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Engineering Of Lipid Nanoparticles For Advanced Drug Delivery Applications, Stephen L. Hayward 2015 University of Nebraksa-Lincoln

Engineering Of Lipid Nanoparticles For Advanced Drug Delivery Applications, Stephen L. Hayward

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

‘Nanomedicine’, the application of nanotechnology principles to the field of medicine, has stimulated the development of nano-platforms for next generation drug delivery. By exploiting nanoscale properties of materials to selectively alter intrinsic characteristics of therapeutics, researchers have improved the efficacy and pharmacokinetic profiles for a variety of drug types. Despite preliminary commercial and clinical success, there still remains a need to develop an improved delivery platform that can provide high cargo entrapment, efficient intracellular delivery, evasion of intracellular degradation pathways, and provide cell population specific targeting.

In this study we engineered a nanocarrier system composed of a core bilayer structure ...


Titanium Dioxide Nanoparticles Trigger Loss Of Hepatic Function And Perturbation Of Mitochondrial Dynamics In Primary Hepatocytes, Vaishaali Natarajan 2015 University of Nebraska-Lincoln

Titanium Dioxide Nanoparticles Trigger Loss Of Hepatic Function And Perturbation Of Mitochondrial Dynamics In Primary Hepatocytes, Vaishaali Natarajan

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

Titanium dioxide (TiO2) nanoparticles are one of the most highly manufactured nanomaterials in the world with applications in copious industrial and consumer products. The liver is a major accumulation site for many nanoparticles, including TiO2, directly through intentional ingestion or indirectly through increased environmental contamination and unintentional ingestion via water, food or animals. Growing concerns over the current usage of TiO2 coupled with the lack of mechanistic understanding of its potential health risk is the motivation for this study. Here we determined the toxic effect of three different TiO2 nanoparticles (commercially available rutile, anatase and P25 ...


A Study On The Micro Electro-Discharge Machining Of Aerospace Materials, Mychal-Drew Moses 2015 Western Kentucky University

A Study On The Micro Electro-Discharge Machining Of Aerospace Materials, Mychal-Drew Moses

Masters Theses & Specialist Projects

Electrical Discharge Machining (EDM) is a non-traditional machining process that uses hundreds of thousands of minute electrical sparks per second to machine any electrically conductive material, no matter the hardness or how delicate it is. EDM allows a much greater range of design possibilities, unconstrained from the traditional machining processes, in which material is removed mechanically by either rotating the cutting tool or the work piece. Shapes that were impossible to machine by any other method, such as deep, precision, square holes and slots with sharp inside corners, are readily produced. It provides accurate geometries in high- aspect ratio holes ...


A Comprehensive Study Of Esterification Of Free Fatty Acid To Biodiesel In A Simulated Moving Bed System, Nillohit Mitra Ray 2015 The University of Western Ontario

A Comprehensive Study Of Esterification Of Free Fatty Acid To Biodiesel In A Simulated Moving Bed System, Nillohit Mitra Ray

University of Western Ontario - Electronic Thesis and Dissertation Repository

Simulated Moving Bed (SMB) systems are used for separations that are difficult using traditional separation techniques. Due to the advantage of adsorption-based chromatographic separation, SMB has shown promising application in petrochemical and sugar industries, and of late, for chiral drug separations. In recent years, the concept of integration of reaction and in-situ separation in a single unit has achieved considerable attention. The simulated moving bed reactor (SMBR) couples both these unit operations bringing down the operation costs while improving the process performance, particularly for products that require mild operating conditions. However, its application has been limited due to complexity of ...


