Open Access. Powered by Scholars. Published by Universities.®

Analytical Chemistry Commons

Open Access. Powered by Scholars. Published by Universities.®

1637 Full-Text Articles 2053 Authors 234869 Downloads 76 Institutions

All Articles in Analytical Chemistry

Faceted Search

1637 full-text articles. Page 1 of 38.

Ryan Caylor, Ryan Caylor 2016 Concordia University - Portland

Ryan Caylor, Ryan Caylor

Matthew E. Wise

Ryan is a senior majoring in chemistry at Concordia University. He plans on graduating in the spring of 2017. After graduation Ryan plans on attending graduate school in the field of meteorology with an interest in becoming a weather man. Ryan is returning to the Pacific Northwest National Laboratory in the summer of 2015 to study the chemical composition of secondary organic aerosol particles. He is also a pitcher on the Concordia University baseball team.


The Corrosion Of Carbon Steel Under Deep Geologic Nuclear Waste Disposal Conditions, Shannon L.W. Hill 2016 The University of Western Ontario

The Corrosion Of Carbon Steel Under Deep Geologic Nuclear Waste Disposal Conditions, Shannon L.W. Hill

Electronic Thesis and Dissertation Repository

The proposed disposal scenario for high-level nuclear waste (spent fuel) in Canada is emplacement within a sealed, deep geological repository (DGR) located in either granitic rock or sedimentary clay. Disposal is based on a multi-barrier approach, with the primary barrier being a sealed container which could be either dual-walled with a copper shell over an inner carbon steel vessel for granitic rock or a single thick-walled steel container for sedimentary clay. This study focuses on the corrosion behaviour of A516 Gr70 carbon steel as well as the corrosion products formed in a variety of groundwater compositions and concentrations expected within ...


Aqueous Photochemistry Of Glyoxylic Acid, Alexis J. Eugene, Sha-Sha Xia, Marcelo I. Guzman 2016 University of Kentucky

Aqueous Photochemistry Of Glyoxylic Acid, Alexis J. Eugene, Sha-Sha Xia, Marcelo I. Guzman

Chemistry Faculty Publications

Aerosols affect climate change, the energy balance of the atmosphere, and public health due to their variable chemical composition, size, and shape. While the formation of secondary organic aerosols (SOA) from gas phase precursors is relatively well understood, studying aqueous chemical reactions contributing to the total SOA budget is the current focus of major attention. Field measurements have revealed that mono-, di-, and oxo-carboxylic acids are abundant species present in SOA and atmospheric waters. This work explores the fate of one of these 2-oxocarboxylic acids, glyoxylic acid, which can photogenerate reactive species under solar irradiation. Additionally, the dark thermal aging ...


The Study Of Drug Interactions During Separation Using Gas Chromatography – Mass Spectrometry, Leanne Mocniak 2016 Seton Hall University

The Study Of Drug Interactions During Separation Using Gas Chromatography – Mass Spectrometry, Leanne Mocniak

Undergraduate Honors Theses

There are numerous existing techniques for forensic toxicological testing, but each one has limitations. Although there have been significant improvements in these techniques over the past 10 years, it still remains very difficult to successfully identify a wide range of drugs from one sample using a single method [12]. This difficulty arises from the major differences in molecular structure, volatility and stability in solution between these drugs. The overall goal of this study is to develop a method using gas chromatography (GC) coupled with triple quadrupole mass spectrometry (GC/MS/MS) to separate and accurately identify 10 different drugs of ...


Dendrimer Modified Silica Nanoparticles As Fluorescent Chemosensors For The Detection Of Copper And Cyanide Ions, Alicia Luhrs 2016 University of San Francisco

Dendrimer Modified Silica Nanoparticles As Fluorescent Chemosensors For The Detection Of Copper And Cyanide Ions, Alicia Luhrs

Master's Theses

A series of silica nanoparticle-based fluorescent chemosensors were synthesized for the sensitive and selective detection of Cu2+ ions in aqueous solution and subsequent CN- ion detection. Silica nanoparticles (SNP) were modified with branching polyamidoamine (PAMAM) dendrimers, which function as selective turn-off Cu2+ ion chelators and platforms for the attachment of rhodamine isothiocyanate (RITC) or fluorescein isothiocyanate (FITC) fluorescent dyes. In the presence of Cu2+ ions, the emission of the fluorescent dye is quenched by Forster resonance energy transfer (FRET) and is dependent upon dendrimer generation, pH, fluorescent dye, and surface charge. The quenching effectiveness was analyzed by ...


