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Biochemical and Biomolecular Engineering Commons

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Activated Carbon-Based Carbon Dioxide Adsorption Process, Eric Chen, Katie Rolin, Zachary Stillman 2017 University of Pennsylvania

Activated Carbon-Based Carbon Dioxide Adsorption Process, Eric Chen, Katie Rolin, Zachary Stillman

Senior Design Reports (CBE)

This process uses activated carbon to adsorb 65 tonnes of CO2 from a coal-fired power plant per day using activated carbon sorbents at 93% purity using a two-stage adsorption process that uses vacuum-swing adsorption. The flue gas first is pressurized and dehydrated using cooling and chilled water. The stream is then sent into a packed activated carbon column at 1.11 bar until CO2 saturation, upon which the column is depressurized to 0.5 bar and the CO2 is desorbed. The gas is then sent into a second adsorption stage at 1 bar until CO2 saturation ...


Brewer's Spent Grain To Xylitol & Polylactic Acid, Alexander George, Kelsey Simet, Anthony Carradorini, Nabila Faour 2017 University of Pennsylvania

Brewer's Spent Grain To Xylitol & Polylactic Acid, Alexander George, Kelsey Simet, Anthony Carradorini, Nabila Faour

Senior Design Reports (CBE)

With this project, the authors seek to present a desirable and novel process for converting brewers’ spent grain into two value-added products: the alternative sweetener, xylitol, and a biodegradable plastic, polylactic acid. This particular process is based in the Philadelphia Naval Yard, and uses the spent grain from surrounding breweries and microbreweries as its input. However, while the collection logistics and input quantity may change, the process is one that may be implemented anywhere, with varying degrees of success.

The process consists of collection, universal pretreatment, then a split to feed one of two continuous fermenters. A highly acidophilic strain ...


On The Production Of High-Purity Docosahexaenoic Acid From Heterotrophic Microalgae, Andrew Zhu, Lea Nowack, Min Young Jeong 2017 University of Pennsylvania

On The Production Of High-Purity Docosahexaenoic Acid From Heterotrophic Microalgae, Andrew Zhu, Lea Nowack, Min Young Jeong

Senior Design Reports (CBE)

Omega-3 fatty acids provide significant health benefits and are a popular nutritional supplement in the nutraceuticals industry. Omega-3 fatty acids such as docosahexaenoic Acid (DHA) and eicosapentaenoic Acid (EPA) have been reported to improve heart health and mental health. In addition, DHA consumption has been tied to improvements in infant cognitive development. Therefore, high-purity DHA is a desired ingredient in the production of infant formula. The omega-3 oils originating from fish tend to have carcinogenic risks in addition to a bad odor. In recent years, the industry trend has shifted to producing these omega-3 fatty acids via microalgae species– making ...


Optimization Of Oleosin 30g Production For Echocardiography, Annette Krysiewicz, Andrew Parsons, Sergio Rodriguez-Labra 2017 University of Pennsylvania - Biostatistics

Optimization Of Oleosin 30g Production For Echocardiography, Annette Krysiewicz, Andrew Parsons, Sergio Rodriguez-Labra

Senior Design Reports (CBE)

Provided they are uniform in size, monodisperse microbubbles behave as contrast agents to enhance echocardiographic imaging. Compounds like Oleosin 30G with surfactant-like properties help stabilize microbubbles - thereby ensuring their uniform size. Designed herein is an industrial-scale plant to produce medical-grade Oleosin 30G with a process consisting of three steps: 1) upstream production via recombinant E. coli in an integrated batch bioprocessing model, 2) downstream purification, and 3) processing by microfluidic manifolds. Ultimately Oleosin 30G-coated microbubbles are manufactured, ready for injection within one month. Owing to its unique properties and cost-effective production, Oleosin 30G has the potential to outcompete current market ...