Disinfection And Advanced Oxidation Of Highly Absorbing Fluids By Uv/Vuv Light: Process Modeling And Validation, Ferdinando Crapulli 2015 The University of Western Ontario

Disinfection And Advanced Oxidation Of Highly Absorbing Fluids By Uv/Vuv Light: Process Modeling And Validation, Ferdinando Crapulli

University of Western Ontario - Electronic Thesis and Dissertation Repository

One of the limitations in treating highly absorbing fluids with ultraviolet photoreactors is the short light penetration into the fluid leading to the following issues: (a) if not engineered properly, ultraviolet photoreactors dealing with highly absorbing fluids are likely to be energy-inefficient due to a non-ideal use of emitted photons and non-uniform dose distribution (b) the quantification of photo-chemical rate constants could be a challenging task due to the severe mixing-limited conditions of the experimental apparatus used during the investigation. As a result, new lab-scale apparatus (alternative to the conventional collimated beam system) and modeling approaches are needed in order ...


Flavour Chemicals In Electronic Cigarette Fluids, Peyton A. Tierney, Clarrissa D. Karpinski, Jessica E. Brown, Wentai Luo, James F. Pankow 2015 Portland State University

Flavour Chemicals In Electronic Cigarette Fluids, Peyton A. Tierney, Clarrissa D. Karpinski, Jessica E. Brown, Wentai Luo, James F. Pankow

Chemistry Faculty Publications and Presentations

Background: Most e-cigarette liquids contain flavour chemicals. Flavour chemicals certified as safe for ingestion by the Flavor Extracts Manufacturers Association may not be safe for use in e-cigarettes. This study identified and measured flavour chemicals in 30 e-cigarette fluids.

Methods: Two brands of single-use e-cigarettes were selected and their fluids in multiple flavour types analysed by gas chromatography/mass spectrometry. For the same flavour types, and for selected confectionary flavours (eg, bubble gum and cotton candy), also analysed were convenience samples of e-cigarette fluids in refill bottles from local ‘vape’ shops and online retailers.

Results: In many liquids, total flavour ...


Micro‐Textured Boron Nitride Nanoplatelet Modified Polyethylene Films, Ozgun Ozdemir, Amod A. Ogale 2015 Clemson University

Micro‐Textured Boron Nitride Nanoplatelet Modified Polyethylene Films, Ozgun Ozdemir, Amod A. Ogale

Chemical and Biomolecular Graduate Research Symposium

Linear low density polyethylene (LLDPE) micro‐textured films filled with boron nitride nanoplatelets (BNN) were produced by continuous melt extrusion. Nanoparticles displayed a significant extent of dispersion inside the matrix. The addition of BNN led to more than 10‐fold increase of the in‐plane thermal conductivity (TC) of the nanocomposite (7.7 W/m.K vs 0.3 W/m.K for pure LLDPE), and 1.3‐fold increase of through thickness TC. To increase the surface area available for convective heat transfer, micro‐textured films (T‐BNN) were produced from a micro‐patterned die. Nanoplatelets were aligned parallel ...


Polymer Sensors For The Quantification Of Waterborne Uranium, C E. Duval, A F. Seliman, T A. DeVol, S M. Husson 2015 Clemson University

Polymer Sensors For The Quantification Of Waterborne Uranium, C E. Duval, A F. Seliman, T A. Devol, S M. Husson

Chemical and Biomolecular Graduate Research Symposium

No abstract provided.


Optimal Design Of Hybrid Renewable Energy Systems, Alphonse Hakizimana, Joseph Scott 2015 Clemson University

Optimal Design Of Hybrid Renewable Energy Systems, Alphonse Hakizimana, Joseph Scott

Chemical and Biomolecular Graduate Research Symposium

Utilization of renewable energy sources such as wind and solar can overcome environmental threats associated with fossil fuels. But expensive power producing and storage components are required to harness and store renewable energy. In addition renewable sources are intermittent, thus unreliable when used independently.


