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Full-Text Articles in Chemistry

Archean Phosphorus Liberation Induced By Iron Redox Geochemistry, Barry Herschy, Sae Jung Chang, Ruth Blake, Aivo Lepland, Heather Abbott-Lyon, Jacqueline Sampson, Zachary Atlas, Terence P. Kee, Matthew A. Pasek Sep 2018

Archean Phosphorus Liberation Induced By Iron Redox Geochemistry, Barry Herschy, Sae Jung Chang, Ruth Blake, Aivo Lepland, Heather Abbott-Lyon, Jacqueline Sampson, Zachary Atlas, Terence P. Kee, Matthew A. Pasek

Faculty Publications

The element phosphorus (P) is central to ecosystem growth and is proposed to be a limiting nutrient for life. The Archean ocean may have been strongly phosphorus-limited due to the selective binding of phosphate to iron oxyhydroxide. Here we report a new route to solubilizing phosphorus in the ancient oceans: reduction of phosphate to phosphite by iron(II) at low (<200 >°C) diagenetic temperatures. Reduction of phosphate to phosphite was likely widespread in the Archean, as the reaction occurs rapidly and is demonstrated from thermochemical modeling, experimental analogs, and detection of phosphite in early Archean rocks. We further demonstrate that the ...


Analysis Of Metallic Components Of Gsr From Various Types Of Ammunition And Firearms Utilizing An Sem-Edx, Jenna A. Campbell May 2018

Analysis Of Metallic Components Of Gsr From Various Types Of Ammunition And Firearms Utilizing An Sem-Edx, Jenna A. Campbell

Graduate Student Research Symposium

Gunshot residue (GSR) is a chemical reaction that occurs when a firearm is discharged, which emits a cloud of gases from the barrel of the gun. It consists of both the burned and unburned propellant and primer components. These components are either organic or inorganic in nature, respectively. The organic components are located in the gunpowder part of the bullet, while the inorganic components are located in the primer part of the bullet. The primer consists of lead, barium, and antimony. These elements are considered heavy metals. Additionally, lead, barium, and antimony are the three key elements found in the ...


Tumor-Targeting Fluorinated Phthalocyanines For Theranostic Applications, Erik Nathaniel Carrión May 2018

Tumor-Targeting Fluorinated Phthalocyanines For Theranostic Applications, Erik Nathaniel Carrión

Seton Hall University Dissertations and Theses (ETDs)

Hydrocarbon-based therapeutics and imaging agents are prone to chemical oxidation and degradation resulting in loss of activity and limited functional utility. Thus, more material is required to achieve long-lasting therapeutic effects. Phthalocyanines (Pcs) and their metal complexes (PcMs) can be utilized as prodrugs requiring only renewable energy resources namely, air and light, for cancer therapy and diagnostic (theranostic) applications related to photodynamic therapy (PDT). Replacement of labile C-H bonds in the Pc scaffold with a combination of fluoro and perfluoroisopropyl groups has resulted in a stable yet reactive oxidation catalyst of biological significance and importance. For example, F64PcZn ...


Assessment Of The Viability Of Microwell Plates As Sample Holders For Analytical Excitation-Emission Spectroscopy Of Polyaromatic Hydrocarbons In 75% Ethanol, Lauren M. Ridley-Hoffman May 2018

Assessment Of The Viability Of Microwell Plates As Sample Holders For Analytical Excitation-Emission Spectroscopy Of Polyaromatic Hydrocarbons In 75% Ethanol, Lauren M. Ridley-Hoffman

Seton Hall University Dissertations and Theses (ETDs)

Polyaromatic hydrocarbons (PAHs) in the environment are a significant concern as many compounds in this class are potential carcinogens. PAHs resulting from petroleum spills can contaminate natural waters and the products obtain from them (fish and fish products in particular). Previous studies by Pena, et. al. on ethanolic extracts of organs from menhaden captured in the vicinity of the Deepwater Horizon (Macondo oil well) spill have shown that fluorescence excitation spectroscopy is a useful technique for detecting the presence of PAH metabolites and fluorescent vitamins. The study has also concluded that previous methods for analyzing PAHs using fluorescence spectroscopy used ...


