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Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett 2017 East Tennessee State University

Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett

Undergraduate Honors Theses

Pyrrolobenzodiazepines (PBDs) are a group of naturally occurring compounds that were discovered in the cultures of Streptomyces in the 1960s. Some natural PBDs discovered in these cultures, such as anthramycin and sibiromycin, were shown to possess a broad spectrum of anti-tumor activity. Since cancer is still a leading cause of death globally, the development of novel anti-proliferative derivatives of PBDs is essential for human welfare worldwide. Further synthesis and structure-activity relationship (SAR) studies of the parent natural products and their tetracyclic analogs will lead to the discovery of drug candidates. In this work, thirteen PBD analogues were synthesized using no ...


Safer Chemicals Design Diagrams, Longzhu Shen, Fjodor Melnikov, John Roethle, Aditya Gudibanda, Richard Judson, Julie Zimmerman, Paul Anastas 2017 Yale University

Safer Chemicals Design Diagrams, Longzhu Shen, Fjodor Melnikov, John Roethle, Aditya Gudibanda, Richard Judson, Julie Zimmerman, Paul Anastas

Yale Day of Data

The NRF2-ARE antioxidant pathway is an important biological sensing and regulating system that responds to chemical insults. At minute level, it protects a living species to go through hard environmental conditions. However, when the external disruption exceeds the inherent resilience, cellular damage can occur, eventually leading to cytotoxicity. Therefore, studying the likelihood of a chemical activating the NRF2-ARE pathway is interesting to discovering therapeutic agents and designing safer chemicals. In this research, we engaged a combination of computational chemistry, statistical learning and mechanistic toxicology to estimate the likelihood of a chemical to perturb this critical toxicological pathway and derive a ...


Directed Solid Phase Peptide Synthesis Of Alpha-Conotoxin Mii, Jenny Fothergill, Vanessa Bowman, Matt Turner, Matt King, Owen McDougal (Mentor) 2017 Boise State University

Directed Solid Phase Peptide Synthesis Of Alpha-Conotoxin Mii, Jenny Fothergill, Vanessa Bowman, Matt Turner, Matt King, Owen Mcdougal (Mentor)

Idaho Conference on Undergraduate Research

Conotoxins—short, disulfide-rich peptides found in the venom of cone snails—exhibit unprecedented receptor binding selectivity. α-Conotoxin MII (α-CTxMII) targets the α3β2-nicotinic acetylcholine receptor (nAChR) isoform; studying the interaction of this peptide with nAChRs provides an understanding of binding determinants that may benefit therapeutic development for diseases like Alzheimer’s and Parkinson’s. Linear peptide was synthesized on solid support RINK resin by automated peptide synthesis followed by cleavage from resin and subsequent oxidative folding to form disulfide bridges. Mass spectral analysis validated proper synthesis and initial fold formation. QTOF-MS (m/z): [M + H]+ calculated for ...


Phage Display To Identify Functional Resistance Mutations To Rigosertib, Nedim Filipovic 2017 Claremont McKenna College

Phage Display To Identify Functional Resistance Mutations To Rigosertib, Nedim Filipovic

CMC Senior Theses

In vitro protein selection has had major impacts in the field of protein engineering. Traditional screens assay individual proteins for specific function. Selection, however, analyzes a pool of mutants and yields the best variants. Phage display, a successful selection technique, also provides a reliable link between variant phenotype and genotype. It can also be coupled with high throughput sequencing to map protein mutations; potentially highlighting vital mutations in variants. We propose to apply this technique to cancer therapy. RAF, a serine/threonine kinase, is critical for cell regulation in mammals. RAF can be activated by oncogenic RAS, found in over ...


Using Atto Dyes To Probe The Photocatalytic Activity Of Au−Cds Nanoparticles, Ujjal Bhattacharjee, Long Men, Bryan A. Rosales, Samuel R. Alvarado, Javier Vela, Jacob W. Petrich 2017 Iowa State University

Using Atto Dyes To Probe The Photocatalytic Activity Of Au−Cds Nanoparticles, Ujjal Bhattacharjee, Long Men, Bryan A. Rosales, Samuel R. Alvarado, Javier Vela, Jacob W. Petrich

Chemistry Publications

Metal−semiconductor nanohybrids (or heterostructures), such as Au−CdS, have become an important class of materials because of their role in photochemical hydrogen production and in other catalytic reactions. Here we report the results of photophysical studies of the interactions of these particles with ATTO dyes (ATTO 590 and 655), which are used as fluorescent probes in a wide range of spectroscopic techniques, most notably super-resolution microscopies. The most important feature of the Au−CdS particles is that they provide the possibility of selective excitation at either their CdS or their Au domains, which absorb preferentially at wavelengths shorter or ...


Ryan Caylor, Ryan Caylor 2016 Concordia University - Portland

Ryan Caylor, Ryan Caylor

Matthew E. Wise

Determination of the optical and physical properties of secondary organic aerosol particles
Measurement of the peroxide content of secondary organic aerosol particles


Cole Crosby, Cole Crosby 2016 Concordia University - Portland

Cole Crosby, Cole Crosby

Matthew E. Wise

Measurement of NOx concentrations on the Concordia University campus
Assessment of ozone formation in sparsely monitored areas using passive sampling


Avery Hong, Avery Hong 2016 Concordia University - Portland

Avery Hong, Avery Hong

Matthew E. Wise

Measurement of NOx concentrations on the Concordia University campus


Abstract Template Resrb 2017, Wojciech M. Budzianowski 2016 Wroclaw University of Technology

Abstract Template Resrb 2017, Wojciech M. Budzianowski

Wojciech Budzianowski

No abstract provided.


