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Ryan Caylor, Ryan Caylor 2016 Concordia University - Portland

Ryan Caylor, Ryan Caylor

Matthew E. Wise

Ryan is a senior majoring in chemistry at Concordia University. He plans on graduating in the spring of 2017. After graduation Ryan plans on attending graduate school in the field of meteorology with an interest in becoming a weather man. Ryan is returning to the Pacific Northwest National Laboratory in the summer of 2015 to study the chemical composition of secondary organic aerosol particles. He is also a pitcher on the Concordia University baseball team.


Silver-Polymer Nanocomposites, Anita N. Paul 2016 East Tennessee State Universtiy

Silver-Polymer Nanocomposites, Anita N. Paul

Electronic Theses and Dissertations

The objective of this research was the development of an efficient method for the preparation of silver-polymer nanocomposites containing finely dispersed silver nanoparticles. The surface of nanosilver was functionalized by thiolation with 2-aminoethanethiol. Amino-modified nanosilver was covalently bonded to polyacrylic acid, biodegradable polymers like acid terminated polylactic acid, ester terminated poly(DL-lactide-co-glycolide) and acid terminated poly(DL lactide-co-glycolide) in the presence of diisopropylcarbodiimide by carbodiimide method. Esterification of the carboxyl groups of Ag-polyacrylic acid by hydrochloric acid in methanol resulted in the formation of a stable colloidal dispersion of Ag nanoparticles in the polymer matrix. It was observed that not ...


Ogden College Of Science And Engineering Newsletter, Cheryl Stevens, Dean, Ogden College of Science and Engineering 2016 Ogden College of Science & Engineering

Ogden College Of Science And Engineering Newsletter, Cheryl Stevens, Dean, Ogden College Of Science And Engineering

Ogden College of Science & Engineering Publications

No abstract provided.


Interaction Of Spliceosomal U2 Snrnp Protein P14 With Its Branch Site Rna Target, William Perea Vargas 2016 Graduate Center, City University of New York

Interaction Of Spliceosomal U2 Snrnp Protein P14 With Its Branch Site Rna Target, William Perea Vargas

All Graduate Works by Year: Dissertations, Theses, and Capstone Projects

Newly transcribed precursor messenger RNA (pre-mRNA) molecules contain coding sequences (exons) interspersed with non-coding intervening sequences (introns). These introns must be removed in order to generate a continuous coding sequence prior to translation of the message into protein. The mechanism through which these introns are removed is known as pre-mRNA splicing, a two-step reaction catalyzed be a large macromolecular machine, the spliceosome, located in the nucleus of eukaryotic cells. The spliceosome is a protein-directed ribozyme composed of small nuclear RNAs (snRNA) and hundreds of proteins that assemble in a very dynamic process. One of these snRNAs, the U2 snRNA, is ...


Enhanced Adhesion Of Superhydrophobic Zno Surface, liqiu zheng Dr., Chan Kwaichow B. 2016 Albany State University

Enhanced Adhesion Of Superhydrophobic Zno Surface, Liqiu Zheng Dr., Chan Kwaichow B.

Georgia Journal of Science

The superhydrophobicity and the strong solid-liquid adhesion of the dually structured ZnO surface are attributed to the suitable size of microstructure and nanostructure. This phenomenon, so different from the Lotus effect, can be called the Petal effect— the super hydrophobicity and the enhanced solid-liquid adhesion coexist on the same surface. The Cassie impregnating model was proposed to understand the underlying reason.


Predicted Structure And Binding Motifs Of Collagen A1(Xi), Julia Oxford, Owen McDougal, Lisa Warner, Chris Mallory 2016 Boise State University

Predicted Structure And Binding Motifs Of Collagen A1(Xi), Julia Oxford, Owen Mcdougal, Lisa Warner, Chris Mallory

Lisa Warner

The amino propeptide of collagen a1(XI) (NPP) has been shown to bind glycosaminoglycans and to form a dimer. While these are independent biochemical events, it is likely that dimerization facilitates the interaction with glycosaminoglycans or alternatively, that glycosaminoglycan interaction facilitates the formation of an NPP:NPP dimer. The computer program MODELLER was used to generate a homology model of the collagen a1(XI) NPP monomer using the crystal structure of the closely related noncollagenous-4 (NC4) domain of collagen a1(IX) (PDB:2UUR) as the template. Additionally, a dimer model of collagen a1(XI) NPP domain was created based upon ...


