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Recent Articles in Chemistry
Iron Citrate Toxicity Causes Aco1Δ-Induced Mtdna Loss In Saccharomyces Cerevisiae, Muhammad Ali Farooq 
University of New Orleans
Iron Citrate Toxicity Causes Aco1Δ-Induced Mtdna Loss In Saccharomyces Cerevisiae, Muhammad Ali Farooq
Senior Honors Theses
Aconitase is an enzyme of the Krebs cycle that catalyzes the isomerization of citrate to isocitrate. In addition to its enzymatic activity, Aco1 has been reported to bind to mitochondrial DNA (mtDNA) and mediate its maintenance in the budding yeast S. cerevisiae. In the absence of Aco1, cells rapidly lose mtDNA and become “petite” mutants. The purpose of this study is to uncover the mechanism behind mtDNA loss due to an aco1 deletion mutation. We found that an aco1 mutation activates the mitochondria-to-nucleus retrograde (RTG) signaling pathway, resulting in increased expression of citrate synthases (CIT) through the activation of two ...
Synthesis Of Dibenzofurans Via A Palladium Catalyzed Oxidative Ring Closure Reaction, Sadia Akram University of New Orleans
Synthesis Of Dibenzofurans Via A Palladium Catalyzed Oxidative Ring Closure Reaction, Sadia Akram
Senior Honors Theses
The cannabinoid partial agonist BAY 59-3704 has been identified as an attractive target to explore structure-activity relationships at cannabinoid receptors for the development of a therapeutic agent for psychostimulant addiction. This thesis will describe the studies associated with the optimization of a palladium-catalyzed oxidative ring closure reaction for the synthesisof dibenzofuran analogues from substituted diaryl ethers. These dibenzofurans are viewed as rigid analogues of BAY 59-3704 and will provide useful information about molecular interactions at cannabinoid receptors. The scope and limitations of the palladium-catalyzed oxidative ring closure reaction as it relates to the synthesis of the target dibenzofuran analogues will ...
Means And Method Of Detection In Chemical Separation Procedures, Edward S. Yeung, Lance B. Koutny, Barry L. Hogan, Chan K. Cheung, Yinfa Ma 
Iowa State University
Means And Method Of Detection In Chemical Separation Procedures, Edward S. Yeung, Lance B. Koutny, Barry L. Hogan, Chan K. Cheung, Yinfa Ma
Iowa State University Patents
A means and method for indirect detection of constituent components of a mixture separated in a chemical separation process. Fluorescing ions are distributed across the area in which separation of the mixture will occur to provide a generally uniform background fluorescence intensity. For example, the mixture is comprised of one or more charged analytes which displace fluorescing ions where its constituent components separate to. Fluorescing ions of the same charge as the charged analyte components cause a displacement. The displacement results in the location of the separated components having a reduced fluorescence intensity to the remainder of the background. Detection ...
Rational Design And Synthesis Of Amplified Therapeutic/Diagnostic Agents Targeting The Estrogen Receptor, Anton Igorevich Kozhushnyan 
Northeastern University
Rational Design And Synthesis Of Amplified Therapeutic/Diagnostic Agents Targeting The Estrogen Receptor, Anton Igorevich Kozhushnyan
Chemistry Master's Theses
Estradiol tolerates the presence of large functional groups off of the 11-beta position while retaining a reasonable relative binding affinity to Estrogen Receptor-alpha; (ER-alpha). Although RU 39,4112, a prototypical 11-beta substituted estradiol derivative, has been considered as a potent therapeutic anti-estrogen, it also has the potential for serving as a highly ER-selective targeting agent. Because there is over-expression of ER in breast cancer cells, it is a logical biological target for compounds like RU 39,411 or its analogs. In this study, I will apply this information to design and synthesize a novel and selective delivery system for breast ...
Spectral Cytopathology: A Dagnostic Tool For The Oral Cavity And The Esophagus, Kathleen Lenau Northeastern University
Spectral Cytopathology: A Dagnostic Tool For The Oral Cavity And The Esophagus, Kathleen Lenau
Chemistry Master's Theses
Spectral cytopathology (SCP), which couples Fourier Transform infrared micro-spectroscopy (IR-MSP) with unsupervised multivariate statistical methods, is an accurate and robust optical tool for the detection of subtle biochemical changes that occur within individual cells. SCP monitors the biochemical composition of cells within a sample and through computer-based algorithms is able to identify and classify unique spectral changes that are induced by disease. These subtle molecular changes can be observed before morphological changes become apparent, allowing earlier diagnostic information to become available for cytologists. When diagnostic information is available earlier the patient can potentially be offered treatment more swiftly, thus improving ...
