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Radiochemistry Commons

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Synthesis Of A Novel Cox-2 Inhibitor Analog For Pet Scan Imaging, Rebecca Neighbor 2016 University of Tennessee, Knoxville

Synthesis Of A Novel Cox-2 Inhibitor Analog For Pet Scan Imaging, Rebecca Neighbor

University of Tennessee Honors Thesis Projects

No abstract provided.


The Design And Synthesis Of Ghrelin Analogues As Non‐Invasive Ghs‐R1a Imaging Probes, Carlie L. Charlton 2016 The University of Western Ontario

The Design And Synthesis Of Ghrelin Analogues As Non‐Invasive Ghs‐R1a Imaging Probes, Carlie L. Charlton

Electronic Thesis and Dissertation Repository

The field of molecular imaging is constantly growing and evolving in order to provide the best possible healthcare for patients in various stages of disease and therapy. Molecular imaging aims to locate specific markers of disease by selectively targeting the markers of interest with high selectivity and visualizing the accumulation using external detection. The growth hormone secretagogue receptor-1a (GHS-R1a) has been shown to be involved in various important biological functions such as energy homeostasis and cardiac contractility. GHS-R1a has shown involvement in proliferation, migration and cell invasion of specific cancer subtypes. Therefore, targeting GHS-R1a is an important marker of different ...


Uses Of Diaryliodonium Salts And Methods For Their Synthesis, Jordan M. Veness 2015 University of Nebraska-Lincoln

Uses Of Diaryliodonium Salts And Methods For Their Synthesis, Jordan M. Veness

Student Research Projects, Dissertations, and Theses - Chemistry Department

Diaryliodonium salts have been studied continuously since the first report of their synthesis in 1894. Diaryliodonium salts are I(III) derivatives that are air- and moisturestable. The reactivity of these compounds resembles the organometallic chemistry of heavy transition metal ions such as Pb(IV), Hg(II), Th(III), and Pd(II). A significant advantage of diaryliodonium salts is that they can carry undergo many of the aryl functionalization reactions of heavy metal organometallic complexes, yet they have little to no toxicity and they are relatively inexpensive to prepare. The DiMagno laboratory uses diaryliodonium salts as precursors in the final synthetic ...


The Development Of Cyclic Rgd Peptides Stabilized Through 99mtc/Re(Co)3+, Aagam Patel 2015 The University of Western Ontario

The Development Of Cyclic Rgd Peptides Stabilized Through 99mtc/Re(Co)3+, Aagam Patel

Electronic Thesis and Dissertation Repository

Protein secondary structure can be mimicked by incorporating structural constraints into peptides and this can be facilitated by metal coordination. The objective of this project is to establish a chelation system with a cancer targeting peptide sequence, where the coordination to a metal centre results in a cyclic metallopeptide. Cyclic RGD peptides are antagonists for αvβ3 and other integrins, which are present during tumour angiogenesis. Arg-Gly-Asp (RGD) sequence is employed in the peptide backbone, with an un-natural amino acid (3-Pal) and a chelating molecule (pyridyl-triazole, pyta) present on opposite ends of the peptide sequence to form a ...


Advances In High-Throughput Analysis: Automated Radiochemical Separations And Nanopillar Based Separations And Field Enhanced Spectroscopy, Jennifer Jeanne Charlton 2015 University of Tennessee - Knoxville

Advances In High-Throughput Analysis: Automated Radiochemical Separations And Nanopillar Based Separations And Field Enhanced Spectroscopy, Jennifer Jeanne Charlton

Doctoral Dissertations

Often the need to analyze a large number of samples coincide with critical time consternates. At such times, the implementation of high-throughput technologies is paramount. In this work we explore some viable pathways for high-throughput analysis and develop advancements in novel forms of detection of materials that are vital in the environmental, biological as well as national security arenas. Through the use of new protocols with high sensitivity and specificity as well as simplified chemical processing and sample preparation we aim to allow for improved throughput, fieldable detection, and rapid data acquisition of extensive sample sets. The methods developed in ...


Laser Ablation Icp-Ms Of Actinide Oxides As Simulated Used Nuclear Fuels, Keri Campbell 2015 University of Nevada, Las Vegas

Laser Ablation Icp-Ms Of Actinide Oxides As Simulated Used Nuclear Fuels, Keri Campbell

UNLV Theses, Dissertations, Professional Papers, and Capstones

The ability to examine elemental and isotopic ratios of fuels, waste forms, and other solids by direct analysis using laser ablation techniques can greatly reduce analysis costs and time. This is particularly true for actinide elements, as they contain useful information of the fuel cycle and nuclear forensics. Current methods to evaluate the composition of used fuel include a lengthy process of digestion, separations and often require multiple techniques and sample preparations to determine the elemental and isotopic composition. Furthermore all spatial information is lost during the digestion process, eliminating potentially useful data for detailed analysis. The goal of this ...


