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Design Of Car-T Cell Manufacturing Process, Liam J. Bartie, Lauren R. Duhamel, Ruby C. Pan 2020 University of Pennsylvania

Design Of Car-T Cell Manufacturing Process, Liam J. Bartie, Lauren R. Duhamel, Ruby C. Pan

Senior Design Reports (CBE)

CAR T-cell therapy is at the frontier of personalized immunotherapy. It is a therapy that essentially reprograms a patient’s own T-cells to attack certain blood cancers. A sample of a patient's T cells are collected from the blood, then modified to produce chimeric antigen receptors (CARs) on their surface. When these CAR T cells are reinfused into the patient, the new receptors enable them to latch onto a specific antigen on the patient's tumor cells and kill them, ideally sending the patient into remission and essentially curing their cancer. Currently, CAR T-cell therapy is FDA approved as ...


Ammonia Fiber Expansion (Afex) Pretreatment Of Lignocellulosic Biomass, Shishir P. S. Chundawat, Ramendra K Pal, Chao Zhao, Timothy Campbell, Farzaneh Teymouri, Josh Videto, Chandra Nielson, Bradley Wieferich, Leonardo Sousa, Bruce E Dale, Venkatesh Balan, Sarvada Chipkar, Jacob Aguado, Emily Burke, Rebecca Garlock Ong 2020 Rutgers-State University of New Jersey

Ammonia Fiber Expansion (Afex) Pretreatment Of Lignocellulosic Biomass, Shishir P. S. Chundawat, Ramendra K Pal, Chao Zhao, Timothy Campbell, Farzaneh Teymouri, Josh Videto, Chandra Nielson, Bradley Wieferich, Leonardo Sousa, Bruce E Dale, Venkatesh Balan, Sarvada Chipkar, Jacob Aguado, Emily Burke, Rebecca Garlock Ong

Michigan Tech Publications

Lignocellulosic materials are plant-derived feedstocks, such as crop residues (e.g., corn stover, rice straw, and sugar cane bagasse) and purpose-grown energy crops (e.g., miscanthus, and switchgrass) that are available in large quantities to produce biofuels, biochemicals, and animal feed. Plant polysaccharides (i.e., cellulose, hemicellulose, and pectin) embedded within cell walls are highly recalcitrant towards conversion into useful products. Ammonia fiber expansion (AFEX) is a thermochemical pretreatment that increases accessibility of polysaccharides to enzymes for hydrolysis into fermentable sugars. These released sugars can be converted into fuels and chemicals in a biorefinery. Here, we describe a laboratory-scale batch ...


A97 Electrostatic Precipitator (Esp) Waste Elimination, Brian Acosta, Alyssa Young, Austin Straw 2020 Olivet Nazarene University

A97 Electrostatic Precipitator (Esp) Waste Elimination, Brian Acosta, Alyssa Young, Austin Straw

Scholar Week 2016 - present

This project focuses on the development of a waste elimination system. the Kankakee BASF site produces a waste known as acid ester waste through their air pollution system in area 97; this waste is highly corrosive and is causing damage to their process sewer. A waste elimination system had to be developed in order to remove the acid ester was from the process sewer without compromising the operation of the BASF Kankakee site.



Reconstitution Efficiency On Elution Process, Brandon Winter, Landon Beachy, Samantha Stejskal, Zachary Rice 2020 Olivet Nazarene University

Reconstitution Efficiency On Elution Process, Brandon Winter, Landon Beachy, Samantha Stejskal, Zachary Rice

Scholar Week 2016 - present

Our group is presenting on the Reconstitution Efficiency on Elution Process for MilliporeSigma. The process that we are working with is the mixing of BAAP (Bovine Albumin Acetone Powder) into reverse osmosis water. This process is the first step of many in the making of medical test kits, of which include HIV/AID, strep throat, and pregnancy tests. Our initial task was to reduce the mixing time by 50%, however after further exploration of the problem, a more stable and consistent process turned into our primary goal and a significant reduction in time became a secondary goal. Initially, we were ...


