Examining The Interaction Of Neonatal Alcohol And Hypoxia In Vitro,
2013
University of Kentucky
Examining The Interaction Of Neonatal Alcohol And Hypoxia In Vitro, Megan L. Carter
Theses and Dissertations--Psychology
Exposure to ethanol (ETOH) during fetal development results in a range of cognitive/behavioral deficits. There are differences in sensitivity to the effects of ETOH that could be explained by other factors, such as hypoxia. Similar mechanisms of damage underlie both ETOH, more specifically ETOH withdrawal, and hypoxia. Based on this overlap, it was hypothesized that sub threshold levels of these insults may interact to produce increased damage in sensitive brain regions. This study used a rodent organotypic hippocampal slice culture model to investigate the interaction of hypoxia and ETOH withdrawal and to determine possible developmental differences in the sensitivity to …
Expression Of Borderline Personality Disorder Symptoms Across The Ovulatory Cycle: A Multilevel Investigation,
2013
University of Kentucky
Expression Of Borderline Personality Disorder Symptoms Across The Ovulatory Cycle: A Multilevel Investigation, Tory A. Eisenlohr-Moul
Theses and Dissertations--Psychology
Borderline Personality Disorder (BPD) is a disabling condition characterized by chronic emotion dysregulation and behavioral impulsivity. Prospective studies that test proposed mechanisms of within-person change in BPD hold the key to improving symptom predictability and control in this disorder. A small body of evidence suggests that fluctuations in estradiol such as those occurring naturally at ovulation during the monthly female reproductive cycle may increase symptoms in women with BPD (DeSoto et al., 2003). Furthermore, there is preliminary evidence that both self-esteem and feelings of social rejection are highest at ovulation, when estradiol peaks (Durante and Hill, 2009; Eisenlohr-Moul et al., …
Characterizing Consumption, Dependence, And The Role Of Glucocorticoids In An Animal Model Of Voluntary Ethanol Consumption,
2013
University of Kentucky
Characterizing Consumption, Dependence, And The Role Of Glucocorticoids In An Animal Model Of Voluntary Ethanol Consumption, Lynda Sharrett-Field
Theses and Dissertations--Psychology
Alcohol abuse disorders (AUD) represent a serious worldwide health problem with far reaching social, financial, and interpersonal implications. One of the most devastating facets of these disorders is the propensity to relapse following periods of abstinence. Ethanol withdrawal (EWD) is believed to promote relapse by increasing anxiety and craving, and may contribute to the development of cognitive decline associated with long-term dependence. Clinical data suggest that stress also plays a main role in both the development of AUD as well as relapse to drinking. As a physiological stressor, EtOH elevates levels of stress hormones (cortisol in humans, corticosterone (CORT) in …
Prenatal Stress, Depression, And Herpes Viral Titers,
2013
University of South Florida
Prenatal Stress, Depression, And Herpes Viral Titers, Pao-Chu Hsu
USF Tampa Graduate Theses and Dissertations
Recent studies suggest that some cases of prenatal depression may be associated with reactivation of latent infections of the herpesvirus family. The possible relationships among stress, prenatal depression, and herpes viral reactivation in pregnancy are understudied and the molecular pathways such as the neuroimmune biogenic amine pathway are unidentified. Chronic stress shifts the T helper-1 cell (Th1) cytokine profile to a Th2 profile, which favors virus induced pathogenesis and survival. Pregnancy is also associated with a similar Th2 dominance. In non-pregnant individuals, exposure to psychological or physical stress may be associated with latent herpes viral reactivation and could result in …
Placental Corticotropin-Releasing Hormone Mediates The Association Between Prenatal Social Support And Postpartum Depression,
2013
Chapman University
Placental Corticotropin-Releasing Hormone Mediates The Association Between Prenatal Social Support And Postpartum Depression, Jennifer Hahn-Holbrook, Christine Dunkel Schetter, Chander Arora, Calvin J. Hobel