Multi-Reference Systems In Chemistry; Unconventional Bonding In Organic Chemistry; Covalent Bonding In Transition Metal Clusters, Alan Wilfred Humason May 2018

Multi-Reference Systems In Chemistry; Unconventional Bonding In Organic Chemistry; Covalent Bonding In Transition Metal Clusters, Alan Wilfred Humason

Chemistry Theses and Dissertations

The geometries, chemical properties, and reactivities of molecules are determined by their electronic structure. The field of ab initio computational chemistry works to calculate the kinetic and potential energies between the nuclei and electrons of a molecule. These calculations usually begin with the determination the electronic ground state.

Molecules that cannot be adequately described with a single, ground state configuration are called \textit{multi-reference systems}, which require the calculation of a linear combination of all pertinent electronic configurations, with a corresponding increase in computational cost. This is not `black box' methodology, because solving these systems requires a good understanding of ...


Concentration Of Atmospheric Ammonia From Kenyon College Monitoring Station, Vivian Ezeh, David Heithaus, Simon Garcia, Matthew F. Rouhier May 2018

Concentration Of Atmospheric Ammonia From Kenyon College Monitoring Station, Vivian Ezeh, David Heithaus, Simon Garcia, Matthew F. Rouhier

Data Sets

Kenyon College is hosting an ammonia (NH3) monitoring station as part of the National Atmospheric Deposition Program (NADP). The Kenyon College (OH32) site is one of six locations around the state of Ohio.


Archaeometric Approaches To The Roman Near East, Gayatri Nandwani May 2018

Archaeometric Approaches To The Roman Near East, Gayatri Nandwani

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

The purpose of my research this summer has been to participate in a full suite of archaeometric and geoarchaeological analyses, particularly as they are applied to sedimentology. The first section of my research has focused on an introduction to these procedures at ARL including laboratory safety procedures, proper sample collection and processing methods, and introduction to methods and purposes for a variety of laboratory analyses including grain size distribution analysis using a state of the art Malvern Mastersizer 3000 laser diffraction particle size analyzer, organic matter and inorganic carbon analysis, and microartifact analysis. During the field collection phase I worked ...


Modeling Adsorption And Diffusion Of Atomic Oxygen On The Ag(111) Surface Using Kinetic Monte Carlo Simulations, Seth Spencer Street, Sharani Roy, Sara Isbill May 2018

Modeling Adsorption And Diffusion Of Atomic Oxygen On The Ag(111) Surface Using Kinetic Monte Carlo Simulations, Seth Spencer Street, Sharani Roy, Sara Isbill

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

Oxidized silver surfaces are widely used as industrial heterogeneous catalysts to oxidize small organic compounds, such as ethylene. While surface-adsorbed oxygen is known to participate in catalysis, it has been suggested that ‘subsurface’ oxygen adsorbed in the near-surface region of silver also plays important roles in surface reconstruction and reactivity. However, the formation, motion, and chemical behavior of subsurface oxygen in silver are not well understood. In the present work, a kinetic Monte Carlo (KMC) simulation has been developed using the Python programming language to computationally model the diffusion kinetics of atomic oxygen (AO) at the Ag(111) surface. This ...


Assessment Of Energetic Heterogeneity Of Reversed-Phase Surfaces Using Excess Adsorption Isotherms For Hplc Column Characterization, Leih-Shan Yeung May 2018

Assessment Of Energetic Heterogeneity Of Reversed-Phase Surfaces Using Excess Adsorption Isotherms For Hplc Column Characterization, Leih-Shan Yeung

Seton Hall University Dissertations and Theses (ETDs)

This research is to explore a more general column categorization method using the test attributes in alignment with the common mobile phase components. As we know, the primary driving force for solute retention on a reversed-phase surface is hydrophobic interaction, thus hydrophobicity of the column will directly affect the analyte retention. This research describes a method to determine the column hydrophobicity by the ratio of adsorbed acetonitrile and methanol to water on the column surface using excess adsorption isotherm estimation. An excess adsorption isotherm for a binary mobile phase system represents a competitive interaction of both solvent components with the ...


