The Scientific Problems With Using Non-Human Animals To Predict Human Response To Drugs And Disease,
2019
Americans For Medical Advancement
The Scientific Problems With Using Non-Human Animals To Predict Human Response To Drugs And Disease, Ray Greek, Lisa A. Kramer
Pharmacology and Animal Models in Research Collection
Every year, and in countries around the world, significant time and resources are devoted to the noble cause of developing drugs to treat and cure human disease. With rare exception, drug interventions cannot reach commercialization without safety and efficacy having first been demonstrated in animal models. The intention of regulations, which require the use of animal models in such contexts, is to ensure that only safe and effective drugs end up being used by patients. Similarly, it is standard practice for researchers to employ animal models in their attempts to understand the way diseases present and progress in humans. Unfortunately, …
Modernizing Biomedical Training: Replacing Live Animal Laboratories With Human Simulation,
2019
Beth Israel Deaconess Medical Center
Modernizing Biomedical Training: Replacing Live Animal Laboratories With Human Simulation, John Pawlowski, David Feinstein, Marie L. Crandall, Shalin Gala
Biomedicine and Animal Models in Research Collection
This chapter reviews the global trend towards a modernization of biomedical education in favor of simulation-based training methods, which studies confirm improve student learning and transference of applied skills to clinical practice, reduce laboratory costs, and spare animals from harmful procedures.
Animal Research For Alzheimer Disease: Failures Of Science And Ethics,
2019
Physicians Committee for Responsible Medicine
Animal Research For Alzheimer Disease: Failures Of Science And Ethics, John J. Pippin, Sarah E. Cavanaugh, Francesca Pistollato
Biomedicine and Animal Models in Research Collection
This chapter addresses the epidemiology and current understanding of AD as a scientific and societal challenge, reviews the uses and results of animal research in basic science and drug development, and discusses risk factors and funding. Important follow-up topics, including current and in-development, human-relevant approaches for replacement of the failed animal research paradigm, deserve comparable treatment and hence are not addressed here. The reader is referred to the list of recommended readings at the end of the chapter for further discussion of these topics.
Behavioral Research On Captive Animals: Scientific And Ethical Concerns,
2019
Animal Defenders International
Behavioral Research On Captive Animals: Scientific And Ethical Concerns, Kimberley Jayne, Adam See
Morality and Ethics of Animal Experimentation Collection
The first half of this chapter focuses exclusively on animals that are used in laboratory behavioral research to model wild behavior, what is typically involved, problems associated with this practice, and how behavioral research has revealed scientific problems in the animal model. The second half of this chapter then addresses the ethical questions of whether scientific curiosity of animal behavior in general provides any justification for carrying out this research in this first place, with specific focus on non-human primates (nhps).
Ethics, Efficacy, And Decision-Making In Animal Research,
2019
University of California - San Diego
Ethics, Efficacy, And Decision-Making In Animal Research, Lawrence A. Hansen, Kori Ann Kosberg
Morality and Ethics of Animal Experimentation Collection
Few would disagree with the ethical contention that if cruelty to animals is not wrong, then nothing is wrong. In fact, it is not only wrong, but in most states in the us, it is a crime, a felony no less. And yet, intentionally inflicting pain and suffering upon animals, which meets Webster’s definition of cruelty, is routinely countenanced when vivisection (from the Latin vivi, to be alive, and secare, to cut) is performed under license for biomedical research. Deciding to embrace, or reject, or limit animal research demands our best ethical judgment; and it is complicated by factual disputes …
Elevated Sensitivity To Tactile Stimuli In Stereotypic Horses,
2019
Agroscope - Swiss National Stud Farm
Elevated Sensitivity To Tactile Stimuli In Stereotypic Horses, Sabrina Briefer Freymond, Déborah Bardou, Sandrine Beuret, Iris Bachmann, Klaus Zuberbühler, Elodie Briefer
Personality Collection
