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Advancing Learning Health Systems Through Embedded Research: The 23rd Annual Conference Of The Health Care Systems Research Network, Harold S. Luft, Ming Tai-Seale, Sarah M. Greene 2017 University of California, San Francisco

Advancing Learning Health Systems Through Embedded Research: The 23rd Annual Conference Of The Health Care Systems Research Network, Harold S. Luft, Ming Tai-Seale, Sarah M. Greene

Journal of Patient-Centered Research and Reviews

The 23rd annual conference of the Health Care Systems Research Network (HCSRN, formerly the HMO Research Network) was held in San Diego, California, March 21–23, 2017, attracting 387 attendees. As a consortium of 20 research organizations embedded in or affiliated with large health care delivery organizations, the HCSRN has held annual research conferences since 1994. The overall aim of the conferences is to bring researchers, project staff, research funders and other stakeholders together to share latest scientific findings and foster new research ideas and collaborations. The 2017 conference was hosted by the Palo Alto Medical Foundation Research Institute.

Each ...


A Study On Factors Affecting Sleep During Pregnancy In Clinical Trials, Zihan Yan 2017 Washington University in St. Louis

A Study On Factors Affecting Sleep During Pregnancy In Clinical Trials, Zihan Yan

Arts & Sciences Electronic Theses and Dissertations

Regular sleep is required for sensory processing, learning, and brain plasticity. During pregnancy, poor sleep quality and dysregulation of hormones are all associated with increased risk for diseases like postpartum major depression[1]. Seventy-eight percent of pregnant women experience sleep problems at some point during pregnancy according to the National Sleep Foundation's 1998 Women and Sleep poll. Chronodisruption is a frequent sleep disturbance experienced by pregnant women that can be primary or due to co-morbid conditions[2]. For this reason, chronodisruption, which includes insomnia, is currently regarded as one of the most important factors determining pregnancy outcome. Therefore, the ...


History Of Periodontitis Diagnosis And Edentulism As Predictors Of Cardiovascular Disease, Stroke, And Mortality In Postmenopausal Women, Michael J. LaMonte, Robert J. Genco, Kathleen M. Hovey, Robert B. Wallace, Jo L. Freudenheim, Dominique S. Michaud, Xiaodan Mai, Lesley Tinker, Christian R. Salazar, Christopher A. Andrews, Wenjun Li, Charles Eaton, Lisa W. Martin, Jean Wactawski-Wende 2017 SUNY University at Buffalo

History Of Periodontitis Diagnosis And Edentulism As Predictors Of Cardiovascular Disease, Stroke, And Mortality In Postmenopausal Women, Michael J. Lamonte, Robert J. Genco, Kathleen M. Hovey, Robert B. Wallace, Jo L. Freudenheim, Dominique S. Michaud, Xiaodan Mai, Lesley Tinker, Christian R. Salazar, Christopher A. Andrews, Wenjun Li, Charles Eaton, Lisa W. Martin, Jean Wactawski-Wende

Wenjun Li

BACKGROUND: Few studies have reported associations between periodontitis and cardiovascular disease (CVD) risk in older women, which is the objective of the present investigation. METHODS AND RESULTS: Participants were 57 001 postmenopausal women ages 55 to 89 years (mean 68 years; > 85% 60 and older) who were enrolled (1993-1998) in the Women's Health Initiative Observational Study, and were without known CVD when history of periodontitis and edentulism was assessed by questionnaire at study Year-5 (1998-2003). There were 3589 incident CVD events and 3816 total deaths during a mean follow-up of 6.7 years. In multivariable analysis, periodontitis was not ...


