Concentration Of Atmospheric Ammonia From Kenyon College Monitoring Station, 2018 Kenyon College
Concentration Of Atmospheric Ammonia From Kenyon College Monitoring Station, Vivian Ezeh, David Heithaus, Simon Garcia, Matthew F. Rouhier
Kenyon College is hosting an ammonia (NH3) monitoring station as part of the National Atmospheric Deposition Program (NADP). The Kenyon College (OH32) site is one of six locations around the state of Ohio.
Archaeometric Approaches To The Roman Near East, 2018 University of Tennessee, Knoxville
Archaeometric Approaches To The Roman Near East, Gayatri Nandwani
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
The purpose of my research this summer has been to participate in a full suite of archaeometric and geoarchaeological analyses, particularly as they are applied to sedimentology. The first section of my research has focused on an introduction to these procedures at ARL including laboratory safety procedures, proper sample collection and processing methods, and introduction to methods and purposes for a variety of laboratory analyses including grain size distribution analysis using a state of the art Malvern Mastersizer 3000 laser diffraction particle size analyzer, organic matter and inorganic carbon analysis, and microartifact analysis. During the field collection phase I worked ...
Modeling Adsorption And Diffusion Of Atomic Oxygen On The Ag(111) Surface Using Kinetic Monte Carlo Simulations, 2018 University of Tennessee, Knoxville
Modeling Adsorption And Diffusion Of Atomic Oxygen On The Ag(111) Surface Using Kinetic Monte Carlo Simulations, Seth Spencer Street, Sharani Roy, Sara Isbill
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Oxidized silver surfaces are widely used as industrial heterogeneous catalysts to oxidize small organic compounds, such as ethylene. While surface-adsorbed oxygen is known to participate in catalysis, it has been suggested that ‘subsurface’ oxygen adsorbed in the near-surface region of silver also plays important roles in surface reconstruction and reactivity. However, the formation, motion, and chemical behavior of subsurface oxygen in silver are not well understood. In the present work, a kinetic Monte Carlo (KMC) simulation has been developed using the Python programming language to computationally model the diffusion kinetics of atomic oxygen (AO) at the Ag(111) surface. This ...
Assessment Of Energetic Heterogeneity Of Reversed-Phase Surfaces Using Excess Adsorption Isotherms For Hplc Column Characterization, Leih-Shan Yeung
Seton Hall University Dissertations and Theses (ETDs)
This research is to explore a more general column categorization method using the test attributes in alignment with the common mobile phase components. As we know, the primary driving force for solute retention on a reversed-phase surface is hydrophobic interaction, thus hydrophobicity of the column will directly affect the analyte retention. This research describes a method to determine the column hydrophobicity by the ratio of adsorbed acetonitrile and methanol to water on the column surface using excess adsorption isotherm estimation. An excess adsorption isotherm for a binary mobile phase system represents a competitive interaction of both solvent components with the ...
Treatment Of Mci And Alzheimer's Disease, 2018 University of Kentucky
Treatment Of Mci And Alzheimer's Disease, Mark A. Lovell, Bert C. Lynn
Chemistry Faculty Patents
The present invention provides, among other things, therapeutic compositions and methods that can effectively treat, slow or prevent a neurological disease (e.g., a neurodegenerative disease, e.g., mild cognitive impairment (MCI) or Alzheimer's disease (AD)), in particular, based on therapeutically effective amount of nifedipine, oxidized or nitroso nifedipine derivatives, lactam (e.g., a compound of formula (Ic) or (Ic-i), e.g., NFD-L1), thyroxine (T4), triiodothyronine (T3) and combinations thereof.
E-Cigarettes Can Emit Formaldehyde At High Levels Under Conditions That Have Been Reported To Be Non-Averse To Users, 2018 Portland State University
E-Cigarettes Can Emit Formaldehyde At High Levels Under Conditions That Have Been Reported To Be Non-Averse To Users, James C. Salamanca, Jiries Meehan-Attrash, Shawna Vreeke, Jorge O. Escobedo, David H. Peyton, Robert M. Strongin
Chemistry Faculty Publications and Presentations
E-cigarette aerosol emission studies typically focus on benchmarking toxicant levels versus those of cigarettes. However, such studies do not fully account for the distinct chemical makeup of e-liquids and their unique properties. These approaches often conclude that there are fewer and lower levels of toxins produced by e-cigarettes than by cigarettes. In 2015, we reported the discovery of new hemiacetals derived from the reaction of formaldehyde and the e-liquid solvents. The main finding was that they constituted a significant proportion of potentially undetected formaldehyde. Moreover, unlike gaseous formaldehyde, the hemiacetals reside in the aerosol particulate phase, and thus are capable ...
