked to elevated breast cancer risk. However, it is unknown whether reduced TDLU involution mediates the risk associated with circulating EMs. In a cross-sectional analysis of 94 premenopausal and 92 postmenopausal women referred for clinical breast biopsy at an academic facility in Vermont, we examined the associations of 15 EMs, quantified using liquid chromatography-tandem mass spectrometry, with ...


Microfilariae Of Brugia Malayi Inhibit The Mtor Pathway And Induce Autophagy In Human Dendritic Cells, Prakash Babu Narasimhan, Sasisekhar Bennuru, Zhaojing Meng, Rachel N Cotton, Kathleen R Elliott, Sundar Ganesan, Renee McDonald-Fleming, Timothy Veenstra, Thomas B Nutman, Roshanak Tolouei Semnani 2019 Cedarville University

Microfilariae Of Brugia Malayi Inhibit The Mtor Pathway And Induce Autophagy In Human Dendritic Cells, Prakash Babu Narasimhan, Sasisekhar Bennuru, Zhaojing Meng, Rachel N Cotton, Kathleen R Elliott, Sundar Ganesan, Renee Mcdonald-Fleming, Timothy Veenstra, Thomas B Nutman, Roshanak Tolouei Semnani

Timothy Veenstra, Ph.D.

Immune modulation is a hallmark of patent filarial infection, including suppression of antigen-presenting cell function and downmodulation of filarial antigen-specific T cell responses. The mammalian target of rapamycin (mTOR) signaling pathway has been implicated in immune regulation, not only by suppressing T cell responses but also by regulating autophagy (through mTOR sensing amino acid availability). Global proteomic analysis (liquid chromatography-tandem mass spectrometry) of microfilaria (mf)-exposed monocyte-derived dendritic cells (DC) indicated that multiple components of the mTOR signaling pathway, including mTOR, eIF4A, and eIF4E, are downregulated by mf, suggesting that mf target this pathway for immune modulation in DC. Utilizing ...


Integrated Proteotranscriptomics Of Breast Cancer Reveals Globally Increased Protein-Mrna Concordance Associated With Subtypes And Survival, Wei Tang, Ming Zhou, Tiffany H Dorsey, DaRue A Prieto, Xin W Wang, Eytan Ruppin, Timothy Veenstra, Stefan Ambs 2019 Cedarville University

Integrated Proteotranscriptomics Of Breast Cancer Reveals Globally Increased Protein-Mrna Concordance Associated With Subtypes And Survival, Wei Tang, Ming Zhou, Tiffany H Dorsey, Darue A Prieto, Xin W Wang, Eytan Ruppin, Timothy Veenstra, Stefan Ambs

Timothy Veenstra, Ph.D.

BACKGROUND: Transcriptome analysis of breast cancer discovered distinct disease subtypes of clinical significance. However, it remains a challenge to define disease biology solely based on gene expression because tumor biology is often the result of protein function. Here, we measured global proteome and transcriptome expression in human breast tumors and adjacent non-cancerous tissue and performed an integrated proteotranscriptomic analysis.

METHODS: We applied a quantitative liquid chromatography/mass spectrometry-based proteome analysis using an untargeted approach and analyzed protein extracts from 65 breast tumors and 53 adjacent non-cancerous tissues. Additional gene expression data from Affymetrix Gene Chip Human Gene ST Arrays were ...


A Randomized Controlled Study To Evaluate The Effect Of Bexarotene On Amyloid-Β And Apolipoprotein E Metabolism In Healthy Subjects, Kaushik Ghosal, Michael Haag, Philip B Verghese, Tim West, Timothy Veenstra, Joel B Braunstein, Randall J Bateman, David M Holtzman, Gary E Landreth 2019 Cedarville University

A Randomized Controlled Study To Evaluate The Effect Of Bexarotene On Amyloid-Β And Apolipoprotein E Metabolism In Healthy Subjects, Kaushik Ghosal, Michael Haag, Philip B Verghese, Tim West, Timothy Veenstra, Joel B Braunstein, Randall J Bateman, David M Holtzman, Gary E Landreth

Timothy Veenstra, Ph.D.

INTRODUCTION: We conducted a phase Ib proof of mechanism trial to determine whether bexarotene (Targretin) increases central nervous system (CNS) apolipoprotein E (apoE) levels and alters Aβ metabolism in normal healthy individuals with the

METHODS: We used stable isotope labeling kinetics (SILK-ApoE and SILK-Aβ) to measure the effect of bexarotene on the turnover rate of apoE and Aβ peptides and stable isotope spike absolute quantitation (SISAQ) to quantitate their concentrations in the cerebrospinal fluid (CSF). Normal subjects were treated for 3 days with bexarotene (n = 3 women, 3 men, average 32 years old) or placebo (n = 6 women, average 30 ...


