Organic Chemistry I & Ii (Ccga), 2018 College of Coastal Georgia
Organic Chemistry I & Ii (Ccga), Colleen Knight, Leon Gardner, Joseph Lodmell, Ernest Pascoe, Andrea Wallace, Lisa Mcneal
Chemistry Grants Collections
This Grants Collection for Organic Chemistry I & II was created under a Round Seven ALG Textbook Transformation Grant.
Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.
Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:
- Linked Syllabus
- Initial Proposal
- Final Report
Discovery And Development Of A Three-Component Oxidopyrylium Cycloaddition And Its Application Towards Alpha-Hydroxytropolone Synthesis, 2018 The Graduate Center, City University of New York
Discovery And Development Of A Three-Component Oxidopyrylium Cycloaddition And Its Application Towards Alpha-Hydroxytropolone Synthesis, Michael P. D'Erasmo
All Dissertations, Theses, and Capstone Projects
Historically, natural products have provided unique research opportunities and challenges for organic synthesis, chemical biology, and medicinal chemistry due to their molecular complexity and effects on physiological systems. The total synthesis of natural products has not only produced novel reaction methods and strategies capable of efficiently generating complex structural motifs but also granted access to sufficient quantities of otherwise scarce natural product material for clinical evaluation. These synthetic efforts have facilitated the formation of a transdisciplinary partnership between chemistry, biology, and medicine that has been paramount in elucidating the chemical and pharmaceutical utility of natural products. Chapter I of this ...
Comparison Of Processed And Non-Processed Biomass Digestion, 2018 Rose-Hulman Institute of Technology
Comparison Of Processed And Non-Processed Biomass Digestion, Richard Bruce Clark
Graduate Theses – Chemistry and Biochemistry
Lignocellulosic ethanol is the main focus of second-generation biofuels . Because cellulose is the most abundant organic material on earth, second-generation biofuels are a more sustainable option than the classical first-generation biofuels that use foodstuffs as the main feedstock in ethanol production . Furthermore, biofuel can be produced not only from unprocessed biomass such as corn husks but also from processed material like paper . Ionic liquids have shown to be quite effective in dissolving naturally occurring, and traditionally insoluble, polymers such as cellulose into solution, and cellulase enzymes have been shown to effectively digest cellulose into simple sugars [2 ...
Oxidation Of Β-O-4 Lignin Model Compounds And Application To Lignin Linkage Degradation Facilitated By Mechanochemical Treatment And Two-Step Oxidative Depolymerization, Soledad G. Yao
Theses and Dissertations--Chemistry
The oxidation of lignin model compounds was studied in conventional solvents in parallel with oxidations in ionic liquid solvents. Catalyst systems were investigated in ionic liquid solvents to determine how reaction rates and the selectivity for benzylic carbon oxidation were affected. Oxidation rates were often lower in ionic liquids than in conventional solvents ‒ as indicated by lower conversion in a standard reaction time ‒ likely due, at least in part, to the higher viscosity of ionic liquids. Mechano chemical treatment of Indulin AT kraft lignin by ball milling with KOH and toluene produced significant carbonyl functionality, among other changes. The chemical ...
Light-Harvesting And Light-Responsive Materials For Optoelectronic And Biological Applications, 2018 University of Massachusetts Amherst
Light-Harvesting And Light-Responsive Materials For Optoelectronic And Biological Applications, Youngju Bae
In photodynamic therapy, several critical standards are required of photosensitizers including high singlet oxygen quantum yield, biocompatibility in dark, and long term photochemical stability. In addition, current PDT systems lack active targeting strategies to tumor cells, and instead mainly rely on the natural distribution of PS in the body following injection and application of near-infrared light treatment in the tumor region. This thesis describes a series of BODIPY-based molecules that were designed, synthesized and studied as photosensitizers with high singlet oxygen generation capacity through utilizing the heavy atom effect. Additionally, aqueous solubility and active targeting capability were introduced by photosensitizer ...
Identifying Low-Coverage Surface Species On Supported Noble Metal Nanoparticle Catalysts By Dnp-Nmr, 2017 Iowa State University
Identifying Low-Coverage Surface Species On Supported Noble Metal Nanoparticle Catalysts By Dnp-Nmr, Robert L. Johnson, Frederic A. Perras, Takeshi Kobayashi, Thomas J. Schwartz, James A. Dumesic, Brent H. Shanks, Marek Pruski
Brent H. Shanks
DNP-NMR spectroscopy has been applied to enhance the signal for organic molecules adsorbed on γ-Al2O3-supported Pd nanoparticle catalysts. By offering >2500-fold time savings, the technique enabled the observation of 13C–13C cross-peaks for low coverage species, which were assigned to products from oxidative degradation of methionine adsorbed on the nanoparticle surface.