Culturally Adaptive Storytelling Intervention Versus Didactic Intervention To Improve Hypertension Control In Vietnam: A Cluster-Randomized Controlled Feasibility Trial, Hoa L. Nguyen, Jeroan J. Allison, Duc A. Ha, German Chiriboga, Ha N. Ly, Hanh T. Tran, Cuong K. Nguyen, Diem M. Dang, Ngoc T. Phan, Nguyen C. Vu, Quang P. Nguyen, Robert J. Goldberg 2017 University of Massachusetts Medical School

Culturally Adaptive Storytelling Intervention Versus Didactic Intervention To Improve Hypertension Control In Vietnam: A Cluster-Randomized Controlled Feasibility Trial, Hoa L. Nguyen, Jeroan J. Allison, Duc A. Ha, German Chiriboga, Ha N. Ly, Hanh T. Tran, Cuong K. Nguyen, Diem M. Dang, Ngoc T. Phan, Nguyen C. Vu, Quang P. Nguyen, Robert J. Goldberg

Robert J. Goldberg

BACKGROUND: Vietnam is experiencing an epidemiologic transition with an increased prevalence of non-communicable diseases. Novel, large-scale, effective, and sustainable interventions to control hypertension in Vietnam are needed. We report the results of a cluster-randomized feasibility trial at 3 months follow-up conducted in Hung Yen province, Vietnam, designed to evaluate the feasibility and acceptability of two community-based interventions to improve hypertension control: a "storytelling" intervention, "We Talk about Our Hypertension," and a didactic intervention. METHODS: The storytelling intervention included stories about strategies for coping with hypertension, with patients speaking in their own words, and didactic content about the importance of healthy ...


Culturally Adaptive Storytelling Intervention Versus Didactic Intervention To Improve Hypertension Control In Vietnam: A Cluster-Randomized Controlled Feasibility Trial, Hoa L. Nguyen, Jeroan J. Allison, Duc A. Ha, German Chiriboga, Ha N. Ly, Hanh T. Tran, Cuong K. Nguyen, Diem M. Dang, Ngoc T. Phan, Nguyen C. Vu, Quang P. Nguyen, Robert J. Goldberg 2017 University of Massachusetts Medical School

Culturally Adaptive Storytelling Intervention Versus Didactic Intervention To Improve Hypertension Control In Vietnam: A Cluster-Randomized Controlled Feasibility Trial, Hoa L. Nguyen, Jeroan J. Allison, Duc A. Ha, German Chiriboga, Ha N. Ly, Hanh T. Tran, Cuong K. Nguyen, Diem M. Dang, Ngoc T. Phan, Nguyen C. Vu, Quang P. Nguyen, Robert J. Goldberg

Jeroan J. Allison

BACKGROUND: Vietnam is experiencing an epidemiologic transition with an increased prevalence of non-communicable diseases. Novel, large-scale, effective, and sustainable interventions to control hypertension in Vietnam are needed. We report the results of a cluster-randomized feasibility trial at 3 months follow-up conducted in Hung Yen province, Vietnam, designed to evaluate the feasibility and acceptability of two community-based interventions to improve hypertension control: a "storytelling" intervention, "We Talk about Our Hypertension," and a didactic intervention. METHODS: The storytelling intervention included stories about strategies for coping with hypertension, with patients speaking in their own words, and didactic content about the importance of healthy ...


Plasmonic Gold Nanoparticle For Detection Of Fungi And Human Cutaneous Fungal Infections, Tobiloba Sojinrin, Kangze Liu, Joao Conde, Hugh Byrne, James Curtin, Daxiang Cui, Furong Tian 2017 Dublin Institute of Technology

Plasmonic Gold Nanoparticle For Detection Of Fungi And Human Cutaneous Fungal Infections, Tobiloba Sojinrin, Kangze Liu, Joao Conde, Hugh Byrne, James Curtin, Daxiang Cui, Furong Tian

Articles

Fungi, which are common in the environment, can cause a multitude of diseases. Warm, humid conditions allow fungi to grow and infect humans via the respiratory, digestive and reproductive tracts, genital area and other bodily interfaces. Fungi can be detected directly by microscopy, using the potassium hydroxide (KOH) test, which is the gold standard and most popular method for fungal screening. However, this test requires trained personnel operating specialist equipment, including a fluorescent microscope and culture facilities. As most acutely infected patients seek medical attention within the first few days of symptoms, the optimal diagnostic test would be rapid and ...


