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Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett 2017 East Tennessee State University

Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett

Undergraduate Honors Theses

Pyrrolobenzodiazepines (PBDs) are a group of naturally occurring compounds that were discovered in the cultures of Streptomyces in the 1960s. Some natural PBDs discovered in these cultures, such as anthramycin and sibiromycin, were shown to possess a broad spectrum of anti-tumor activity. Since cancer is still a leading cause of death globally, the development of novel anti-proliferative derivatives of PBDs is essential for human welfare worldwide. Further synthesis and structure-activity relationship (SAR) studies of the parent natural products and their tetracyclic analogs will lead to the discovery of drug candidates. In this work, thirteen PBD analogues were synthesized using no ...


Genetically Encoded Fluorescent Protein Biosensor For Nitric Oxide, Wenjia Zhai 2017 University of Nebraska-Lincoln

Genetically Encoded Fluorescent Protein Biosensor For Nitric Oxide, Wenjia Zhai

Student Research Projects, Dissertations, and Theses - Chemistry Department

Nitric oxide (NO) is an important molecule in living cells for signaling, thus a specific sensor to detect its level in live cells is needed. Currently there are a few small molecule probes for the detection of NO. A common shortcoming of these probes is their unavoidable leakage from the target cells. In this project, I seek to develop a novel green fluorescent protein (GFP)-based biosensor to detect cellular NO. This GFP-based sensor is genetically encodable and can potentially avoid the possible false positive result due to the leakage. I synthesized an unnatural amino acid (unAA) and examined its ...


Fluorescence And Uv-Vis Studies Of Quinone-Induced Protein Modifications, Charles A. Thomas Jr 2017 University of Tennessee at Chattanooga

Fluorescence And Uv-Vis Studies Of Quinone-Induced Protein Modifications, Charles A. Thomas Jr

Honors Theses

Quinones are the metabolites of a class of chemicals known as polycyclic aromatic hydrocarbons. These chemicals have been found to be toxic in the environment, especially when interacting with certain proteins. In this study, we investigated the modification of Lysozyme and Ribonuclease A by a series of benzoquinones as well as few naphthoquinones. Fluorescence spectroscopy was used to measure the degree of modification of Lysozyme and Ribonuclease A when incubated with quinones at differing concentrations and for various times. All reactions, unless noted, were carried out in a phosphate buffer (pH=7.0) at 37°C to mimic physiological conditions ...


Role Of Nanoparticles In Voltammetric Signal Enhancement Exhibited By Layer-By-Layer (Lbl) Gold Nanoparticle-Modified Screen-Printed Carbon Electrodes (Spces), Ben K. Ahiadu 2017 East Tennessee State University

Role Of Nanoparticles In Voltammetric Signal Enhancement Exhibited By Layer-By-Layer (Lbl) Gold Nanoparticle-Modified Screen-Printed Carbon Electrodes (Spces), Ben K. Ahiadu

Electronic Theses and Dissertations

Screen-printed electrodes (SPEs) have found wide use as sensing platforms due to their simple fabrication, customizability in terms of geometry and composition, and relatively low cost of production. Nanoparticles have been incorporated in or interfaced with SPEs in order to improve sensor response or provide electrocatalytic capabilities. Though nanomaterial-modified SPEs are becoming increasingly common sensing platforms, the benefits provided by nanomaterials are often determined through voltammetric studies with common redox probes, such as ferricyanide. However, recent reports have documented the ferri-/ferrocyanide redox couple to be an unreliable system for characterizing some carbon-based electrodes due to the dependence of its ...


Functionalized Silica Gel For Adsorption Of Cesium From Solution, Kenneth Marshall Seaton III 2017 East Tennessee State University

Functionalized Silica Gel For Adsorption Of Cesium From Solution, Kenneth Marshall Seaton Iii

Electronic Theses and Dissertations

Mesoporous silica gel containing embedded phosphotungstic acid (PTA) was synthesized by sol-gel co-condensation of tetraethyl orthosilicate with PTA in acidic media. The obtained material had high Brunauer-Emmett-Teller Theory (BET) surface area and pore volume. A characteristic band of the Keggin structure of PTA was present in its FT-IR spectrum while its X-ray diffraction patterns were absent. This proved the embedding of PTA on a sub-molecular level and not as a second phase. Acidic sites were determined by neutralization with base in aprotic solvent, followed by titration of the remaining base with an acid. The material demonstrated high adsorption capacity of ...