Synthesis And Evaluation Of Biological Activity Of A Potential Immunomodulatory Zwitterionic Polysaccharide, Vikram Basava 2016 Seton Hall University

Synthesis And Evaluation Of Biological Activity Of A Potential Immunomodulatory Zwitterionic Polysaccharide, Vikram Basava

Seton Hall University Dissertations and Theses (ETDs)

The gram-negative anaerobic bacterium Bacteroides fragilis is an integral component of the normal gastrointestinal flora. The bacterium colonizes the intestinal tract of human beings as it has no reservoir other than mammals. An unprecedented proportion of the genomic DNA of B. fragilus is involved in the production of capsular polysaccharides. These capsular polysaccharides are important virulence factors in most extracellular bacterial pathogens. Eight of these polysaccharides have been identified thus far, out of which two were found to be zwitterionic polymers, PSA1 and PSA2. PSA1 was found to stimulate T-cell lineage of the immune system because of the dual charge ...


Application Of An Ionic Liquid Column To The Analysis Of Flavor And Fragrance Ingredients, Nicole L. Curto 2016 Seton Hall University

Application Of An Ionic Liquid Column To The Analysis Of Flavor And Fragrance Ingredients, Nicole L. Curto

Seton Hall University Dissertations and Theses (ETDs)

Traditional, polar (polyethylene glycol/wax) stationary phase gas chromatography columns pose challenges for flavor and fragrance analysis particularly in regards to thermal instability at high temperatures, degradation when exposed to water, unchanging selectivity, and relatively short shelf lives. Recently, capillary columns using ionic liquids as stationary phases have become available. Ionic liquid columns offer a potential combination of high polarity and high temperature stability with unique selectivity. An in depth discussion about the history and development of column phase characterization, with specific emphasis on selectivity and polarity, will allow for a critical look at the polarity scale currently employed to ...


Molten Nitrite Eutectics: The Reaction Of Four Lanthanide(Iii) Chlorides, Dhia A. Habboush, D. H. Kerridge, S. A. Tariq 2016 Sacred Heart University

Molten Nitrite Eutectics: The Reaction Of Four Lanthanide(Iii) Chlorides, Dhia A. Habboush, D. H. Kerridge, S. A. Tariq

Dhia A. Habboush

Cerium(III) chloride reacted with sodium nitrite—potassium nitrite eutectic, initially in the solid state but more rapidly on melting, to form cerium(IV) oxide, while lanthanum(III) chloride, praseodymium(III) chloride and europium(III) chloride reacted, very largely in the liquid state, undergoing anion exchange and a partial Lux—Flood acid—base reaction to form oxide nitrites (LnONO2) initially. At higher temperatures the latter two chlorides reacted further to form the oxides (Pr6O11 and Eu2O3, respectively). In lithium nitrite—potassium nitrite eutectic, the course of the reactions was similar but the temperatures at which reaction commenced were lower.


A Faster Way To Better Reactions: 'One-Pot' Approach Could Speed Syntheses Of New Products, Gregory W. O'Neil, Christopher M. Reddy 2016 Western Washington University

A Faster Way To Better Reactions: 'One-Pot' Approach Could Speed Syntheses Of New Products, Gregory W. O'Neil, Christopher M. Reddy

Gregory W. O'Neil

When we tell people that we are chemists, they occasionally crinkle their noses in a subtle but unmistakable expression of pain. Often this is followed by a retelling of the time they almost caused a fire or explosion when attempting to make soap, aspirin, or other products in chem lab.

Many factors go into chemical reactions, opening up many avenues for things to go wrong. On the other hand, myriad possible chemical reactions exist to synthesize new commercial and industrial compounds, from shampoo to silicon chips. Many potential reactions have still not been discovered.

It is big business and a ...


A Pilot Study Analyzing Solvents In Electronic Cigarette “E-Liquid” Using High Performance Liquid Chromatography, Austin Matranga, Olivia Sellers, Matthew Gartner 2016 Chapman University

A Pilot Study Analyzing Solvents In Electronic Cigarette “E-Liquid” Using High Performance Liquid Chromatography, Austin Matranga, Olivia Sellers, Matthew Gartner

Student Research Day Abstracts and Posters

Introduction: Electronic cigarettes, also known as an e-cigarette, are battery-powered devices that use a heating element to convert a liquid (“e-liquid”) into an inhalable aerosol. Their advertised use is as a nicotine delivery system minus the harmful chemicals. Since “e-liquids” and the electronic cigarettes are not regulated by the Food and Drug Administration, it is not well known under what conditions, if any, carcinogenic compounds are produced. There has been little research on the toxicity of electronic cigarettes. The aim of this study was to determine if formaldehyde or acetaldehyde are formed from the e-liquid by the high heat of ...