Process Water Recycling, Adrian Barron, Josiah Snider, Kyle Serpe 2020 Olivet Nazarene University

Process Water Recycling, Adrian Barron, Josiah Snider, Kyle Serpe

Scholar Week 2016 - present

The Millipore Sigma-Kankakee Site uses high volumes of water for many operations. One operation utilizes approximately 3600 L of water per batch every couple days and more than 3.8MM liters of water per year. The water is utilized as a component of the buffer washes used in the extraction process for cholesterol that involves various other components such as silica and ions such as sodium, sulfur, and phosphate. The washes that go through the process involve these components and large amounts of water that are then drained out of the facility. This volume is roughly 7% of the site ...


Inducing Increased Bioplastic Production In R. Palustris Cga009, Cameron Gilley, Dylan Hoppner, Brandi J. Brown 2020 University of Nebraska - Lincoln

Inducing Increased Bioplastic Production In R. Palustris Cga009, Cameron Gilley, Dylan Hoppner, Brandi J. Brown

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

PHA’s (polyhydroxyalkanoates) are important bio polymers in different industries such as petroleum, medicine, and nano technology. In the microorganisms in which they are produced, they serve as an energy storage material by storing both carbon and usable electrons. This is useful in environments where the organisms are nutrient starved. PHA’s have a practical use especially in the medical field as bio-plastics because they are biodegradable and bio-compatible. Rhodopseudomonas. palustris, a common soil bacterium, is notable for its uncommon metabolic flexibility. Its diverse metabolism means that it can fix CO 2 and grow on many lignin based monomers in ...


Improvement Of Fluidization Ability For Group A Powders By Fine Powder Additives, Xiaowei Zhang 2020 The University of Western Ontario

Improvement Of Fluidization Ability For Group A Powders By Fine Powder Additives, Xiaowei Zhang

Electronic Thesis and Dissertation Repository

Group A powders are widely utilized in the industry because of the great quality of fluidization, which can be affected by the fine content. This project investigates the feasibility that employing the fine powders (≤ 20 μm) as additives to further improve the fluidization ability of Group A powders. Three additives, Coal-15, GB-6, and SiO2-5 are added into FCC-76, based on various volume fractions. The minimum fluidization velocity (Umf), bed expansion ratio (BER), and dense phase expansion ratio (DER) are tested to evaluate the quality of fluidization. Coal-15 can slightly improve the fluidization quality. High content of GB-6 ...


Effective Dispersion Of Mgo Nanostructure On Biochar Support As A Basic Catalyst For Glucose Isomerization, Season S. Chen, Yang Cao, Daniel C.W. Tsang, Jean-Philippe Tessonnier, Jin Shang, Deyi Hou, Zhengtao Shen, Shicheng Zhang, Yong Sik Ok, Kevin C.-W. Wu 2020 The Hong Kong Polytechnic University and National Taiwan University

Effective Dispersion Of Mgo Nanostructure On Biochar Support As A Basic Catalyst For Glucose Isomerization, Season S. Chen, Yang Cao, Daniel C.W. Tsang, Jean-Philippe Tessonnier, Jin Shang, Deyi Hou, Zhengtao Shen, Shicheng Zhang, Yong Sik Ok, Kevin C.-W. Wu

Chemical and Biological Engineering Publications

Glucose isomerization to fructose is one of the most important reactions in the field of biomass valorization. We demonstrate wood waste valorization with MgCl2 salt to synthesize an environment-friendly catalyst (i.e., MgO-biochar), which exhibits effective glucose-to-fructose isomerization with over 30% fructose yield and 80% selectivity at only 100 °C for 30 min in water as a green medium. This study highlights that one-step synthesis can effectively disperse and tether MgO nanostructures to the biochar matrix, which displays a significant reduction of Mg leaching compared to MgO-biochars produced by two-step synthesis and pure MgO. The MgCl2 acts as a porogen ...


