Pharmacology, Toxicology and Environmental Health Commons^™

Indole Alkaloids From The Fruits Of Alstonia Scholaris(อินโดลแอลคาลอยด์จากผลของพญาสัตบรรณ), Sumphan Wongseripipatana, Lakhana Chaisri, Boonchoo Sritularak, Kittisak Likhitwitayawuid

The Thai Journal of Pharmaceutical Sciences

A MeOH extract prepared from the fruits of Alstonia scholaris, after acid-base treatment, gave a crude alkaloid extract which was then subjected to chromatographic separation to afford four indole alkaloids, namely 19-77-picrinine (l),19-A,-akuammidine (...

Author Index, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Mind, Brain, Body : Cognitive-Behavioral Therapy And Buddhist Concept(ร่างกาย สมอง และจิตใจ : ประซาน-พฤติกรรมบำบัดและแนวคิดเชิงพุทธ), Chamlong Disayavanish, Primprao Disayavanish

The Thai Journal of Pharmaceutical Sciences

Several studies have identified neural circuitry and signaling pathway of the brain that is involved in depression. Stress can cause cellular atrophy and suppress neurogenesis of neurons in the hippocampus resulting in the decrease of its volume. There i...

Development And Validation Of An Instrument To Assess The Attitudes Of Patients With Diabetes(การสร้างและทดสอบความตรงของเครื่องมือเพื่อใช้วัดทัศนคต..., Supakit Wongwiwatthananukit, Sarinee Krittiyanunt, Aunchalee Wannapinyo

The Thai Journal of Pharmaceutical Sciences

The purpose of this methodological study was to develop a reliable and valid instrument to assess attitudes of patients with diabetes. This study was implemented through three major steps: (1) instrument development, (2) expert review of the instrument, ...

Development And Validation Of An Instrument To Assess The General Knowledge Of Patients With Diabetes(การสร้างและทดสอบความตรงของเครื่องมือเพื่อใช้วัดควา..., Supakit Wongwiwatthananukit, Sarinee Krittiyanunt, Aunchalee Wannapinyo

The Thai Journal of Pharmaceutical Sciences

The purpose of this methodological study was to develop a reliable and valid instrument to assess the general knowledge of diabetic patients. The study was implemented through three major steps: (1) instrument development, (2) expert review of the instru...

Knowledge Of Emergency Contraceptive Pills Among Undergraduate Students In Bangkok(ความรู้เกี่ยวกับยาเม็ดคุมกำเนิดฉุกเฉินในนักศึกษาระดับปริญ..., Khemin Aimnoi, Wirangrong Taeborisutikul, Wirote Chuenbunngam, Sasithon Ngaechareankul, Watcharee Lermankul

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to ascertain the extent of knowledge and source(s) of information on emergency contraceptive (EC) pills among undergraduate students in Bangkok. The study was conducted in December 2003. Students from 10 of 37 possible institute...

Renal Effects Of Celecoxib And Naproxen In Elderly Patients(ผลต่อไตของยาซีลีคอกซิบและยานาพรอกเซนในผู้ป่วยสูงอายุ), Sungchai Angtharak, Sasiporn Dangthongdee, Wanchai Treyaprasert

The Thai Journal of Pharmaceutical Sciences

The purpose of this study was to compare renal effects between celecoxib and naproxen. The study was conducted in forty-eight elderly patients with musculoskeletal problems in Rheumatology Clinic at Rajavithi Hospital. Patients were treated with either n...

Modified Glutinous Starch As A Hydrophilic Matrix Substance(แป้งข้าวเหนียวดัดแปรเพื่อใช้เป็นสารเมทริกซ์ชนิดชอบน้ำ), Jomjai Peerapattana, Arom Tattawasart, Voranuch Srijesdaruk

The Thai Journal of Pharmaceutical Sciences

The aim of this study is to modify the glutinous starch for hydrophilic matrix substance. Glutinous starch from glutinous rice was therm ally modified using single screw extruder at the tem peratures of 75, 75 and 80°c for zone 1, 2 and 3, respectively....

