Parallel Synthesis And High Throughput Dissolution Testing Of Biodegradable Polyanhydride Copolymers, 2018 National Institute of Standards and Technology
Parallel Synthesis And High Throughput Dissolution Testing Of Biodegradable Polyanhydride Copolymers, Brandon M. Vogel, Joao T. Cabral, Naomi Eidelman, Balaji Narasimhan, Surya K. Mallapragada
Brandon M Vogel
We have demonstrated that polycondensation reactions can be carried out in a combinatorial fashion and that the polymer library can be screened at high throughput using a rapid prototyping technique to fabricate multiwell substrates. A linearly varying compositional library of 100 different biodegradable polyanhydride random copolymers that are promising carriers for controlled drug delivery was designed, fabricated, and characterized by IR microscopy within a few hours. The polyanhydride copolymer library was based on 1,6-bis(p-carboxyphenoxy)hexane (CPH) and sebacic anhydride (SA) and was characterized with infrared microspectroscopy to determine the composition within each well. Since degradation and release rates ...
Surface Engineering And Monomer Design For Light-Mediated Ring Opening Metathesis Polymerization, 2018 University of Kentucky
Surface Engineering And Monomer Design For Light-Mediated Ring Opening Metathesis Polymerization, Ishan A. Fursule
Theses and Dissertations--Chemical and Materials Engineering
Stimuli-responsive materials are changing the landscape of actuated materials, optoelectronics, molecular machines, solar cells, temporary memory storage, and biomedical materials. Specifically, photo-responsive polymers have gained acceleration in research and application since the last two decades in the form of a surface coating and micro-patterns. Light as a stimulus can be coherent, mono or polychromatic, tunable for power (intensity) and energy (wavelength), and has precise spatiotemporal control. Conventional surface coating techniques such as spin coating are unable to impart properties to the coatings in terms of sturdiness, homogeneity, uniformity over the complex surface, post deposition modification, and process efficiency. Also, in ...
Responsive Pentablock Copolymers For Sirna Delivery, 2017 Iowa State University
Responsive Pentablock Copolymers For Sirna Delivery, Surya K. Mallapragada, Metin Uz, Sacide Alsoy Altinkaya
Surya K. Mallapragada
In this study, temperature and pH responsive cationic and amphiphilic pentablock copolymers, which consist of the temperature responsive triblock Pluronic F127 sandwiched between pH responsive PDEAEM (poly(2-diethylaminoethyl methacrylate)) end blocks, were used for the first time in the development of polyplex and gold nanoparticle (AuNP) based multicomponent siRNA delivery systems (MCSs). Copolymers in both systems protected siRNA from external effects, provided cell entry and endosomal escape. The thermoreversible micellization of the hydrophobic PPO block facilitated the cellular entry while the PDEAEM blocks enhanced the endosomal escape through protonated tertiary amine groups by pH buffering. The synergistic advantages of the ...
Spray-Dried Cellulose Nanofibril-Reinforced Polypropylene Composites For Extrusion-Based Additive Manufacturing, 2017 The University of Maine
Spray-Dried Cellulose Nanofibril-Reinforced Polypropylene Composites For Extrusion-Based Additive Manufacturing, Lu Wang
Electronic Theses and Dissertations
Compared to conventional manufacturing process, additive manufacturing (AM) offers free-form design, lighter and more ergonomic products, short lead time and less waste. Extrusion-based AM can be used to print thermoplastics. However, extrusion-based AM has processing challenges in printing semi-crystalline thermoplastics, for instance, polypropylene (PP). Cellulose nanofibrils (CNF) are one type of cellulose nanofibers that are produced from pulp fibers. CNF has extraordinary properties which make it an ideal candidate to reinforce polymers. Spray-dried CNF (SDCNF) is able to be incorporated into thermoplastic matrices without modifying conventional processing procedures.
The mechanical properties of 3D printed plastic parts have been considered significantly ...