Study Of Recombinant Protein Fractions From The Bombyx Mori And Pichia Pastoris Using "Native Page" Method, Abdurhakhmanov aloliddin, Sasmakov Sobirdjan, Khasanov Shuhrat, Ashirov Оybek 2020 Institute of the Chemistry of Plant Substances

Study Of Recombinant Protein Fractions From The Bombyx Mori And Pichia Pastoris Using "Native Page" Method, Abdurhakhmanov Aloliddin, Sasmakov Sobirdjan, Khasanov Shuhrat, Ashirov Оybek

CHEMISTRY AND CHEMICAL ENGINEERING

We have studied the recombinant protein fractions of ̴ 24-34 kDa obtained from Bombyx mori - silkworm larvae and yeast Pichia pastoris. Fractions, containing the recombinant proteins by gel-electrophoresis using the “Native PAGE” method, which allows for differentiation of proteins according to their natural (surface) charge and conformational properties were studied. The results showed that the recombinant protein fraction from Bombyx mori (̴ 34 kDa) consisted of four components and fraction from Pichia pastoris (̴ 24 kDa) consisted one component. The most optimal conditions for the “Native PAGE”- the main gel: Tris HCl (pH-8.8) 244 mM, Bis-Acrylamide 10%, TEMED 0.08%, APS 0 ...


Pressure-Compensated Temperature Control In Rectification Column, Norkobilov Adham, Turakulov Zafar, Kamolov Azizbek, Talipov Hojiakbar 2020 Shahrisabz Branch of the Tashkent Institute of Chemical Technology

Pressure-Compensated Temperature Control In Rectification Column, Norkobilov Adham, Turakulov Zafar, Kamolov Azizbek, Talipov Hojiakbar

CHEMISTRY AND CHEMICAL ENGINEERING

The focus of this work is to study the control of a rectification column (RC) for separating n-butane (nC4) and n-pentane (nC5) mixtures. Two control structures based on conventional temperature control (TC) and pressure-compensated control (PTC) structures are studied and compared using Aspentech software. The control performance of TC and PTC are investigated in terms of the control of component purities in both distillate and bottoms streams, under various disturbances in feed and pressure conditions. Due to pressure compensation, PTC is superior to TC in terms of purity and impurity control under disturbances in feed and pressure conditions. Accordingly, simulation ...


Research Of Kinetic Characteristics Of The Process Of Decomposition Of Zinc Concentrate With Hydrochloric Acid, Rosilov Mansur, Deng Tianlong, Usmanov Ilham, Samadiy Murodjon 2020 Tashkent Chemical Technological Institute

Research Of Kinetic Characteristics Of The Process Of Decomposition Of Zinc Concentrate With Hydrochloric Acid, Rosilov Mansur, Deng Tianlong, Usmanov Ilham, Samadiy Murodjon

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of the study was the theoretical justification of the kinetic characteristics of the process of producing zinc chloride from zinc concentrate of the Khandiza deposit. For this, the effect of temperature and duration of the process of autoclave zinc extraction in a 28% hydrochloric acid solution was studied at a ratio of Zn: HCI = 1:1.1. Variable parameters were the temperature of 70, 80 and 90 °C and the duration of the leaching process of 6, 8 and 10 hours. The optimal parameters for the production of zinc chloride were determined.