A Study Of The Photoacoustic Effect In Ethylene Gas, Jay Nguyen 2017 University of Tennessee at Chattanooga

A Study Of The Photoacoustic Effect In Ethylene Gas, Jay Nguyen

Honors Theses

Ethylene, C2H4, is a plant hormone produced and released naturally by plants and soil microorganisms. This colorless, flammable gas has a slightly sweet odor usually only recognized by those who have handled ethylene before. In situ analyses of this gas and many other potentially harmful gases outside of the laboratory are often difficult to perform due to the lack of a portable yet reliable unit capable of precisely and accurately detecting and measuring the concentrations of these gases at trace gas concentrations of a few parts per billion. In this research project, photoacoustic spectroscopy was used to detect and measure ...


Effect Of Chain Rigidity On Network Architecture And Deformation Behavior Of Glassy Polymer Networks, Kyler Reser Knowles 2017 University of Southern Mississippi

Effect Of Chain Rigidity On Network Architecture And Deformation Behavior Of Glassy Polymer Networks, Kyler Reser Knowles

Dissertations

Processing carbon fiber composite laminates creates molecular-level strains in the thermoset matrix upon curing and cooling which can lead to failures such as geometry deformations, micro-cracking, and other issues. It is known strain creation is attributed to the significant volume and physical state changes undergone by the polymer matrix throughout the curing process, though storage and relaxation of cure-induced strains remain poorly understood. This dissertation establishes two approaches to address the issue. The first establishes testing methods to simultaneously measure key volumetric properties of a carbon fiber composite laminate and its polymer matrix. The second approach considers the rigidity of ...


An Investigation Of The Use Of Cerium And Polyhedral Oligomeric Silsesquioxanes For The Protection Of Polymeric Epoxy Compounds In The Low Earth Orbit Environment, Jessica Miriam Piness 2017 University of Southern Mississippi

An Investigation Of The Use Of Cerium And Polyhedral Oligomeric Silsesquioxanes For The Protection Of Polymeric Epoxy Compounds In The Low Earth Orbit Environment, Jessica Miriam Piness

Dissertations

Low Earth orbit presents many hazards for composites including atomic oxygen, UV radiation, thermal cycling, micrometeoroids, and high energy protons. Atomic oxygen and vacuum ultraviolet radiation are of concern for space-bound polymeric materials as they degrade the polymers used as matrices for carbon fiber composites, which are used in satellites and space vehicles due to their high strength to weight ratios. Epoxy-amine thermosets comprise a common class of matrix due to processability and good thermal attributes. Polyhedral oligomeric silsesquioxanes (POSS) have shown the ability to reduce erosion in polyimides, polyurethanes, and other polymers when exposed to atomic oxygen. The POSS ...


Inheritance Of Carbohydrates And Fat In Crosses Of Dent And Sweet Corn, E. W. Lindstrom, Fisk Gerhardt 2017 Iowa State College

Inheritance Of Carbohydrates And Fat In Crosses Of Dent And Sweet Corn, E. W. Lindstrom, Fisk Gerhardt

Research Bulletin (Iowa Agriculture and Home Economics Experiment Station)

Dent and sweet varieties of corn (maize) are sharply differentiated in the chemical constitution of their seed, especially in relative amounts of sugars, dextrins, starches and fat. This fact, together with our knowledge of the mechanism of heredity in this species, provides an excellent background for an exact. determination of the mode of inheritance of these chemical characters. Another advantage in the genetic analysis, lies in the precise, cellular mechanism of double fertilization in the embryo sac whereby the endosperm tissue is developed as the result of a triple fushion of nuclei, two from the female and one from the ...


Certain Physical And Chemical Changes Of Grimes Apples During Ripening And Storage Pr, H. H. Plagge, T. J. Maney, Fisk Gerhardt 2017 Iowa State College

Certain Physical And Chemical Changes Of Grimes Apples During Ripening And Storage Pr, H. H. Plagge, T. J. Maney, Fisk Gerhardt

Research Bulletin (Iowa Agriculture and Home Economics Experiment Station)

These studies of changes in Grimes Apples, incident to ripening and storage, include rate of softening, increase in size, color changes of fruit and seeds, other common tests used by the growr to determine time of picking, and chemical analyses of changes within the apple.


March For Science - Dayton, Earth Day, Audrey E. McGowin 2017 Wright State University - Main Campus

March For Science - Dayton, Earth Day, Audrey E. Mcgowin

Chemistry Faculty Publications

March for Science speech given by Audrey McGowin, PhD in Dayton, Ohio on Earth Day 2017.