Psychology Faculty Articles and Research
Three decades of research point to both biological and psychological risk factors for postpartum depression, but very little research integrates the two. This study bridged this gap by testing whether prenatal social support predicted depressive symptoms at 8 weeks postpartum in a multiethnic sample of 210 women and whether the stress hormone placental corticotropinreleasing hormone (pCRH), measured at 19, 29, and 37 weeks’ gestation, mediated this relationship. We found that prenatal family support predicted significantly fewer depressive symptoms postpartum and more gradual increases in pCRH from 29 to 37 weeks’ gestation. Furthermore, steeper increases in pCRH during this same period …
Effects Of Neonatal Hypoxic Ischemic Brain Injury On Spatial Working Memory,
2012
University of Connecticut
Effects Of Neonatal Hypoxic Ischemic Brain Injury On Spatial Working Memory, Amanda L. Smith
Master's Theses
Children born prematurely or at very low birth weight (VLBW) have an increased risk for hypoxic ischemic brain injury (HI). HI refers to a lack of adequate blood and oxygen flow in the brain. HI can also occur in the term infant due to birth complications such as prolonged labor, placental dysfunction, or cord prolapse. In both populations (though exact patterns of neuropathology vary) brain damage is likely to occur in the form of decreased hippocampal and cortical volume, and enlargement of the ventricles (Kesler et al., 2004, Nagy et al., 2009). Resulting neuropathology can in turn lead to cognitive …
Autonomic And Behavioral Reactivity To An Acute Laboratory Stressor,
2012
LSU New Orleans
Autonomic And Behavioral Reactivity To An Acute Laboratory Stressor, Jeremy C. Peres
LSU New Orleans Theses and Dissertations
Stress has been widely shown to directly influence people’s emotional and behavioral processing as well as their underlying biological systems. This project examined physiological and behavioral responses as indicators of stress and coping in the context of a psychosocial stressor in a controlled laboratory setting. We examined the association between indicators of behavioral coping and underlying physiological reactivity within participants while experiencing stress. Participants included 68 emerging adults. Physiological measures include autonomic biomarkers (e.g., heart-rate, skin conductance) at rest and during the stressor while behavioral indicators that were coded include acute verbal and non-verbal actions exhibited by participants during the …
Distinct Retinohypothalamic Innervation Patterns Predict The Developmental Emergence Of Species-Typical Circadian Phase Preference In Nocturnal Norway Rats And Diurnal Nile Grass Rats,
2012
University of Iowa
Distinct Retinohypothalamic Innervation Patterns Predict The Developmental Emergence Of Species-Typical Circadian Phase Preference In Nocturnal Norway Rats And Diurnal Nile Grass Rats, William D. Todd, Andrew J. Gall, Joshua A. Weiner, Mark S. Blumberg
Faculty Publications
How does the brain develop differently to support nocturnality in some mammals, but diurnality in others? To answer this question, one might look to the suprachiasmatic nucleus (SCN), which is entrained by light via the retinohypothalamic tract (RHT). However, because the SCN is more active during the day in all mammals studied thus far, it alone cannot determine circadian phase preference. In adult Norway rats (Rattus norvegicus), which are nocturnal, the RHT also projects to the ventral subparaventricular zone (vSPVZ), an adjacent region that expresses an in-phase pattern of SCN-vSPVZ neuronal activity. In contrast, in adult Nile grass rats (Arvicanthis …
Asymmetry In Resting Alpha Activity: Effects Of Handedness,
2012
Montclair State University
Asymmetry In Resting Alpha Activity: Effects Of Handedness, Ruth E. Propper, Jenna Pierce, Mark W. Geisler, Stephen D. Christman, Nathan Bellorado
Department of Psychology Faculty Scholarship and Creative Works
