Pharmacology, Toxicology and Environmental Health Commons^™

Metals In Apple Cider Produced And Marketed In Connecticut, Dennis W. Hill, Thomas R. Kelley, Gale R. Morrow, Sylvia W. Matiuck

Storrs Agricultural Experiment Station

No abstract provided.

Enantiomeric Influences In Neuroleptic Binding To Models Of The Dopamine Receptor, Timothy A. Robert

Electronic Theses and Dissertations

No abstract provided.

Bulletin 3967 - Cyanogenetic Plants Of Western Australia, T E H Aplin

Bulletins - 3000 - 3999

This article deals with those native, naturalized and cultivated plants, which by virtue of contained cyanogenetic glycosides, are known to be poisonous or potentially poisonous to livestock in Western Australia.

Cyanogenetic glycosides are chemical compounds which contain a cyanogen (cyanide) radical combined with a sugar molecule. The sugar moiety may differ in glycosides obtained from different plants, and as a consequence glycosides from different plants, containing different sugar moieties, may be given different names.

When a cyanogenetic glycoside is broken down by enzyme action, through injury to the plant or by microbial action in the digestive system of the animal, …

The Toxicity, Metabolism And Distribution Of Carbaryl In Three Species Of Labops With And Without Piperonyl Butoxide Treatment (Hemiptera:Miridae), Deifalla H. Osman

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Carbaryl toxicity, metabolism, and distribution in adults of three species of grass bugs from the genus Labops were studied in relation to species, sex, and treatment with piperonyl butoxide. LC₅₀ values for 8 hour exposure periods ranged from 0.02-0.14, 0.03-0.3, and 0.2-0.7 μg carbaryl/vial for L. utahensis, L. hirtus, and L. hesperius respectively. The males were more susceptible to carbaryl than females. Males of L. utahensis were more susceptible than L. hirtus and L. hesperius respectively.

The synergist difference values (LC₅₀ of carbaryl alone - LC₅₀ values of carbaryl after piperonyl butoxide treatment) were measured. …

The Covalent Interaction Of Hepatic Metabolites Of The Insecticide Chlordane With Cellular Macromolecules In The Rat And Mouse In Vitro, Alan A. Brimfield

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This investigation addressed several aspects of the covalent interaction of metabolites of the insecticide chlordane with cellular macromolecules in vitro. Microsomal preparations from the liver of mice and rats were used and covalent binding to microsomal protein and RNA or to added calf thymus DNA was studied. Pure ¹⁴C-labelled cis- and trans-chlordane isomers as well as an isomeric mixture (¹⁴C-cis-chlordane plus ¹⁴C-trans-chlordane 3:1, w:w) were used as substrates for the in vitro system. Biochemical parameters investigated included inhibition of microsomal mixed-function oxidase and epoxide hydratase plus the induction of these enzymes by pretreatment with chlordane …

A Rapid And Specific Gas Chromatographic Analysis For Cysteine-S-Sulfonate To Determine The Distribution Of Sulfite In Mammalian Plasma, Joseph Don Debethizy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

It has been shown in previous studies that when sulfite is absorbed by rabbits via either inhalation of SO₂ or oral exposure to sulfite, the hydrated form, bisulfite, interacts with plasma disulfides where it is suspected to be in the form, cysteine-S-sulfonate. A rapid and specific gas chromatographic analysis procedure for cysteine-S-sulfonate has been developed to better study the distribution of sulfite in biological systems. Sulfonated proteins are enzymatically hydrolyzed to ensure stability of the acid labile S-sulfonate disulfide. The hydrolysate is then applied to a 6 cm cation-exchange column and eluted with 0.1 N HCl which elutes the …

Central Nervous System Toxicity Of Alpha-Chaconine In Rats, Charles Newell Aldous Iii

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Effects of alpha-chaconine were examined in the central nervous system on the basis of electrophysiological tests and by assaying for changes in the levels of several known neurotransmitters of the brain. The possibility that brain acetylcholine levels might increase corresponding to acetylcholinesterase inhibition in treated rats was investigated where an increase would suggest that the anti-acetylcholinesterase activity of alpha-chaconine was physiologically significant.

Various doses of alpha-chaconine were given to rats prepared for physiological tests. Some symptoms were observed at relatively low doses (8 to 10 milligrams per kilogram). These included constriction of abdominal muscles, respiratory impairment, and sedation. At the …

Proceedings Of The Conference On Environmental Law -- Toxic Substances, William & Mary Law School

One-Time Conferences: Programs

Held on February 9-10, 1979 at William & Mary Law School.

Funded by the Virginia Environmental Endowment.