The Study Of The Component Composition Of The Reaction Mixture Containing Formaldehyde Reaction Products, Hurramov Lochinbek, Alimukhamedova Nozima, Adilov Ravshan, Alimukhamedov Muzafar 2020 Tashkent Chemical-Technological Institute

The Study Of The Component Composition Of The Reaction Mixture Containing Formaldehyde Reaction Products, Hurramov Lochinbek, Alimukhamedova Nozima, Adilov Ravshan, Alimukhamedov Muzafar

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of this work is to study the effect of the conditions of the reaction of monoethanolamine (Meol) with formaldehyde (FD) on the composition of the reaction mixture. Interaction of monoethanolamine with formaldehyde leads to the formation of N,N’,N”-tris(β-oxyethyl) hexahydro-S-triazine or N,N-bisoxazolidine. The type of final product was determined by the conditions of the reaction and the molar ratio of aminoalcohol:formaldehyde. The chromatogram of the vacuum-distilled final product obtained at the molar ratio of monoethanolamine:formaldehyde=1:1 shows on an individual compound with a retention time of 4.173 s. With increase ...


Evaluation Of The Embedded Environmental Impacts Of The Sanitary Sewer System Using Life Cycle Assessment, Kimberly Law 2020 University of Nebraska-Lincoln

Evaluation Of The Embedded Environmental Impacts Of The Sanitary Sewer System Using Life Cycle Assessment, Kimberly Law

UCARE Research Products

This study identifies the overall impact that the installation and construction phase of sanitary sewer systems have on the environment. Construction data on sanitary sewer systems from small Nebraska communities was collected and compared to the operating phase of the sanitary sewer. The operating phase is the energy required for the lift station. Analyzing sanitary sewers during their entire life cycle involved the raw materials, infrastructure construction, installation, operation of the system, and maintenance.

Wastewater treatment systems are meant to reduce the negative impact that humans have on the environment. The purpose of the system is to treat and disinfect ...


Modeling Unconventional Water Production In The Northeast Elm Coulee Field, Bakken Formation, Jan Branning 2020 Montana Tech

Modeling Unconventional Water Production In The Northeast Elm Coulee Field, Bakken Formation, Jan Branning

Graduate Theses & Non-Theses

Wells within the Northeast (NE) Elm Coulee produce significantly higher water cuts than wells within Elm Coulee Proper. The purpose of this work was to identify the source of produced water in the NE Elm Coulee. An area within the NE Elm Coulee was selected for a numerical flow simulation analysis, and a total of three models of the project area were constructed by isolating production mechanisms to determine the source of produced water in the NE Elm Coulee. A Separate Tank model was constructed to determine if the source of the produced water was matrix water saturation in the ...


Fabrication Of Composite Membranes For Solar-Thermal Desalination, Andrew Mason, Mahdi Mohammadighaleni, Siamak Nejati 2020 University of Nebraska - Lincoln

Fabrication Of Composite Membranes For Solar-Thermal Desalination, Andrew Mason, Mahdi Mohammadighaleni, Siamak Nejati

UCARE Research Products

With rising human populations, the demand for freshwater is an ever-growing problem. One emerging technology to combat this problem is membrane distillation (MD). MD has several advantages for water desalination such as:

•100% rejection of solute (salt, heavy metals, etc.) •Mergeable with other affordable energy sources (solar heat, electric resistance, etc.)

However, at the moment the specific energy consumption (SEC) of MD is very high due to low water production rates and large energy inputs to heat water. In a solar-assisted design for MD, the high cost of solar collectors (~$200/m2) inhibits low cost of water production in comparison ...


Tunable Luminescence Of Rare Earth Doped Nanophosphors Via Adaptive Optical Properties Of Transition Metals, Pragathi Darapaneni 2020 Louisiana State University

Tunable Luminescence Of Rare Earth Doped Nanophosphors Via Adaptive Optical Properties Of Transition Metals, Pragathi Darapaneni

LSU Doctoral Dissertations

Over the past decades, the development of light-emitting diodes (LEDs) to produce a wide range of wavelengths has revolutionized the solid-state lighting industry due to their higher energy efficiency and operational lifetimes. These LEDs employ rare earth (RE) doped phosphors due to their stable emission wavelengths which can be amplified when sensitized by other RE dopants (Yb, Ce) or shell layer passivation. However, there has been a push to replace the RE elements in LEDs due to increased socioeconomic issues. One proposed alternative, transition metal (TM) dopants, is typically avoided due to their susceptibility to the local crystal environment resulting ...