Analyzing The Kinetics Of A Bromophenol Blue Fading Reaction In Basic Conditions For An Undergraduate Lab, Zeljka Popovic 2017 Georgia College and State University

Analyzing The Kinetics Of A Bromophenol Blue Fading Reaction In Basic Conditions For An Undergraduate Lab, Zeljka Popovic

Georgia College Student Research Events

Bromophenol blue is a common pH indicator and dye used in many different industries. Once a solution of bromophenol blue is placed in a concentrated basic solution, the color fades from a blue/violet color to clear solution with a pH of 4.6 or greater. The rate law of the reaction is analyzed through the use of a small footprint visible-near-infrared spectrometer (Vis-NIR) with a diode array detector. An absorbance wavelength of 590 nm as a function of time was collected using Ocean Optics OceanView software. The results contained in the data collection file are exported to a spreadsheet ...


Kinetics Of Crystal Violet Color Fading Via A Small Footprint Diode Array Spectrometer, Paige Lott 2017 Georgia College & State University

Kinetics Of Crystal Violet Color Fading Via A Small Footprint Diode Array Spectrometer, Paige Lott

Georgia College Student Research Events

Crystal violet is a pH indicator and is commonly used to classify bacteria. In acidic solutions, crystal violet is yellow in color and at approximately the pH of 1.6, it transitions to a violet color. Over time, this violet color fades as it reacts with the CO 2 in the air until it is clear. A small footprint visible-near- infrared spectrometer (Vis-NIR) with diode array detector was employed in this investigation. Using the software that operates the spectrometer, the absorbance of crystal violet solutions can be measured at 585 nm at high concentrations of base as a function of ...


Rebecca Roesner, 2017 Dougan Award Presentation, Brian Brennan, IWU Chapter of the AAUP, Illinois Wesleyan University 2017 Chapter President, Illinois Wesleyan University

Rebecca Roesner, 2017 Dougan Award Presentation, Brian Brennan, Iwu Chapter Of The Aaup, Illinois Wesleyan University

Dougan Award Winners

No abstract provided.


Synthesis Of Cyanine Dyes And Their Use As Duplex Dna Photocleavage Agents, Hector Argueta-Gonzalez 2017 Georgia State University

Synthesis Of Cyanine Dyes And Their Use As Duplex Dna Photocleavage Agents, Hector Argueta-Gonzalez

Georgia State Undergraduate Research Conference

No abstract provided.


Characterization Of Active Site Residues In Class I Nitronate Monooxygenase From Pseudomonas Aeruginosa Pao1, Christopher Aguillon 2017 Georgia State University

Characterization Of Active Site Residues In Class I Nitronate Monooxygenase From Pseudomonas Aeruginosa Pao1, Christopher Aguillon

Georgia State Undergraduate Research Conference

No abstract provided.


Hydration Site Of Cyclophilin A And Its Allosteric Effects On The Enzyme's Function, Abdullah Shouaib, Jonathan Lopez 2017 Georgia State University

Hydration Site Of Cyclophilin A And Its Allosteric Effects On The Enzyme's Function, Abdullah Shouaib, Jonathan Lopez

Georgia State Undergraduate Research Conference

No abstract provided.


Characterization Of Α-Anomeric Damaged Dna In Complex With Endonuclease Iv Using Fluorescence Resonance Energy Transfer (Fret), Beatrice Edjah 2017 Georgia State University

Characterization Of Α-Anomeric Damaged Dna In Complex With Endonuclease Iv Using Fluorescence Resonance Energy Transfer (Fret), Beatrice Edjah

Georgia State Undergraduate Research Conference

No abstract provided.


Synthesis Of 1-Phenyl-3,5-Diaryl-4-Bromopyrazoles, 1-Phenyl-3-T-Butyl-5-Aryl-4-Bromopyrazoles, And 1-Phenyl-3-T-Butyl-5-Aryl-4-Bromoisoxazoles., Keren Antoine, Anne K. Jean, Roseleen Almenord, Sierra A. Fleming, Titilope Akinwe, Paula Garzon, Julio C. Falcon 2017 Georgia State University

Synthesis Of 1-Phenyl-3,5-Diaryl-4-Bromopyrazoles, 1-Phenyl-3-T-Butyl-5-Aryl-4-Bromopyrazoles, And 1-Phenyl-3-T-Butyl-5-Aryl-4-Bromoisoxazoles., Keren Antoine, Anne K. Jean, Roseleen Almenord, Sierra A. Fleming, Titilope Akinwe, Paula Garzon, Julio C. Falcon

Georgia State Undergraduate Research Conference

No abstract provided.


Sustainable Polymers: Plastics From Plants, Chris Schaller 2017 College of Saint Benedict/Saint John's University

Sustainable Polymers: Plastics From Plants, Chris Schaller

Forum Lectures

Plastics and related soft materials are ubiquitous in today's world. This presentation takes a look at why polymers have useful properties, where they come from, and why attention has shifted toward new, biorenewable materials.


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