A Descriptive Study Of The Elderly In California Substance Abuse Treatment Programs, David Berenschot 2017 California State University - San Bernardino

A Descriptive Study Of The Elderly In California Substance Abuse Treatment Programs, David Berenschot

Electronic Theses, Projects, and Dissertations

As gerontologists may know, there are a great deal of studies and a variety of academic literature on the misuse of alcohol and prescription medication amongst the elderly population. While there is a plethora of information on alcohol and prescription misuse, there is little reported data about the prevalence of other substance misuse experienced by this population. This study aims to help to fill that gap in the data by using quantitative methods to describe the scope of substance abuse of individuals 55-years or older. This study utilizes data from the Treatment Data Set Admission (TEDS-A). The TEDS-A is a ...


Optimizing Medication Appropriateness In Older Adults: A Randomized Clinical Interventional Trial To Decrease Anticholinergic Burden, Daniela C. Moga, Erin L. Abner, Dorinda N. Rigsby, Lynne Eckmann, Mark Huffmyer, Richard R. Murphy, Beth B. Coy, Gregory A. Jicha 2017 University of Kentucky

Optimizing Medication Appropriateness In Older Adults: A Randomized Clinical Interventional Trial To Decrease Anticholinergic Burden, Daniela C. Moga, Erin L. Abner, Dorinda N. Rigsby, Lynne Eckmann, Mark Huffmyer, Richard R. Murphy, Beth B. Coy, Gregory A. Jicha

Pharmacy Practice and Science Faculty Publications

Background

The complexity of medication therapy in older adults with multiple comorbidities often leads to inappropriate prescribing. Drugs with anticholinergic properties are of particular interest because many are not recognized for this property; their use may lead to increased anticholinergic burden resulting in significant health risks, as well as negatively impacting cognition. Medication therapy management (MTM) interventions showed promise in addressing inappropriate medication use, but the effectiveness of targeted multidisciplinary team interventions addressing anticholinergic medications in older populations is yet to be determined.

Methods

We conducted an 8-week, parallel-arm, randomized trial to evaluate whether a targeted patient-centered pharmacist–physician team ...


Using Hospital Discharge Data To Assess Trends Of Carbapenem-Resistant Enterobacteriaceae In Rhode Island, Seth Peters, Sarah Hart Shuford 2017 Rhode Island Department of Health

Using Hospital Discharge Data To Assess Trends Of Carbapenem-Resistant Enterobacteriaceae In Rhode Island, Seth Peters, Sarah Hart Shuford

UMass Center for Clinical and Translational Science Research Retreat

In 2017, Carbapenem-resistant Enterobacteriaceae (CRE) will become a reportable infectious disease in Rhode Island. To prepare for this updated regulation, the Center for Acute Infectious Disease Epidemiology (CAIDE) analyzed Rhode Island Hospital Discharge Data (HDD), internal epidemiologic line lists, as well as antibiograms from local laboratories to gauge past incidence of CRE in Rhode Island healthcare facilities.

CAIDE used the HDD for a retrospective assessment of statewide CRE incidence in acute care hospitals from 2011-2015 using SAS 9.3 (SAS Institute, Cary, NC). Epidemiologists compiled lists of ICD-9/ICD-10 diagnosis codes that when combined indicate CRE. Codes included specific infections ...


Response To Quality Of Life Surveying: An Analysis Of Patients With Wiskott-Aldrich Syndrome, Tara Bani-Hashemi 2017 The University of San Francisco

Response To Quality Of Life Surveying: An Analysis Of Patients With Wiskott-Aldrich Syndrome, Tara Bani-Hashemi

Master's Projects and Capstones

Patient-reported outcomes and surveying has increased in clinical settings in order to assess outcomes and patient health status. However, there is a lack of these assessments from a pediatric standpoint, an inpatient standpoint, and family perspective. In addition to health status and overall clinic experience, expanding the self-reported evaluation to include quality of life on physical and psychosocial levels will provide a more comprehensive evaluation of the patients’ health services. The PedsQL ™ scale scores four domains: physical, emotional, social, and school/work functioning. It includes a parent-proxy report as well as self-report for patients ages 5 to 18 years. Infant ...