Ethanol Purification With Ozonation, Activated Carbon Adsorption, And Gas Stripping, Shinnosuke Onuki, Jacek A. Koziel, William S. Jenks, Lingshuang Cai, Somchai Rice, Johannes van Leeuwen 2019 Iowa State University

Ethanol Purification With Ozonation, Activated Carbon Adsorption, And Gas Stripping, Shinnosuke Onuki, Jacek A. Koziel, William S. Jenks, Lingshuang Cai, Somchai Rice, Johannes Van Leeuwen

Somchai Rice

Fermentation of sugar to produce ethanol also produces volatile byproducts. This study was aimed at purifying corn-based ethanol for industrial and pharmaceutical use. The research was on treatment for 10 impurities removal after distillation. The ethanol headspace was sampled with solid-phase microextraction and analyzed with gas chromatography–mass spectrometry. A 40 mg/L ozone treatment resulted in >56% and >36% removal of styrene and 2-pentylfuran, respectively, without significant generation of byproducts. A 60 g/L activated carbon (AC) treatment with 270 min adsorption time resulted in 84%, >72%, and >78% removal of ethyl hexanoate, ethyl octanoate, and ethyl decanoate respectively ...


Optimization Of Extraction Parameters For Quantification Of Fermentation Volatile By‐Products In Industrial Ethanol With Solid‐Phase Microextraction And Gas Chromatography, Shinnosuke Onuki, Jacek A. Koziel, William S. Jenks, Lingshuang Cai, Somchai Rice, Johannes van Leeuwen 2019 Iowa State University

Optimization Of Extraction Parameters For Quantification Of Fermentation Volatile By‐Products In Industrial Ethanol With Solid‐Phase Microextraction And Gas Chromatography, Shinnosuke Onuki, Jacek A. Koziel, William S. Jenks, Lingshuang Cai, Somchai Rice, Johannes Van Leeuwen

Somchai Rice

The rapid growth of the biofuels industry resulted in new research needs in chemical analysis. Methods for screening and quantification of impurities resulting from changes in feedstock, process and purification are needed. Direct sample injection methods are often not sensitive for lower concentrations. This research, developed an analytical method to simultaneously quantify fermentation volatile by‐products in industrial corn‐based ethanol. These include acetaldehyde, ethyl vinyl ether, 1,1‐diethoxyethane, isoamyl alcohol, isoamyl acetate, styrene, 2‐pentylfuran, ethyl hexanoate, ethyl octanoate, and ethyl decanoate. Headspace solid‐phase microextraction (SPME) coupled with gas chromatography–mass spectrometry (GC–MS) and GC‐FID ...


Further Purification Of Food‐Grade Alcohol To Make A Congener‐Free Product, Lingshuang Cai, Somchai Rice, Jacek A. Koziel, William S. Jenks, Johannes van Leeuwen 2019 DuPont Crop Protection

Further Purification Of Food‐Grade Alcohol To Make A Congener‐Free Product, Lingshuang Cai, Somchai Rice, Jacek A. Koziel, William S. Jenks, Johannes Van Leeuwen

Somchai Rice

Most alcoholic beverages contain small amounts of chemicals other than ethanol, the congeners. These are byproducts of the fermentation process of the substrate. Congeners are implicated in contributing to hangover (veisalgia) symptoms and it is therefore considered expedient to remove these substances. This research compared 12 established vodka brands with a new product by GC‐MS‐olfactometry. A new vodka produced in Iowa from corn was found to be the purest while another corn‐based vodka and a potato‐based vodka contained eight and 12 impurities each. Eight other commercially available vodkas contained 15–19 impurities and three vodkas showed ...


Effects Of Harvest Time On The Aroma Of White Wines Made From Cold-Hardy Brianna And Frontenac Gris Grapes Using Headspace Solid-Phase Microextraction And Gas Chromatography-Mass Spectrometry-Olfactometry, Somchai Rice, Madina Tursumbayeva, Matthew Clark, David Greenlee, Murlidhar Dharmadhikari, Anne Fennell, Jacek A. Koziel 2019 Iowa State University

Effects Of Harvest Time On The Aroma Of White Wines Made From Cold-Hardy Brianna And Frontenac Gris Grapes Using Headspace Solid-Phase Microextraction And Gas Chromatography-Mass Spectrometry-Olfactometry, Somchai Rice, Madina Tursumbayeva, Matthew Clark, David Greenlee, Murlidhar Dharmadhikari, Anne Fennell, Jacek A. Koziel

Somchai Rice

The Midwest wine industry has shown a marked increase in growers, hectares planted, wineries, and wine production. This growth coincides with the release of cold-hardy cultivars such as Brianna and Frontenac gris, in 2001 and 2003, respectively. These white grape varieties account for one-third of the total area grown in the state of Iowa. It is generally accepted that the wine aroma profile plays a crucial role in developing a local, sustainable brand. However, the identity of Brianna/Frontenac Gris-based wine aromas and their link to the grape berry chemistry at harvest is unknown. This study aims to preliminarily characterize ...