Effects Of A Green Chemistry Laboratory Design On First- Semester General Chemistry Students' Transformative Experiences In Chemistry, Lurea Joan Doody May 2018

Effects Of A Green Chemistry Laboratory Design On First- Semester General Chemistry Students' Transformative Experiences In Chemistry, Lurea Joan Doody

Electronic Theses and Dissertations

The purpose of this study was to understand if a green chemistry laboratory design facilitated students’ transformative experiences in a first-semester general chemistry course for science majors. The study population consisted of 18 college students enrolled in the course at a small, rural, mid-Atlantic university. Traditional chemistry laboratories were replaced with three signature green chemistry laboratories over a period of 6-weeks at the end of the spring semester. Impact data were collected pre- and post, of the three labs using the Transformative Experience Questionnaire (TEQ) surveys. Open ended guided reflection questions were coded for elements of transformative experience (TE): expansion ...


Polymer Nanocomposites Containing High Aspect Ratio Particulates: Innovation In Co-Extruded Multilayer Barrier Films, Kevin Meyers May 2018

Polymer Nanocomposites Containing High Aspect Ratio Particulates: Innovation In Co-Extruded Multilayer Barrier Films, Kevin Meyers

Dissertations

Delaminated montmorillonite (MMT) clay/ maleic anhydride grafted LLDPE nanocomposite multilayer films with alternating layers of LDPE were produced through multilayer co-extrusion. The MMT concentration within the nanocomposite layers was increased through annealing the films in the melt due to a mismatch in interdiffusion rates of the polymer layers. Analysis of the nanocomposite layers upon annealing revealed that the platelets impinged upon one another resulting in significant improvement in oxygen barrier in the multilayer system, exceeding the results of bulk nanocomposites.

Model analysis demonstrated that increasing the nanoplatelet aspect ratio or initial concentration in the filled layers would lead to even ...


New Reactions Of Strained Allyl Silacycles, Elizabeth Cummins May 2018

New Reactions Of Strained Allyl Silacycles, Elizabeth Cummins

Graduate Student Symposium

Ring-strained allylsilanes exhibit both electrophilic and nucleophilic characteristics, allowing for simultaneous activation and allylation of carbonyl compounds. Results are presented describing an optimized synthesis of certain allylsilacyclobutanes and their use in several selective carbon-carbon bond forming reactions.


The Coastal Monitor: Fall 2017/ Spring 2018, John T. Tanacredi Ph.D. May 2018

The Coastal Monitor: Fall 2017/ Spring 2018, John T. Tanacredi Ph.D.

Dr. John T. Tanacredi

As I sat there in the Members Lounge at the Explorers Club; the world center for exploration, getting ready for our first Spring Saturday Science for Students @the EC lecture, I was putting together some notes on the accomplishments of our science students and CERCOM over the last few months since our last newsletter. Our visit to the Galapagos, a spectacular academic experience for our Molloy College students was at the top of my list! This was certainly not an epiphany but as I accumulated the items on this list, I was impressed not only with what we have conducted ...


Novel Role Of Hypoxia In Ovarian Cancer Chemo Resistance Through Epigenetic Regulation Of Hif1Α, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Liam Gallagher, Michael O'Sullivan, Benjamin Honigsfeld, Kim Doyle, Nevenka Dimitrova, Robert Lucito May 2018

Novel Role Of Hypoxia In Ovarian Cancer Chemo Resistance Through Epigenetic Regulation Of Hif1Α, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Liam Gallagher, Michael O'Sullivan, Benjamin Honigsfeld, Kim Doyle, Nevenka Dimitrova, Robert Lucito

Noelle Cutter

Ovarian cancer is the fifth deadliest cancer in woman, and epithelial malignancies account for 90% of cases. Tumor recurrence after chemotherapy or radiation remains a major obstacle to successful ovarian cancer treatment. Despite the large number of studies, molecular events that govern the emergence of aggressive therapy-resistant cells after chemotherapy are poorly defined. Genetic modifications, such as copy number variation (CNV), play an important role in controlling the expression of genes that are involved in chemo resistance. We analyzed CNV data that is publically available through the Cancer Genome Atlas and others. Of particular interest was the transcription factor HIF1α ...


Inhibitions Of Gsk3Β Modulates Cell Death In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Naeha Pathak May 2018

Inhibitions Of Gsk3Β Modulates Cell Death In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Naeha Pathak

Noelle Cutter

Epithelial ovarian cancer is one of the most common gynecological malignancies and the fifth most frequent cause of cancer death in women, affecting over 22,000 women annually. Nearly 15,500 affected women die from this disease annually, and chemoresistance from the commonly prescribed platinum-based drug, carboplatin, is a major contributor to this mortality rate. Previous studies have identified genes with CpG islands that are methylated and transcriptionally silenced in resistant epithelial ovarian cancer patients. One of these genes is GSK3β, an important regulator of apoptosis and cell growth in the Wnt pathway. Thus, understanding the role of GSK3β suppression ...