Order Form Resrb 2017, Wojciech M. Budzianowski 2016 Wroclaw University of Technology

Order Form Resrb 2017, Wojciech M. Budzianowski

Wojciech Budzianowski

No abstract provided.


C.V., Wojciech M. Budzianowski 2016 Wroclaw University of Technology

C.V., Wojciech M. Budzianowski

Wojciech Budzianowski

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Table Of Contents, 2016 University of Tennessee, Knoxville

Table Of Contents

International Journal of Nuclear Security

No abstract provided.


Letter From The Editor, 2016 University of Tennessee, Knoxville

Letter From The Editor

International Journal of Nuclear Security

No abstract provided.


Nuclear Power: Black Sky Liability Or Black Sky Asset?, Sherrell R. Greene 2016 Advanced Technology Insights, LLC (ATI)

Nuclear Power: Black Sky Liability Or Black Sky Asset?, Sherrell R. Greene

International Journal of Nuclear Security

Ready access to abundant electricity is a key enabler of modern life. During the past decade the vulnerability of Critical Infrastructure sectors in the U.S. to a variety of natural hazards and man-made threats has become increasingly apparent. The electrical infrastructure (the “Grid”) is the foundation for all other critical civil infrastructures upon which our society depends. Therefore, protection of the Grid is an energy security, homeland security, and national security issue of highest importance. Geomagnetic disturbances (GMD) induced by solar coronal mass ejections (CMEs), electromagnetic pulse (EMP) attacks, and cyber attacks are three events having the potential to ...


Modern Advancements In Post-Detonation Nuclear Forensic Analysis, S. Adam Stratz, Jonathan A. Gill, John D. Auxier II, Howard L. Hall 2016 University of Tennessee, Knoxville

Modern Advancements In Post-Detonation Nuclear Forensic Analysis, S. Adam Stratz, Jonathan A. Gill, John D. Auxier Ii, Howard L. Hall

International Journal of Nuclear Security

Deterring nuclear terrorism is a critical national asset to support the preclusion of non-state actors from initiating a nuclear attack on the United States. Successful attribution of a detonated nuclear weapon allows for timely responsive measures that prove essential in the period following a nuclear event. In conjunction with intelligence and law enforcement evidence, the technical nuclear forensics (TNF) post-detonation community supports this mission through the development and advancement of expertise to characterize weapon debris through a rapid, accurate, and detailed approach. Though the TNF field is young, numerous strides have been made in recent years toward a more robust ...


Improving Nuclear Safety, Security, And Nonproliferation In Northeast Asia Through Multinational Approach, Viet Phuong Nguyen 2016 Korea Advanced Institute of Science and Technology

Improving Nuclear Safety, Security, And Nonproliferation In Northeast Asia Through Multinational Approach, Viet Phuong Nguyen

International Journal of Nuclear Security

No abstract provided.


Prospects For Cooperation On Tackling Nuclear And Radiological Terrorism In South Asia: India–Pakistan Nuclear Detection Architecture, Muhammad Umer Khan 2016 Middlebury Institute of International Studies (MIIS)

Prospects For Cooperation On Tackling Nuclear And Radiological Terrorism In South Asia: India–Pakistan Nuclear Detection Architecture, Muhammad Umer Khan

International Journal of Nuclear Security

No abstract provided.


Janus Realized: The Use Of Social Media As A Means Of Transparency Nuclear Communication To The Public, Frances Bachstein 2016 University of Tennessee, Knoxville

Janus Realized: The Use Of Social Media As A Means Of Transparency Nuclear Communication To The Public, Frances Bachstein

International Journal of Nuclear Security

No abstract provided.


Evaluation Of Covert Plutonium Production From Unconventional Uranium Sources, Ondrej Chvala, Steven Skutnik, Tyrone Christopher Harris, Emily Anne Frame 2016 University of Tennessee

Evaluation Of Covert Plutonium Production From Unconventional Uranium Sources, Ondrej Chvala, Steven Skutnik, Tyrone Christopher Harris, Emily Anne Frame

International Journal of Nuclear Security

The potential for a relatively non-advanced nation to covertly acquire a significant quantity of weapons-grade plutonium using a gas-cooled, natural uranium-fueled reactor based on relatively primitive early published designed is evaluated in this article. The economic and technical issues that would influence the design decisions of a covert 239Pu production program are considered.

Several unconventional uranium acquisition approaches were explored. Methods for extracting uranium from enrichment tails, seawater, and coal ash sources were considered. The evaluation indicated that uranium extraction from coal ash or insitu leaching from underground deposits could be performed in economical manner that might be difficult ...


Student Competition Cover, 2016 University of Tennessee, Knoxville

Student Competition Cover

International Journal of Nuclear Security

No abstract provided.


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