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Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett 2017 East Tennessee State University

Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett

Undergraduate Honors Theses

Pyrrolobenzodiazepines (PBDs) are a group of naturally occurring compounds that were discovered in the cultures of Streptomyces in the 1960s. Some natural PBDs discovered in these cultures, such as anthramycin and sibiromycin, were shown to possess a broad spectrum of anti-tumor activity. Since cancer is still a leading cause of death globally, the development of novel anti-proliferative derivatives of PBDs is essential for human welfare worldwide. Further synthesis and structure-activity relationship (SAR) studies of the parent natural products and their tetracyclic analogs will lead to the discovery of drug candidates. In this work, thirteen PBD analogues were synthesized using no ...


Effect Of Chain Rigidity On Network Architecture And Deformation Behavior Of Glassy Polymer Networks, Kyler Reser Knowles 2017 University of Southern Mississippi

Effect Of Chain Rigidity On Network Architecture And Deformation Behavior Of Glassy Polymer Networks, Kyler Reser Knowles

Dissertations

Processing carbon fiber composite laminates creates molecular-level strains in the thermoset matrix upon curing and cooling which can lead to failures such as geometry deformations, micro-cracking, and other issues. It is known strain creation is attributed to the significant volume and physical state changes undergone by the polymer matrix throughout the curing process, though storage and relaxation of cure-induced strains remain poorly understood. This dissertation establishes two approaches to address the issue. The first establishes testing methods to simultaneously measure key volumetric properties of a carbon fiber composite laminate and its polymer matrix. The second approach considers the rigidity of ...


One-Pot Dialkylation Of Cycloalkanones And Their Ring-Closing Metathesis To Make Bridged Bicyclic Compounds, Dylan Sacenti, Ashley Yoon, Nathan Behrens 2017 Pepperdine University

One-Pot Dialkylation Of Cycloalkanones And Their Ring-Closing Metathesis To Make Bridged Bicyclic Compounds, Dylan Sacenti, Ashley Yoon, Nathan Behrens

Seaver College Research And Scholarly Achievement Symposium

No abstract provided.


Chemistry 100-051w Online Introduction To Chemistry Fall 2015, Christina Beatty 2017 Parkland College

Chemistry 100-051w Online Introduction To Chemistry Fall 2015, Christina Beatty

Christina Beatty

No abstract provided.


Building Data And Information Literacy In The Undergraduate Chemistry Curriculum, Yasmeen Shorish, Barbara A. Reisner 2017 James Madison University

Building Data And Information Literacy In The Undergraduate Chemistry Curriculum, Yasmeen Shorish, Barbara A. Reisner

Yasmeen Shorish

The Literature and Seminar sequence at James Madison University has been used to develop the chemistry information literacy skills of chemistry majors for over four decades. These courses have been continually updated to emphasize information literacy skills for the twenty-first century. This chapter describes the methods that have been developed to improve chemical, data and general information literacy at a large, public, primarily undergraduate institution. The focus of the first semester course, described in this chapter, is on skill building rather than teaching specific resources. It is a model of integration and collaboration between chemistry faculty and chemistry librarians. Changes ...


A Ship-In-A-Bottle Strategy To Synthesize Encapsulated Intermetallic Nanoparticle Catalysts: Exemplified For Furfural Hydrogenation, Raghu V. Maligal-Ganesh, Chaoxian Xiao, Tian Wei Goh, Lin-Lin Wang, Jeffrey Gustafson, Yuchen Pei, Zhiyuan Qi, Duane D. Johnson, Shiran Zhang, Franklin Feng Tao, Wenyu Huang 2017 Iowa State University

A Ship-In-A-Bottle Strategy To Synthesize Encapsulated Intermetallic Nanoparticle Catalysts: Exemplified For Furfural Hydrogenation, Raghu V. Maligal-Ganesh, Chaoxian Xiao, Tian Wei Goh, Lin-Lin Wang, Jeffrey Gustafson, Yuchen Pei, Zhiyuan Qi, Duane D. Johnson, Shiran Zhang, Franklin Feng Tao, Wenyu Huang