The Role Of Catalytic Residue PKA On The Hydrolysis/Transglycosylation Partition In Family 3 Β-Glucosidases, 2017 Swedish University of Agricultural Sciences, Sweden
The Role Of Catalytic Residue PKA On The Hydrolysis/Transglycosylation Partition In Family 3 Β-Glucosidases, Inacrist Geronimo, Christina M. Payne, Mats Sandgren
Chemical and Materials Engineering Faculty Publications
β-Glucosidases (βgls) primarily catalyze the hydrolysis of the terminal glycosidic bond at the non-reducing end of β-glucosides, although glycosidic bond synthesis (called transglycosylation) can also occur in the presence of another acceptor. In the final reaction step, the glucose product or another substrate competes with water for transfer to the glycosyl-enzyme intermediate. The factors governing the balance between the two pathways are not fully known; however, the involvement of ionizable residues in binding and catalysis suggests that their pKa may play a role. Through constant pH molecular dynamics simulations of a glycoside hydrolase Family 3 (GH3) βgl, we ...
Preparation And Characterization Of Poly(Ethylene Oxide)(Mw 35k And 100k)/ Silica Nanoparticle Composites, 2017 Atlanta University Center
Preparation And Characterization Of Poly(Ethylene Oxide)(Mw 35k And 100k)/ Silica Nanoparticle Composites, Reem Alfinaikh
Electronic Theses & Dissertations Collection for Atlanta University & Clark Atlanta University
In recent years, polymer-inorganic nanoparticle compositions have been a subject of considerable interest in order to achieve desired chemical, physical properties and mechanical properties. In this study a polymer nanocomposites have been prepared by incorporating silica nanoparticles (~20 nm) as fillers into poly(ethylene oxide) matrix. The composites of poly(ethylene oxide) and silica nanoparticles were prepared by solution blending. The product composites were powders. The thermal properties of the composites were investigated using the Differential Scanning Calorimetry. The Nuclear Magnetic Resonance (13C solid state, T1ρ), Atomic Force Microscopy, X-ray diffraction and Fourier Transform Infrared Spectroscopy were used ...
Liquid Organic Electrolytes: Blends Of Low Molecular Weight Methoxyoligooxyethylene (Mpegs)/Litfsi Salt, 2017 Atlanta University Center
Liquid Organic Electrolytes: Blends Of Low Molecular Weight Methoxyoligooxyethylene (Mpegs)/Litfsi Salt, Rasha Alshahrani
Electronic Theses & Dissertations Collection for Atlanta University & Clark Atlanta University
Blends containing methoxyoligooxyethyleneglycol (MPEGs) (MW 350 and 550) and bis(trifluoromethane)sulfonimide lithium (LiTFSI) salt were prepared by solution blending process using tetrahydrofuran (THF) as a solvent. The ionic conductivity of the blends of different compositions were determined at four temperatures i.e. 25°C, 40°C, 60°C and 70°C. A maximum ionic conductivity value of 3.9x10-3 S cm-1 at 25°C was obtained for the blends containing MPEG-350 at an ethylene oxide to lithium salt ratio of 1:10. The ionic conductivity increases with increasing temperature and shows that the ion transport is aided ...
Layer-By-Layer Assembled Membranes With Immobilized Porins, 2017 University of Kentucky
Layer-By-Layer Assembled Membranes With Immobilized Porins, Sebastián Hernández, Cassandra Porter, Xinyi Zhang, Yinan Wei, Dibakar Bhattacharyya
Chemical and Materials Engineering Faculty Publications
New and advanced opportunities are arising for the synthesis and functionalization of membranes with selective separation, reactivity, and stimuli-responsive behavior. One such advancement is the integration of bio-based channels in membrane technologies. By a layer-by-layer (LbL) assembly of polyelectrolytes, outer membrane protein F trimers (OmpF) or “porins” from Escherichia coli with central pores ∼2 nm in diameter at their opening and ∼0.7 × 1.1 nm at their constricted region are immobilized within the pores of poly(vinylidene fluoride) microfiltration membranes, in contrast to traditional ruptured lipid bilayer or vesicle processes. These OmpF-membranes demonstrate selective rejection of non-charged organics over ...