Although stereotypic behaviors are a common problem in captive animals, why certain individuals are more prone to develop them remains elusive. In horses, individuals show considerable differences in how they perceive and react to external events, suggesting that this may partially account for the emergence of stereotypies in this species. In this study, we focused on crib-biting, the most common stereotypy displayed by horses. We compared how established crib-biters (“CB” = 19) and normal controls (“C” = 18) differed in response to a standard “personality” assessment test battery, i.e., reactivity to humans, tactile sensitivity, social reactivity, locomotor activity, and curiosity …
Consequences And Management Of Canine Brachycephaly In Veterinary Practice: Perspectives From Australian Veterinarians And Veterinary Specialists,
2019
University of Sydney
Consequences And Management Of Canine Brachycephaly In Veterinary Practice: Perspectives From Australian Veterinarians And Veterinary Specialists, Anne Fawcett, Vanessa Barrs, Magdoline Awad, Georgina Child, Laurencie Brunel, Erin Mooney, Fernando Martinez-Taboada, Beth Mcdonald, Paul Mcgreevy
Professional Veterinary Ethics Collection
This article, written by veterinarians whose caseloads include brachycephalic dogs, argues that there is now widespread evidence documenting a link between extreme brachycephalic phenotypes and chronic disease, which compromises canine welfare. This paper is divided into nine sections exploring the breadth of the impact of brachycephaly on the incidence of disease, as indicated by pet insurance claims data from an Australian pet insurance provider, the stabilization of respiratory distress associated with brachycephalic obstructive airway syndrome (BOAS), challenges associated with sedation and the anaesthesia of patients with BOAS; effects of brachycephaly on the brain and associated neurological conditions, dermatological conditions associated …
Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions,
2019
University of Lisbon, Portugal
Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions, Constança Carvalho, Augusta Gaspar, Andrew Knight, Luís Vicente
Morality and Ethics of Animal Experimentation Collection
Basic and applied laboratory research, whenever intrusive or invasive, presents substantial ethical challenges for ethical committees, be it with human beings or with non-human animals. In this paper we discuss the use of non-human primates (NHPs), mostly as animal models, in laboratory based research. We examine the two ethical frameworks that support current legislation and guidelines: deontology and utilitarianism. While human based research is regulated under deontological principles, guidelines for laboratory animal research rely on utilitarianism. We argue that the utilitarian framework is inadequate for this purpose: on the one hand, it is almost impossible to accurately predict the benefits …
Just Preservation,
2019
University of Wisconsin-Madison
Just Preservation, A. Treves, F. J. Santiago-Ávila, W. S. Lynn
Anthropogenics and Population Decline Collection
We are failing to protect the biosphere. Novel views of conservation, preservation, and sustainability are surfacing in the wake of consensus about our failures to prevent extinction or slow climate change. We argue that the interests and well-being of non-humans, youth, and future generations of both human and non-human beings (futurity) have too long been ignored in consensus-based, anthropocentric conservation. Consensus-based stakeholder-driven processes disadvantage those absent or without a voice and allow current adult humans and narrow, exploitative interests to dominate decisions about the use of nature over its preservation for futurity of all life. We propose that authentically non-anthropocentric …
Protecting Biodiversity In British Columbia: Recommendations For Developing Species At Risk Legislation,
2019
Yellowstone to Yukon Conservation Initiative
Protecting Biodiversity In British Columbia: Recommendations For Developing Species At Risk Legislation, Alana R. Westwood, Sarah P. Otto, Arne Mooers, Chris Darimont, Karen E. Hodges, Chris Johnson, Brian M. Starzomski, Cole Burton, Kai M. A. Chan, Marco Festa-Bianchet, Shaun Fluker, Sumeet Gulati, Aerin L. Jacob, Dan Kraus, Tara G. Martin, Wendy J. Palen, John D. Reynolds, Jeannette Whitton
Threatened and Endangered Animal Populations Collection
British Columbia has the greatest biological diversity of any province or territory in Canada. Yet increasing numbers of species in British Columbia are threatened with extinction. The current patchwork of provincial laws and regulations has not effectively prevented species declines. Recently, the Provincial Government has committed to enacting an endangered species law. Drawing upon our scientific and legal expertise, we offer recommendations for key features of endangered species legislation that build upon strengths and avoid weaknesses observed elsewhere. We recommend striking an independent Oversight Committee to provide recommendations about listing species, organize Recovery Teams, and monitor the efficacy of actions …