Changes In The Inflammatory Potential Of Diet Over Time And Risk Of Colorectal Cancer In Postmenopausal Women, Fred K. Tabung, Susan E. Steck, Yunsheng Ma, Angela D. Liese, Jiajia Zhang, Dorothy S. Lane, Gloria Y. Ho F, Lifang Hou, Linda Snetselaar, Judith K. Ockene, James R. Hebert 2017 Harvard T. H. Chan School of Public Health

Changes In The Inflammatory Potential Of Diet Over Time And Risk Of Colorectal Cancer In Postmenopausal Women, Fred K. Tabung, Susan E. Steck, Yunsheng Ma, Angela D. Liese, Jiajia Zhang, Dorothy S. Lane, Gloria Y. Ho F, Lifang Hou, Linda Snetselaar, Judith K. Ockene, James R. Hebert

University of Massachusetts Medical School Faculty Publications

We examined the associations between changes in dietary inflammatory potential and risk of colorectal cancer (CRC) in 87,042 postmenopausal women recruited from 1993-1998 into the Women's Health Initiative. Food frequency questionnaire data were used to compute patterns of change in dietary inflammatory index (DII) scores and cumulative average DII scores over 3 years. Cox regression models were used to estimate hazard ratios for CRC risk. After a median 16.2 years follow-up, 1,038 CRC cases were diagnosed. DII changes were not substantially associated with overall CRC, but proximal colon cancer risk was higher in the pro-inflammatory change ...


Culturally Adaptive Storytelling Intervention Versus Didactic Intervention To Improve Hypertension Control In Vietnam: A Cluster-Randomized Controlled Feasibility Trial, Hoa L. Nguyen, Jeroan J. Allison, Duc A. Ha, German Chiriboga, Ha N. Ly, Hanh T. Tran, Cuong K. Nguyen, Diem M. Dang, Ngoc T. Phan, Nguyen C. Vu, Quang P. Nguyen, Robert J. Goldberg 2017 University of Massachusetts Medical School

Culturally Adaptive Storytelling Intervention Versus Didactic Intervention To Improve Hypertension Control In Vietnam: A Cluster-Randomized Controlled Feasibility Trial, Hoa L. Nguyen, Jeroan J. Allison, Duc A. Ha, German Chiriboga, Ha N. Ly, Hanh T. Tran, Cuong K. Nguyen, Diem M. Dang, Ngoc T. Phan, Nguyen C. Vu, Quang P. Nguyen, Robert J. Goldberg

Open Access Articles

BACKGROUND: Vietnam is experiencing an epidemiologic transition with an increased prevalence of non-communicable diseases. Novel, large-scale, effective, and sustainable interventions to control hypertension in Vietnam are needed. We report the results of a cluster-randomized feasibility trial at 3 months follow-up conducted in Hung Yen province, Vietnam, designed to evaluate the feasibility and acceptability of two community-based interventions to improve hypertension control: a "storytelling" intervention, "We Talk about Our Hypertension," and a didactic intervention.

METHODS: The storytelling intervention included stories about strategies for coping with hypertension, with patients speaking in their own words, and didactic content about the importance of healthy ...


Systematic Review Of The Effects Of Care Provided With And Without Diagnostic Clinical Prediction Rules, Sharon L. Sanders, John Rathbone, Katy J L Bell, Paul P. Glasziou, Jenny A. Doust 2017 Bond University

Systematic Review Of The Effects Of Care Provided With And Without Diagnostic Clinical Prediction Rules, Sharon L. Sanders, John Rathbone, Katy J L Bell, Paul P. Glasziou, Jenny A. Doust

Faculty of Health Sciences & Medicine Publications

Background Diagnostic clinical prediction rules (CPRs) are worthwhile if they improve patient outcomes or provide benefits such as reduced resource use, without harming patients. We conducted a systematic review to assess the effects of diagnostic CPRs on patient and process of care outcomes.

Methods We searched electronic databases and a trial registry and performed citation and reference checks, for randomised trials comparing a diagnostic strategy with and without a CPR. Included studies were assessed for risk of bias and similar studies meta-analysed.