Developing Functionalized Peroxide Precursors For The Synthesis Of Cyclic And Spirocyclic Ethers, 2017 University of Nebraska-Lincoln
Developing Functionalized Peroxide Precursors For The Synthesis Of Cyclic And Spirocyclic Ethers, Anna J. Diepenbrock
Student Research Projects, Dissertations, and Theses - Chemistry Department
There is increasing interest in the development of methods for the synthesis of oxetanes and spirocyclic oxetanes, a class of molecules of interest to chemists as they synthesize libraries of possible drug target scaffolds with tunable physiochemical and biological properties.1,2 Although most ethers are prepared through reaction of nucleophilic oxygen with electrophilic carbon, this work explores new reagents and routes for the synthesis of spirocyclic oxetanes based upon an application of "umpolung" or polarity reversal involving attack of nucleophilic carbon on the electrophilic oxygen of a peroxide (Scheme 1). In this work, a 2-carbon peroxide synthon for reverse ...
Development Of An Improved Synthesis Of S-D-Ribosyl-L-Homocysteine (Srh) And Progress Toward Srh Analogs Modified At The C3 Position, 2017 The University of San Francisco
Development Of An Improved Synthesis Of S-D-Ribosyl-L-Homocysteine (Srh) And Progress Toward Srh Analogs Modified At The C3 Position, Emily Rouse
Quorum sensing is a system that facilitates bacteria turning on and off gene expression depending on population density. System 2 quorum sensing is utilized by both Gram positive and Gram negative bacteria, and the quorum sensing molecule used in this system is AI-2. AI-2 is biosynthesized by the enzyme LuxS from the precursor SRH. This thesis describes an improved synthesis of SRH through the exploration of different protecting group strategies. The knowledge gained from the improved synthesis of SRH is then applied toward the synthesis of SRH analogues with increased steric bulk installed through use of a stereoselective anti-Mannich reaction ...
Tunable Copper Complexes For Sustainable Photocatalysis, 2017 Murray State University
Tunable Copper Complexes For Sustainable Photocatalysis, David Kline
Photoredox catalysis has direct applications in sustainable chemistry and thus an immense impact on our environment. With the ability to harness energy directly from the sun to catalyze useful chemical reactions, photocatalysts can help to eliminate the need for harsh reaction conditions and reduce generation of hazardous chemical waste. Photocatalysts based on Earth-abundant metals such as copper have recently emerged as sustainable alternatives to rare-earth metals including iridium and ruthenium, which are no longer required for many photocatalyzed chemical transformations.
Formation Of Highly Functionalized Indole Through Carbon-Carbon Bond Cleavage, 2017 University of New Mexico
Formation Of Highly Functionalized Indole Through Carbon-Carbon Bond Cleavage, Ryan A. S. Pike
Indoles are one of the most abundant heterocycles found in nature and have a wide range of functions. There are a wide variety of indole synthesis methods known both in synthetic chemistry and through biosynthesis. Many of the known indole synthesis routes use a benzene derivative or cyclized ring structure derivative as a starting material. Here, we describe a novel synthetic method utilizing 1, 3-diketones and fumaronitrile with a catalytic amount of base to form a highly functionalized indole as our product. We have isolated and characterized 12 functionalized indoles.
Progress Toward Phidianidine Analogues Containing A 1,2,3-Triazole Ring, 2017 Coastal Carolina University
Progress Toward Phidianidine Analogues Containing A 1,2,3-Triazole Ring, David Laws Iii, Dillon King, Bryan H. Wakefield
Journal of the South Carolina Academy of Science
Phidianidines are a class of compound that has been extracted from the sea mollusk Phidianis militaris. These compounds have been shown to exhibit a variety of useful properties such as antihistamine effects, anti-cancer activity, agonism of the µ-opioid receptor and neuroprotection. The biological activities are thought to be caused by the 1,2,4- oxadiazole ring found within the molecule. The goal of this project is to synthesize analogues of phidianidine that contain a 1,2,3-triazole instead of the 1,2,4 oxadiazole ring using a method that will allow for other regions of the molecule to be changed ...