Frontal electroencephalographic (EEG) alpha band power during rest shows increased right, and/or decreased left, hemisphere activity under conditions of state or trait withdrawal-associated effect. Non-right-handers (NRH) are more likely to have mental illnesses and dispositions that involve such withdrawal-related effect. The aim of the study was to examine whether NRH might be characterized by increased right, relative to left, hemisphere activity during rest. Methods: The present research investigated that hypothesis by examining resting EEG alpha power in consistently-right-handed (CRH) and NRH individuals. Results: In support of the hypothesis, NRH demonstrated decreased right hemisphere alpha power, and therefore increased right hemisphere …
Development Of Scn Connectivity And The Circadian Control Of Arousal: A Diminishing Role For Humoral Factors?,
2012
Hope College
Development Of Scn Connectivity And The Circadian Control Of Arousal: A Diminishing Role For Humoral Factors?, Andrew J. Gall, William D. Todd, Mark S. Blumberg
Faculty Publications
The suprachiasmatic nucleus (SCN) is part of a wake-promoting circuit comprising the dorsomedial hypothalamus (DMH) and locus coeruleus (LC). Although widely considered a "master clock," the SCN of adult rats is also sensitive to feedback regarding an animal's behavioral state. Interestingly, in rats at postnatal day (P)2, repeated arousing stimulation does not increase neural activation in the SCN, despite doing so in the LC and DMH. Here we show that, by P8, the SCN is activated by arousing stimulation and that selective destruction of LC terminals with DSP-4 blocks this activational effect. We next show that bidirectional projections among the …
The Relationship Between Suicide Ideation And Parasuicide: An Electrophysiological Investigation Using The Loudness Dependence Of Auditory Evoked Potential,
2012
University of Southern Mississippi
The Relationship Between Suicide Ideation And Parasuicide: An Electrophysiological Investigation Using The Loudness Dependence Of Auditory Evoked Potential, Angelika Marsic
Dissertations
The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as a promising valid and a non-invasive indicator of behaviorally relevant central 5-HT functioning. There is limited research on the utility of the LDAEP in discriminating individuals who engage in various degrees of suicidal behavior. The primary purpose of the present study was to examine if the LDAEP, as a measure of central serotonergic functioning, can be useful in distinguishing groups of individuals who: (a) solely experience suicidal ideation (SI group); (b) experience suicidal ideation and have engaged in deliberate self-harm acts (SH group); and (c) individuals with …
The Effects Of An Online Sleep Hygiene Intervention On Students' Sleep Quality,
2012
Old Dominion University
The Effects Of An Online Sleep Hygiene Intervention On Students' Sleep Quality, Giuliana Farias
Psychology Theses & Dissertations
Students in college or in their first year of medical school undergo increased educational and social pressure. To cope, students may sacrifice sleep to meet demands. Poor sleep affects learning, performance, and health. Studies have been successful at improving sleep quality through the use of in-person recruitment or cognitive-behavioral therapy delivered over the internet (Trockel, Manber, Chang, Thurston, & Tailor, 2011). The purpose of the current study was to investigate whether an online sleep hygiene intervention could improve sleep quality. One hundred thirty-eight students from one undergraduate institution in Southeast Virginia completed this study. Students were divided into groups; one …
Physiological Politics: Stress And Dominance Responses To Political News,
2012
University of Connecticut
Physiological Politics: Stress And Dominance Responses To Political News, Erin Strauts
Master's Theses
No abstract provided.
Effect Of Nicotine On Body Composition,
2012
University of Texas at El Paso
Effect Of Nicotine On Body Composition, Laura O'Dell
Selected Works Temporary Series
No abstract provided.