Duane D. Johnson

Intermetallic compounds are garnering increasing attention as efficient catalysts for improved selectivity in chemical processes. Here, using a ship-in-a-bottle strategy, we synthesize single-phase platinum-based intermetallic nanoparticles (NPs) protected by a mesoporous silica (mSiO2) shell by heterogeneous reduction and nucleation of Sn, Pb, or Zn in mSiO2-encapsulated Pt NPs. For selective hydrogenation of furfural to furfuryl alcohol, a dramatic increase in activity and selectivity is observed when intermetallic NPs catalysts are used in comparison to Pt@mSiO2. Among the intermetallic NPs, PtSn@mSiO2 exhibits the best performance, requiring only one-tenth of the quantity of Pt used ...


Influence Of Condition On Maintenance Requirements Of Dairy Cattle, A. C. McCandlish, W. G. Gaessler 2017 Iowa State College

Influence Of Condition On Maintenance Requirements Of Dairy Cattle, A. C. Mccandlish, W. G. Gaessler

Research Bulletin (Iowa Agriculture and Home Economics Experiment Station)

The ration of the dairy cow is used for maintenance, growth, the formation of body fat, the building up of the foetus and milk production, so the problem of feed utilizaton is a complicated one. 'rhe maintenance ration is more easily studied than are the requirements for growth and productive purposes and yet many of the factors controlling it are not thoroly understood.

Condition in dairy cattle has received little attention in investigational work and its influence on the maintenance requirements of animals has not been studied. In fact, the influence of condition on the maintenance requirements of all classe ...


Composition And Digestibility Of Sudan Grass Hay, W. G. Gaessler, A. C. McCandlish 2017 Iowa State College

Composition And Digestibility Of Sudan Grass Hay, W. G. Gaessler, A. C. Mccandlish

Research Bulletin (Iowa Agriculture and Home Economics Experiment Station)

ThE.J introduction of Sudan grass (Andropogon sorglwrn var.) into the United States took place less than nine years ago, but since then this .crop has become widely known and its popularity is rapidly increasing. Sudan grass, being an annual, does not make a good pasture plant, but gives excellent results as a hay or soiling crop; it might also be successfully made into silage if mixed with a legume.


Cytotoxic And Antimicrobial Effects Of Silver-Containing Surfaces, Sarah Goderecci 2017 Rowan University

Cytotoxic And Antimicrobial Effects Of Silver-Containing Surfaces, Sarah Goderecci

Theses and Dissertations

This study examines applications of sputtered silver coatings as alternatives to traditional antibiotic treatments. Given the increase in reports of antibiotic-resistant bacteria, new treatments and coatings for in-dwelling medical devices such as catheters and orthopedic implants are necessary. Silver oxide films were deposited onto Ti surfaces to examine the efficacy of such coatings against a variety of bacterial species both in vitro and in vivo. Bacterial growth studies showed that coatings exhibited antimicrobial activity against a range of bacterial species acting either in a bacteriostatic or bactericidal mechanism, depending on the target. Limited toxicity to in vitro mammalian cells was ...


Energy Efficient Process Heating: Insulation And Thermal Mass, Kevin Carpenter, J. Kelly Kissock 2017 Energy & Resource Solutions

Energy Efficient Process Heating: Insulation And Thermal Mass, Kevin Carpenter, J. Kelly Kissock

J. Kelly Kissock

Open tanks and exterior surfaces of process heating equipment lose heat to the surroundings via convection, radiation, and/or evaporation. A practical way of reducing heat loss is by insulating or covering the surfaces. This paper presents methods to quantify heat loss and energy savings from insulating hot surfaces and open tanks. The methods include radiation and evaporation losses, which are ignored by simplified methods. In addition, thermal mass, such as refractory, conveyor and racking equipment, acts as a heat sink and increases heating energy use in process heating applications. This paper presents lumped capacitance and finite-difference methods for estimating ...


