Injectable, Magnetic Plum Pudding Hydrogel Composites For Controlled Pulsatile Drug Release, 2014 McMaster University
Injectable, Magnetic Plum Pudding Hydrogel Composites For Controlled Pulsatile Drug Release, Danielle Maitland
Open Access Dissertations and Theses
Injectable, in-situ gelling magnetic plum pudding hydrogel composites were fabricated by entrapping superparamagnetic iron oxide nanoparticles (SPIONs) and thermosensitive N-isopropylacrylamide (NIPAM)-co–N-isopropylmethacrylamide (NIPMAM) microgels in a pNIPAM-hydrazide/carbohydrate-aldehyde hydrogel matrix. The resulting composites exhibited significant, repeatable pulsatile release of 4 kDa FITC-dextran upon exposure to an alternating magnetic field. The pulsatile release from the composites could be controlled by altering the volume phase transition temperatures of the microgel particles (with VPTTs over 37°C corresponding to improved pulsatile release) and changing the microgel content of the composite (with higher microgel content corresponding to higher pulsatile release). By changing the ...
Opto-Electronic Devices With Nanoparticles And Their Assemblies, 2014 University of Nebraska - Lincoln
Opto-Electronic Devices With Nanoparticles And Their Assemblies, Chieu Van Nguyen
Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research
Nanotechnology is a fast growing field; engineering matters at the nano-meter scale. A key nanomaterial is nanoparticles (NPs). These sub-wavelength (< 100nm) particles provide tremendous possibilities due to their unique electrical, optical, and mechanical properties. Plethora of NPs with various chemical composition, size and shape has been synthesized. Clever designs of sub-wavelength structures enable observation of unusual properties of materials, and have led to new areas of research such as metamaterials. This dissertation describes two self-assemblies of gold nanoparticles, leading to an ultra-soft thin film and multi-functional single electron device at room temperature. First, the layer-by-layer self-assembly of 10nm Au nanoparticles and polyelectrolytes is shown to behave like a cellular-foam with modulus below 100 kPa. As a result, the composite thin film (~ 100nm) is 5 orders of magnitude softer than an equally thin typical polymer film. The thin film can be compressed reversibly to 60% strain. The extraordinarily low modulus and high compressibility are advantageous in pressure sensing applications. The unique mechanical properties of the composite film lead to development of an ultra-sensitive tactile imaging device capable of screening for breast cancer. On par with human finger sensitivity, the tactile device can detect a 5mm imbedded object up to 20mm below the surface with low background noise. The second device is based on a one-dimensional (1-D) self-directed self-assembly of Au NPs mediated by dielectric materials. Depending on the coverage density of the Au NPs assembly deposited on the device, electronic emission was observed at ultra-low bias of 40V, leading to low-power plasma generation in air at atmospheric pressure. Light emitted from the plasma is apparent to the naked eyes. Similarly, 1-D self-assembly of Au NPs mediated by iron oxide was fabricated and exhibits ferro-magnetic behavior. The multi-functional 1-D self-assembly of Au NPs has great potential in modern electronics such as solid state lighting, plasma-based nanoelectronics, and memory devices.
Adviser: Ravi F. Saraf
Study Of High Pressure Steaming On Lipid Recovery From Microalgae, 2014 Western University
Study Of High Pressure Steaming On Lipid Recovery From Microalgae, Ana-Maria Aguirre
University of Western Ontario - Electronic Thesis and Dissertation Repository
Sustainable and clean fuels are in demand due to the perceived negative effects on health and environment with current use of fossil fuels. Lipids from microalgae offer a potential approach to obtain sustainable biofuels. In this study a two step process was adopted: investigation of culture conditions to find optimal points for lipid productivity and cellulose content, followed by an investigation of microalgae disruption for lipid recovery.
In the first phase of the research the effect of culture conditions on Chlorella vulgaris biomass concentration and the ratio of lipid productivity/cellulose content were studied. Response surface methodology was applied to ...
Pharmacokinetic Characterization Of Procoagulation Proteins, 2014 University of Nebraska - Lincoln
Pharmacokinetic Characterization Of Procoagulation Proteins, Nicholas C. Vanderslice
Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research
The cessation of bleeding in mammals occurs due to a well-conserved sequence of protein activation known as the coagulation cascade. However, people who have a deficiency in one or more proteins in this cascade, whether due to genetics or blood loss, struggle to maintain hemostasis. In order to aid patients in the restoration of hemostasis, exogenous proteins are often administered in response to bleeding events. However, these proteins are limited and costly due to limited supply of donor blood available for the production of plasma-derived proteins and the high cost of mammalian cell bio-reactors required for the production of recombinant ...