Results Twenty-seven studies evaluating diagnostic CPRs for 14 conditions were included. A clinical management decision was the primary ...


Nortex Spring 2017 Newsletter, North Texas Primary Care Practice-Based Research Network 2017 University of North Texas Health Science Center

Nortex Spring 2017 Newsletter, North Texas Primary Care Practice-Based Research Network

North Texas Primary Care Practice-Based Research Network (NorTex) Newsletter

No abstract provided.


Evidence Of Potential Bias In A Comparison Of Beta Blockers And Calcium Channel Blockers In Patients With Chronic Obstructive Pulmonary Disease And Acute Coronary Syndrome: Results Of A Multinational Study, Yaa-Hui Dong, Matthew Alcusky, Vittorio Maio, Jun Liu, Mengdan Liu, Li-Chiu Wu, Chia-Hsuin Chang, Mei-Shu Lai, Joshua J. Gagne 2017 Harvard Medical School

Evidence Of Potential Bias In A Comparison Of Beta Blockers And Calcium Channel Blockers In Patients With Chronic Obstructive Pulmonary Disease And Acute Coronary Syndrome: Results Of A Multinational Study, Yaa-Hui Dong, Matthew Alcusky, Vittorio Maio, Jun Liu, Mengdan Liu, Li-Chiu Wu, Chia-Hsuin Chang, Mei-Shu Lai, Joshua J. Gagne

Open Access Articles

OBJECTIVES: A number of observational studies have reported that, in patients with chronic obstructive pulmonary disease (COPD), beta blockers (BBs) decrease risk of mortality and COPD exacerbations. To address important methodological concerns of these studies, we compared the effectiveness and safety of cardioselective BBs versus non-dihydropyridine calcium channel blockers (non-DHP CCBs) in patients with COPD and acute coronary syndromes (ACS) using a propensity score (PS)-matched, active comparator, new user design. We also assessed for potential unmeasured confounding by examining a short-term COPD hospitalisation outcome.

SETTING AND PARTICIPANTS: We identified 22 985 patients with COPD and ACS starting cardioselective BBs ...


History Of Periodontitis Diagnosis And Edentulism As Predictors Of Cardiovascular Disease, Stroke, And Mortality In Postmenopausal Women, Michael J. LaMonte, Robert J. Genco, Kathleen M. Hovey, Robert B. Wallace, Jo L. Freudenheim, Dominique S. Michaud, Xiaodan Mai, Lesley Tinker, Christian R. Salazar, Christopher A. Andrews, Wenjun Li, Charles Eaton, Lisa W. Martin, Jean Wactawski-Wende 2017 SUNY University at Buffalo

History Of Periodontitis Diagnosis And Edentulism As Predictors Of Cardiovascular Disease, Stroke, And Mortality In Postmenopausal Women, Michael J. Lamonte, Robert J. Genco, Kathleen M. Hovey, Robert B. Wallace, Jo L. Freudenheim, Dominique S. Michaud, Xiaodan Mai, Lesley Tinker, Christian R. Salazar, Christopher A. Andrews, Wenjun Li, Charles Eaton, Lisa W. Martin, Jean Wactawski-Wende

University of Massachusetts Medical School Faculty Publications

BACKGROUND: Few studies have reported associations between periodontitis and cardiovascular disease (CVD) risk in older women, which is the objective of the present investigation.

METHODS AND RESULTS: Participants were 57 001 postmenopausal women ages 55 to 89 years (mean 68 years; > 85% 60 and older) who were enrolled (1993-1998) in the Women's Health Initiative Observational Study, and were without known CVD when history of periodontitis and edentulism was assessed by questionnaire at study Year-5 (1998-2003). There were 3589 incident CVD events and 3816 total deaths during a mean follow-up of 6.7 years. In multivariable analysis, periodontitis was not ...


