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Articles 1 - 30 of 28037

Full-Text Articles in Chemistry

Growth, Lipid Production And Biodiesel Potential Of Chromulina Freiburgensis Dofl., An Acidophilic Chrysophyte Isolated From Berkeley Pit Lake, June E. Mohler Mitman Mar 2109

Growth, Lipid Production And Biodiesel Potential Of Chromulina Freiburgensis Dofl., An Acidophilic Chrysophyte Isolated From Berkeley Pit Lake, June E. Mohler Mitman

Graduate Theses & Non-Theses

Microalgae remain a promising, but underdeveloped source of lipids for sustainable biodiesel. Some of the obstacles to cost-effective commercial-scale production have been culture contamination and expensive harvest methods. A chrysophyte isolated from Berkeley Pit Lake and identified as Chromulina freiburgensis, was found to grow rapidly in a pH 2.5 liquid medium and to amass numerous intracellular lipid bodies. This research addresses the scarcity of published knowledge on the topic of chrysophyte species as potential lipid sources for biodiesel. It investigates how growth phase, culture conditions, and harvest timing influence the quantity and composition of lipids produced by this alga ...


Understanding Students’ Global Interdependence In Science Instruction, Walter S. Smith Dec 2021

Understanding Students’ Global Interdependence In Science Instruction, Walter S. Smith

Journal of Global Education and Research

Multiple American educational organizations such as the National Education Association, Association for Supervision and Curriculum Development, and the Council of Chief State School Officers have advocated for globalizing the K-12 curriculum. The National Science Teaching Association (NSTA) in a position statement on international education and the Next Generation Science Standards have produced goals and standards for internationalizing the science curriculum by addressing topics such as climate change, environment, and disease that cross borders. In contrast to those pronouncements on the curriculum, this article views global science education through an instructional lens that focuses on a students’ global interdependence in science ...


Stay Calm And Focus On The Learning Outcomes: Tools For Taking Biophysical Chemistry Online, Maria Ballester, Brian L. Van Hoozen Jr., Arthur Sikora Aug 2021

Stay Calm And Focus On The Learning Outcomes: Tools For Taking Biophysical Chemistry Online, Maria Ballester, Brian L. Van Hoozen Jr., Arthur Sikora

Chemistry and Physics Faculty Articles

Course specific learning outcomes are an important tool to define the scope of a course and can be very helpful when designing experiments and assessments. With slight modification, these learning outcomes can serve as a guide when transitioning to the distance learning format especially in courses with a traditional lab. Here we present such an example for the biophysical chemistry course.


Mechanistic And Synthetic Studies Of Oxidopyrylium Cycloaddition Reactions, Lauren P. Bejcek Jun 2021

Mechanistic And Synthetic Studies Of Oxidopyrylium Cycloaddition Reactions, Lauren P. Bejcek

Dissertations, Theses, and Capstone Projects

Cycloaddition chemistry has historically served as a robust route to stereo-rich and highly functionalized cyclic and heterocyclic compounds. Herein we describe our examination of 3-hydroxy-4-pyrone-derived oxidopyrylium cycloadditions in both mechanistic considerations as well as the unique synthetic advancements of their corresponding cycloadducts. Chapter 1 is a literature review where we specifically outline the use of oxidopyrylium cycloadditions in the synthesis of natural products. This includes the mention of previous syntheses prior to 2008, and a more thorough examination of the natural products synthesized from 2008 to present. The work exploits this chemistry as a facile route to highly complex 7-membered ...


Synthetic And Biological Studies On Benzazepine Derivatives As Dopamine Receptor Ligands, Rajan Giri Jun 2021

Synthetic And Biological Studies On Benzazepine Derivatives As Dopamine Receptor Ligands, Rajan Giri

Dissertations, Theses, and Capstone Projects

Dopamine (DA) receptors, members of the G-protein coupled receptors (GPCRs) family, are divided in two groups based on their transmembrane structural homology domains: D1R-like (D1R, D5R sub-types) and D2R-like DA receptors (D2R, D3R and D4R sub-types). Disturbances in dopaminergic neurotransmission are associated with several CNS disorders. Hence, DA receptor selective ligands have been sought as pharmacological agents to normalize perturbations in the dopaminergic system. Despite several notable efforts, the discovery of highly selective ligands for dopamine receptor sub-types has proved challenging due to close transmembrane structural similarity, especially between DA receptor sub-types within the same group.