Calculated Vs. Experimental Values For Volume And Surface Resistivity In Various Polymer Compounds, 2014 University of Tennessee, Knoxville
Calculated Vs. Experimental Values For Volume And Surface Resistivity In Various Polymer Compounds, Megan Webster
Pursuit - The Journal of Undergraduate Research at the University of Tennessee
Versatile due to their resistance to high stress environments including but not limited to extreme temperature, pressure, and stress, polymers additionally have many uses in electrical applications wherein antistatic or conductive properties are preferential, i.e. conductive seals, oil pipeline spheres, and gaskets, to name a few. Being a complex material, many factors may affect the electrical resistivity of a given polymer compound including type and amount of carbon black, type of rubber, cure time and temperature, and dispersion, amongst other factors. External conditions such as relative humidity and temperature also play key roles. This paper will analyze five different ...
Energy Economy In Extractive Metallurgy, 2014 SelectedWorks
Energy Economy In Extractive Metallurgy, Fathi Habashi
Fuel, heat, and electricity are costly items in metallurgical processes and should be used with great efficiency to decrease production costs. To this end, the recent trend in metallurgical plants is focused towards the following goals: • Increased use of heat recovery systems • Increased use of oxygen instead of air • Increased use of direct heating systems • Improved equipment design• Improved process design • Improved methods of operation • Improved process design • Improved methods of operation • Attempts to economize energy in the aluminum industry industry
Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, 2014 California Polytechnic State University
Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes
Master's Theses and Project Reports
The American Cancer Society predicts that 1,665,540 people will be diagnosed with cancer, and 585,720 people will die from cancer in 2014. One of the most common types of cancer in the United States is skin cancer. Melanoma alone is predicted to account for 10,000 of the cancer related deaths in 2014. As a highly mobile and aggressive form of cancer, melanoma is difficult to fight once it has metastasized through the body. Early detection in such varieties of cancer is critical in improving survival rates in afflicted patients. Present methods of detection rely on visual ...
Mechanism Of Insulin Aggregation: Applied To Alzheimer's Disease, 2014 University of Connecticut
Mechanism Of Insulin Aggregation: Applied To Alzheimer's Disease, Milos Atz
Honors Scholar Theses
Alzheimer’s disease, a debilitating neurodegenerative illness, is caused by the irreversible aggregation of beta-amyloid proteins in the brain. In Alzheimer’s brains, the protein can become disfigured, causing it to aggregate into long, insoluble fibers that deposit on brain tissue. Studying the aggregation mechanisms of amyloid proteins can lead to a deeper understanding of the progression of Alzheimer’s disease and possibly point towards a potential cure or treatment for the disease. Heat induced aggregation of insulin provides a model system to study the aggregation of amyloidogenic proteins. This study investigates the early stages of heat induced insulin aggregation ...
Head Unit Pioneer Avh - P4200dvd, 2014 SelectedWorks
Head Unit Pioneer Avh - P4200dvd, Tri Nenty Uny
Tri nenty UNY
Pioneer AVH - P4200DVD
Menyambung telephone ke unit ini cukup menyakitkan. Aktifkan modus penemuan telephone serta unit selekasnya mendengarkan. Sesudah telephone sudah dibentuk pertama kalinya, itu benar-benar gampang. Hanya satu hal yang dibutuhkan, yaitu Bluetooth mesti diaktifkan, di telephone. Head unit automatis mendengarkan saat dekat. Menghubungkan amat cepat, umumnya kurun waktu satu atau dua detik. Pabrik Bluetooth bakal mengonsumsi saat seputar 30 detik. Modul ini dilengkapi dengan mikrofon bahwasanya saya sudah dipasang oleh kaca spion saya.
Greenscreen: Software To Improve Campus Water And Energy Use, 2014 University of Connecticut
Greenscreen: Software To Improve Campus Water And Energy Use, Andrew T. Silva
University Scholar Projects
Water and energy are intrinsically linked together. Energy is required to produce clean water and water is used heavily to generate energy. These two resources are constantly held in check, as they are vital to the sustained operation of towns, cities, and campuses. At the University of Connecticut (UConn), the consumption of water and energy is reduced by an efficient power plant and a brand new water reclamation facility. To reach beyond these accolades, it is essential that a deeper understanding of campus water usage is developed. Linking this knowledge with information about the energy consumption of UConn facilities will ...