Method For The Conversion Of Cellulose And Related Carbohydrate Materials To Low-Molecular-Weight Compounds, Walter S. Trahanovsky, Ronald C. Holtan, Kyle W. Quasdorf, Normon K. Olson, Alyse A. Hurd, Joseph A. Marshall Iowa State University
Method For The Conversion Of Cellulose And Related Carbohydrate Materials To Low-Molecular-Weight Compounds, Walter S. Trahanovsky, Ronald C. Holtan, Kyle W. Quasdorf, Normon K. Olson, Alyse A. Hurd, Joseph A. Marshall
Iowa State University Patents
Methods of converting cellulose or related biorenewable carbohydrate materials into high-value chemical compounds. The methods provide a means of converting low-cost materials such as cellulose and biomass into high yields of compounds such as ethylene glycol, propylene glycol, glycerin, methanol, hydroxyacetone, glycolaldehyde and dihydroxyacetone.
Process For The Conversion Of Cyclic Amines Into Lactams, L. Keith Woo, Robert J. Angelici Iowa State University
Process For The Conversion Of Cyclic Amines Into Lactams, L. Keith Woo, Robert J. Angelici
Iowa State University Patents
Converting cyclic amines to lactams using gold supported catalysts.
Probing The Low Temperature Oxidation Of Furanic Biofuels, 2-Methyltetrahydrofuran And 2,5-Dimethylfuran, Utilizing Orthogonal Time-Of-Flight Mass Spectrometry Coupled To Synchrotron Radiation, Matthew McManus 
University of San Francisco
Probing The Low Temperature Oxidation Of Furanic Biofuels, 2-Methyltetrahydrofuran And 2,5-Dimethylfuran, Utilizing Orthogonal Time-Of-Flight Mass Spectrometry Coupled To Synchrotron Radiation, Matthew Mcmanus
Master Theses
Concern over natural resources and global climate shifts has increased the focus of sourcing transportation fuels from depleting oil wells to regenerative, biological based solutions. One avenue of biologically sourced fuel involves the extraction of C5 and C6 sugars from the woody, fibrous, and inedible plant materials, otherwise known as lignocellulosic biomass. These cellulosic sugars can be converted to target biofuels and biofuel additives like the furanic compounds, 2,5-dimethylfuran and 2-methylfuran. In this thesis, the low temperature oxidation of two compounds, 2,5-dimethylfuran and 2-methylfuran, are explored. These reactions were conducted at the Advanced Light Source in Berkeley, CA ...
Aerobic Degradation Of Α-, Β-, Γ-Hexachlorocyclohexane By Narragansett Bay Bacterioplankton, Ian M. Rambo 
University of Rhode Island
Aerobic Degradation Of Α-, Β-, Γ-Hexachlorocyclohexane By Narragansett Bay Bacterioplankton, Ian M. Rambo
Senior Honors Projects
Hexachlorocyclohexanes (HCHs) are a family of chlorinated organic compounds that were previously used as agricultural insecticides. HCHs are recognized as persistent organic pollutants due to their toxicity, recalcitrant properties, and tendency to bioaccumulate in food webs. Although HCH was first synthesized in 1825, its use was not widespread until the discovery of the insecticidal activity of the γ-HCH isomer in 1942. γ-HCH and its toxic waste isomers α-HCH and β-HCH were banned from production and use by the United Nations in 2009, yet these chemicals still present environmental problems due to their persistence in soils and surface waters. HCHs continue ...
Searching For A New Epoxide Precursor In Tmm Cycloaddition Reactions, Christopher Miko 
Valparaiso University
Searching For A New Epoxide Precursor In Tmm Cycloaddition Reactions, Christopher Miko
Celebration of Undergraduate Scholarship
In order to explore the feasibility of Pd(0)-catalyzed trimethylenemethane (TMM) cycloaddition reactions with epoxides, the precursor trimethyl-(2-oxiranyl-2-propenyl)-silane (1) was synthesized in a three-step process from propargyl alcohol and reacted with dimethyl malonate, with Pd(PPh3)4 acting as a catalyst, in both THF and toluene. This reaction was performed to examine whether the π-allyl Palladium complex forms and whether the epoxide ring opens. NMR spectra show support for π-allyl Palladium complex formation, the epoxide ring opening, and the presence of the expected product, although the solvent used may affect which product forms. Efforts to characterize the ...