Perceptions Of On-Farm Emergency Slaughter For Dairy Cows In British Columbia,
2019
University of British Columbia
Perceptions Of On-Farm Emergency Slaughter For Dairy Cows In British Columbia, Katherine E. Koralesky, David Fraser
Slaughter and Slaughtering Practices Collection
Some jurisdictions permit on-farm emergency slaughter (OFES) as one end-of-life option for dairy cows and other animals that cannot be transported humanely but are deemed fit for human consumption. Anecdotal reports suggest that OFES is controversial among dairy industry professionals, but to date their perceptions of OFES have not been studied systematically. Twentyfive individual interviews and 3 focus groups with 40 dairy producers, veterinarians, and other professionals in British Columbia, Canada, revealed positive and negative perceptions of OFES influenced by (1) individual values, (2) the perceived operational legitimacy of OFES, and (3) concern over social responsibility and public perception of …
The Impacts Of The City And County Of Denver’S Breed Specific Legislation,
2019
University of Denver
The Impacts Of The City And County Of Denver’S Breed Specific Legislation, Sloane M. Hawes, Devrim Ikizler, Katy Loughney, Justin F. Marceau, Philip Tedeschi, Kevin N. Morris
Speciesism and Breed Discrimination Collection
In August of 1989, the City and County of Denver, CO, USA enacted legislation that prohibits the presence of all “pit bull” type dogs (PBTD) (defined in Denver as: American Pit Bull Terrier, American Staffordshire Terrier, or Staffordshire Bull Terrier) within the city limits. In the 30 years the “pit bull ban” has been in place, the City and County of Denver and its animal control agency, Denver Animal Protection, have committed substantial resources to removing PBTDs from the community, including patrolling communities and/or responding to complaints made by neighbors, conducting thorough breed evaluations of suspected PBTDs, and kenneling PBTDs …
Carnivore-Livestock Conflicts In Chile: Evidence And Methods For Mitigation,
2019
Virginia Tech
Carnivore-Livestock Conflicts In Chile: Evidence And Methods For Mitigation, Valeska Rodriguez, Daniela A. Poo-Muñoz, Luis E. Escobar, Francisca Astorga, Gonzalo Medina-Vogel
Human–Wildlife Interactions
Human population growth and habitat loss have exacerbated human–wildlife conflicts worldwide. We explored trends in human–wildlife conflicts (HWCs) in Chile using scientific and official reports to identify areas and species with higher risk of conflicts and tools available for their prevention and mitigation. The puma (Puma concolor) was considered the most frequent predator; however, fox (Lycalopex spp.) and free-ranging or feral dog (Canis lupus familiaris) attacks were also common. Our results suggest that the magnitude of puma conflicts may be overestimated. Domestic sheep (Ovis spp.) and poultry (Galliformes) were the most common species predated. …
Size Estimation Of Pre‐Columbian Caribbean Fish,
2019
Muséum national d'Histoire naturelle
Size Estimation Of Pre‐Columbian Caribbean Fish, Sandrine Grouard, Sophia Perdikaris, Nídia Cristina Espíndola Rodrigues, Irvy R. Quitmyer
School of Global Integrative Studies: Faculty Publications
In this contribution, we present a methodological approach to the identification of pre‐Columbian Caribbean fisheries and examine the interrelationships of exploitation according to size for eight fish families, in a diachronic perspective for the Lesser Antilles. Based on the principles of size and growth allometries, biometric repositories have been reconstructed for modern families that represent different ecological environments: Holocentridae, Serranidae, Carangidae, Lutjanidae, Haemulidae, Scaridae, Acanthuridae, and Scombridae. The measured fish bone elements were selected based on their robustness and potential for recovery at archaeological sites. This resulted in a sample size totaling 563 modern osteological specimens, which provided reconstructed standard, …
A Non-Selective Serotonin Antagonist Promotes Rapid Habituation In The Terrestrial Hermit Crab,
2019
University of Mary Washington
A Non-Selective Serotonin Antagonist Promotes Rapid Habituation In The Terrestrial Hermit Crab, Kirandeep Sumra, W. David Stahlman
Psychological Science Articles