Effects Of A Green Chemistry Laboratory Design On First- Semester General Chemistry Students' Transformative Experiences In Chemistry, Lurea Joan Doody
Electronic Theses and Dissertations
The purpose of this study was to understand if a green chemistry laboratory design facilitated students’ transformative experiences in a first-semester general chemistry course for science majors. The study population consisted of 18 college students enrolled in the course at a small, rural, mid-Atlantic university. Traditional chemistry laboratories were replaced with three signature green chemistry laboratories over a period of 6-weeks at the end of the spring semester. Impact data were collected pre- and post, of the three labs using the Transformative Experience Questionnaire (TEQ) surveys. Open ended guided reflection questions were coded for elements of transformative experience (TE): expansion ...
Polymer Nanocomposites Containing High Aspect Ratio Particulates: Innovation In Co-Extruded Multilayer Barrier Films, 2018 The University of Southern Mississippi
Polymer Nanocomposites Containing High Aspect Ratio Particulates: Innovation In Co-Extruded Multilayer Barrier Films, Kevin Meyers
Delaminated montmorillonite (MMT) clay/ maleic anhydride grafted LLDPE nanocomposite multilayer films with alternating layers of LDPE were produced through multilayer co-extrusion. The MMT concentration within the nanocomposite layers was increased through annealing the films in the melt due to a mismatch in interdiffusion rates of the polymer layers. Analysis of the nanocomposite layers upon annealing revealed that the platelets impinged upon one another resulting in significant improvement in oxygen barrier in the multilayer system, exceeding the results of bulk nanocomposites.
Model analysis demonstrated that increasing the nanoplatelet aspect ratio or initial concentration in the filled layers would lead to even ...
New Reactions Of Strained Allyl Silacycles, 2018 Western Washington University
New Reactions Of Strained Allyl Silacycles, Elizabeth Cummins
Graduate Student Symposium
Ring-strained allylsilanes exhibit both electrophilic and nucleophilic characteristics, allowing for simultaneous activation and allylation of carbonyl compounds. Results are presented describing an optimized synthesis of certain allylsilacyclobutanes and their use in several selective carbon-carbon bond forming reactions.
The Coastal Monitor: Fall 2017/ Spring 2018, 2018 Molloy College
The Coastal Monitor: Fall 2017/ Spring 2018, John T. Tanacredi Ph.D.
Dr. John T. Tanacredi
As I sat there in the Members Lounge at the Explorers Club; the world center for exploration, getting ready for our first Spring Saturday Science for Students @the EC lecture, I was putting together some notes on the accomplishments of our science students and CERCOM over the last few months since our last newsletter. Our visit to the Galapagos, a spectacular academic experience for our Molloy College students was at the top of my list! This was certainly not an epiphany but as I accumulated the items on this list, I was impressed not only with what we have conducted ...
Novel Role Of Hypoxia In Ovarian Cancer Chemo Resistance Through Epigenetic Regulation Of Hif1Α, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Liam Gallagher, Michael O'Sullivan, Benjamin Honigsfeld, Kim Doyle, Nevenka Dimitrova, Robert Lucito
Ovarian cancer is the fifth deadliest cancer in woman, and epithelial malignancies account for 90% of cases. Tumor recurrence after chemotherapy or radiation remains a major obstacle to successful ovarian cancer treatment. Despite the large number of studies, molecular events that govern the emergence of aggressive therapy-resistant cells after chemotherapy are poorly defined. Genetic modifications, such as copy number variation (CNV), play an important role in controlling the expression of genes that are involved in chemo resistance. We analyzed CNV data that is publically available through the Cancer Genome Atlas and others. Of particular interest was the transcription factor HIF1α ...
Inhibitions Of Gsk3Β Modulates Cell Death In Epithelial Ovarian Cancer, 2018 Molloy College
Inhibitions Of Gsk3Β Modulates Cell Death In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Naeha Pathak
Epithelial ovarian cancer is one of the most common gynecological malignancies and the fifth most frequent cause of cancer death in women, affecting over 22,000 women annually. Nearly 15,500 affected women die from this disease annually, and chemoresistance from the commonly prescribed platinum-based drug, carboplatin, is a major contributor to this mortality rate. Previous studies have identified genes with CpG islands that are methylated and transcriptionally silenced in resistant epithelial ovarian cancer patients. One of these genes is GSK3β, an important regulator of apoptosis and cell growth in the Wnt pathway. Thus, understanding the role of GSK3β suppression ...
Abstract 70: A Role For The Chromatin Remodeling Protein Chd3 In Ovarian Cancer Therapy Response, Noelle L. Cutter Ph.D., Nila Banerjee, Michelle Vigliotti, Angel Janevski, Douglas Levine, Robert Lucito, Nevenka Dimitrova
Carboplatin and cisplatin are chemotherapeutic agents that are used extensively for treating epithelial ovarian cancer. These drugs can be highly effective, yet tumors are frequently refractory to treatment or become resistant upon tumor relapse. Epigenetic silencing, particularly at promoter regions of genes regulates important cell function and has been associated with all stages of tumor formation and progression and may contribute to therapy response. We analyzed the epigenome of 50 primary ovarian tumors and 12 normal ovarian samples using an array based method previously developed in our lab and associated Affymetrix U133 expression data. We then identified gene candidates that ...