Comparison Study Between Post-Fermentation Stillage And Pre-Fermentation Mash Utilizing Acidification And Steam Explosion Techniques For Cellulose Saccharification, 2017 The University of Southern Mississippi
Comparison Study Between Post-Fermentation Stillage And Pre-Fermentation Mash Utilizing Acidification And Steam Explosion Techniques For Cellulose Saccharification, Daniel Mckee
Pre-fermentation mash fiber and post-distillation stillage fiber were examined and compared using a variety of preparatory techniques to determine the better source for cellulose fiber saccharification. Once screened, dried, and diluted to a 10% solution, mash fiber and stillage fiber were exposed to increasing temperatures for steam explosion techniques as well as increasing acidification techniques. Both underwent enzymatic saccharification to convert the exposed cellulose to glucose and other sugars. Once the optimum steam explosion technique parameters and acidification parameters were determined to be 2.5% sulfuric acid at 127.8°C for 1 hour, a comparison of the saccharification of ...
Development Of Starch-Polyvinyl Alcohol (Pva) Biodegradable Film: Effect Of Cross-Linking Agent And Antimicrobials On Film Characteristics, 2017 Agricultural and Food Engineering Department, Indian Institute of Technology, Kharagpur
Development Of Starch-Polyvinyl Alcohol (Pva) Biodegradable Film: Effect Of Cross-Linking Agent And Antimicrobials On Film Characteristics, Aniket Satish More, Chandani Sen, Madhusweta Das
Journal of Applied Packaging Research
To satisfy the need of developing eco-friendly flexible antimicrobial packaging film with minimum use of synthetic chemical ingredients, the present study examined the efficacy of citric acid (CA) as cross-linking agent and essential oils (EOs), viz., cinnamon essential oil (CEO) and oregano essential oil (OEO) as natural antimicrobials in corn starch-polyvinyl alcohol (CS-PVA) film. Compared to film prepared from filmogenic solution (FS) containing 75 kg CS+8.75 kg PVA+24.6 kg glycerol per m3 FS, film additionally containing CA at 0.07 kg/kg CS indicated 95% higher ultimate tensile strength (UTS) and 27% lower water vapor ...
Creating Renewable Tunable Polymers From Hydroxymethylfurfural, 2017 University of Maine
Creating Renewable Tunable Polymers From Hydroxymethylfurfural, Meredith C. Allen
Electronic Theses and Dissertations
The research here deals with the conversion of 5-hydroxymethylfurfural (HMF) into a tunable polymer. HMF is a known derivative that can be acquired from biomass via hydrolysis of cellulose followed by isomerization and finally selective dehydration. The process considered here is being developed to create tunable polymers from HMF and involves several different steps, three of which are covered here. The first step, an etherification, is the reaction of HMF with an alcohol. This step is significant because in this step the R-group from the alcohol is added to HMF and the branching portion formed is carried over to the ...
Cellulose Reinforced Thermoplastic Composites By In-Situ Ring-Opening Polymerization, 2017 University of Southern Mississippi
Cellulose Reinforced Thermoplastic Composites By In-Situ Ring-Opening Polymerization, Shahab Kashani Rahimi
Over the past two decades, the increasing concern about the negative environmental impacts of synthetic materials has led to rising interests in utilizing renewable natural resources to develop polymer materials with comparable properties and performance to their synthetic counterparts. One of the major fields of interest is polymer composites where the replacement of synthetic fibers with bio renewable natural fibers is of great potential. However, the processing difficulties, in terms of fiber dispersion and thermal stability have limited the application of cellulosic fibers to polymers with low processing temperatures which are mostly hydrophobic polymers. As a result, the true reinforcing ...
Book Review: Controlled And Living Polymerizations: From Mechanisms To Applications, 2017 Iowa State University
Book Review: Controlled And Living Polymerizations: From Mechanisms To Applications, Jennifer M. Heinen
Jennifer M. Heinen
Controlled/living polymerization makes it possible to synthesize polymers of low polydispersity with a predefined molecular weight and specified chain architecture. Such polymers are desirable for a broad range of applications, including coatings, adhesives, and lubricants. Although living polymerization was first discovered in anionic polymerizations in 1956, several decades passed prior to the development of living polymerization techniques for carbocationic polymerization (1984) and ring-opening metathesis polymerization (1986). During the 1990s, several techniques were developed for controlled/living free radical polymerizations. The development of these techniques led to a dramatic increase in the number of research publications dedicated to improving the ...
