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An Assessment Of Potential Causal Pathways Between Two Autoimmune Diseases: Mendelian Randomization Studies Of Rheumatoid Arthritis And Crohn’S Disease; And A Phenome-Wide Association Study To Assess Potential New Targets For Tocilizumab, An Interleukin-6 Inhibitor, Staci Abramsky Risman 2020 CUNY School of Public Health

An Assessment Of Potential Causal Pathways Between Two Autoimmune Diseases: Mendelian Randomization Studies Of Rheumatoid Arthritis And Crohn’S Disease; And A Phenome-Wide Association Study To Assess Potential New Targets For Tocilizumab, An Interleukin-6 Inhibitor, Staci Abramsky Risman

Dissertations and Theses

Background

Rheumatoid arthritis (RA) and Crohn’s disease (CD) are two among a group of immune-mediated inflammatory diseases (IMIDs). These diseases are common, collectively affecting as many as two million Americans and as many as 28 million people worldwide. They have different clinical presentations but may have a common pathogenesis. An over-expression of tumor necrosis factor (TNF) and interleukin-6 (IL-6) have been proffered as a causal factor for IMIDs. These and other IMIDs may co-occur in patients, and it has been shown that patients with one IMID may have an increased risk of another IMID. What is not clear is ...


Differential Relationships Between Waist Circumference And Cardiorespiratory Fitness Among People With And Without Type 2 Diabetes, Andrew Ortaglia, Samantha M. McDonald, Christina Supino, Michael D. Wirth, Xuem Sui, Matteo Bottai 2020 University of South Carolina - Columbia

Differential Relationships Between Waist Circumference And Cardiorespiratory Fitness Among People With And Without Type 2 Diabetes, Andrew Ortaglia, Samantha M. Mcdonald, Christina Supino, Michael D. Wirth, Xuem Sui, Matteo Bottai

Faculty Publications

Adults with type 2 diabetes mellitus tend to exhibit an increased level of central adiposity, augmenting their risk of further non-communicable diseases (NCDs). Importantly, consistent evidence demonstrates a significant, negative association between cardiorespiratory fitness (CRF) and waist circumference (WC). However, no previous studies have investigated differences in these CRF-related reductions in WC between adults with and without diabetes.

This study used data from the Aerobic Center for Longitudinal Studies, conducted between 1970 and 2006 among predominately Non-Hispanic White, middle-to-upper class adults in Texas. Quantile regression models were used to estimate CRF-related differences in WC between persons with and without diabetes ...


Abo Blood Group Type And Susceptibility To Covid-19 Infection, G. Rafael Fernandez-Botran 2020 Associate Professor, Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA

Abo Blood Group Type And Susceptibility To Covid-19 Infection, G. Rafael Fernandez-Botran

The University of Louisville Journal of Respiratory Infections

Since December 2019, the SARS-CoV2 (COVID-19) pandemic has continued to extend over most of the world, infecting over four million people and causing well over 300,000 deaths so far (https://coronavirus.jhu.edu/map.html, accessed on May 14, 2020). A significant percentage of infected patients develop severe symptoms and life-threatening conditions. While COVID-19 infection can affect all ages, available evidence points to older age and pre-existing comorbidities such as hypertension, diabetes and coronary heart disease, as important risk factors related to increased mortality rates. [1-3] Moreover, recent reports from China and the U.S. have suggested that the ...


Outcomes Of Patients Hospitalized With Community-Acquired Pneumonia With Liver Disease Or Cirrhosis., Bibodh Jung Karki, Sravan K. Ponnekanti, Vidyulata Salunkhe, Nishita Tripathi, Mahder A. Tella, Stephen P. Furmanek, Forest W. Arnold 2020 University of Louisville, Louisville

Outcomes Of Patients Hospitalized With Community-Acquired Pneumonia With Liver Disease Or Cirrhosis., Bibodh Jung Karki, Sravan K. Ponnekanti, Vidyulata Salunkhe, Nishita Tripathi, Mahder A. Tella, Stephen P. Furmanek, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

Background: Liver disease and cirrhosis are common causes of mortality worldwide. Community-acquired pneumonia is recognized as a significant cause of morbidity and mortality in this population. There is lack of data showing outcomes or prognosis in patients with liver dysfunction who develop CAP. The objective of this study was to evaluate the clinical characteristics, incidence, and outcomes of hospitalized patients with CAP and liver disease.

Methods: This was a secondary analysis of the University of Louisville Pneumonia Study which was a prospective population-based cohort study of adults with community-acquired pneumonia. All patients were divided into three groups: 1)patients without ...