Abstract 70: A Role For The Chromatin Remodeling Protein Chd3 In Ovarian Cancer Therapy Response, Noelle L. Cutter Ph.D., Nila Banerjee, Michelle Vigliotti, Angel Janevski, Douglas Levine, Robert Lucito, Nevenka Dimitrova May 2018

Abstract 70: A Role For The Chromatin Remodeling Protein Chd3 In Ovarian Cancer Therapy Response, Noelle L. Cutter Ph.D., Nila Banerjee, Michelle Vigliotti, Angel Janevski, Douglas Levine, Robert Lucito, Nevenka Dimitrova

Noelle Cutter

Carboplatin and cisplatin are chemotherapeutic agents that are used extensively for treating epithelial ovarian cancer. These drugs can be highly effective, yet tumors are frequently refractory to treatment or become resistant upon tumor relapse. Epigenetic silencing, particularly at promoter regions of genes regulates important cell function and has been associated with all stages of tumor formation and progression and may contribute to therapy response. We analyzed the epigenome of 50 primary ovarian tumors and 12 normal ovarian samples using an array based method previously developed in our lab and associated Affymetrix U133 expression data. We then identified gene candidates that ...


Abstract 4525: Hypoxia Signaling Pathway Plays A Role In Ovarian Cancer Chemoresistance, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Kim Doyle, Ryan Frank May 2018

Abstract 4525: Hypoxia Signaling Pathway Plays A Role In Ovarian Cancer Chemoresistance, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Kim Doyle, Ryan Frank

Noelle Cutter

Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor that when induced regulates the expression of many genes involved in cytoprotective stimuli, which attenuates apoptosis and improves survival. Increased expression of HIF-1α gene (HIF1A) has been found in several carcinomas, including ovarian cancer. Ovarian cancers are generally refractory to platinum-based chemotherapy. Despite the large number of studies, molecular events that govern the emergence of aggressive therapy-resistant cells after chemotherapy are poorly defined. Genomic instabilities, such as copy number variation(CNV), may play an important role in chemoresistance and have been implicated in many complex diseases, like cancer.. We analyzed ...


Abstract 3144: A Role For Dok2 Methylation In Platinum Resistance And Tumor Suppression In Ovarian Cancer, Noelle L. Cutter Ph.D., Elena Lum, Michelle Vigliotti, Sohail Khan, Douglas Levine, Nevenka Dimitrova, Robert Lucito May 2018

Abstract 3144: A Role For Dok2 Methylation In Platinum Resistance And Tumor Suppression In Ovarian Cancer, Noelle L. Cutter Ph.D., Elena Lum, Michelle Vigliotti, Sohail Khan, Douglas Levine, Nevenka Dimitrova, Robert Lucito

Noelle Cutter

Ovarian cancer is the 5th leading cause of cancer in women, affecting close to 22,000 women in the year 2011, of which nearly 15,500 will die. It is difficult to detect until it reaches advanced stages and becomes malignant. Currently, the standard treatment for ovarian cancer is platinum-based therapeutics, such as Carboplatin or Cisplatin, combined with Taxol. Unfortunately, approximately 25% of patients are inherently platinum-resistant and all patients who suffer from recurrence will have developed acquired platinum resistance. The genetic/epigenetic causes of this resistance are poorly understood. Epigenetic events are reversible and the identification of genes altered ...


Abstract 2934: Gsk3Β Modulates Chemoresistance In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Naeha Pathak May 2018

Abstract 2934: Gsk3Β Modulates Chemoresistance In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Naeha Pathak

Noelle Cutter

Introduction: Epithelial ovarian cancer is one of the most common gynecological malignancies and the fifth most frequent cause of cancer death in women, affecting over 22,000 women annually. Nearly 15,500 affected women die from this disease annually, and chemoresistance from the commonly prescribed platinum-based drug, carboplatin, is a major contributor to this mortality. Previous studies have identified genes with CpG islands that are methylated and transcriptionally silenced in resistant epithelial ovarian cancer patients. One of these genes is GSK3β, an important regulator of apoptosis and cell growth in the Wnt pathway. Thus, understanding the role of GSK3β suppression ...