Effect Of Nicotine On Body Composition,
2012
University of Texas at El Paso
Effect Of Nicotine On Body Composition, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
A Multigroup Analysis Of The Psychological Factors That Contribute To Persisting Working Attention Problems In Mild Traumatic Brain Injury And Chronic Pain,
2012
University of New Orleans
A Multigroup Analysis Of The Psychological Factors That Contribute To Persisting Working Attention Problems In Mild Traumatic Brain Injury And Chronic Pain, Kelly L. Curtis
LSU New Orleans Theses and Dissertations
A significant subset of mild traumatic brain injury (mild TBI) and chronic pain (CP) patients report, and sometimes show objective evidence of, persisting cognitive problems. Despite differences in injury mechanisms, there is considerable overlap in the types of persisting cognitive symptoms that are reported by the two populations. Psychogenic, rather than physiogenic, factors are thought to play an important role in the maintenance of these persisting symptoms. The current investigation examined the contributions somatization, depression, and anxiety had on an objective measure of “working attention.” In order to best elucidate the influences these psychological factors had on attentional performance, only …
The Effects Of Rhes, A Striatal Specific Protein, On The Expression Of Behavioral And Neuropathological Symptoms In A Transgenic Mouse Model Of Huntington's Disease,
2012
University of New Orleans
The Effects Of Rhes, A Striatal Specific Protein, On The Expression Of Behavioral And Neuropathological Symptoms In A Transgenic Mouse Model Of Huntington's Disease, Brandon A. Baiamonte
LSU New Orleans Theses and Dissertations
Huntington's disease (HD) is a neuropsychiatric disorder characterized by choreiform movement of the limbs, cognitive disability, psychosis and dementia. It is untreatable, incurable, and ultimately fatal. HD is invariably associated with an abnormally long CAG expansion within the IT15 gene on human chromosome 4. Although the mutant huntingtin protein (mHtt) is ubiquitously expressed in HD patients, cellular degeneration occurs only in neurons within the striatum and cerebral cortex. The Ras homolog Rhes is expressed very selectively in the precise brain areas affected by HD. Recent work using cultured cells suggests that Rhes may be a co-factor with mHtt in cell …
Sleep Deprivation And Delusion Proneness: Influence On Dream Bizarreness,
2012
Butler University
Sleep Deprivation And Delusion Proneness: Influence On Dream Bizarreness, Anna Leigh Lezon
Undergraduate Honors Thesis Collection
While evidence for many types of psychotic experience exists in the general population, dreams have been a particularly prominent model for hallucinations and delusions in otherwise healthy individuals. This definition of "bizarreness" in dreams mirrors the description of psychosis in schizophrenia patients when their psychosis remits (Colace, 2003). Babkoff et al, (1989) found a linear association - less sleep caused more waking-state hallucinations. While the relationship between psychotic symptoms and sleep deprivation is well established, most existing data regard waking-state psychotic symptomology. The relationship between sleep deprivation and dream-state psychotic symptomology has not been investigated. Further, no sleep deprivation study …
Ketamine Can Disrupt Episodic Memory (Hours To Days) Consolidation: Effects Of Varying Dose And Retention Intervals,
2012
University of Connecticut - Storrs
Ketamine Can Disrupt Episodic Memory (Hours To Days) Consolidation: Effects Of Varying Dose And Retention Intervals, Ryan Darius Tabtabai
Honors Scholar Theses
Memory consolidation is the process wherein short-term, episodic memories are converted into stable, long-term representations. Forebrain N-methy-d-aspartate receptors (NMDARs), particularly frontal cortical and hippocampal receptors, are thought to play a key role in neuronal plasticity and memory consolidation. Ketamine is an NMDA antagonist that disrupts memory, particularly encoding and retrieval processes. Previously we have observed no effect of post-acquisition ketamine treatment (50-100 mg/kg) on memory consolidation in rats performing a delayed-match-to place radial water maze task. The current study reexamined the effects of ketamine (25-100 mg/kg) on memory consolidation in this task over varying retention intervals (4, 24, and 48 …
Adenosine-Dopamine Interactions In The Open Field Arena: Studies Related To Locomotion And Anxiety,
2012
University of Connecticut - Storrs
Adenosine-Dopamine Interactions In The Open Field Arena: Studies Related To Locomotion And Anxiety, Rothem Kovner
Honors Scholar Theses
Nucleus accumbens dopamine (DA) is an important regulator of locomotion. The neuromodulator adenosine also has a role in regulating locomotion. The adenosine A2A receptor subtype is colocalized with DA D2 receptors on medium spiny neurons in the striatum and nucleus accumbens. Interactions between adenosine A2A and DA D2 receptor antagonists are significant for regulating various aspects of motor and motivational function. The adenosine A2A antagonist MSX-3 has been shown to reverse the suppression of locomotion induced by the DA D2 antagonist eticlopride. The structure of MSX-3 was modified to produce the prodrug MSX-4 which has high oral …