Biogenic Volatiles Emitted From Four Cold-Hardy Grape Cultivars During Ripening, Somchai Rice, Devin L. Maurer, Anne Fennell, Murlidhar Dharmadhikari, Jacek A. Koziel 2019 Iowa State University

Biogenic Volatiles Emitted From Four Cold-Hardy Grape Cultivars During Ripening, Somchai Rice, Devin L. Maurer, Anne Fennell, Murlidhar Dharmadhikari, Jacek A. Koziel

Somchai Rice

In this research dataset, we summarize for the first time volatile organic compounds (VOCs) emitted in vivo from ripening wine grapes. We studied four cold-hardy cultivars grown in the Midwestern U.S.: St. Croix, Frontenac, Marquette, and La Crescent. These cultivars have gained popularity among local growers and winemakers, but still very little is known about their performance compared with long-established V. viniferagrapes. Volatiles were collected using two novel approaches: biogenic emissions from grape clusters on a vine and single grape berries. A third approach was headspace collection of volatiles from crushed grapes. Solid-phase microextraction (SPME) was used to collect ...


Biogenic Volatiles Emitted From Four Cold-Hardy Grape Cultivars During Ripening, Somchai Rice, Devin L. Maurer, Anne Fennell, Murlidhar Dharmadhikari, Jacek A. Koziel 2019 Iowa State University

Biogenic Volatiles Emitted From Four Cold-Hardy Grape Cultivars During Ripening, Somchai Rice, Devin L. Maurer, Anne Fennell, Murlidhar Dharmadhikari, Jacek A. Koziel

Devin L. Maurer

In this research dataset, we summarize for the first time volatile organic compounds (VOCs) emitted in vivo from ripening wine grapes. We studied four cold-hardy cultivars grown in the Midwestern U.S.: St. Croix, Frontenac, Marquette, and La Crescent. These cultivars have gained popularity among local growers and winemakers, but still very little is known about their performance compared with long-established V. viniferagrapes. Volatiles were collected using two novel approaches: biogenic emissions from grape clusters on a vine and single grape berries. A third approach was headspace collection of volatiles from crushed grapes. Solid-phase microextraction (SPME) was used to collect ...


Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22, 2019 University of Louisville

Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22

Sustain Magazine

No abstract provided.


Sustainable Communities, Fall/Winter 2010, Issue 21, 2019 University of Louisville

Sustainable Communities, Fall/Winter 2010, Issue 21

Sustain Magazine

No abstract provided.


Sustainable Building, Spring/Summer 2009, Issue 20, 2019 University of Louisville

Sustainable Building, Spring/Summer 2009, Issue 20

Sustain Magazine

No abstract provided.


Environmental History, Fall/Winter 2009, Issue 19, 2019 University of Louisville

Environmental History, Fall/Winter 2009, Issue 19

Sustain Magazine

No abstract provided.


Student Research, Spring/Summer 2008, Issue 18, 2019 University of Louisville

Student Research, Spring/Summer 2008, Issue 18

Sustain Magazine

No abstract provided.


Evolving Pollution Prevention, Fall/Winter 2008, Issue 17, 2019 University of Louisville

Evolving Pollution Prevention, Fall/Winter 2008, Issue 17

Sustain Magazine

No abstract provided.


Climate Change, Spring/Summer 2007, Issue 16, 2019 University of Louisville

Climate Change, Spring/Summer 2007, Issue 16

Sustain Magazine

No abstract provided.


Our Energy Future, Fall/Winter 2007, Issue 15, 2019 University of Louisville

Our Energy Future, Fall/Winter 2007, Issue 15

Sustain Magazine

No abstract provided.


Land Conservation, Spring/Summer 2006, Issue 14, 2019 University of Louisville

Land Conservation, Spring/Summer 2006, Issue 14

Sustain Magazine

No abstract provided.


Pollution And Heart Disease, Fall/Winter 2006, Issue 13, 2019 University of Louisville

Pollution And Heart Disease, Fall/Winter 2006, Issue 13

Sustain Magazine

No abstract provided.


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