Electrode Architectures For Efficient Ionic And Electronic Transport Pathways In High-Power Lithium Ion Batteries, 2014 Northeastern University
Electrode Architectures For Efficient Ionic And Electronic Transport Pathways In High-Power Lithium Ion Batteries, Ankita Shah Faulkner
Electrical Engineering Dissertations
As the demand for clean energy sources increases, large investments have supported R&D programs aimed at developing high power lithium ion batteries for electric vehicles, military, grid storage and space applications. State of the art lithium ion technology cannot meet power demands for these applications due to high internal resistances in the cell. These resistances are mainly comprised of ionic and electronic resistance in the electrode and electrolyte. Recently, much attention has been focused on the use of nanoscale lithium ion active materials on the premise that these materials shorten the diffusion length of lithium ions and increase the ...
Investigation Of Tio2 And Invo4-Tio2 Semiconductors For The Photocatalytic Degradation Of Aqueous Organics, 2014 University of South Florida
Investigation Of Tio2 And Invo4-Tio2 Semiconductors For The Photocatalytic Degradation Of Aqueous Organics, Sandra L. Pettit
Graduate School Theses and Dissertations
Water is a vital natural resource. To develop more sustainable water systems, we must focus efforts on the removal of persistent contaminants. Aqueous organic contaminants include azo dyes, halogenated organics (e.g. pesticides), and algal and bacterial metabolites. The latter are common to surface waters and freshwater aquaculture systems and can cause taste and odor problems. Two of the principal organoleptic compounds are geosmin and 2-methylisoborneol (MIB). Traditional oxidation treatment methods, utilizing chlorine, hydrogen peroxide, and potassium permanganate, have been employed with varying levels of efficacy for removal of these and other organic contaminants. Advanced Oxidation Processes (AOPs) have greater ...
Structure-Magnetic Property Correlations In Tio2 Nanotube Arrays, 2014 Northeastern University
Structure-Magnetic Property Correlations In Tio2 Nanotube Arrays, Pegah Mohammad Hosseinpour
Chemical Engineering Dissertations
TiO2 nanotube arrays are promising candidates for applications such as photocatalysis and for potential employment in spin-electronic (spintronic) devices. The functionality of TiO2-based nanotubes is highly dependent on their structure (microstructure and crystallographic symmetry) and magnetic properties. Unified understanding of the influence of these factors on the electronic structure of TiO2 is of paramount importance towards engineering these materials.
This Dissertation aims at investigating the correlations of the morphology, crystallinity, crystal structure, electronic structure and magnetic properties of TiO2 nanotubes, with potential relevance to their functionality. Self-ordered arrays of amorphous TiO2 nanotubes (pure and ...
Study Of The Structure-Property Relationships That Determine The Effects Of Latexes And Starch Containing Latex Emulsions On The Performance Of The Barrier Coatings (Sub-Coat) For Paper, 2014 The University of Southern Mississippi
Study Of The Structure-Property Relationships That Determine The Effects Of Latexes And Starch Containing Latex Emulsions On The Performance Of The Barrier Coatings (Sub-Coat) For Paper, Joanna Marie Monfils
The history of carbonless paper dates back to the 1940s. Before this, a carbon copy sheet was needed between sheets of paper to be able to produce one or more copies simultaneously during writing. The pressure from a pen or typewriter would help deposit the ink of the carbon paper onto the blank sheet of paper under the original written sheet to create a “carbon copy.” This method did however, have its disadvantages. Not only did it produce a limited number of copies, but it was also a messy process. So came the creative process of using microencapsulated dyes to ...
Probing Cell Membrane And Biofilm Extracellular Matrix Interactions With Tumor Necrosis Factor-Alpha And Interleukin-6 Through Molecular Dynamics Simulations Using A Detailed Chemical Description, 2014 Syracuse University
Probing Cell Membrane And Biofilm Extracellular Matrix Interactions With Tumor Necrosis Factor-Alpha And Interleukin-6 Through Molecular Dynamics Simulations Using A Detailed Chemical Description, Stephen Desalvo
Syracuse University Honors Program Capstone Projects
Bacterial biofilms are a major cause of persistent infections and diseases with known antibiotic and host immune defense resistances. The interaction of signaling factors, namely small cytokines, with the biofilm and host cell is considered vital to the survival of bacterial biofilms. In this study, molecular dynamics (MD) simulations are performed using coarse-grained biomolecular systems to provide significant insight into medical therapeutic advancements in treating persistent and chronic infections. Specifically, MD simulations of the interaction between signaling factors tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) with a model biofilm matrix with detailed description were performed. Additional simulations were used to ...