Application Of An Ionic Liquid Column To The Analysis Of Flavor And Fragrance Ingredients, Nicole L. Curto 2016 Seton Hall University

Application Of An Ionic Liquid Column To The Analysis Of Flavor And Fragrance Ingredients, Nicole L. Curto

Seton Hall University Dissertations and Theses (ETDs)

Traditional, polar (polyethylene glycol/wax) stationary phase gas chromatography columns pose challenges for flavor and fragrance analysis particularly in regards to thermal instability at high temperatures, degradation when exposed to water, unchanging selectivity, and relatively short shelf lives. Recently, capillary columns using ionic liquids as stationary phases have become available. Ionic liquid columns offer a potential combination of high polarity and high temperature stability with unique selectivity. An in depth discussion about the history and development of column phase characterization, with specific emphasis on selectivity and polarity, will allow for a critical look at the polarity scale currently employed to ...


A Pilot Study Analyzing Solvents In Electronic Cigarette “E-Liquid” Using High Performance Liquid Chromatography, Austin Matranga, Olivia Sellers, Matthew Gartner 2016 Chapman University

A Pilot Study Analyzing Solvents In Electronic Cigarette “E-Liquid” Using High Performance Liquid Chromatography, Austin Matranga, Olivia Sellers, Matthew Gartner

Student Research Day Abstracts and Posters

Introduction: Electronic cigarettes, also known as an e-cigarette, are battery-powered devices that use a heating element to convert a liquid (“e-liquid”) into an inhalable aerosol. Their advertised use is as a nicotine delivery system minus the harmful chemicals. Since “e-liquids” and the electronic cigarettes are not regulated by the Food and Drug Administration, it is not well known under what conditions, if any, carcinogenic compounds are produced. There has been little research on the toxicity of electronic cigarettes. The aim of this study was to determine if formaldehyde or acetaldehyde are formed from the e-liquid by the high heat of ...


Immobilization Of Heteropolyacids In Silica Gel, Opeyemi Adetola 2016 East Tennessee State University

Immobilization Of Heteropolyacids In Silica Gel, Opeyemi Adetola

Electronic Theses and Dissertations

Silica gels containing incorporated heteropolyacids (HPAs) were synthesized in acidic media by co-condensation of tetraethoxysilane (TEOS) with phosphotungstic or phosphomolybdic acids using sol-gel technique. Effect of the synthesis conditions on their structure and morphology was studied. Yields of modified materials were some lower as compared to non-modified silica gels. All materials were mesoporous but contained micropores in their structures. Presence of bands of Keggin’s structures in FT-IR spectra along with absence of XRD patterns of crystalline HPAs confirmed their fine incorporation into silica network. Particle sizes of modified materials were 800-1100 nm excepting for W-containing sample obtained with trimethylstearylammonium ...


Facilitating Conceptual Learning In Quantitative Chemistry, Sarah R. Johnson 2016 East Tennessee State University

Facilitating Conceptual Learning In Quantitative Chemistry, Sarah R. Johnson

Electronic Theses and Dissertations

Traditional chemistry laboratory courses have a manual consisting of “step-by-step” experiments; instructions are given to complete experiments, requiring minimal information/concepts processing to be successful. This experience leaves students unprepared for the real-world, where critical thinking skills are needed to conduct research. This study focused on building analytical techniques, conceptual knowledge, and critical thinking skills used to solve research problems. A new quantitative chemistry laboratory manual was developed to transition students from traditional to inquiry-based experiments, requiring analytical method development. Data showed students having less difficulty using the new manual (0.8281 average difficulty) on method development exam questions and ...


An Experimental And Theoretical Study Of Proton Affinity In Proline-Containing Dipeptides: Exploring The “Proline Effect”, Anton Luke Lachowicz 2016 College of William and Mary

An Experimental And Theoretical Study Of Proton Affinity In Proline-Containing Dipeptides: Exploring The “Proline Effect”, Anton Luke Lachowicz

College of William & Mary Undergraduate Honors Theses

Mass Spectrometry is a very useful technique for proteomics studies. Currently Bottom-up proteomics uses peptide-sequencing databases to identify peptides from fragmentation spectra. However, these databases lack information about selective fragmentation of proline containing peptides, resulting in the failure of that peptide being sequenced. The selective cleavage proline causes during low-energy dissociations in the gas-phase is known as the “proline effect.” In order to better understand the proline effect, the proton affinity of proline-containing dipeptides is obtained theoretically using B3LYP and compared to experimental values from an extended kinetic method experiment on a triple quadrupole mass spectrometer. Pro-Pro, Pro-Phe and Phe-Pro ...