Implementation Of The Louisville Covid-19 Surveillance Protocol: Experiences From The University Of Louisville Center Of Excellence For Research In Infectious Diseases [Cerid], Ruth Carrico, Dawn Balcom, William Johnson, Amr Aboelnasr, Mutasem Abuhalaweh, Stephen Furmanek, Montray Smith, Amanda Lasnik, Donghoon Chung, Julio A. Ramirez 2020 University of Louisville Division of Infectious Diseases, Center of Excellence for Research in Infectious Diseases (CERID)

Implementation Of The Louisville Covid-19 Surveillance Protocol: Experiences From The University Of Louisville Center Of Excellence For Research In Infectious Diseases [Cerid], Ruth Carrico, Dawn Balcom, William Johnson, Amr Aboelnasr, Mutasem Abuhalaweh, Stephen Furmanek, Montray Smith, Amanda Lasnik, Donghoon Chung, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

The lack of available testing for SARS-CoV-2 has been one of the primary challenges in the development and implementation of a comprehensive approach to infection prevention and transmission in the United States (US). In response to the need for increased testing capacities and capabilities, the University of Louisville (UofL) Division of Infectious Diseases, Center of Excellence for Research in Infectious Diseases (CERID) initiated the Louisville Coronavirus Surveillance Program, a comprehensive approach to surveillance and testing of patients and healthcare workers. The first specimens were accepted on March 12, 2020 and parallel testing was done using a high-capacity testing process and ...


Pleural Effusion As A Manifestation Of Pulmonary Cryptococcosis, Mercedes Toranzo, Marisol Arrojo, Alejandra González, Mariano Fielli 2020 Alejandro Posadas National Hospital, Buenos Aires, Argentina

Pleural Effusion As A Manifestation Of Pulmonary Cryptococcosis, Mercedes Toranzo, Marisol Arrojo, Alejandra González, Mariano Fielli

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Integrated Multiple Mediation Analysis: A Robustness–Specificity Trade-Off In Causal Structure, An-Shun Tai, Sheng-Hsuan Lin 2020 Institute of Statistics, National Chiao Tung University, Hsinchu, Taiwan.

Integrated Multiple Mediation Analysis: A Robustness–Specificity Trade-Off In Causal Structure, An-Shun Tai, Sheng-Hsuan Lin

Harvard University Biostatistics Working Paper Series

Recent methodological developments in causal mediation analysis have addressed several issues regarding multiple mediators. However, these developed methods differ in their definitions of causal parameters, assumptions for identification, and interpretations of causal effects, making it unclear which method ought to be selected when investigating a given causal effect. Thus, in this study, we construct an integrated framework, which unifies all existing methodologies, as a standard for mediation analysis with multiple mediators. To clarify the relationship between existing methods, we propose four strategies for effect decomposition: two-way, partially forward, partially backward, and complete decompositions. This study reveals how the direct and ...


Odds Of Autism At 5 To 10 Years Of Age For Children Who Did Not Pass Their Aabr Newborn Hearing Screen, But Were Diagnosed With Normal Hearing, Shihfen Tu, Craig A. Mason, Deborah L. Rooks-Ellis, Patricia Lech 2020 University of Maine

Odds Of Autism At 5 To 10 Years Of Age For Children Who Did Not Pass Their Aabr Newborn Hearing Screen, But Were Diagnosed With Normal Hearing, Shihfen Tu, Craig A. Mason, Deborah L. Rooks-Ellis, Patricia Lech

Journal of Early Hearing Detection and Intervention

Background: Research has found atypical Auditory Brainstem Response (ABR) activity in some children with Autism Spectrum Disorder (ASD). The current study examined whether an association may also be found between ASD and pass/refer results obtained via Automated Auditory Brainstem Response (AABR) screening. As stewards of large-scale AABR data, an AABR – ASD association may be of interest to EHDI programs.

Methods: State EHDI data for 29,350 children born in Maine between 2003 and 2005 were linked with education records, including special education status, for the 2010/2011 and 2013/2014 school years.

Results: Children who did not pass their ...


Impact Of Dogs With Deltamethrin-Impregnated Collars On Prevalence Of Visceral Leishmaniasis, Mondal H. Zahid 2020 University of Texas at Arlington

Impact Of Dogs With Deltamethrin-Impregnated Collars On Prevalence Of Visceral Leishmaniasis, Mondal H. Zahid

Biology and Medicine Through Mathematics Conference

No abstract provided.


The Role Of Variation In Mate Choice And Wolbachia Infection On Aedes Aegypti Population Dynamics, Bernardo Ameneyro 2020 University of Tennessee

The Role Of Variation In Mate Choice And Wolbachia Infection On Aedes Aegypti Population Dynamics, Bernardo Ameneyro

Biology and Medicine Through Mathematics Conference

No abstract provided.