“Fkamathamnareshbabusp18”.Pdf, Nareshbabu Kamatham May 2018

“Fkamathamnareshbabusp18”.Pdf, Nareshbabu Kamatham

Nareshbabu Kamatham

No abstract provided.


Metallodithiolate Ligands For Reversing Metal Ion Induced Aggregation Of Beta Amyloid, Eleanor K. Adams, Marilyn Rampersad Mackiewicz May 2018

Metallodithiolate Ligands For Reversing Metal Ion Induced Aggregation Of Beta Amyloid, Eleanor K. Adams, Marilyn Rampersad Mackiewicz

Student Research Symposium

Alzheimer’s Disease (AD) is the sixth leading cause of death in the United States with no known methods to cure, reverse or halt disease progression. The “metal hypothesis” states that FeII, CuII, ZnII, and AlII bind to truncated Aβ peptides and form soluble oligomers which deposit as senile plaques. These plaques play a crucial role in AD pathogenesis. For example, metallated-Aβ aggregates are hypothesized to disrupt membranes or generate a reactive oxygen species (ROS) through redox cycling in the presence of CuI/II or FeIII/II and a reducing agent. ROS can lead ...


Diagnostic Platform For Current Health Status Monitoring, Albert S. Benight, Megan M. Koslen, Matthew W. Eskew May 2018

Diagnostic Platform For Current Health Status Monitoring, Albert S. Benight, Megan M. Koslen, Matthew W. Eskew

Student Research Symposium

Our approach is based on physical measurements of blood plasma and exploits the plethora of information contained in the human plasma proteome, as a reporter of human health status. The assay involves collection and analysis ofthermograms of plasma from human blood measured by differential scanning calorimetry (DSC).

Plasma thermograms arise from the temperature-induced denaturation profile of proteins within blood plasma measured by DSC. This insightful measurement thereby provides a snapshot of the current state of the human plasma proteome which directly informs on overall systemic health. Such measurements have been shown to be highly accurate and sensitive indicators of health ...


Dissecting Structure-Encoded Determinants Of Allosteric Cross-Talk Between Post-Translational Modification Sites In The Hsp90 Chaperones, Gabrielle Stetz, Amanda Tse, Gennady M. Verkhivker May 2018

Dissecting Structure-Encoded Determinants Of Allosteric Cross-Talk Between Post-Translational Modification Sites In The Hsp90 Chaperones, Gabrielle Stetz, Amanda Tse, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Post-translational modifications (PTMs) represent an important regulatory instrument that modulates structure, dynamics and function of proteins. The large number of PTM sites in the Hsp90 proteins that are scattered throughout different domains indicated that synchronization of multiple PTMs through a combinatorial code can be invoked as an important mechanism to orchestrate diverse chaperone functions and recognize multiple client proteins. In this study, we have combined structural and coevolutionary analysis with molecular simulations and perturbation response scanning analysis of the Hsp90 structures to characterize functional role of PTM sites in allosteric regulation. The results reveal a small group of conserved PTMs ...


Kinetics And Activation Energy Parameters For Hydrolysis Of Acetic Anhydride In A Water-Acetone Cosolvent System, Samson Olowoyo May 2018

Kinetics And Activation Energy Parameters For Hydrolysis Of Acetic Anhydride In A Water-Acetone Cosolvent System, Samson Olowoyo

Electronic Theses and Dissertations

The hydrolysis of acetic anhydride is a widely-studied liquid phase reaction studied since 1906. Different approaches have been used to study the kinetics of this reaction. Approaches used by researchers have involved the use of sophisticated experimental set-ups. In this work, the pH technique has been adopted which involves the use of a pH meter to monitor the hydrolysis reaction. Analysis of the hydrolysis reaction has been performed for water/acetone cosolvent systems over a range of temperatures and mole fractions. Eyring analysis was performed under isomole fraction conditions and activation enthalpy, entropy, and Gibbs free energy for hydrolysis of ...