Effect Of New Synthetic Acyl Aniline And Acyl Aminopyridine Derivatives On Contractility Of Rat Aorta(ผลของสารสังเคราะห์ชนิดใหม่ในกลุ่มเอซิลอะนิลีน และเอ..., Amonrat Khayungarnnawee, Prasan Dhumma-Upakom, Chamnan Patarapanich, Suree Jianmongkol

The Thai Journal of Pharmaceutical Sciences

A number of the synthetic acyl aniline derivatives and acyl aminopyridine derivatives were shown to influence contractility of the smooth muscle such as that of rat duodenum and aorta. Previous studies have shown that the effects of acyl-3-aniline deriva...

Antimalarial Drugs: A Current Situation(ยาต้านมาลาเรีย : สถานการณ์ปัจจุบัน), Nantana Sittichai

The Thai Journal of Pharmaceutical Sciences

Malaria occurs throughout most of the tropical countries. Integrated approaches for prevention of malaria include chemoprophylaxis and other measures. Over the last decade has found the emergence of drug-resistant malarial parasites, especially among Pla...

Do Recent Data From The Seychelles Islands Alter The Conclusions Of The Nrc Report On The Toxicological Effects Of Methylmercury?, Alan H. Stern, Joseph L. Jacobson, Louise Ryan, Thomas A. Burke

Wayne State University Associated BioMed Central Scholarship

Abstract

In 2000, the National Research Council (NRC), an arm of the National Academy of Sciences, released a report entitled, "Toxicological Effects of Methylmercury." The overall conclusion of that report was that, at levels of exposure in some fish- and marine mammal-consuming communities (including those in the Faroe Islands and New Zealand), subtle but significant adverse effects on neuropsychological development were occurring as a result of in utero exposure. Since the release of that report, there has been continuing discussion of the public health relevance of current levels of exposure to Methylmercury. Much of this discussion has been linked to …

Balancing Ease And Accuracy In Assessing Pharmaceutical Exclusion Payments, Mark D. Janis, Herbert Hovenkamp, Mark A. Lemley

Articles by Maurer Faculty

No abstract provided.

Diseases, Drugs, And Brain Plasticity: Lessons Learned From The Study Of Headache, Anan Srikiatkhachorn

The Thai Journal of Pharmaceutical Sciences

Plasticity of the nervous system is an important factor that determines the clinical presentation of several neurological conditions including headache and pain. In case of neuropathic pain, the sensitization and reorganization of neural circuitry involv...

บทคัดย่อ โปสเตอร์ นำเสนอในการประชุมเสนอผลงานวิจัยทางเภสัชศาสตร์ ครั้งที่ 21, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

The Diarrheic Shellfish Poisoning Toxins In Marine Environment Determined Using Liquid Chromatography - Mass Spectrometry Techniques, Patricia Fernández Puente

Theses

A highly specific and sensitive LC-MS/MS analytical method was developed and validated using gradient reversed phase liquid chromatography-tandem mass spectrometry (LC- MS/MS), interfaced using turbo-assisted electrospray ionisation (ESI) in negative mode for the analysis of DSP (okadaic acid (OA), dinophysistoxins (DTXs) and pectenotoxins (PTXs)) toxins in a variety of samples. There were no matrix effects present, proved by the good reproducibility achieved and the linearity of the calibration curves (r" > 0.999) in spiked mussel samples and standards. A DSP toxin profile study was conducted with bulk phytoplankton and mussels samples from the west coast of Ireland. All the samples were …

Depressive Disorders And Brain Plasticity, Surachai Unchern

The Thai Journal of Pharmaceutical Sciences

Previous hypotheses to explain the cause and treatment of depression have been based in part on the acute actions of antidepressants. However, the time lag for a therapeutic response has led to the hypothesis that adaptations to the acute actions of anti...

How Much Do We Pay For Medicines? A Drugstore Price Surveya Cross Thailand(ราคาขายของยา: การสำรวจราคายาจากร้านยาทั่วประเทศ), Puree Anantachoti, Chanpen Choompon, Boonsuchin Chatpitun, Rossukon Siwamutita

The Thai Journal of Pharmaceutical Sciences

Products and services that serve fundamental needs, including medicines, are normally price controlled. The Ministry of Commerce required that all drug prices be declared and monitored. However, most declared drug prices are much higher than actual price...