Density Functional Theory Simulations Of Mofs Encapsulated-Catalyzed Systems, Jiazhou Zhu, Rachel B. Getman 2015 Clemson University

Density Functional Theory Simulations Of Mofs Encapsulated-Catalyzed Systems, Jiazhou Zhu, Rachel B. Getman

Chemical and Biomolecular Graduate Research Symposium

The research is mainly on Computational Design of Highly Selective Transition Metal Catalysts Encapsulated by Metal-­‐Organic Frameworks for Butane Oxidation to 1-­‐Butanol. Metal Organic Framework (MOF) grown over a heterogeneous catalyst. Pores of framework allow only certain molecules of correct size, orientation, or chemical properties to access catalyst. The framework will force molecule into desired orientation where only the terminal atoms will “see” the catalyst. In our simulation we would like to use the helium ring to simulate the MOFs pores, since He is inert and exhibits the no chemical reactivity. The reaction we are looking into is ...


Effect Of Process Variables On Mechanical And Transport Properties Of Carbon Fibers From Mesophase Pitch, Victor Bermudez, Amod Ogale 2015 Clemson University

Effect Of Process Variables On Mechanical And Transport Properties Of Carbon Fibers From Mesophase Pitch, Victor Bermudez, Amod Ogale

Chemical and Biomolecular Graduate Research Symposium

To obtain mesophase pitch-based carbon fibers with improved mechanical strength while retaining superior electrical and thermal properties by

i) Systematic investigation of the relationship between DDR versus longitudinal and transverse microstructure of mesophase MP fibers; and

ii) Developing a novel type of microstructure


Development Of Anti-Fouling, Anti-Microbial Membranes By Chemical Patterning, Steven Weinman, Na Li, Viatcheslav Freger, Moshe Herzberg, Scott Husson 2015 Clemson University

Development Of Anti-Fouling, Anti-Microbial Membranes By Chemical Patterning, Steven Weinman, Na Li, Viatcheslav Freger, Moshe Herzberg, Scott Husson

Chemical and Biomolecular Graduate Research Symposium

Over 1 billion people lack access to clean drinking water. Membranes are a tool that can help provide clean water to these people. However, treatment of impaired waters for beneficial use exposes the membranes to feed waters containing biological and abiotic species, which leads to fouling and loss of membrane productivity over time. Since reduction in flux due to fouling is one of the largest costs associated with membrane processes in water treatment, new coatings that limit fouling would have significant economic and societal impacts. Developing these advanced coatings is the focus of our work.


Heterogeneous Catalysis Of Aqueous Phase Reforming Of Glycerol With First Principle Calculations And Molecular Dynamics Simulations, Tianjun Xie, Rachel B. Getman 2015 Clemson University

Heterogeneous Catalysis Of Aqueous Phase Reforming Of Glycerol With First Principle Calculations And Molecular Dynamics Simulations, Tianjun Xie, Rachel B. Getman

Chemical and Biomolecular Graduate Research Symposium

No abstract provided.


Dendrimer-Guest Interactions: Challenging Conventional Wisdom, Ryan S. DeFever, Sapna Sarupria 2015 Clemson University

Dendrimer-Guest Interactions: Challenging Conventional Wisdom, Ryan S. Defever, Sapna Sarupria

Chemical and Biomolecular Graduate Research Symposium

Solutions to many future challenges - including water purification, drug delivery, and energy storage - will require innovative new materials. Dendrimers are a class of materials with wide-ranging applications whose behavior is not fully understood. In many potential applications, dendrimers interact with small molecules. Our work focuses on describing the fundamental mechanisms governing the interactions between dendrimers and hydrocarbons using molecular modeling and computer simulations. A common view of dendrimer host-guest interactions is that the guest molecules are encapsulated in protected interior voids within the dendrimer structure. Our results present an alternative picture and show that the association of a model aromatic ...