Evaluating Lignin Valorization Via Pyrolysis And Vapor-Phase Hydrodeoxygenation For Production Of Aromatics And Alkenes, Alireza Saraeian, Alvina Aui, Yu Gao, Mark M. Wright, Marcus Foston, Brent H. Shanks 2020 Iowa State University

Evaluating Lignin Valorization Via Pyrolysis And Vapor-Phase Hydrodeoxygenation For Production Of Aromatics And Alkenes, Alireza Saraeian, Alvina Aui, Yu Gao, Mark M. Wright, Marcus Foston, Brent H. Shanks

Chemical and Biological Engineering Publications

Lignin valorization to chemicals is an important component of creating economically viable biofuels production from lignocellulosic biomass. Any such strategy should aim at producing chemicals used at scales that can appropriately match lignin availability. Herein, a combined pyrolysis and low-pressure hydrodeoxygenation (HDO) process configuration is proposed to achieve total oxygen removal and obtain hydrocarbon (aromatic and alkene) products. This approach is tested for its robustness for lignin feedstocks obtained from a variety of sources and extracted using different procedures. The experimental results demonstrate that regardless of the lignin source, the HDO process using a MoO3 catalyst was able to funnel ...


The Effect Of Oxygen On Properties Of Zirconium Metal, Jie ZHAO 2020 University of Massachusetts Amherst

The Effect Of Oxygen On Properties Of Zirconium Metal, Jie Zhao

Doctoral Dissertations

The influence of oxygen on the thermophysical properties of zirconium has been investigated using MSL-EML (Material Science Laboratory Electromagnetic Levitator) on ISS (International Space Station) in collaboration with NASA (National Aeronautics and Space Administration), ESA (European Space Agency), and DLR (German Aerospace Center). Zirconium samples with different oxygen concentrations was subjected to multiple melt cycles during which the thermophysical properties, such as density, viscosity and surface tension, have been measured at various undercooled and superheated temperatures. Also, there are melt cycles for verifying the solidification mechanism. Similar samples were found to show anomalous nucleation of the solid for certain ranges ...


Surface Driven Flows : Liquid Bridges, Drops And Marangoni Propulsion, Samrat Sur 2020 University of Massachusetts Amherst

Surface Driven Flows : Liquid Bridges, Drops And Marangoni Propulsion, Samrat Sur

Doctoral Dissertations

Molecules sitting at a free liquid surface against vacuum or gas have weaker binding than molecules in the bulk. The missing (negative) binding energy can therefore be viewed as a positive energy added to the surface itself. Since a larger area of the surface contains larger surface energy, external forces must perform positive work against internal surface forces to increase the total area of the surface. Mathematically, the internal surface forces are represented by surface tension, defined as the normal force per unit of length. One common manifestation of surface tension is the difference in pressure it causes across a ...


Investigation Of Tracer-Surfactant-Foam Processes In Shallow Subsurface Environmental Remediation: History-Matching And Performance Prediction, Hazem Fleifel 2020 Louisiana State University and Agricultural and Mechanical College

Investigation Of Tracer-Surfactant-Foam Processes In Shallow Subsurface Environmental Remediation: History-Matching And Performance Prediction, Hazem Fleifel

LSU Master's Theses

In-situ subsurface remediation has been widely used as an efficient means of cleaning up non-aqueous phase liquid (NAPL) from contaminated soils and aquifer. The use of tracer, surfactant, and foam are often considered to keep track of the propagation of injected fluids in the medium, dissolve and mobilize contaminants trapped by capillary forces, and overcome the level of heterogeneity and improve displacement and sweep efficiencies.

This study shows an actual remediation process to reduce NAPL within a military base in South Korea, by injecting tracer and surfactant solutions together for a duration of 10 days. The site consists of 5 ...


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