Pathways For Tailoring The Magnetostructural Response Of Ferh-Based Systems, 2014 Northeastern University
Pathways For Tailoring The Magnetostructural Response Of Ferh-Based Systems, Radhika Barua
Chemical Engineering Dissertations
Materials systems that undergo magnetostructural phase transitions (simultaneous magnetic and structural phase changes) have the capability of providing exceptional functional effects (example: colossal magnetoresistance effect (CMR), giant magnetocaloric (GMCE) and giant volume magnetostriction effects) in response to small physical inputs such as magnetic field, temperature and pressure. It is envisioned that magnetostructural materials may have significant potential for environmental and economic impact as they can be incorporated into a wide array of devices ranging from sensors for energy applications to actuators for tissue engineering constructs. From the standpoint of fundamental scientific research, these materials are interesting as they serve as ...
Study Of Water Transport Phenomena On Cathode Of Pemfcs Using Monte Carlo Simulation, 2014 University of Nevada, Las Vegas
Study Of Water Transport Phenomena On Cathode Of Pemfcs Using Monte Carlo Simulation, Karn Soontrapa
UNLV Theses/Dissertations/Professional Papers/Capstones
This dissertation deals with the development of a three-dimensional computational model of water transport phenomena in the cathode catalyst layer (CCL) of PEMFCs. The catalyst layer in the numerical simulation was developed using the optimized sphere packing algorithm. The optimization technique named the adaptive random search technique (ARSET) was employed in this packing algorithm. The ARSET algorithm will generate the initial location of spheres and allow them to move in the random direction with the variable moving distance, randomly selected from the sampling range, based on the Lennard-jones potential of the current and new configuration. The solid fraction values obtained ...
Simulations Of Interfacial Electrokinetics With Applications To Microfluidic Systems, 2014 University of Nevada, Las Vegas
Simulations Of Interfacial Electrokinetics With Applications To Microfluidic Systems, Sebastian Uppapalli
UNLV Theses/Dissertations/Professional Papers/Capstones
Electrokinetics plays an important role in facilitating fluid transport and particle manipulation in microfluidic systems. This dissertation studies the mechanics of electrokinetic phenomena for microscale particles and drops. The work aims to increase the understanding of complex electrokinetic phenomena for applications in Lab-on-Chip technology, assembly of colloidal particles and two-phase flow sensing. The standard model consisting of the Poisson-Nernst-Planck equations is used to study the electric double layer polarization of charged dielectric particles and channel wall which plays a major role in control and manipulation of colloidal particles and understanding of electrohydrodynamic flow field.
The cases of polarization of "soft ...
Optimizing Polymer Fluorescence For Explosives Detection, 2014 University of Connecticut
Optimizing Polymer Fluorescence For Explosives Detection, Rose K. Cersonsky
Honors Scholar Theses
Pyrene is commonly used for explosives detection, as when mixed with polystyrene, the fluorescence intensity of the resulting film can be used as an indicator of the presence of nitro-aromatic, nitro-ether, or nitro-amine explosives. Previous studieshave tested a three-component system including pyrene, polystyrene, and a salt, tetrabutylammonium hexafluorophosphate (TBAHP). From these previous studies, it has been seen that vapor pressure of the preparation area is a governing factor in the formation of excimers, which are instrumental in achieving and maintaining fluorescence intensity. In this study, three parameters – solution concentration, film thickness, and molecular weight of polystyrene are examined to determine ...
Outlining The Biocidal Mechanisms Of Synthetic Antimicrobial Peptide Mimics, 2014 The University of Southern Mississippi
Outlining The Biocidal Mechanisms Of Synthetic Antimicrobial Peptide Mimics, Tyler D. Brown
Each day, antibiotic resistance affects the livelihood of individuals worldwide, especially in relation to hospital-acquired diseases. In an effort to combat this resistance, antimicrobial peptides, small biopolymers produced naturally by multicellular organisms, can be used to selectively eliminate bacteria and have demonstrated great potential as alternatives to conventional antibiotics. Many naturally-occurring antimicrobial peptides possess high concentrations of lysine and arginine amino acid residues, which are protonated and positively-charged at physiological pH. Herein, we describe the design and synthesis of antimicrobial peptide mimics, using amino acid mimics. N-3-aminopropyl methacrylamide (APMA) and 3-guanidinopropyl methacrylamide (GPMA) monomers mimic the amino acid residues lysine ...