Eyring Activation Energy Analysis Of Acetic Anhydride Hydrolysis In Acetonitrile Cosolvent Systems, Nathan Mitchell May 2018

Eyring Activation Energy Analysis Of Acetic Anhydride Hydrolysis In Acetonitrile Cosolvent Systems, Nathan Mitchell

Electronic Theses and Dissertations

Acetic anhydride hydrolysis in water is considered a standard reaction for investigating activation energy parameters using cosolvents. Hydrolysis in water/acetonitrile cosolvent is monitored by measuring pH vs. time at temperatures from 15.0 to 40.0 °C and mole fraction of water from 1 to 0.750. This work utilizes a temperature controlled water bath and a Vernier glass-body pH probe with Vernier Logger Pro 3.10.1 software for automated data collection. Data analysis is used to determine observed kinetic rate constants under the assumption that hydrolysis is a pseudo-first-order reaction. Eyring plots were used to compare activation ...


Molecular Dynamics Simulations Of Apo And Holo Forms Of Fatty Acid Binding Protein 5 And Cellular Retinoic Acid Binding Protein Ii Reveal Highly Mobile Protein, Retinoic Acid Ligand, And Water Molecules, Nathanael H. Hunter, Blair C. Bakula, Chrystal D. Bruce May 2018

Molecular Dynamics Simulations Of Apo And Holo Forms Of Fatty Acid Binding Protein 5 And Cellular Retinoic Acid Binding Protein Ii Reveal Highly Mobile Protein, Retinoic Acid Ligand, And Water Molecules, Nathanael H. Hunter, Blair C. Bakula, Chrystal D. Bruce

2018 Faculty Bibliography

Structural and dynamic properties from a series of 300 ns molecular dynamics, MD, simulations of two intracellular lipid binding proteins, iLBPs, (Fatty Acid Binding Protein 5, FABP5, and Cellular Retinoic Acid Binding Protein II, CRABP-II) in both the apo form and when bound with retinoic acid reveal a high degree of protein and ligand flexibility. The ratio of FABP5 to CRABP-II in a cell may determine whether it undergoes natural apoptosis or unrestricted cell growth in the presence of retinoic acid. As a result, FABP5 is a promising target for cancer therapy. The MD simulations presented here reveal distinct differences ...


Sds-Page Analysis Of Modified Lysozyme By Substituted Benzoquinones And Naphthoquinones, Neethu Kurien May 2018

Sds-Page Analysis Of Modified Lysozyme By Substituted Benzoquinones And Naphthoquinones, Neethu Kurien

Honors Theses

Quinones are molecules that are commonly found in the environment, as cofactors for proteins or an electron carrier in the mitochondrial electron transport chain. However, quinones also can come from polycyclic aromatic hydrocarbons as their metabolites, harming cellular integrity. In this study, we investigated protein modification of lysozyme in the presence of substituted benzoquinones and naphthoquinones. To simulate physiological conditions, all reactions used phosphate buffer (50.0 mM). While the majority of the experiments were performed at 37 C and pH 7.0, there were also temperature dependence (27 C and 42 C) and pH dependence (6.0 and 8 ...


Size Exclusion Chromatography Based Liposomal Protein Extraction (Selpe), Carolyn Barnes May 2018

Size Exclusion Chromatography Based Liposomal Protein Extraction (Selpe), Carolyn Barnes

University of Tennessee Honors Thesis Projects

No abstract provided.


Design And Development Of A Quartz Crystal Microbalance Immunosensor For Exosomes, Wesley Cox May 2018

Design And Development Of A Quartz Crystal Microbalance Immunosensor For Exosomes, Wesley Cox

University of Tennessee Honors Thesis Projects

No abstract provided.


Detection And Assay Of Isoniazid Utilizing Isocratic High-Performance Liquid Chromatography, Cassandra Nguyen May 2018

Detection And Assay Of Isoniazid Utilizing Isocratic High-Performance Liquid Chromatography, Cassandra Nguyen

Theses/Capstones/Creative Projects

To demonstrate an analysis for isoniazid from aqueous mixtures and solid tablets, utilizing isocratic conditions, with high performance liquid chromatography (HPLC) and UV detection. Isoniazid in solid and liquid samples is assayed utilizing HPLC. Isoniazid is a tuberculostat, that is assayed by high performance liquid chromatography that utilizes a reversed-phase C-18 column. The eluent solvent is 5.3% ethanol, 93.7% water, and 1% acetic acid. Aqueous samples are prepared in distilled water as the solvent. The ultraviolet-visible detection of isoniazid is accomplished at 265 nm, which is the wavelength having the highest sensitivity for isoniazid. Having a column pump ...