The Chemistry Of Photography, Nichole Marie Witten 2016 University of South Carolina - Columbia

The Chemistry Of Photography, Nichole Marie Witten

Theses and Dissertations

People nowadays are used to instant gratification when it comes to taking photographs. They look at a digital display, click a button, and get a perfectly focused and lighted picture that they can see right away. New technologies enable people to have pocket-sized digital cameras, their smart phones, with them at all times, and they’re easy convenient, and fast. Behind a single lens reflex (SLR) film camera, the scenario is much different. More time is needed in framing the image and adjusting the aperture and shutter speed to get the correct exposure, and the film must be processed darkroom ...


From The Sewing Room To The Ballroom, The Evolution Of Ballroom Dance Costumes, Jessica Marie Russell 2016 University of South Carolina - Columbia

From The Sewing Room To The Ballroom, The Evolution Of Ballroom Dance Costumes, Jessica Marie Russell

Theses and Dissertations

Although I have danced all my life, I only began to ballroom dance and dance socially after starting college at the University of South Carolina. While dancing with the Carolina Ballroom Club, I learned some of the history of ballroom dance from our instructors, but I never quite understood how we went from having very conservative court dances to the wide variety of ballroom dances where dancers wear extravagant costumes. I also have been sewing since I was a child; I helped do minor repairs in the costume room for ballet productions, and recently began making clothing for myself. I ...


Thiophene Based Molecular Sensors Towards Mercury Detection, Austin K. Shigemoto, Carolyn N. Virca, Sam Underwood, Lauren Shetterly, Theresa M. McCormick 2016 Portland State University

Thiophene Based Molecular Sensors Towards Mercury Detection, Austin K. Shigemoto, Carolyn N. Virca, Sam Underwood, Lauren Shetterly, Theresa M. Mccormick

Student Research Symposium

Toxic heavy metals such as mercury have increased in concentration in the environment due to pollution. Inorganic mercury in the environment can be later converted to a more toxic form: methylmercury. Regular consumption of fish containing methylmercury can lead to several cognitive and motor disorders as well as Minamata disease. The current methods used to detect both methylmercury and inorganic mercury in sea life and drinking water involve long sample preparation and cost. In order to more efficiently track this toxic metal in the environment and identify contaminated food and water sources, a cheaper and faster method of detection is ...


Modification Of Cellular Dna By Synthetic Aziridinomitosenes, Chris M. Mallory, Ryan P. Carfi, SangPhil Moon, Kenneth A. Cornell, Don L. Warner 2016 Boise State University

Modification Of Cellular Dna By Synthetic Aziridinomitosenes, Chris M. Mallory, Ryan P. Carfi, Sangphil Moon, Kenneth A. Cornell, Don L. Warner

Don Warner

Two synthetic aziridinomitosenes (AZMs), Me-AZM and H-AZM, structurally related to mitomycin C (MC) were evaluated for their anticancer activity against six cancer cell lines (HeLa, Jurkat, T47D, HepG2, HL-60, and HuT-78) and tested for their DNA-modifying abilities in Jurkat cells. Cytotoxicity assays showed that Me-AZM is up to 72-fold and 520-fold more potent than MC and H-AZM, respectively. Me-AZM also demonstrated increased DNA modification over MC and H-AZM in alkaline COMET and Hoechst fluorescence assays that measured crosslinks in cellular DNA. Me-AZM and H-AZM treatment of Jurkat cells was found to sponsor significant DNA-protein crosslinks using a K-SDS assay. The ...


Modification Of Cellular Dna By Synthetic Aziridinomitosenes, Chris M. Mallory, Ryan P. Carfi, SangPhil Moon, Kenneth A. Cornell, Don L. Warner 2016 Boise State University

Modification Of Cellular Dna By Synthetic Aziridinomitosenes, Chris M. Mallory, Ryan P. Carfi, Sangphil Moon, Kenneth A. Cornell, Don L. Warner

Kenneth Cornell

Two synthetic aziridinomitosenes (AZMs), Me-AZM and H-AZM, structurally related to mitomycin C (MC) were evaluated for their anticancer activity against six cancer cell lines (HeLa, Jurkat, T47D, HepG2, HL-60, and HuT-78) and tested for their DNA-modifying abilities in Jurkat cells. Cytotoxicity assays showed that Me-AZM is up to 72-fold and 520-fold more potent than MC and H-AZM, respectively. Me-AZM also demonstrated increased DNA modification over MC and H-AZM in alkaline COMET and Hoechst fluorescence assays that measured crosslinks in cellular DNA. Me-AZM and H-AZM treatment of Jurkat cells was found to sponsor significant DNA-protein crosslinks using a K-SDS assay. The ...