Novel Cell Penetrating Peptide-Adaptors Effect Intracellular Delivery And Endosomal Escape Of Protein Cargos, John C. Salerno, Verra M. Ngwa, Scott J. Nowak, Carol A. Chrestensen, Allison N. Healey, Jonathan L. McMurry 2017 Kennesaw State University

Novel Cell Penetrating Peptide-Adaptors Effect Intracellular Delivery And Endosomal Escape Of Protein Cargos, John C. Salerno, Verra M. Ngwa, Scott J. Nowak, Carol A. Chrestensen, Allison N. Healey, Jonathan L. Mcmurry

Jonathan McMurry

The use of cell penetrating peptides (CPPs) as biomolecular delivery vehicles holds great promise for therapeutic and other applications, but development has been stymied by poor delivery and lack of endosomal escape. We have developed a CPP-adaptor system capable of efficient intracellular delivery and endosomal escape of user-defined protein cargos. The cell penetrating sequence of HIV transactivator of transcription was fused to calmodulin, which binds with subnanomolar affinity to proteins containing a calmodulin binding site. Our strategy has tremendous advantage over prior CPP technologies because it utilizes high affinity noncovalent, but reversible coupling between CPP and cargo. Three different cargo ...


Helicobacter Pylori Flha Binds The Sensor Kinase And Flagellar Gene Regulatory Protein Flgs With High Affinity, Jennifer Tsang, Takanori Hirano, Timothy R. Hoover, Jonathan L. McMurry 2017 Kennesaw State University

Helicobacter Pylori Flha Binds The Sensor Kinase And Flagellar Gene Regulatory Protein Flgs With High Affinity, Jennifer Tsang, Takanori Hirano, Timothy R. Hoover, Jonathan L. Mcmurry

Jonathan McMurry

Flagellar biogenesis is a complex process that involves multiple checkpoints to coordinate transcription of flagellar genes with the assembly of the flagellum. In Helicobacter pylori, transcription of the genes needed in the middle stage of flagellar biogenesis is governed by RpoN and the two-component system consisting of the histidine kinase FlgS and response regulator FlgR. In response to an unknown signal, FlgS autophosphorylates and transfers the phosphate to FlgR, initiating transcription from RpoNdependent promoters. In the present study, export apparatus protein FlhA was examined as a potential signal protein. Deletion of its N-terminal cytoplasmic sequence dramatically decreased expression of two ...


Session C-1: Modeling Stem Activities Into Classroom Practice, Sowmya Anjur 2017 Illinois Mathematics and Science Academy

Session C-1: Modeling Stem Activities Into Classroom Practice, Sowmya Anjur

Sowmya Anjur

Students understand concepts better when they have had a chance to work hands on with relevant material. Examples will be presented from my classroom where difficult concepts have been modeled into simple experiments with considerable success in enhancing student understanding. Special focus will be given to selected topics that students seem to have the most difficulty grasping. The objective is to enable students to transfer their understanding to solve complex problems with considerable ease and apply their understanding to real world scenarios on assessments. Suggestions will also be provided for implementation of various concepts into the high school classroom.


Development Of A Novel Pd-Based Heterogeneous Catalyst For Co2 Conversion, Susanna Mirabelli 2017 Long Island University

Development Of A Novel Pd-Based Heterogeneous Catalyst For Co2 Conversion, Susanna Mirabelli

Post & Beyond

As global warming caused by CO2 emission is becoming a serious issue that is threatening our life, various efforts have been attempted to mitigate the climate change by reducing the CO2 emission. The primary objective of this project is to develop a novel Pd-based heterogeneous catalyst to enhance the catalytic conversion of CO2 by H2 for the synthesis of value- added chemicals such as CO, methanol and fuels. The Pdbased solution we developed can be tuned to be either acidic or basic to adapt to different catalyst support. The solution was characterized by Ultraviolet-visible spectroscopy and the Pd adsorption was ...


The Occurance And Significance Of Mannitol In Silage, Arthur W. Dox, G. P. Plaisance 2017 Iowa State College

The Occurance And Significance Of Mannitol In Silage, Arthur W. Dox, G. P. Plaisance

Research Bulletin (Iowa Agriculture and Home Economics Experiment Station)

Mannitol, which may come into important industrial uses, particularly in the manufacture of explosives, is a normal constituent of corn silage and of silage made from other plants containing sucrose. Moreover, it occurs in sufficient amounts to suggest the possibility of its successful production from silage. These facts were brought out by the studies in silage fermentation carried on by the authors at the Iowa Agricultural Experiment station.