Effect Of Factors On Cell Culture Used In Potency Test Of Viral Vaccines(ป้จจัยที่มีผลต่อเซลล์เพาะเลี้ยงที่ใช้ในการตรวจสอบความแรงของว..., Supapom Phumiamom, Sakalin Trisiriwanich, Choompon Noktong, Komnika Kullabutr, Teeranart Jivapaisampong

The Thai Journal of Pharmaceutical Sciences

(Factors which influence on potency assay of measles, rubella and polio vaccines were investigated by using Vero, RK-13 and Hep-2 cells, respectively. The result showed that cultures of Vero, RK-13 and Hep-2 cells in the presence of 5% CO2 produced 23 ti...

Safety Performance On 20 Construction Sites In Dublin, Paul Mcevoy

Masters

Abstract The aim of this research was to assess factors affecting safety performance on twenty apartment construction sites in Dublin using qualitative and quantitative risk assessment techniques. The quantitative techniques involved observing compliance with recommended safety procedures. The qualitative techniques involved an assessment of site safety management documentation and semi structured interviews with site management regarding site safety procedures. The field work was carried out between November 2003 and October 2004. The results showed that five sites out of twenty had high standards of safety and prevented all possible falls from heights. The five best performing sites were characterised by …

Heavy Metal Contamination Of Mangrove Sediments And The Associated Biota In Dar Es Salaam, Tanzania, Sd Mremi, Jf Machiwa

Tanzania Journal of Science

Mangrove wetlands are efficient in trapping pollutants that may have detrimental effects on mangrove dependent food chains. Mangrove ecosystems that are within urban areas are likely to suffer more from chemical pollution than those in rural areas. Heavy metals in mangrove plant parts, sediments and crabs from mbweni, msimbazi and mtoni mangrove ecosystems in Dar es salaam were analysed using an atomic absorption spectrophotometer, in order to assess the impact of heavy metal pollution on mangrove biota. Sediment samples from msimbazi and mtoni mangrove areas which are located within the city, had higher levels of pb, zn and cu than …

Interaction Between Adrenergic And Nitric Oxide-Releasing Nerves In Cerebral Arteries, Emmanuel Ngu Mbaku

Loma Linda University Electronic Theses, Dissertations & Projects

Of all body tissues, the brain is the least tolerant of ischemia so much that interruption of cerebral blood flow by 5 sec can cause syncope, with irreversible tissue damage if the ischemia last a few minutes. In this respect, the body has an imperative duty of ensuring constant and adequate blood supply to the brain. It does so through a series of intrinsic and extrinsic control factors of which adrenergic and nitric oxide-releasing nerves are components. My research examined the interaction between these two nerve-types with emphasis on the mechanisms involved as well as on changes in their functions …

Cellular Proliferation, Death And Histology In Gambusia Affinis Livers After Exposure To 2-Aminofluorene And Benzidine, Susan J. Lentz

Dissertations

A fundamental need exists for aquatic animals in the biomonitoring of aquatic ecosystems for environmental carcinogens. G. affinis, a small fish species, is selected for this study due to its hardiness, non-migratory nature, geographic diversity and ability to develop tumors. Molecular tools for cellular proliferation and death are examined for use with G. affinis. Additionally, these tools are used to investigate the early carcinogenic effects of 2-aminofluorene and benzidine, both individually and combined, on G. affinis livers.

Antibodies to proliferating cell nuclear antigen (PCNA), p53, cleaved caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP) were examined for use in G. …

Studies On The Regulation Of Mu Opioid Receptor Mrna Expression In Shsy-5y Human Neuroblastoma Cells, Xin Yu

Seton Hall University Dissertations and Theses (ETDs)

Prolonged exposure to morphine down-regulates mu opioid receptors (MOR) on both undifferentiated and differentiated (retinoic acid or phorbol ester treated) SHSY-5Y cells. However, morphine pretreatment does not alter MOR receptor affinity for morphine. To investigate the molecular basis for MOR regulation after exposure to its selective agonists, we have developed a quantitative competitive reverse transcriptase-polymerase chain reaction (QC-RT PCR) to quantify the expression of MOR in SHSY-SY cells. Differentiation of SHSY-5Y cells with retinoic acid or phorbol ester up regulated MOR mRNA expression by 30 % and 78%, respectively. A 24 hours treatment with morphine (10 µM) down regulated MOR …

The Effects Of Alternative-Site Blood Glucose Monitoring On Testing Frequency, Pain Rating, And Glycosylated Hemoglobin, Nancy Bennion