Als Surveillance In Massachusetts: A One-Of-A-Kind Registry For Tracking An Elusive Disease, Vannalyn Abille, Alicia Fraser, Robert Knorr 2017 Massachusetts Department of Public Health

Als Surveillance In Massachusetts: A One-Of-A-Kind Registry For Tracking An Elusive Disease, Vannalyn Abille, Alicia Fraser, Robert Knorr

Community Engagement and Research Symposia

Background: Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neuromuscular disease with an etiology not yet fully understood. The Massachusetts Argeo Paul Cellucci ALS Registry is a unique population-based surveillance system used to monitor the occurrence of ALS throughout the state and to explore possible environmental causes of the disease.

Methods: The Registry gathers annual reports of ALS cases from physicians, hospitals, and clinics in accordance with state regulations. Medical records are obtained and abstracted for each case, and eligible cases are reviewed by a consulting neurologist to confirm diagnosis. Necessary clinical and demographic information are recorded in a ...


Risk Of Gastrointestinal Bleeding Among Dabigatran Users - A Self Controlled Case Series Analysis, Wenze Tang, Hsien-Yen Chang, Meijia Zhou, Sonal Singh 2017 The George Washington University Law School

Risk Of Gastrointestinal Bleeding Among Dabigatran Users - A Self Controlled Case Series Analysis, Wenze Tang, Hsien-Yen Chang, Meijia Zhou, Sonal Singh

Open Access Articles

This article aims to evaluate the real world risk of gastrointestinal bleeding among users naive to dabigatran. We adopted a self-controlled case series design. We sampled 1215 eligible adult participants who were continuous insured users between July 1, 2010 and March 31, 2012 with use of dabigatran and at least one gastrointestinal bleeding episode. We used a conditional Poisson regression to estimate incidence rate ratios. The population consisted of 64.69% of male and 60.25% patients equal to or greater than age 65 at start of observation. After adjustment for time-variant confounders, the incidence rate of gastrointestinal bleeding was ...


Breast Cancer Care In California And Ontario: Primary Care Protections Greatest Among The Most Socioeconomically Vulnerable Women Living In The Most Underserved Places, Kevin M. Gorey, Caroline Hamm, Isaac N. Luginaah, Guangyong Zou, Eric J. Holowaty 2017 University of Windsor

Breast Cancer Care In California And Ontario: Primary Care Protections Greatest Among The Most Socioeconomically Vulnerable Women Living In The Most Underserved Places, Kevin M. Gorey, Caroline Hamm, Isaac N. Luginaah, Guangyong Zou, Eric J. Holowaty

Social Work Publications

Background: Better health care among Canada’s socioeconomically vulnerable versus America’s has not been fully explained. We examined the effects of poverty, health insurance and the supply of primary care physicians on breast cancer care. Methods: We analyzed breast cancer data in Ontario (n = 950) and California (n = 6300) between 1996 and 2000 and followed until 2014. We obtained socioeconomic data from censuses, oversampling the poor. We obtained data on the supply of physicians, primary care and specialists. The optimal care criterion was being diagnosed early with node negative disease and received breast conserving surgery followed by adjuvant radiation ...


Demographic Differences And Annual Trends In Childhood And Adolescent Cancer Incidence And Mortality In Michigan During The Period 1999-2012, Gergana Kodjebacheva, Jeremy Blankenship, Lenwood Hayman, Shan Parker 2017 University of Michigan - Flint

Demographic Differences And Annual Trends In Childhood And Adolescent Cancer Incidence And Mortality In Michigan During The Period 1999-2012, Gergana Kodjebacheva, Jeremy Blankenship, Lenwood Hayman, Shan Parker

Journal of Health Disparities Research and Practice

Background. Michigan has declining economic conditions and factories that release pollutants. During the period 1999-2012, only 10 out of 50 states had an overall cancer incidence rate that was higher than that in Michigan. It is not known how children’s cancer rates in Michigan vary by age, gender, race/ethnicity, and year as well as how these rates compare to those in the U.S.

Method: The Center for Disease Control and Prevention WONDER database obtained cancer incidence and mortality data from cancer registries and death certificates. We compared age-adjusted incidence and mortality cancer rates by gender, race/ethnicity ...


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