The Relative Influence Of Microorganisms And Plant Enzyms On Corn Silage Fermentation, Alvin R. Lamb 2017 Iowa State College

The Relative Influence Of Microorganisms And Plant Enzyms On Corn Silage Fermentation, Alvin R. Lamb

Research Bulletin (Iowa Agriculture and Home Economics Experiment Station)

Ever since the fermentation of silage has been studied and discussed the question of the agent causing the fermentation has been ill controversy. Some investigators have made the statement, based on evidence more or less incomplete, that microorganisms are solely responsible for the changes undergone by the ensiled forage. Other workers, who have based their conclusions on equally incomplete data, have held that in silage produced under proper conditions bacteria and yeasts do not figure to any appreciable extent, but that the plant cell itself is the cause of the chemical changes which take place in its constituents. Still other ...


Environmental Influences On Nectar Secretion, Leslie Alva Kenoyer 2017 Iowa State College

Environmental Influences On Nectar Secretion, Leslie Alva Kenoyer

Research Bulletin (Iowa Agriculture and Home Economics Experiment Station)

This study was undertaken to summarize and supplement existing knowledge of the factors which stimulate or retard the secretion of nectar. The work was carried out under the direction of the botany section of the Iowa Agricultural State Experiment Station in cooperation with the chemistry section, being done mostly at Ames, Iowa, from June, 1914, to June, 1916.


Estimation Of Calcium In Ash And Forage Plants And Animal Carcasses, S. B. Kuzirian 2017 Iowa State College

Estimation Of Calcium In Ash And Forage Plants And Animal Carcasses, S. B. Kuzirian

Research Bulletin (Iowa Agriculture and Home Economics Experiment Station)

One of the most abundant and important mineral constituents of nearly all agricultural products of both animal and vegetable origin is the element calcium. When such products are ignited, the entire content of calcium remains in the ash, either in the form of oxide or combined with an acid radical, such as phosphate or sulfate. An accurate method for the estimation of calcium is of prime importance in studying the relationship between the growing plant or animal on the one hand, and the soil or food supply on the other. The separation and subsequent estimation of calcium would be comparatively ...


Could O-Aminoquinones Of Estrogen Metabolites Serve As Platforms For Redox Cycling?, Rachel Miller 2017 University of Nebraska at Omaha

Could O-Aminoquinones Of Estrogen Metabolites Serve As Platforms For Redox Cycling?, Rachel Miller

Student Research and Creative Activity Fair

The metabolism of estrogen can lead to the formation of two isomeric o-quinones, estrogen-2,3-quinone (E-2,3-Q) and estrogen-3,4-Q (E-3,4-Q). The more reactive E-3,4-Q is genotoxic and can damage DNA by forming apurinic sites; whereas, E-2,3-Q does not form apurinic sites. Estrogen quinones may also be involved in redox cycling to produce reactive oxygen species (ROS), which is another genotoxic pathway. What is not yet clear, is why E-3,4-Q would undergo redox cycling while the non-carcinogenic E-2,3-Q would not. Nitrogen nucleophiles react with the E-3,4-Q at the 1-position. With DNA bases as the ...


Synthesis Of Small Molecule Anti-Trypanosomal Drugs, Samuel Anderson 2017 University of Nebraska at Omaha

Synthesis Of Small Molecule Anti-Trypanosomal Drugs, Samuel Anderson

Student Research and Creative Activity Fair

Demand for novel chemotherapeutic agents that treat Human African Trypanosomaiasis (HAT) persists. A series of compounds sharing a 3,4’diphephyl ether skeleton were prepared for a structure activity relationship (SAR) study evaluating antitrypansomal drug candidates. Trypanocidal assays performed in vitro by the Swiss Tropical and Public Health Institute identified a lead with an IC50 of 1.35 μg/mL analogous to a compound previously made in our laboratory. A slight improvement in activity (10%) was observed when changing the molecular substitution pattern from 4,4’ to 3,3’; however, the result is equivocal. Furthermore, in vitro test results demonstrated ...


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