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A crossover design study was conducted to determine if reducing pain, by using alternative sites off the finger tip, would increase testing frequency and improve clinical outcome as measured by glycosylated hemoglobin. Subjects with type 1 and type 2 diabetes tested with the FreeStyle alternative-site meter (group 1) or tested with their original meter (group 2). After 3 months the subjects used the alternate meter. Testing frequency and blood glucose concentrations were recorded for the month before the study began and monthly thereafter. Glycosylated hemoglobin was tested initially, at the crossover point, and at study conclusion. Insulin users increased testing …

Stochastic Intra-Cellular Modeling, Thomas E. Hopkins

Theses and Dissertations

Air Force personnel may sometimes come into contact with potentially harmful chemicals while performing their duties. Of course the Air Force desires to keep any potential health risks to its members to a minimum. To this end the Air Force would like to identify which chemicals are toxic, their level of toxicity, and the processes by which these chemicals disrupt normal biological activities at the cellular level. The development of mathematical models can be of great benefit to toxicity studies. Because real world systems involve randomness, that is noise, and the desire is to create mathematical models to represent those …

Deterministic Intracellular Modeling, Jacqueline B. Young

Theses and Dissertations

The United States Air Force is interested in the potential side effects at the cellular level from exposure to mission-essential chemicals. Presently, Air Force toxicology studies are conducted to help shed light in identifying potential hazards to workers. However, it takes a considerable amount of money, resources, and time to obtain and analyze experimental results from toxicology studies. The necessity for innovative methods that enable researchers to more effectively generate and analyze data is apparent.

The Two Isoforms Of Rat Metallothionein Are Coordinately Regulated In Vivo, Diane M. Todd

Browse all Theses and Dissertations

Metallothionein (MT) is an inducible protein whose unique structure contributes to its many functions. One of MT’s functions is the detoxification of heavy metals. Cadmium (Cd), which is an environmental pollutant and a hazard to both humans and animals, is detoxified by MT. There are four known MT isoforms (MT I-IV) and this study focuses on only MT I and MT II. Even though a lot is known about the effect of Cd on MT induction little has been reported about the MT isoforms and their pattern of mRNA expression. It is the aim of this study to investigate the …

Joint Effects Of Population Density And Toxicant Exposure On Population Dynamics Of Capitella Sp. I, Valery E. Forbes, Richard M. Sibly, Inez Linke-Gamenick

Valery Forbes Publications

Very few studies have analyzed the dependence of population growth rate on population density, and even fewer have considered interaction effects of density and other stresses, such as exposure to toxic chemicals. Yet without such studies we cannot know whether chemicals harmful at low density have effects on carrying capacity or, conversely, whether chemicals reducing carrying capacity are also harmful at low density, impeding a population’s capacity to recover from disturbance. This study examines the combined effects of population density and a toxicant (fluoranthene) on population growth rate (pgr) and carrying capacity using the deposit-feeding polychaete Capitella sp. I as …

Assessment Of Outpatient Knowledge, Attitudes, And Satisfaction With Service In Diabetic Clinic At King Chulalongkorn Memorial Hospital(การประเมินความรู้ทัศนคติและความพึงพอใจต..., Supakit Wongwiwatthananukit, Rathaporn Lohavisavapanich

The Thai Journal of Pharmaceutical Sciences

The purpose of this cross-sectional survey study was to assess outpatient knowledge, attitudes, and satisfaction with service in diabetic clinic at King Chulalongkorn Memorial Hospital. The study was conducted between May 9 and June 10, 2003. A sample of...

Screening Of Some Rubiaceous Plants For Cytotoxic Activity Against Cervix Carcinoma (Kb-3-1) Cell Line (การคัดกรองความป็นพิษต่อเซลล์มะเร็งปากมดลูกชนิด Kb-3-1 ข..., Patcharawan Tanamatayarat, Porn-Ngarm Limtrakul, Sunee Chunsakaow, Chadarat Duangrat

The Thai Journal of Pharmaceutical Sciences

Twenty plants in the family Rubiaceae collected from Northern Thailand were extracted and compared for their cytotoxic activities against a human cervix carcinoma cell line (KB-3T). MTT assay was the technique utilized for cell survival determination. Th...