Research has indicated that serotonin (5-HT) modulates non-associative learning in a variety of invertebrate species. Recent work has demonstrated that the terrestrial hermit crab is a suitable animal model for non-associative learning phenomena, including habituation, sensitization, and dishabituation. We examined the potential role of a non-selective 5-HT antagonist, methysergide, in non-associative learning in the hermit crab. We administered methysergide prior to delivering repeated stimulus presentations of a looming visual predator. We found evidence for more rapid habituation relative to a control condition in which crabs did not receive the drug. These results indicate a role for 5-HT in the defensive …
A Multi-Scale Analysis Of Jaguar (Panthera Onca) And Puma (Puma Concolor) Habitat Selection And Conservation In The Narrowest Section Of Panama.,
2019
Antioch University of New England
A Multi-Scale Analysis Of Jaguar (Panthera Onca) And Puma (Puma Concolor) Habitat Selection And Conservation In The Narrowest Section Of Panama., Kimberly A. Craighead
Antioch University Dissertations & Theses
Over the past two centuries, large terrestrial carnivores have suffered extreme population declines and range contractions resulting from the synergistic anthropogenic threats of land-use change and indirect effects of climate change. In Panama, rapid land use conversion coupled with climate change is predicted to negatively impact jaguar (Panthera onca) and puma (Puma concolor). This dissertation examined the environmental variables and scales influencing jaguar and puma habitat selection by season (annual, wet, and dry), using multi-scale optimized habitat suitability models and a machine-learning algorithm (Random Forests), in the narrowest section of Panama. The models derived from the data of an intensive …
The Philosopher's Journey: A Chapter In Kindness And Animals,
2019
University of North Florida
The Philosopher's Journey: A Chapter In Kindness And Animals, Vaughn E. Sayers
UNF Undergraduate Capstone Projects and Honors Theses
We each are presented with a choice; do we remain in the cave of ignorance or embark on the philosopher’s journey. Your choice will determine the way in which you interpret this paper. However, I will confidently make the assumption that you, like myself, desire to embrace an existence guided by the light of wisdom. This thesis is one of many chapters in the philosopher’s journey, dealing with animals and (cutting through the jargon) kindness. I have found that a lot of scholarship on animal ethics acknowledges a truth, but does not acknowledge that the application of such a truth …
Psychologists' Use Of Dogs In Psychotherapy: A Therapeutic Exploration,
2019
Antioch University Seattle
Psychologists' Use Of Dogs In Psychotherapy: A Therapeutic Exploration, Christine A. Treece
Antioch University Dissertations & Theses
The current fund of literature documents the many benefits of using dogs as adjunct healing agents for both physical and psychological ailments. Despite the ever-growing body of research about dogs as adjunct interventions, there is a meager amount of information available about clinician’s experience of bringing their dogs to work with them. This dissertation is an in-depth exploration of six psychologists licensed in the state of Washington who brought their dogs with them to work. Each participant’s interview was analyzed using Interpretative Phenomenological Analysis. From their interviews, nine primary themes were identified: Reason for the Acquisition of Dog, Nature of …
Reconciling Just Preservation,
2019
University of Calgary
Reconciling Just Preservation, Shelley M. Alexander
Animal Sentience
Treves et al.’s target article can play an important role in reconciling the needs of future generations and non-human animals in conservation. Human capacities are adequate for interpreting and defining many non-human animal needs. Worldviews are more complex, however, and conservation science, like the target article itself, suffers from a lack of diversity and inclusiveness. This may pose practical impediments to realizing just preservation.
Sheep Are Sentient, But Not Identical,
2019
University College Dublin
Sheep Are Sentient, But Not Identical, Alison Hanlon
Animal Sentience
Marino & Merskin (M&M) provide a timely reminder that sheep have advanced cognitive abilities, but do we still have to provide evidence to justify animal sentience? In the EU, regulations are designed to support farm animal welfare. Whilst the regulations are imperfect, they do emphasize behavioural needs and other concepts relevant to sentience. The persistence of sheep welfare issues such as lamb mortality indicates that regulations may not be achieving their desired goal. We can quibble about the science described by M&M yet reach the same conclusion: sheep (lambs, ewes and rams) are not all identical, but they are all …