Direct Route To Phenol From Benzene, Bryan Daowdat, Gerard D. Hoeltzel, Robert Tannenbaum 2017 University of Pennsylvania

Direct Route To Phenol From Benzene, Bryan Daowdat, Gerard D. Hoeltzel, Robert Tannenbaum

Senior Design Reports (CBE)

Phenol production, expected to exceed 13MM metric tons in 2017, is a significant global industry with many flaws in its current manufacturing method. The Hock process essentially converts high value propylene to low value acetone. The proposed process design, detailed in this report, provides an alternative reaction pathway that utilizes a direct synthesis from benzene, as developed at the Council of Scientific and Industrial Research (CSIR) in New Delhi, India. The endorsed proposal is in accordance with US Patent 8,772,552 B2, that describes the production of phenol via vapor phase oxidation of benzene over a copper chromium oxide ...


An Efficient And Safe Cooking Stove For Las Delicias, El Salvador, Maria Castaner, Daniel Li, Nicolas Minor 2017 University of Pennsylvania

An Efficient And Safe Cooking Stove For Las Delicias, El Salvador, Maria Castaner, Daniel Li, Nicolas Minor

Senior Design Reports (CBE)

The primary objective of this project was to design an efficient and safe cooking stove based on the resources available in El Salvador while ensuring it could be inexpensive to produce. The stove is a cuboid, 18"×18"×12" in dimension, and weighs 75 lbs. It has a top cover to cook on, and a unique three-chamber design: a chamber for combustion, a chamber to pump hot air into the combustion chamber with a bellows, and a third chamber to add insulation material. A ventilation tube connects the inner chamber with the exterior to safely vent flue gas to the ...


Polyether Plant Design, Christina Hum, Carol Wang, Mauricio Tassano 2017 University of Pennsylvania

Polyether Plant Design, Christina Hum, Carol Wang, Mauricio Tassano

Senior Design Reports (CBE)

In recent years, the global market for polyethers has seen rapid expansion due to the growth of the construction, automobile, and foam industries. Polyethers are principally sold to polyurethane plants to produce a wide range of flexible and rigid foams that are used in a wide range of applications from automotive upholstery to inks. Consequently, the process for manufacturing polyethers is extremely vital to the consumer goods market and for maintaining the quality of life to which many people have grown accustomed. In this report, a plant has been designed in the Asia-Pacific region to produce 100 million pounds of ...


Coffee To Biofuels, Chelsea Giller, Bhavish Malkani, Josh Parasar 2017 University of Pennsylvania

Coffee To Biofuels, Chelsea Giller, Bhavish Malkani, Josh Parasar

Senior Design Reports (CBE)

This project proposes a production plant that will utilize 9.58 million kg/year of spent coffee grounds in order to produce 1.03 million liters/year of coffee biofuel and 2.56 million kg/year of biomass pellets. This plant will be located in northern New Jersey, where the maximum amount of spent coffee grounds can be obtained every day from each of the five boroughs in New York City. Practically, trucks could obtain grounds from 875 Starbucks and Dunkin Donuts coffee shops, collected 3-4 times per week. Overall uptime is taken to be 90%. The biodiesel is formed ...


Food Waste To Bio-Products, Elizabeth Handen, Mauricio Diaz Padilla, Hannah Rears, Lyle Rodgers 2017 University of Pennsylvania

Food Waste To Bio-Products, Elizabeth Handen, Mauricio Diaz Padilla, Hannah Rears, Lyle Rodgers

Senior Design Reports (CBE)

The goal of this project was to design and evaluate a project for the collection and processing of food waste and spent oil in Philadelphia. The project was designed to handle 5% of the total commercial waste generated in Philadelphia. This amounted to approximately 9,700 tons/year of food waste and 73,000 gallons/year of spent oil. The process was designed to utilize a BIOFerm™ Dry Fermentation Digestion System. Following the digestion, the biogas produced is passed through a Caterpillar CG132-12 Generator Set, producing electricity to be sold back to the local grid. The digestate from the anaerobic ...