Release Of Phosphorus From Sediment Into Pore Water, Adam Dickey, Wang Hang, Dr. Zhang ZhiJian Valparaiso University
Release Of Phosphorus From Sediment Into Pore Water, Adam Dickey, Wang Hang, Dr. Zhang Zhijian
Celebration of Undergraduate Scholarship
As global climate change becomes an increasing problem, it is important to understand the effects that it may cause. One possible set of effects are changes in solubility of various pollutants in aqueous systems. Phosphorus (P) and nitrogen are two important nutrients that become pollutants when present at elevated concentrations. Phosphorus is particularly worrisome because it is generally the nutrient that limits plant growth. It also binds to particles and is difficult to eliminate from aqueous systems. In collaboration with researchers at Zhejiang University, we determined the total amount of phosphorus released from six different types of wetland sediment into ...
Water Quality Monitoring Of The Little Calumet East Branch Watershed, Nicholas H. Feller, Melissa Dorton Valparaiso University
Water Quality Monitoring Of The Little Calumet East Branch Watershed, Nicholas H. Feller, Melissa Dorton
Celebration of Undergraduate Scholarship
The Little Calumet East Branch (LCEB) is a 10-digit hydrologic unit code (HUC) watershed that ultimately discharges into Lake Michigan. The watershed begins in unincorporated LaPorte County and discharges west through unincorporated Porter County, converges with the West Branch of the Little Calumet River, and finally discharges into Lake Michigan via the Burns Ditch Waterway. A water quality monitoring study was performed in the summer of 2012 as part of the watershed management process led by a not-for-profit organization, Save the Dunes. Save the Dunes’ Great Lakes Innovative Stewardship through Education Network (GLISTEN) liaisons initiated weekly monitoring at eleven LCEB ...
Investigations Of The Application Of Black Carbon For The Retention And Stabilization Of Nonylphenol In Soil, Kelly Belisle, Laura Mattson, Caitlin Soley Valparaiso University
Investigations Of The Application Of Black Carbon For The Retention And Stabilization Of Nonylphenol In Soil, Kelly Belisle, Laura Mattson, Caitlin Soley
Celebration of Undergraduate Scholarship
We used black carbon (BC) to absorb and stabilize nonylphenol (NP) that was present in soil samples. BC is an efficient material for absorbing and stabilizing hydrophobic organic compounds because this material has a high absorption capacity and strongly binds organic molecules. Thus, black carbon has the ability to retain NP in the soil minimizing loss to runoff while providing microbes with longer times (up to several hundred years) to metabolize the NP to less hazardous compounds. NP is both an endocrine-disrupter and a toxic pollutant. It also serves as a model compound for the study of stabilization of organic ...
N-Doped Multiwalled Carbon Nanotubes: Functionalization, Characterization And Application In Li Ion Batteries, Aman Preet Kaur 
University of Kentucky
N-Doped Multiwalled Carbon Nanotubes: Functionalization, Characterization And Application In Li Ion Batteries, Aman Preet Kaur
Theses and Dissertations--Chemistry
The focus of this dissertation is to utilize chemical functionalization as a probe to investigate the reactivity of N-doped multiwalled carbon nanotubes (N-MWCNTs). The surface of N-MWCNTs, being a set of potentially reactive graphene edges, provides a large number of reactive sites for chemical modification, so considerable changes in chemical and physical properties can be envisaged. We observed that both reduction (dissolving metal reduction/alkylation) and oxidation (H2SO4/HNO3 and H2SO4/KMnO4 mixtures) of N-MWCNTs lead to formation of interesting spiral channels and spiraled carbon nanoribbons. A variety of techniques, including TGA ...
Synthesis Of Rhenium And Manganese Pyridazoal Complexes, Jesse Evans 
Western Kentucky University
Synthesis Of Rhenium And Manganese Pyridazoal Complexes, Jesse Evans
Masters Theses & Specialist Projects
Pyridazines are a heterocyclic aromatic compound containing a characteristic N-N bond that are utilized in many fields, including medicine and electronics. It is this latter field that Dr. Snyder's research group is focused upon. Organometallic compounds are a better conducting material than the current inorganic compounds used in electronics due to better conductance of electricity, lower production cost, and the ability to be formed into thin films. With this in mind, Dr. Snyder's research group has set out to synthesize organometallic compounds for this purpose. Following procedures set forth by Snyder etc, and altered to form an off-metal ...