The 1-phenylbenzazepine scaffold is ...


Emergent Photophyiscs In Diketopyrrolopyrrole Superstructures, Andrew Levine Jun 2021

Emergent Photophyiscs In Diketopyrrolopyrrole Superstructures, Andrew Levine

Dissertations, Theses, and Capstone Projects

Organic semiconductors have received substantial attention as active components in optoelectronic devices because of their processability and customizable electronic properties. Tailoring the organic active layer in these devices to exhibit desirable optoelectronic properties requires understanding the complex and often subtle structure-property relationships governing their photophysical response to light. Both structural organization and frontier molecular orbitals (FMO) play pivotal roles in energy relaxation processes, and complex interplay between organization and orbital energies are difficult to anticipate based upon the molecular structure of the components alone, especially in systems comprised of multiple components. In pursuit of design rules, there is a need ...


Theranostic Applications Of Sirna Bioconjugates In Cancer Detection And Treatment, Sunil S. Shah May 2021

Theranostic Applications Of Sirna Bioconjugates In Cancer Detection And Treatment, Sunil S. Shah

Seton Hall University Dissertations and Theses (ETDs)

Abstract

The emerging field of RNA nanotechnology has led to rapid advances in the applications of RNA in chemical biology, medicinal chemistry, and biotechnology. At the forefront of its utility is the ability to self-assemble multiple siRNAs into nanostructure formulations capable of targeting selected oncogenes and potentiating the gene therapy of malignant tumors. Self-assembled siRNA integrates multiple siRNAs within a single molecular platform for silencing multiple oncogenic mRNA targets with high precision and efficacy to potentially induce cancer cell apoptosis through the RNA interference (RNAi) pathway. Furthermore, the conjugation of siRNA self-assemblies with bio-active probes results in multi-functional theranostic (therapy ...


Cu-Promoted C-H Bond Hydroxylation Inspired By Cu-Dependent Metalloenzymes, Rachel Trammell May 2021

Cu-Promoted C-H Bond Hydroxylation Inspired By Cu-Dependent Metalloenzymes, Rachel Trammell

Chemistry Theses and Dissertations

From 2003 to 2015, Schӧnecker and Baran proposed a dinuclear Cu/O2 species in their mechanistic proposal for the hydroxylation of sp3 C-H bonds within their systems (proposed based on yields). Inspired from the site selectivity of this methodology and poor analysis of the mechanism, the first project was inspired to re-examine the sp3 C-H bond hydroxylation by Schrӧnecker and Baran and perform an intensive investigation into understanding how Cu/O2 interact which led us to propose a new mechanism based on the evidence collected (i.e., LCuII-hydroperoxide species that undergoes homolytic O-O bond ...


Explorations Of Thermus Thermophilus Hb8 Transcription Factors Ttha1437 And Ttha1719 Using The Combinatorial Selection Method Repsa, Sarah Claire Sneed May 2021

Explorations Of Thermus Thermophilus Hb8 Transcription Factors Ttha1437 And Ttha1719 Using The Combinatorial Selection Method Repsa, Sarah Claire Sneed

Master of Science in Chemical Sciences Theses

In all organisms, genes exist that encode for regulatory proteins, called transcription factors (TFs) that can activate or repress transcription of specific genes depending on their biological function. Thermus thermophilus HB8 is speculated to contain 2,245 genes, of which 70 are postulated to be transcription factors. However, but for very few, little is known regarding the genes they regulate and their biological functions. The novel combinatorial method Restriction Endonuclease Protection, Selection, and Amplification (REPSA) has been successful for identifying and validating consensus binding sequences in T. thermophilus HB8 with previously studied TFs. Here REPSA was explored as a technique ...


Milan Italy - 1994 May 2021

Milan Italy - 1994

World Data - Europe

No abstract provided.