Cover, 2015 University of Tennessee, Knoxville

Cover

International Journal of Nuclear Security

No abstract provided.


Masthead, 2015 University of Tennessee, Knoxville

Masthead

International Journal of Nuclear Security

No abstract provided.


From The Editor, 2015 University of Tennessee, Knoxville

From The Editor

International Journal of Nuclear Security

No abstract provided.


Student Writing Competition, 2015 University of Tennessee, Knoxville

Student Writing Competition

International Journal of Nuclear Security

No abstract provided.


Impurity Diffusion As A Possible Metal Chronometer For Pre-Detonation Nuclear Forensics, Edward T. Peskie, Howard L. Hall 2015 United States Military Academy

Impurity Diffusion As A Possible Metal Chronometer For Pre-Detonation Nuclear Forensics, Edward T. Peskie, Howard L. Hall

International Journal of Nuclear Security

The ability to determine the time since forming of seized nuclear material would provide crucial data to be used in its investigation. The time dependent processes of diffusion relevant to this need are examined; to include grain boundary diffusion, and discontinuous precipitation, and an assessment is performed of the utility of examination of impurity and alloying element concentration profiles for use as a pre-detonation nuclear forensics tool for determining the age of a metal sample. Several examples illustrate the effects of time on both binary alloys and multi-component systems. Parallels are drawn from studies of diffusion in mineral samples under ...


Radiation Damage As A Possible Metal Chronometer For Pre-Detonation Nuclear Forensics, Edward T. Peskie, Howard L. Hall 2015 United States Military Academy

Radiation Damage As A Possible Metal Chronometer For Pre-Detonation Nuclear Forensics, Edward T. Peskie, Howard L. Hall

International Journal of Nuclear Security

The ability to determine the time since the forming of seized nuclear material would provide crucial data to be used in its investigation. This paper examines the effects of radiolytic damage caused by the decay of uranium isotopes and assesses the potential forensic utility of examination of these damage regions for determining the time since forming of a metal sample. This paper draws parallels from studies of fission track dating in mineral samples under geologic time and proposes modifications to previously published work in the field of α-recoil track dating in order to determine the time since a metal sample ...


New Radiocarbon Dates From East Texas Caddo Sites, Timothy Perttula, Robert Selden 2015 Archeological & Environmental Consultants, LLC

New Radiocarbon Dates From East Texas Caddo Sites, Timothy Perttula, Robert Selden

Robert Z. Selden Jr.

In this article, we report on new radiocarbon dates obtained from five Caddo sites in East Texas. The radiocarbon samples are charred organic remains scraped off of one surface of whole vessels or sherds. These samples are from the Johns (41CP12), Shelby Mound (41CP71), Gilbert (41RA13), Henry Spencer (41UR315), and Henry Williams (41UR318) sites. All of the dates are calibrated using OxCal v4.1.7 (Bronk Ramsey 2012), with atmospheric data from Reimer et al. (2009).


A Preliminary Temporal Analysis Of The East Texas Archaic, Robert Selden 2015 Center for Regional Heritage Research, Stephen F. Austin State University

A Preliminary Temporal Analysis Of The East Texas Archaic, Robert Selden

Robert Z. Selden Jr.

This article presents preliminary findings of a temporal analysis of the East Texas Archaic based upon the examination of radiocarbon dates that have deposits that date to the period. All assays employed in this effort were collected from research and cultural resource management reports and publications, synthesized, then recalibrated in version 4.1.7 of OxCal.


Additional New Radiocarbon Dates From East Texas Caddo Sites, Timothy Perttula, Robert Selden 2015 Archeological & Environmental Consultants, LLC

Additional New Radiocarbon Dates From East Texas Caddo Sites, Timothy Perttula, Robert Selden

Robert Z. Selden Jr.

As a follow-up to the radiocarbon analyses reported by Perttula and Selden (2013), in this article, we report on five new radiocarbon dates obtained from Caddo sites in East Texas. The radiocarbon samples are charred organic remains scraped off of one surface of whole vessels or sherds. These samples are from the Ware Acres site (41GG31), the H. C. Slider site in Cherokee County, an unknown site in the upper Neches River basin in Smith County (9-SC), and an unknown Titus phase site (11-BCJ) in the Big Cypress Creek basin. All of the dates are calibrated using OxCal v4.1 ...