Abstract 4525: Hypoxia Signaling Pathway Plays A Role In Ovarian Cancer Chemoresistance, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Kim Doyle, Ryan Frank
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor that when induced regulates the expression of many genes involved in cytoprotective stimuli, which attenuates apoptosis and improves survival. Increased expression of HIF-1α gene (HIF1A) has been found in several carcinomas, including ovarian cancer. Ovarian cancers are generally refractory to platinum-based chemotherapy. Despite the large number of studies, molecular events that govern the emergence of aggressive therapy-resistant cells after chemotherapy are poorly defined. Genomic instabilities, such as copy number variation(CNV), may play an important role in chemoresistance and have been implicated in many complex diseases, like cancer.. We analyzed ...
Abstract 3144: A Role For Dok2 Methylation In Platinum Resistance And Tumor Suppression In Ovarian Cancer, Noelle L. Cutter Ph.D., Elena Lum, Michelle Vigliotti, Sohail Khan, Douglas Levine, Nevenka Dimitrova, Robert Lucito
Ovarian cancer is the 5th leading cause of cancer in women, affecting close to 22,000 women in the year 2011, of which nearly 15,500 will die. It is difficult to detect until it reaches advanced stages and becomes malignant. Currently, the standard treatment for ovarian cancer is platinum-based therapeutics, such as Carboplatin or Cisplatin, combined with Taxol. Unfortunately, approximately 25% of patients are inherently platinum-resistant and all patients who suffer from recurrence will have developed acquired platinum resistance. The genetic/epigenetic causes of this resistance are poorly understood. Epigenetic events are reversible and the identification of genes altered ...
Abstract 2934: Gsk3Β Modulates Chemoresistance In Epithelial Ovarian Cancer, 2018 Molloy College
Abstract 2934: Gsk3Β Modulates Chemoresistance In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Naeha Pathak
Introduction: Epithelial ovarian cancer is one of the most common gynecological malignancies and the fifth most frequent cause of cancer death in women, affecting over 22,000 women annually. Nearly 15,500 affected women die from this disease annually, and chemoresistance from the commonly prescribed platinum-based drug, carboplatin, is a major contributor to this mortality. Previous studies have identified genes with CpG islands that are methylated and transcriptionally silenced in resistant epithelial ovarian cancer patients. One of these genes is GSK3β, an important regulator of apoptosis and cell growth in the Wnt pathway. Thus, understanding the role of GSK3β suppression ...
“Fkamathamnareshbabusp18”.Pdf, 2018 University of Miami
“Fkamathamnareshbabusp18”.Pdf, Nareshbabu Kamatham
No abstract provided.
Metallodithiolate Ligands For Reversing Metal Ion Induced Aggregation Of Beta Amyloid, 2018 Portland State University
Metallodithiolate Ligands For Reversing Metal Ion Induced Aggregation Of Beta Amyloid, Eleanor K. Adams, Marilyn Rampersad Mackiewicz
Student Research Symposium
Alzheimer’s Disease (AD) is the sixth leading cause of death in the United States with no known methods to cure, reverse or halt disease progression. The “metal hypothesis” states that FeII, CuII, ZnII, and AlII bind to truncated Aβ peptides and form soluble oligomers which deposit as senile plaques. These plaques play a crucial role in AD pathogenesis. For example, metallated-Aβ aggregates are hypothesized to disrupt membranes or generate a reactive oxygen species (ROS) through redox cycling in the presence of CuI/II or FeIII/II and a reducing agent. ROS can lead ...
Diagnostic Platform For Current Health Status Monitoring, 2018 Portland State University
Diagnostic Platform For Current Health Status Monitoring, Albert S. Benight, Megan M. Koslen, Matthew W. Eskew
Student Research Symposium
Our approach is based on physical measurements of blood plasma and exploits the plethora of information contained in the human plasma proteome, as a reporter of human health status. The assay involves collection and analysis ofthermograms of plasma from human blood measured by differential scanning calorimetry (DSC).
Plasma thermograms arise from the temperature-induced denaturation profile of proteins within blood plasma measured by DSC. This insightful measurement thereby provides a snapshot of the current state of the human plasma proteome which directly informs on overall systemic health. Such measurements have been shown to be highly accurate and sensitive indicators of health ...
Dissecting Structure-Encoded Determinants Of Allosteric Cross-Talk Between Post-Translational Modification Sites In The Hsp90 Chaperones, Gabrielle Stetz, Amanda Tse, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
Post-translational modifications (PTMs) represent an important regulatory instrument that modulates structure, dynamics and function of proteins. The large number of PTM sites in the Hsp90 proteins that are scattered throughout different domains indicated that synchronization of multiple PTMs through a combinatorial code can be invoked as an important mechanism to orchestrate diverse chaperone functions and recognize multiple client proteins. In this study, we have combined structural and coevolutionary analysis with molecular simulations and perturbation response scanning analysis of the Hsp90 structures to characterize functional role of PTM sites in allosteric regulation. The results reveal a small group of conserved PTMs ...