Ensemble-Based Modeling And Rigidity Decomposition Of Allosteric Interaction Networks And Communication Pathways In Cyclin-Dependent Kinases: Differentiating Kinase Clients Of The Hsp90-Cdc37 Chaperone, 2017 Chapman University
Ensemble-Based Modeling And Rigidity Decomposition Of Allosteric Interaction Networks And Communication Pathways In Cyclin-Dependent Kinases: Differentiating Kinase Clients Of The Hsp90-Cdc37 Chaperone, Gabrielle Stetz, Amanda Tse, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
The overarching goal of delineating molecular principles underlying differentiation of protein kinase clients and chaperone-based modulation of kinase activity is fundamental to understanding activity of many oncogenic kinases that require chaperoning of Hsp70 and Hsp90 systems to attain a functionally competent active form. Despite structural similarities and common activation mechanisms shared by cyclin-dependent kinase (CDK) proteins, members of this family can exhibit vastly different chaperone preferences. The molecular determinants underlying chaperone dependencies of protein kinases are not fully understood as structurally similar kinases may often elicit distinct regulatory responses to the chaperone. The regulatory divergences observed for members of CDK ...
Spatial Mapping And Profiling Of Metabolite Distributions During Germination, 2017 Iowa State University
Spatial Mapping And Profiling Of Metabolite Distributions During Germination, Robbyn Anand, Adam D. Feenstra, Liza E. Alexander, Zhihong Song, Andrew R. Korte, Marna Yandeaue-Nelson, Basil J. Nikolau, Young-Jin Lee
Germination is a highly complex process by which seeds begin to develop and establish themselves as viable organisms. In this paper, we utilize a combination of GC-MS, LC-fluorescence, and mass spectrometry imaging (MSI) approaches to profile and visualize the metabolic distributions of germinating seeds from two different inbreds of maize seeds, B73 and Mo17. GC and LC analyses demonstrate that the two inbreds are highly differentiated in their metabolite profiles throughout the course of germination, especially with regard to amino acids, sugar alcohols, and small organic acids. Crude dissection of the seed followed by GC-MS analysis of polar metabolites also ...
Reintroducing Explicit Solvent To A Solvent-Free Coarse-Grained Model, 2017 Iowa State University
Reintroducing Explicit Solvent To A Solvent-Free Coarse-Grained Model, Seung Ha Kim, Monica H. Lamm
Monica H. Lamm
A unique coarse-grained modeling scheme that combines a systematic, solvent-free multiscale coarse-graining algorithm for a complex macromolecule with an existing coarse-grained solvent model is proposed. We show that this procedure efficiently and reliably describes the interactions for complex macromolecules, using the specific example of dendrimers binding phenanthrenes in water. The experimentally measured binding capacity is predicted by the unique coarse-grained modeling approach; the conditions for this simulation are beyond what could be reasonably simulated with an all-atom molecular dynamics simulation.
Thermal, Mechanical, And Conductive Properties Of Bisimidazolium Thiol-Ene Pil Networks, 2017 Murray State University
Thermal, Mechanical, And Conductive Properties Of Bisimidazolium Thiol-Ene Pil Networks, Sunny Kwan, Sunny Kwan
Honors College Theses
Polymers made from thiol-ene reactions are versatile – they can be made from a variety of easily obtainable starting materials and show promise as biomedical materials, hydrogels, resins, and nanoparticles. Ionic liquids (ILs) have uniquely exploitable physical and chemical properties, and polymerization of ILs into polymeric ionic liquids (PILs) enhances or changes these properties, allowing an even wider range of potential applications of ILs in technologies such as fuel cells, solar cells, and even artificial muscles. Bisimidazolium thiol-ene PIL (BITPIL) networks are polymers with each monomer consisting of two moles of bis-imidazolium bridged together with either an alkyl or poly(ethylene ...
Synthesis Of N-Heterocycles From Donor Acceptor Cyclopropanes And Progress Towards Flinderole A, B, And C, 2017 The University of Western Ontario
Synthesis Of N-Heterocycles From Donor Acceptor Cyclopropanes And Progress Towards Flinderole A, B, And C, Joanne E. Curiel Tejeda
Electronic Thesis and Dissertation Repository
The first chapter of this thesis describes two projects, one explores the novel reactivity of quaternary donor acceptor cyclopropanes and the second one involves progress toward the total synthesis of the flinderoles A, B, and C. The first project involves the Lewis acid catalyzed nucleophilic ring opening of quaternary donor acceptor cyclopropanes with indoline. It was found that the ring opening reaction worked well with either Sc(OTf)3 or Yb(OTf)3 as the Lewis acids. The ring opened products were also able to be converted into pyrroloindoles via a manganese (III) oxidative radical cyclization reaction. Cyclopropanes bearing alkynyl ...