Low-Cost, Commercial Scale Production Of Sofosbuvir, Joseph Solomon, Jake Hsu, Cynthia Tong, Ryan Bliss 2017 University of Pennsylvania

Low-Cost, Commercial Scale Production Of Sofosbuvir, Joseph Solomon, Jake Hsu, Cynthia Tong, Ryan Bliss

Senior Design Reports (CBE)

Recent advances in antiviral therapeutics have produced highly effective small molecule drugs to treat Hepatitis C, a deadly infection of the liver. Sofosbuvir, a hepatitis C drug developed by Gilead Sciences, is a breakthrough treatment due to its low side effects and high cure rate. However, the cost of treatment is extraordinarily high, priced at $84,000 per treatment in the US. In response to backlash regarding the cost barriers in developing countries, Gilead has reached licensing agreements with generic pharmaceutical companies to produce the drug for markets in low-income countries such as India, Kenya, and Cuba among others. The ...


The Effects Of Adaptogens On The Physical And Psychological Symptoms Of Chronic Stress, Tosin Ajala 2017 Georgia State University

The Effects Of Adaptogens On The Physical And Psychological Symptoms Of Chronic Stress, Tosin Ajala

Georgia State Undergraduate Research Conference

No abstract provided.


Genetic Code Expansion In Biochemical Investigations And Biomedical Applications, Nanxi Wang 2017 University of Nebraska-Lincoln

Genetic Code Expansion In Biochemical Investigations And Biomedical Applications, Nanxi Wang

Student Research Projects, Dissertations, and Theses - Chemistry Department

Genetic code expansion provides a powerful tool for site-specific incorporation of unnatural amino acids (unAAs) with novel biochemical and physiological properties into proteins in live cells and organisms. To achieve this, a nonsense codon suppression system, which consists of an orthogonal aminoacyl-tRNA synthetase (aaRS) and tRNA pair that specifically decodes a nonsense codon (e.g., amber codon and quadruplet codon) with an unAA but do not “cross talk” with their endogenous counterparts, was established. This Ph.D. thesis presents our efforts on evolution and application of nonsense codon suppression systems for biochemical and biomedical investigations.

In Chapter 1, a brief ...


An Expedited, Regiospecific Para-Bromination Of Activated Aryls, Kathryn E. Dudley 2017 Western Kentucky University

An Expedited, Regiospecific Para-Bromination Of Activated Aryls, Kathryn E. Dudley

Masters Theses & Specialist Projects

Electrophilic Aromatic Substitution (EAS) is one of the most frequently used aryl substitution methods. Aside from the fact that most EAS reactions require an acid and an oxidizer to proceed, the reactions involving activated aryls typically produce a mixture of ortho- and para- products as well as an ortho-/para- disubstituted product. Regiospecificity in aromatic substitution is key in the production of many compounds in a variety of disciplines. Since EAS is one of the most often used substitution methods, it is extremely important to develop an efficient method for regiospecific substitutions. Previous research developed a method of ortho-substitution by ...


Removal Of Chlorine From Chlorine-Nitrogen Mixture In A Film Of Liquid Water, Sarwan S. Sandhu 2017 University of Dayton

Removal Of Chlorine From Chlorine-Nitrogen Mixture In A Film Of Liquid Water, Sarwan S. Sandhu

Sarwan S. Sandhu

In industry there are many examples of absorption of a gas with or without chemical reaction in the liquid phase. In physical absorption, a particular gaseous component is removed from a gas mixture due to its larger solubility in the liquid phase solvent. The removal of butane and pentane from a refinery gas mixture by a heavy oil in the liquid phase is an example of physical absorption. In absorption with chemical reaction, the gaseous component to be removed transfers across the gas-liquid interface due to a difference in the bulk chemical potentials or concentrations in the two phases. The ...