Drawing And Twisting Of Graphene Fibers, 2017 California Polytechnic State University, San Luis Obispo
Drawing And Twisting Of Graphene Fibers, Gregory T. Lane, Robert J. Sekerak, Isaias Diaz
The aim of this project was to develop a more automated process for drawing and twisting of graphene fibers than was currently in place. This was implemented by having two chemical baths with variable speed rollers at either end, and intermediate roller to spool fiber between stages, and a twisting cylinder with integral spool to twist the fiber as it is collected. The goal was to have this first iteration deliver a working prototype, however due to manufacturing delays and timing constraints, that will be missed. A second follow-on project would be able to continue the work presented here and ...
An Industrial Process For The Production Of Nylon 6 6 Through The Step-Growth Reaction Of Adipic Acid And Hexamethylenediamine, David Wallace Jacobson
Chemical Engineering Undergraduate Honors Theses
A continuous, two stage, four reactor system process is presented here for the proposed purpose of nylon 6 6 manufacture at the rate of 85 million lbs per year. Report components include: process descriptions, simulation methods and results, economic analysis, EH&S considerations, process control descriptions, and a general recommendation for how to proceed with plans enclosed. The general design of the plant is a two stage system composed of one PFR used for the formation of nylon salt and low molecular weight nylon chains, followed by three CSTR’s used for increasing nylon molecular weight. The overall process has ...
Photoactive Properties Of Nanostructured Titania Modified Polyurethanes, 2017 The University of Western Ontario
Photoactive Properties Of Nanostructured Titania Modified Polyurethanes, Chao Chen
Electronic Thesis and Dissertation Repository
In order to enhance both the photoactivity and physical/mechanical properties of titania/polyurethane (PU) nanocomposites, in-situ polymerization and film casting were investigated. Both self-degrading PU foams and self-cleaning PU coatings were prepared. Functional monomers were prepared usingDMPA (2,2-dimethylolpropionic acid) functionalized anatse TiO2 and P25 for integration into polyurethane foam with a "grafting-from" synthetic method. This technique was found to successfully reduce the agglomeration effect of titania nanoparticles inside the foams. In addition, the photodegradation rate was enhanced by > 120% over unmodified foam at an optimized loading of 3wt% DMPA functionalized anatase TiO2. The presence of DMPA ...
Evaluating The Bond Behavior Between Frp And Grooved Concrete Specimens Using Single Shear Pull Out Test, 2017 Marquette University
Evaluating The Bond Behavior Between Frp And Grooved Concrete Specimens Using Single Shear Pull Out Test, John Omboko
Master's Theses (2009 -)
Surface preparation affects the bond behavior between Fiber Reinforcing Polymer (FRP) composite material and concrete. In this research, a special type of surface preparation known as grooving, which involves cutting transverse grooves, is conducted on concrete blocks (specimens) that are categorized as either Unfilled (U) or Filled (F). This idea is to ascertain how the grooves affect the strength of FRP-bonded-concrete specimen. These two categories are then benchmarked to control (C) specimens which do not have grooves on them. Category U specimens only have the epoxy applied on the concrete surface while category F specimens have epoxy applied on both ...
High-Density Non-Fouling Bioactive Coatings: Development And Characterization, 2017 Oregon State University
High-Density Non-Fouling Bioactive Coatings: Development And Characterization, Bonan Yu, Ramya Raman, Karl Schlike
Biomedical Engineering Western Regional Conference
No abstract provided.
Producing Food Packaging Printing Ink Via Green Emulsion Aggregation Method, 2017 Department of Printing Science and Technology, Institute for Color Science and Technology
Producing Food Packaging Printing Ink Via Green Emulsion Aggregation Method, Maryam Ataeefard, Shohre Rouhani
Journal of Applied Packaging Research
Digital printing will become more and more important in the packaging industry. Digital printing technology is growing because it allows the print suppliers to improve the level of service they offering to their customers, as well as, it opens new opportunities and helps them to make more money. Additives, dyestuffs, resin and other chemicals in packaging printing ink may influence safety of the food. Therefore, choosing suitable materials are very important in food packing ink. Over the last years, many printing ink manufacturers moved toward more sustainable inks. Drivers for this development, besides the resource scarcity and a higher legislative ...