Temporal Dynamics Of East Texas Caddo Sites With 10 Or More Radiocarbon Dates, Robert Selden, Timothy Perttula 2015 Center for Regional Heritage Research, Stephen F. Austin State University

Temporal Dynamics Of East Texas Caddo Sites With 10 Or More Radiocarbon Dates, Robert Selden, Timothy Perttula

Robert Z. Selden Jr.

This article represents supplementary data (see Selden and Perttula 2013) highlighting the specifics of date combination and the subsequent production of summed probability distribution samples for Caddo sites in East Texas. All radiocarbon (14C ) dates employed in this effort were collected from research and cultural resource management (CRM) reports and publications, synthesized, then recalibrated in version 4.1.7 of OxCal (Bronk Ramsey 2012) using IntCal09 (Reimer et al. 2009) (Perttula and Selden 2011).


Characterizing Groundwater Ch4 And 222rn In Relation To Hydraulic Fracturing And Other Environmental Processes In Letcher County, Ky, St. Thomas Majeau LeDoux 2015 University of Tennessee - Knoxville

Characterizing Groundwater Ch4 And 222rn In Relation To Hydraulic Fracturing And Other Environmental Processes In Letcher County, Ky, St. Thomas Majeau Ledoux

Masters Theses

Hydraulic fracturing of shale deposits has greatly increased the productivity of the natural gas industry by allowing it to exploit previously inaccessible reservoirs. However, previous research has demonstrated that this practice can contaminate shallow aquifers with CH4 [methane] from deeper formations. This study compares concentrations and isotope compositions of CH4 sampled from domestic groundwater wells in Letcher County, Kentucky in order to characterize its occurrence and origins in relation to neighboring hydraulically fractured natural gas wells. Additionally, this study tests the reliability of 222Rn [radon] as an alternative tracer to CH4 in identifying processes of gas ...


Green Chemistry As A Tool For Understanding The Toxic Substances Control Act: A Lecture Module For Undergraduate Students, Molly R. Blessing 2015 University of Connecticut - Storrs

Green Chemistry As A Tool For Understanding The Toxic Substances Control Act: A Lecture Module For Undergraduate Students, Molly R. Blessing

Honors Scholar Theses

The Toxic Substances Control Act (TSCA) is the central form of chemical regulation existent in the United States today, yet scientists are often unaware or uncertain of its provisions. Violations of TSCA by unknowing chemists set industry and government unnecessarily at odds. A lecture on TSCA was developed for undergraduate students that uses the concept of green chemistry to promote interest and incentivize learning. Green chemistry methods are cleaner and less wasteful than traditional chemical ones, and many companies using them are at the forefront of technological innovation. The lecture explains both green chemistry and TSCA, includes company case studies ...


An Investigation Of Inorganic Compound Scattering., Karl Jay Bernstein 2015 University of Tennessee - Knoxville

An Investigation Of Inorganic Compound Scattering., Karl Jay Bernstein

Doctoral Dissertations

Raman and its associated forms of spectroscopy are powerful tools that have been under-utilized. Presented within are three inorganic compounds studied with some form of Raman spectroscopy: normal Raman, hyper-Raman (HR), surface-enhanced Raman spectroscopy (SERS), surface-enhanced hyper-Raman spectroscopy (SEHRS), or resonance Raman spectroscopy (RR).

The first study involves the investigation of phosphine binding with silver metal. Phosphines find wide use in synthetic circles yet have had little study into their method of binding, unlike similar compounds comprised of sulfur. In order to understand the binding of phosphines, several tertiary phosphines, secondary phosphines and secondary phosphine oxides are examined with SERS ...


Technetium Sulfide: Fundamental Chemistry For Waste Storage Form's Application, Maryline Ghislaine Ferrier 2014 University of Nevada, Las Vegas

Technetium Sulfide: Fundamental Chemistry For Waste Storage Form's Application, Maryline Ghislaine Ferrier

UNLV Theses, Dissertations, Professional Papers, and Capstones

Technetium is the lightest radioelement. The isotope 99Tc has around a 6% yield from 235U with a half-life of 2.13 x 105 years. The high mobility of TcO4-, the common chemical form of technetium in the environment makes 99Tc an isotope of concern in nuclear waste management. Despite its important role in radiopharmaceuticals and in the nuclear fuel cycle, the fundamental chemistry of technetium is not as well developed as that of the neighboring transition metals; one of the most striking examples being its sulfide chemistry.

Only two technetium binary sulfide compounds had been ...


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