Disinfection By-Products Formation After Coagulation Of Algal Extracellular And Intracellular Organic Matters, Tianyiru Chen 2017 The University of Western Ontario

Disinfection By-Products Formation After Coagulation Of Algal Extracellular And Intracellular Organic Matters, Tianyiru Chen

Electronic Thesis and Dissertation Repository

Algal organic matter (AOM) is found in high concentration during algal bloom season in drinking water systems, which is generally categorized into extracellular organic matter (EOM) and intracellular organic matter (IOM). These compounds are not well removed in traditional water treatment methods such as coagulation, and are the precursors of subsequent disinfection by-products (DBPs) during chlorination of water. In this study, EOM and IOM content of four different algae were quantified measuring dissolved organic carbon (DOC), UV absorbance at 254 nm and turbidity. Coagulation using alum (Al2(SO4)3•16H2O)was used to remove the algal ...


High-Density Non-Fouling Bioactive Coatings: Development And Characterization, Bonan Yu, Ramya Raman, Karl Schlike 2017 Oregon State University

High-Density Non-Fouling Bioactive Coatings: Development And Characterization, Bonan Yu, Ramya Raman, Karl Schlike

Biomedical Engineering Western Regional Conference

No abstract provided.


Molecular Modeling Of Antibody-Antigen Binding Near Solid Surfaces, Derek Bush, Thomas Knotts 2017 Brigham Young University

Molecular Modeling Of Antibody-Antigen Binding Near Solid Surfaces, Derek Bush, Thomas Knotts

Biomedical Engineering Western Regional Conference

Antibody microarrays are biosensors that have the potential to revolutionize molecular detection in medicine, scientific research, and national defense. However, current microarrays are not widely used due to problems including poor reproducibility and signal quality, unbalanced antibody performance, and cross-reactivity. Prior work in the area focused mainly on the stability of the antibody alone and not its affinity for its antigen. This presentation shows results of using molecular simulation to determine how different types of surfaces affect antigen binding to surface-tethered antibodies. The results offer an unprecedented, molecular-level view into these protein-protein-surface interactions and how to drive binding to occur.


Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff 2016 University of Nebraska - Lincoln

Characterization Of Molecular Communication Based On Cell Metabolism Through Mutual Information And Flux Balance Analysis, Zahmeeth Sayed Sakkaff

Computer Science and Engineering: Theses, Dissertations, and Student Research

Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit them for novel purposes, such as the development of ubiquitous and heterogeneous communication networks to interconnect biological cells with nano and biotechnology-enabled devices, i.e., the Internet of Bio-Nano Things. One major problem in realizing these goals stands in the development of reliable techniques to control the engineered cells and their behavior from ...


Lignin Maximization: Analyzing The Impact Of Different Feedstocks And Feedstock Ratios Using Organosolv Fractionation, Marc Banholzer 2016 University of Tennessee, Knoxville

Lignin Maximization: Analyzing The Impact Of Different Feedstocks And Feedstock Ratios Using Organosolv Fractionation, Marc Banholzer

Masters Theses

Over-exploitation of fossil fuels coupled with increasing pressure to reduce carbon emissions are prompting a transition from conventional petrochemical feedstocks to sustainable and renewable sourced carbon. The use of lignocellulosic biomass as a feedstock for integrated biorefining is of current high interest, as separation into its component parts affords process streams of cellulose, hemicellulose and lignin, each of which can serve as a starting point for the production of biobased chemicals and fuels. Given the large number of potential sources of lignocellulosic feedstocks, the biorefinery will need to adapt to the supplies available over a normal growing season. Of particular ...


Membrane Chromatography For Bioseparations: Ligand Design And Optimization, Zizhao Liu 2016 University of Arkansas, Fayetteville

Membrane Chromatography For Bioseparations: Ligand Design And Optimization, Zizhao Liu

Theses and Dissertations

Membrane chromatography, or membrane adsorber, represents an attractive alternative to conventional packed bed chromatography used in downstream processing. Membrane chromatography has many advantages, including high productivity, low buffer consumption and ease to scale up. This doctoral dissertation focuses on developing novel polymeric ligands for protein separations using membrane chromatography. Atom transfer radical polymerization (ATRP), known as a controlled radical polymerization technique, has been used to control the architecture of grafted polymeric ligands. The center theme of this dissertation is to develop new polymeric ligands and investigate how the polymer’s property (e.g. flexibility, hydrophobicity) and architecture (e.g. chain ...


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