Fragmentation Studies Of Lysine And Lysine Analog Containing Tetrapeptides, Zachariah Imran Hasan 2016 College of William and Mary

Fragmentation Studies Of Lysine And Lysine Analog Containing Tetrapeptides, Zachariah Imran Hasan

College of William & Mary Undergraduate Honors Theses

The fragmentation patterns of lysine and lysine-analog containing tetrapeptides were analyzed in this study using collision induced dissociation (CID) in an ESI-ion trap mass spectrometer. Understanding the fragmentation mechanisms of lysine-containing peptides is integral to improving bottom-up proteomics techniques and peptide sequencing and searching algorithms. Lysine and its non-protein amino acid (NPAA) analogs ornithine, DABA, and DAPA have been shown to affect fragmentation patterns based on their basicities in dipeptides and tripeptides. Studies have shown the occurrence of sequence scrambling due to macrocyclization of pentapeptides during fragmentation, which can result in inaccurate database matching. This study of the twenty tetrapeptides ...


Peptide Fragmentation Studies On Doubly Charged Proline And Pipecolic Acid Containing Pentapeptides And Methods Development For An Hplc/Ms Instrument For Proteomics Experiments, Hannah Emily Smith 2016 College of William and Mary

Peptide Fragmentation Studies On Doubly Charged Proline And Pipecolic Acid Containing Pentapeptides And Methods Development For An Hplc/Ms Instrument For Proteomics Experiments, Hannah Emily Smith

College of William & Mary Undergraduate Honors Theses

This thesis presents fragmentation studies as well as proteomics studies performed using mass spectrometry. Peptide fragmentation was performed on both singly and doubly charged peptides containing either a proline or pipecolic acid residue, as well as either an arginine or lysine residue using collision-induced dissociation. Results showed that altering the position of pipecolic acid or proline in relation to arginine or lysine can affect the formation of doubly charged product ions, which may be a result in change of the proton affinity of the basic residue. Proteomics experiments were performed on a new HPLC/LTQ instrument using a standardized sample ...


Assessment Of Calcein Dye Method To Observe Cell Volume Regulation, Danielle M. Precourt 2016 Buffalo State College

Assessment Of Calcein Dye Method To Observe Cell Volume Regulation, Danielle M. Precourt

Forensic Science Theses

Cell volume regulation (CVR) is a crucial mechanism for the maintenance of homeostasis of cells under significant osmotic challenges. When cells are swollen or shrunken in a non-isotonic medium they initiate a regulatory mechanism to restore to their initial volume. Swollen cells in a hypotonic solution show decreases in cell volume by releasing osmolytes and water, through a regulatory volume decrease (RVD) mechanism. On the contrary, shrunken cells in a hypertonic solution exhibit a regulatory volume increase (RVI) by up-taking osmolytes and water. The whole process of CVR is complicated and involves diverse cell sensory mechanisms of a volume change ...


Comparing The Quantitation Of Opiates From Possible Drug Overdose Cases Using Results Of Blood Analysis And Liver Analysis, Lee Ann Garozzo 2016 State University of New York Buffalo State

Comparing The Quantitation Of Opiates From Possible Drug Overdose Cases Using Results Of Blood Analysis And Liver Analysis, Lee Ann Garozzo

Forensic Science Theses

Currently the quantitation of opiates at the Erie County Medical Examiner’s Office Toxicology Laboratory is conducted through whole blood analysis. The objective of this thesis project was to determine if the analysis of opiates could be conducted through liver analysis, and if the analysis of opiates would provide a more accurate quantitation compared to the blood analysis. The quantitation of opiates was conducted from the livers of sixty-four possible overdose cases that were brought into the Erie County Medical Examiner’s Office between 2013 and 2015. Results showed that the opiate drugs could successfully be quantitated using the liver ...


Extracting (1,3/1,6)-Β-Glucans From Saccharomyces Cerevisiae: A Fungal Immunotherapeutic, James C. Elliott 2016 East Tennessee State University

Extracting (1,3/1,6)-Β-Glucans From Saccharomyces Cerevisiae: A Fungal Immunotherapeutic, James C. Elliott

Undergraduate Honors Theses

The goal of this research was the development of a method to extract pure (1,3/1,6)-β-glucans from Saccharomyces cerevisiae. These β-glucans are of pharmaceutical importance because an animal’s immune system can recognize glucan molecules, and these molecules can act as immunomodulators, essentially turning on the immune system. The problem in the past has been that previously published methods produce β-glucans with low side chain lengths and few branching occurrences. This issue was tackled by a multivariable approach that reduced extraction steps, initial sample size, and concentrations of reagents used. This method has been shown to produce ...