Fxxlf Proteomimetics Of Coactivators Binding To The Androgen Receptor, Patrick Thomas Weiser Northeastern University
Fxxlf Proteomimetics Of Coactivators Binding To The Androgen Receptor, Patrick Thomas Weiser
Chemistry Dissertations
A series of novel substituted biphenyl compounds was designed as alpha helical proteomimetics with the aim of inhibiting the binding of coactivator proteins to the nuclear hormone receptor coactivator binding pocket. The final products were evaluated using estrogen receptor reporter gene assays and competitive binding assays to demonstrate their effectiveness as competitive binding inhibitors. The results from this study indicate that these proteomimetics possess the ability to inhibit this protein-protein interaction.
Comparison Of Methodologies For Synthesis Of 3-(Cyclopropylethynyl)Benzisothiazole 1,1-Dioxide, Rachel Lee Naramore 
University of Tennessee, Knoxville
Comparison Of Methodologies For Synthesis Of 3-(Cyclopropylethynyl)Benzisothiazole 1,1-Dioxide, Rachel Lee Naramore
University of Tennessee Honors Thesis Projects
No abstract provided.
Molecular Hospitality: An Examination Of The Interactions Between Brooker’S Merocyanine And Modified Cyclodextrins, Benjamin Averill Valparaiso University
Molecular Hospitality: An Examination Of The Interactions Between Brooker’S Merocyanine And Modified Cyclodextrins, Benjamin Averill
Celebration of Undergraduate Scholarship
The equilibrium of a guest molecule binding to a host occurs through weak molecular interactions instead of through the formation of chemical bonds. A cyclodextrin (CD) is used as the host molecule due to its basket-like shape which is beneficial to complex formation with the guest molecule, Brooker’s merocyanine (BM), which fits well within beta-CD. BM is a highly conjugated dye that can exhibit a charge, allowing for a variety of the weak molecular interactions involved with complex formation, such as hydrogen bonds, to be studied. This project focuses on the effect of different modifications to the CD on ...
Synthesis Of Isotopologues And Nanoparticles For Hyper Raman Spectroscopy, Burton K. Mandrell University of Tennessee, Knoxville
Synthesis Of Isotopologues And Nanoparticles For Hyper Raman Spectroscopy, Burton K. Mandrell
University of Tennessee Honors Thesis Projects
No abstract provided.
An Investigation Into The Sustainability Of Advanced Materials And Systems As Energy Sources In Commuter Transportation, Austin Alan Albert University of Tennessee, Knoxville
An Investigation Into The Sustainability Of Advanced Materials And Systems As Energy Sources In Commuter Transportation, Austin Alan Albert
Chemistry Publications and Other Works
Modern society depends on cheap and plentiful sources of energy. For most of the 20th century, fossil fuel in the form of coal, natural gas, and petroleum have been this energy source. The majority of petroleum in the U.S. goes in to fueling the light duty transportation fleet. However, we know that coal, natural gas, and crude oil have an expiration date, and we have recently learned that their use has caused and is still causing severe damage to the earth’s atmosphere. With these reasons in mind, new sources of inexpensive and abundant energy must be found, which ...
Popular Institutions
Popular Authors
Otto Vogl
University of Massachusetts - Amherst
Suresh Pillai
Dublin Institute of Technology
Michael Seery
Dublin Institute of Technology
Steve Scheiner
Utah State University
Charles Wilkie
Marquette University
VM Rotello
University of Massachusetts - Amherst
Alicia McDaniel
Western Kentucky University
Jeanne Hossenlopp
Marquette University
Richard Day
Glyndŵr University
Nicholas Nolan
Dublin Institute of Technology
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Popular Articles
Synthesis And Characterization Of Bis-Phosphine Complexes With Transition Metals, Alicia McDaniel
A Review On The Visible Light Active Titanium Dioxide Photocatalysts For Environmental Applications, Michael Seery, Suresh Pillai
Aryl Nitro Reduction With Iron Powder Or Stannous Chloride Under Ultrasonic Irradiation, P. Keller
Spectroscopic Investigation Of The Anatase-To-Rutile Transformation Of Sol-Gel Synthesised Tio2 Photocatalysts, Michael Seery, Nicholas Nolan, Suresh Pillai
The Refractive Indices Of Ethyl Alcohol And Water Mixtures
Synthesis And Catalytic Activity Of Nanostructured Cerium Oxide, Neil Lawrence
Analysis Of Biodiesel Quality Using Reversed Phase High-Performance Liquid Chromatography, Kellyann Murphy
New Starches: Physicochemical Properties Of Sweetsop (Annona Squamosa) And Soursop (Annona Muricata) Starches, Peter Williams
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