Effect Of Co Adsorption And Coverage On Ethanol Production From Syngas, Anuradha Gundamaraju, Ming He, David A. Bruce 2015 Clemson University

Effect Of Co Adsorption And Coverage On Ethanol Production From Syngas, Anuradha Gundamaraju, Ming He, David A. Bruce

Chemical and Biomolecular Graduate Research Symposium

Concern over ever decreasing oil supplies, increasing levels of pollution and energy independence have been the primary driving forces behind significant efforts focused on the development of new technologies capable of increasing the production of alternative fuels. To-date, ethanol and to a lesser extent biodiesel have been the only alternative fuels or fuel additives to gain widespread use and be synthesized on a commercial scale. Currently, most of the World’s ethanol is produced from renewable biomass. The biomass feedstocks and fermentation broths used in ethanol production contain high amounts of water, and therefore, the energy efficiency of the process ...


Conducting Polymer Microstructures And Composites For Supercapacitors, Kryssia P. Diaz-Orellana, Mark E. Roberts 2015 Clemson University

Conducting Polymer Microstructures And Composites For Supercapacitors, Kryssia P. Diaz-Orellana, Mark E. Roberts

Chemical and Biomolecular Graduate Research Symposium

To increase the performance of conducting polymer electrodes for supercapacitors by controlling polymer assembly, ion transport, electron transfer, and redox processes. The electrode morphology and electrochemical performance are studied.


Carbon Fibers Derived From Bi-Component Precursors, Jing Jin, Amod A. Ogale 2015 Clemson University

Carbon Fibers Derived From Bi-Component Precursors, Jing Jin, Amod A. Ogale

Chemical and Biomolecular Graduate Research Symposium

No abstract provided.


Alternative Sample Loading Preparation For Thermal Ionization Mass Spectrometry, Scott M. Husson, Brian Powell, Glenn Fugate, David Locklair, Joseph Mannion 2015 Clemson University

Alternative Sample Loading Preparation For Thermal Ionization Mass Spectrometry, Scott M. Husson, Brian Powell, Glenn Fugate, David Locklair, Joseph Mannion

Chemical and Biomolecular Graduate Research Symposium

This contribution describes a new sample loading method for Thermal Ionization Mass Spectrometry (TIMS), which is used in nuclear safeguards and non-proliferation efforts worldwide and is known as the “gold standard” in isotopic ratio measurements of plutonium. TIMS analysis is used to determine grades of nuclear material and the extent of enrichment at production sites. The current sample loading method for TIMS analysis is known as “bead-loading”. While it provides the lowest detection limit of any known method for plutonium analysis, bead-loading is a difficult, time consuming, and expensive method that results in up to 20% sample loss. The major ...


Modification Of Liposome Release Characteristics With Metal Nanoparticles, Saptarshi Chakraborty, Christopher L. Kitchens 2015 Clemson University

Modification Of Liposome Release Characteristics With Metal Nanoparticles, Saptarshi Chakraborty, Christopher L. Kitchens

Chemical and Biomolecular Graduate Research Symposium

Gold nanoparticles have been getting increasing amount of attention due to their stability, optical properties and low toxicity in the field of consumer products and biomedicines. Gold nanoparticles with various surface chemistries have been synthesized in order to take advantage of the size, shape and morphology dependent properties of the nanoparticles which vary greatly from the bulk properties. These properties of gold nanoparticles have made them attractive in optical sensing, targeted drug delivery, bio imaging, chemical, catalytic and photo thermal applications. These surface functionalized nanoparticles were used to study nanoparticle-lipid bilayer interactions using lipid bilayer permeability studies, where permeability of ...


Cellulose Nanofiber Composite Membranes For Water Purification, Nithinart Chitpong, Scott M. Husson 2015 Clemson University

Cellulose Nanofiber Composite Membranes For Water Purification, Nithinart Chitpong, Scott M. Husson

Chemical and Biomolecular Graduate Research Symposium

Global water demand continues to increase because of population growth, urbanization, and climate change. Since there are limited natural water resources, water purification systems play a critical societal role. Membrane technologies are used widely to improve water quality for beneficial use. Therefore, the development of new membranes is an active area of research in the water purification field.


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