Innovative Synthesis Of Diltiazem/Clentiazem Analogs, Emelyn Magtanong 2016 Southern Adventist Univeristy

Innovative Synthesis Of Diltiazem/Clentiazem Analogs, Emelyn Magtanong

Journal of Interdisciplinary Undergraduate Research

Cardiovascular disease defines disorders of the heart and blood vessels, and is the number one cause of death in America. Diltiazem and clentiazem are common calcium channel blockers incorporated into drugs used to treat various cardiovascular diseases. Methods to synthesize 5-[2-(dimethylamino)ethyl]-8-hydroxy-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one, an analog of the core of diltiazem and clentiazem, using cost-efficient starting materials allows for affordable treatment and increased availability to affected individuals. N-(N,N-dimethylethanamine)-4-aminophenol can be oxidized to form a quineoneimine, which can be further reacted with 3-mercaptopropionic acid via Michael addition. Subsequent addition of a coupling ...


Inhibiting Fatty Acid Synthase In Rapidly Dividing Cells: Synthesis Of 5-(Alkylthio)-1h-Benzo[D]Imidazole-2,6-Diones, Andy Hausted 2016 Southern Adventist Univeristy

Inhibiting Fatty Acid Synthase In Rapidly Dividing Cells: Synthesis Of 5-(Alkylthio)-1h-Benzo[D]Imidazole-2,6-Diones, Andy Hausted

Journal of Interdisciplinary Undergraduate Research

Prostate and breast cancer are the number one and number two cancer sites, respectively, for male and females within the United States.1 Increased levels of the enzyme fatty acid synthase have been found in rapidly dividing cancer cells. This enzyme is responsible for the de novo synthesis of fatty acids in human cells, which are essential to cell growth and survival. The goal then for this research is to synthesize and design a new synthesis of 5-(alkylthio)-1Hbenzo[ d]imidazole-2,6-diones intended to successfully inhibit fatty acid synthase (FASN) by binding allosterically to the thioesterase domain of FASN ...


Studies In Asymmetric Catalysis: Supramolecular Catalysis And Borane-Assisted Hydrogenation, Kazuya Toyama 2016 University of Nebraska-Lincoln

Studies In Asymmetric Catalysis: Supramolecular Catalysis And Borane-Assisted Hydrogenation, Kazuya Toyama

Student Research Projects, Dissertations, and Theses - Chemistry Department

Metal-catalyzed catalytic asymmetric reactions have gained enormous attentions and the utilities of such reactions have facilitated natural products syntheses to afford highly bioactive molecules. While these reactions have provided reliable methodologies to transform basic reactants into product(s) with highly enantio- and regioselective manners, the incompatibility with a many functional groups and the associated need to employ protecting groups increases the number of synthetic steps required. Herein, a solution to such an issue has been proposed in catalytic asymmetric hydroboration of styrene derivatives where supramolecular catalysts developed by Takacs et al. were used to achieve highly regio- and stereoselective reaction ...


Molecular Mechanism For The Biosynthesis And Regulation Of Secondary Metabolites In Lysobacter, Simon Tesfamichael Tombosa 2016 University of Nebraska-Lincoln

Molecular Mechanism For The Biosynthesis And Regulation Of Secondary Metabolites In Lysobacter, Simon Tesfamichael Tombosa

Student Research Projects, Dissertations, and Theses - Chemistry Department

This thesis presents regulatory and biosynthetic mechanisms by which microorganisms produce secondary metabolites that can potentially be developed into drugs beneficial to humans. The first section shows the role of small signaling molecules in regulating the production of one of the novel antifungal metabolites, heat stable antifungal factor (HSAF), from Lysobacter enzymogenes.

In the second part of the thesis I report our attempts to isolate and characterize the biosynthesis of WBP, a new secondary metabolite from Lysobacter antibioticus OH13. I have included the in-silico analysis of the gene cluster for WBP and the predicted biosynthetic pathway based on analysis of ...


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