Staphylococcal Nuclease And Ubiquitin Local Folding Energies And Rates Using Peps-Hdx-Esi-Ms, Julie Rhee 2016 University of Arkansas, Fayetteville

Staphylococcal Nuclease And Ubiquitin Local Folding Energies And Rates Using Peps-Hdx-Esi-Ms, Julie Rhee

Chemistry & Biochemistry Undergraduate Honors Theses

In this study, Protein Equilibrium Population Snapshot Hydrogen-Deuterium Exchange Electrospray Ionization Mass Spectrometry (PEPS-HDX-ESI-MS) was applied to study the local regions of model proteins, staphylococcal nuclease and ubiquitin. The hydrogen deuterium exchange (HDX) has become a key technique for studying the structural and dynamic aspects of proteins in solution. This technique creates a rapid exchange between all of the exchangeable hydrogen ions with deuterium when the protein is exposed to a solvent. The PEPS method is an equilibrium-based method used to determine the populations of the closed native and open denatured states of a protein. By combining the applications of ...


Chemoselective Reactions And Their Applications In Metabolite Isolation And Analysis., Sadakatali Shokatali Gori 2016 University of Louisville

Chemoselective Reactions And Their Applications In Metabolite Isolation And Analysis., Sadakatali Shokatali Gori

Electronic Theses and Dissertations

Chemoselectivity is the preferential reaction of a reagent with a select functional group among other plausible reactions. This dissertation describes chemoselective reagents and methods explored to develop more accurate, efficient and high-throughput means to quantify metabolites containing either thiol, carboxylic acid or 1,2-diol moieties directly from biological mixtures. Chapter 1 discusses how dysregulation of thiol- or carboxylic acid-containing metabolites is either the cause or effect of cellular dysfunction. Quantifying such metabolites is important in discovery of pathways to understand etiology of diseases. Chapter 1 also discusses the need for sustainable syntheses using renewable resources and describes the traditional methods ...


A Characterization Study On Catalyst Layers In Proton Exchange Membrane Fuel Cells, Luyue Li 2016 The University of Tennessee, Knoxville

A Characterization Study On Catalyst Layers In Proton Exchange Membrane Fuel Cells, Luyue Li

Doctoral Dissertations

This thesis describes the work for the catalyst layer (CL) characterization study of proton exchange membranes (PEM) for fuel cells. In particular, both the structure and performance of catalyst layers with alternative ionomers were studied. Structure wise, the morphology, surface area and pore size distribution studies were accomplished with scanning electron microscopy (SEM), transmission electron microscope (TEM) and nitrogen adsorption processed through Brunauer–Emmett–Teller (BET) and Barrett-Joyner-Halenda (BJH) theory. Water uptake isotherms of the CLs have been developed under well controlled relative humidity (RH) levels. The performance characterization focuses on polarization study, catalyst layer proton conductivity measurement and estimation ...


Novel Methods And Sensors For The Analysis Of Trace Chemicals With Potential Environmental Applications, Samuel Mason Rosolina 2016 University of Tennessee - Knoxville

Novel Methods And Sensors For The Analysis Of Trace Chemicals With Potential Environmental Applications, Samuel Mason Rosolina

Doctoral Dissertations

The work in this dissertation focuses on the detection and analysis of trace chemicals in biological and environmental samples. Methods for the electrochemical detection of heavy metals Cd(II) [cadmium] and Pb(II) [lead], and the catalytic metal Pd(II) [palladium] in pharmaceutical ingredients have been optimized without the necessity of sample pretreatment. The metals can be analyzed simultaneously as well as individually, and the study includes the first known instance of the use of anodic stripping voltammetry (ASV) to detect metals in dimethyl sulfoxide (DMSO) solutions. Another method, based on ASV, has been optimized and evaluated for the purpose ...


Development Of Novel Analytical Methods With The Aim Of Forensic Analyte Detection Using Ultra-Thin Layer Chromatography, Surface Enhanced Raman Spectroscopy, And Magneto-Elastic Wire Sensing, Nichole Ann Crane 2016 University of Tennessee- Knoxville

Development Of Novel Analytical Methods With The Aim Of Forensic Analyte Detection Using Ultra-Thin Layer Chromatography, Surface Enhanced Raman Spectroscopy, And Magneto-Elastic Wire Sensing, Nichole Ann Crane

Doctoral Dissertations

The purpose of this dissertation is to develop analytical methods that aid in the detection of forensic analytes. Forensic analytes require methods with increased sensitivity and low limit of detection capabilities. Improvements in separation techniques, surface enhanced Raman spectroscopic techniques, and wire-less gas sensing can each assist in the detection of trace evidence.

When surface enhanced Raman is coupled with thin-layer chromatography a mixture of compounds can be separated and transferred to a metal substrate to be detected using Raman spectroscopy. Surface enhanced Raman scattering enhances the Raman signal intensity by placing a metal substrate in close proximity to an ...


Digital Commons powered by bepress