Leicester United Kingdom May 2021

Leicester United Kingdom

World Data - Europe

No abstract provided.


Lisbon Portugal - 1994 May 2021

Lisbon Portugal - 1994

World Data - Europe

No abstract provided.


Hamburg Germany - 1994 May 2021

Hamburg Germany - 1994

World Data - Europe

No abstract provided.


Edinburgh United Kingdom May 2021

Edinburgh United Kingdom

World Data - Europe

No abstract provided.


London United Kingdom May 2021

London United Kingdom

World Data - Europe

No abstract provided.


Auckland - 2003 May 2021

Auckland - 2003

World Data - New Zealand

No abstract provided.


Monterrey Mexico - 1995 May 2021

Monterrey Mexico - 1995

World Data - North America

No abstract provided.


Tokyo Japan - 1995 May 2021

Tokyo Japan - 1995

World Data - Asia

No abstract provided.


Taipei Taiwan - 1993 May 2021

Taipei Taiwan - 1993

World Data - Asia

No abstract provided.


Seoul Korea - 1993 May 2021

Seoul Korea - 1993

World Data - Asia

No abstract provided.


Malaysia - 1995 May 2021

Malaysia - 1995

World Data - Asia

No abstract provided.


Hong Kong - 1993 May 2021

Hong Kong - 1993

World Data - Asia

No abstract provided.


Melbourne - 1992 May 2021

Melbourne - 1992

World Data - Australia

No abstract provided.


Toronto Canada - 1990 May 2021

Toronto Canada - 1990

World Data - North America

No abstract provided.


Mexico City Mexico May 2021

Mexico City Mexico

World Data - North America

No abstract provided.


13c Chemical Shift Concentration Dependence Of Phenol, Anisole, And Their Sulfur Analogs As A Probe Into Anomalous Reactivity In Electrophilic Aromatic Substitution Reactions, Braxton Lowers, Adam Reed May 2021

13c Chemical Shift Concentration Dependence Of Phenol, Anisole, And Their Sulfur Analogs As A Probe Into Anomalous Reactivity In Electrophilic Aromatic Substitution Reactions, Braxton Lowers, Adam Reed

The Pegasus Review: UCF Undergraduate Research Journal

The 13C chemical shift concentration dependence of phenol, anisole, thiophenol, and thioanisole in CDCl3 was acquired and analyzed over various concentration ranges and reported with the intention of observing the effect of hydrogen bonding on the electron density around aromatic nuclei. Of the para carbon chemical shift concentration dependences observed, phenol exhibited the most significant concentration dependence. Attempts were made to determine the functions describing concentration dependence of the 13C chemical shifts observed. Notably, CDCl3 was found to exhibit relatively nonlinear concentration dependence in the same range as the compounds observed, suggesting that trace impurity and ...


Designing A Reactive Warhead To Bind And Inhibit Pseudomonas Aeruginosa’S Periplasmic Protein, Inhibitor Of Vertebrate Lysozyme, Leah Greinke May 2021

Designing A Reactive Warhead To Bind And Inhibit Pseudomonas Aeruginosa’S Periplasmic Protein, Inhibitor Of Vertebrate Lysozyme, Leah Greinke

Master of Science in Chemical Sciences Theses

Pseudomonas aeruginosa is a Gram-negative bacterium commonly found throughout the environment. It is a significant cause of disease and mortality in immunodeficient patients such as those suffering from cystic fibrosis (CF). Due to the emerging antibiotic resistance of P. aeruginosa, it is becoming increasingly more challenging to treat an infection by traditional means. Further complicating treatment, P. aeruginosa secretes a protein known as Inhibitor of Vertebrate Lysozyme (PaIVY) that binds to and inhibits C-type lysozyme, thus preventing the degradation of the bacterium. A reactive chemical warhead was synthesized from a rhenium(I) tricarbonyl derivative inorder to bind to and irreversibly ...


San Jose May 2021

San Jose

United States Data - California

No abstract provided.


Naperville - 1990 May 2021

Naperville - 1990

United States Data - Illinois

No abstract provided.


Chicago - Central & I-290 May 2021

Chicago - Central & I-290

United States Data - Illinois

No abstract provided.