The Class Of 2020, Srinivasan Ragothaman 2020 Srini.Ragothaman@usd.edu

The Class Of 2020, Srinivasan Ragothaman

Creative Work

The is a poem written in honor of the class of 2020. The coronavirus pandemic has robbed them of many fun activities in their final semester in college. The graduating seniors missed out on so many rites of passage such as march madness, commencement, award banquets, sports, labs, practice, face-to-face classes etc. for the last two months. Seniors are encouraged to have fortitude, practice patience, be grateful and show grit. The class of 2020 will conquer the world in due course. It is hoped that graduates will have imagination, will innovate and transform the world.


Understanding Pediatric Injury In Collier County, Florida: A Mixed Methods Analysis, Carmen T. Ramos-Irizarry 2020 KIDZ Medical Specialties/NCH Healthcare Systems

Understanding Pediatric Injury In Collier County, Florida: A Mixed Methods Analysis, Carmen T. Ramos-Irizarry

Florida Public Health Review

Background: The current trauma system in Collier County disperses injured pediatric patients to trauma centers outside the County. There is a critical gap in knowledge in the epidemiology of the County’s pediatric trauma patients.

Purpose: To understand injury patterns in children ages 0-17 years in Collier County and identify challenges in transporting injured children to definitive care.

Methods: This is a cross sectional, descriptive study using a sequential mixed-methods design. A thorough review of the literature and interviews of key stakeholders were conducted in August 2017. Data obtained from the interviews was used to develop a causal loop diagram ...


Applying Modern Immunology To The Plague Of Ancient Athens, Juhi C. Patel 2020 University of Tennessee, Knoxville

Applying Modern Immunology To The Plague Of Ancient Athens, Juhi C. Patel

Pursuit - The Journal of Undergraduate Research at the University of Tennessee

During the 5th century BCE, ancient Athens and Sparta were involved in a major war during which an epidemic disease broke out in Athens, claiming the lives of a substantial part of the population. Although the ancient Greek historian Thucydides provides a first-hand account of the symptoms of the plague, modern historians have not been able to definitively identify the pathogen that caused the deadly epidemic. In 1994, a burial tomb of Athens was unearthed that unveiled the likely remains of plague victims. In 2005, scientists conducted molecular testing on the dental remains and used suicide PCR to compare ...


How Misinformation And Mistrust Compound The Threat Of Epidemics, William Boyd 2020 University of Mississippi

How Misinformation And Mistrust Compound The Threat Of Epidemics, William Boyd

Honors Theses

This thesis was conducted to study the effects of misinformation and medical mistrust on the public health field. I use the events of the Chapare Virus outbreak in Bolivia in the summer of 2019 and the public dialogue during that time period to discuss these themes. I used data from market survey's in La Paz, newspaper articles from Página Siete, and Tweets from the time period of the outbreak. My findings suggest that misinformation and medical mistrust affected public health measures, which has major implications for the way the public health field should address future public health events.


Life During A Pandemic, Srinivasan Ragothaman 2020 Srini.Ragothaman@usd.edu

Life During A Pandemic, Srinivasan Ragothaman

Creative Work

This is a short poem (6 stanzas) about the current pandemic and the trials and tribulations people are going through. This describes the heroic efforts by the doctors, nurses, and other frontline warriors in tackling the virus related illnesses and pays a rich tribute to all heroes from every walk of life who are in the front fighting this disease. It hopes for a plan, a vaccine, and a cure soon. This poem also describes the switchover to remote instruction at a reginal University, student and faculty adjustments to the pandemic and pokes gentle fun at the opportunity to watch ...


Covid-19 Journal | Chloe Brasher, Chloe Brasher 2020 Jacksonville State University

Covid-19 Journal | Chloe Brasher, Chloe Brasher

COVID-19 Student Journal Project

No abstract provided.


Covid-19 Journal | Madison Brooks, Madison Brooks 2020 Jacksonville State University

Covid-19 Journal | Madison Brooks, Madison Brooks

COVID-19 Student Journal Project

No abstract provided.


Covid-19 Journal | Corrin Cadle, Corrin Cadle 2020 Jacksonville State University

Covid-19 Journal | Corrin Cadle, Corrin Cadle

COVID-19 Student Journal Project

No abstract provided.


Covid-19 Journal | Brianna Cagle, Brianna Cagle 2020 Jacksonville State University

Covid-19 Journal | Brianna Cagle, Brianna Cagle

COVID-19 Student Journal Project

No abstract provided.


Covid-19 Journal | Miya Christopher, Miya Christopher 2020 Jacksonville State University

Covid-19 Journal | Miya Christopher, Miya Christopher

COVID-19 Student Journal Project

No abstract provided.


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