Symposium Participants (in order of appearance): Maurice B. Rowe, William R. Moore, Louise Burke, William F. Gilley, James Douglas, Manning Gasch, Jr., Barbara Bitters, Robert Jackson, James Ryan, Robert R. Merhige, Jr., Gus Steph, Steven D. Jellinek, Frederick R. Anderson, Luther Carter, Peter Barton Hutt, Richard Voight, Richard Merrill, George Taylor, Richard Fleming, Hargis, Richard N. Velde, Susan B. King, Jacob Clayman, Nicholas Ashford, James Rogers, Charles O'Connor, Donald F. Hornig, Devra Davis, Scott C. Whitney, and Denis J. Brion.

The Effects Of Streptozotocin-Induced Diabetes On Responses To Opiates And Other Centrally-Acting Pharmacologic Agents, Glenn Stuart Simon

Theses and Dissertations

Diabetes mellitus affects millions of people. Although diabetics can lead relatively normal lives, all treatments for the disease are symptomatic and not curative. The purpose of this investigation was to determine whether the sensitivity to opiates and other selected centrally-acting drugs in animals is altered by streptozotocin (STZ)-induced diabetes. A second objective was to determine which aspect of the diabetic syndrome primarily was responsible for the altered sensitivity. Other experiments were performed in an attempt to elucidate the mechanism whereby this altered sensitivity occurred.

STZ-induced diabetes or dextrose-induced transient hyperglycemia did not have a significant effect on the duration of …

The Distribution Of Cadmium, Chromium And Lead In Crabs, Clams And Oysters From Calcasieu Estuary, Louisiana, Fritz Jaenike

Masters Theses

In November 1978, specimens of oysters (Crassostrea virginica), clams (Rangia cuneata), crabs (Callinectes sapidus) and water and sediment samples were collected from Calcasieu Estuary, Louisiana. The concentrations of cadmium, chromium and lead were determined in the samples with an inductively coupled argon plasma direct reading emission spectrophotometer. Crab claw muscle, gill and carapace tissues were analyzed separately. Oysters and clams were separated into shell and whole soft tissue samples which were analyzed separately. The concentration order of the metals in crab carapace and in oyster shells was similar to that of the sediments, (Pb …

เภสัชวิทยาของไดออสคอรีน : 1. ฤทธิ์ในการกระตุ้นระบบประสาทส่วนกลาง และปฏิกิริยาร่วมกบยากดปร..., บุญยงด์ ตันติสิระ

The Thai Journal of Pharmaceutical Sciences

Purified hydrobromide salt of alkaloid dioscorine was extracted from wild yam tubers (Dioscorea hispida). In mice, this alkaloid had strong central nervous system stimulant effect, resulting in convulsions and death with LD50 being 31.6 mg/kg. The alkalo...

ประมวลบทคัดย่อ, สุวรินทร์ จตุรพิตร

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Pharmaceutical Ambrosia, วิทยา จันทสูตร

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

พระราชบัญญัติยา (ฉบับที่ 3) พ.ศ. 2522, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ประมวลบทคัดย่อ, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Povidone-Lodine U.S.P. Xix, สมเกียรติ รุจิวัฒน์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

บทบรรณาธิการ : อนาคตของวิชาชีพเภสัชกรรม, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ทัศนะปัจจุบันเกี่ยวกับบทบบาทของ โดปะมีนในการทำงานของสมอง, ภาวิช ทองโรจน์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Suppositoires En France(ยาเหน็บในฝรั่งเศส), วิไลลักษณ์ อิ่มอุดม

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Antihistamines กับการบำบัดแผลในกระเพาะอาหารและลำไส้, อุษณา หงส์วารีวัธน์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ไขข้ออักเสบกับยา, วิทยา จันทรสูตร

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ประมวลบทคัดย่อ, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ประมวลบทคัดย่อ, อรอนงค์ เจนสุทธิเวชกุล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

สาส์นปริทัศน์, ศศิบุษบา สืบแสง

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

นอนไม่หลับ-ยาช่วยนอนไม่หลับ, วิทยา จันทสูตร

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

การให้ยาในคนสูงอายุ, ชัชวาลย์ ศรลัมภ์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

พระราชบัญญัติ ยาเสพติดให้โทษ พ.ศ. 2522, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cefamandole(Mandol (R)-Lilly), ศิริภรณ์ ฟุ้งวิทยา

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ประมวลบทคัดย่อ, ศศิบุษบา สืบแสง

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

สาส์นปริทัศน์, พจน์ กุลวานิช

The Thai Journal of Pharmaceutical Sciences

No abstract provided.