Design Of Rubber Extraction Process From Tks Dandelion, 2017 The University of Akron
Design Of Rubber Extraction Process From Tks Dandelion, Trevor A. Cody
Honors Research Projects
A design was developed for a controlled environment agriculture 3D greenhouse to grow and harvest TKS dandelions, as well as a processing plant to extract natural rubber and inulin from the roots. The design capacity was scaled for both pilot- and full-scale production: 100 and 100,000 tonnes of natural rubber per year, respectively. The byproducts of the process were dandelion greens, inulin, cellulose, and glucose; all of these except for cellulose were able to be valorized. The greenhouse was designed based on existing 3D hydroponic growing environments, and the extraction process was designed based on the original TKS dandelion ...
Characterization Of Polyurethane For Use As Substrate In Nanofiber Sensor For Biomedical Applications, 2017 The University of Akron
Characterization Of Polyurethane For Use As Substrate In Nanofiber Sensor For Biomedical Applications, Megan Theaker
Honors Research Projects
The purpose of this project is to begin to determine properties of polymer nanocomposites that make a suitable substrate for nanofiber sensors. In this work, sensitivity of a sodium ion selective sensor constructed with polyurethane was used as a benchmark for comparison with sensors constructed with nylon-6. The sensors were characterized using contact angle and chronoamperometry. Using an ANOVA analysis, the results showed that the multi-walled carbon nanotube type was a significant factor on sensor response both with and without additional functionalization of the polymer by calixarene. The weight percentage of polyurethane in the electrospinning solution was also statistically significant ...
Functionalization Of Silver Nanoparticles On Membranes And Its Influence On Biofouling, 2017 University of Kentucky
Functionalization Of Silver Nanoparticles On Membranes And Its Influence On Biofouling, Conor G. Sprick
Theses and Dissertations--Chemical and Materials Engineering
Ultrafiltration (UF) processes are often used as pretreatment before more retentive/costly processes, such as nanofiltration and reverse osmosis. This study shows the results of low-biofouling nanocomposite membranes, loaded with casein-coated silver nanoparticles (casein-Ag-NPs). Membranes were cast and imbedded with Ag-NPs using two approaches, physical blending of Ag-NPs in the dope solution (PAg-NP/CA membranes) and chemical attachment of Ag-NPs to cast membranes (CAg-NP/CA membranes), to determine their biofouling control properties. The functionalization of Ag-NPs onto the CA membranes was achieved via attachment with functionalized thiol groups with the use of glycidyl methacrylate (GMA) and cysteamine chemistries ...
Stability And Retention Enhancement Of Low Fouling Polystyrene Sulfonic Acid (Pss) And Polyethylene Glycol (Peg) Blend Films With Silane Coupling Agents, Sean Stybel
Honors Research Projects
The goal of this research project was to apply silane coupling agents for enhanced stability and retention of a low fouling polymeric coating to an inorganic substrate. A blend of polystyrene sulfonic acid (PSS) and polyethylene glycol (PEG) was crosslinked in order to create a low fouling film. The film was prepared by spin coating a PSS-PEG solution on an inorganic substrate coated with a layer of a silane coupling agent (3-aminopropyltriethoxysilane, APTES, solution), followed by thermal curing. The research was limited to less than one year and only used lab equipment available at the University of Akron. Stability and ...
Uses For Graphene, 2017 Parkland College
Uses For Graphene, Marcus R. Schmidt
Natural Sciences Poster Sessions
This slide presentation for the Natural Sciences Poster Session at Parkland College discusses graphene, which is a chemically or mechanically produced single layer of pure carbon atoms. The thinnest compound known to man is also one of the strongest, with uses in technology and the health industry from faster charging batteries to motorcycle helmets. The remaining slides summarize a process by which free radicals are reduced in graphene by being treated with butyl acrylate polymerization.