Pharmacology, Toxicology and Environmental Health Commons^™

Limnological Aspects Of Lake Mead, Nevada-Arizona, John R. Baker, James E. Deacon, Thomas A. Burke, Samuel S. Egdorf, Larry J. Paulson, Richard W. Tew, Bureau Of Reclamation

Publications (WR)

Lake Mead is a deep, subtropical, moderately productive, desert impoundment with a negative heterograde oxygen profile occurring during; the summer stratification. investigations of the Boulder Basin of Lake Mead by the University of Nevada were initiated in November 1971. The primary objective of the study was to determine what effects industrial and sewage effluent from the Las Vegas metropolitan area, discharged into Las Vegas Bay, have had on the water quality and limnological conditions of Boulder Basin. Data from the 1975-76 period are presented in detail, with earlier data included in the summaries and discussions. Measurements of water temperature, dissolved …

Toxicological And Biochemical Investigations Of Alpha-Chaconine In Potato (Solanum Tuberosum L. ) Tubers: Physiologic Disposition And Tissue Binding, And Inhibition Of Tissue Cholinesterases And Isoenzymes, Sydney Obodoechina Alozie

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The distribution, absorption, metabolism and tissue binding of radioactivity were studied in hamsters after oral and intraperitoneal administration of alpha-chaconine- (³H). The material was well absorbed from the gastrointestinal tract and nearly 22 percent of the label was excreted via urine and feces in 7 days. The excretion was higher in urine (21 percent) than in feces ( < 1 percent). Tissue concentrations of radioactivity peaked at 12 hours following oral administration, with the highest concentrations found in lungs, liver, spleen, skeletal muscle, kidney and pancreas, with heart and brain containing moderate amounts. Concentrations of radioactivity in tissues following intraperitoneal administration were significantly higher than those observed after oral treatment. Excretion of chloroform-soluble products in the feces was 10 times higher than that of the chloroform-insoluble metabolites after both oral and intraperitoneal administration. In the urine, the activity was predominantly in the chloroform-insoluble form and the chloroform-soluble metabolites were relatively minor in amounts (0.27, 0.85, and 2.45 percent versus 0.005, 0.14 and 0.19 percent of dose for 12, 24 and 72 hours, respectively). After 7 days, the chloroform-soluble metabolites in urine increased to 20 percent of the excreted radioactivity, while the amount of chloroform-insoluble metabolites was less than 1 percent. Subcellular distribution of the labeled compound indicated the highest concentration of radioactivity in the nuclear and microsomal fractions of brain, liver and heart tissues. A small amount of radioactivity, shown by a minor peak, was also observed in the fractions between the mitochondrial and microsomal fractions on a sucrose gradient. Binding of radioactivity was observed in brain, testes, kidney, lung, liver and heart. All of the label in the brain appeared to be in the bound form. The results indicated that alpha-chaconine is slowly absorbed from the gastrointestinal tract after oral administration, and persists in various tissues, much of it in bound (non-extractable) form (in nuclear and microsomal fractions).

Excretion of alpha-chaconine- (3H) and its metabolites was investigated after oral and intraperitoneal administration in hamsters. The separation of the glycoalkaloid and its metabolites in feces and urine was accomplished by thin-layer chromatography. An increase in the concentration of excreted …

Subtle Teratogenic Effects Of Locoweed In Rats, Benjamin K. Nelson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Locoweed, a well-known teratogenic plant affecting livestock, is prevalent in mountain regions of the Western United States. Two common species (Astragalus lentiginosus and A. wootoni), administered to pregnant rats, induced behavioral deviations in their offspring. Treated mothers consumed less feed and gained less wieght during gestation than controls when gavaged locoweed at the rate of 1 gram whole plant per day on days 7 through 17 of gestation. A. lentiginosus reduced pup weight at birth (13% less than controls) and this weight reduction (as much as 29% less than controls) continued at least four weeks. A. lentiginosus also …

Cytogenetic Test Of Captan And Triethylenemelamine In Mouse Bone Marrow, Stephen M. Fry

Honors Theses

Following a single non-toxic i.p. injection with 0.5 or 1.0 mg triethylenemelamine/kig a significant increase in chromosome aberrations in mouse bone marrow was observed 6, 12, 30, but not 54 h after treatment. A single i.p. injection with 250 mg captan/kig caused up to 68% lethality above controls, but no significant increase in chromosome aberrations after the same time intervals. One metacentric chromosome was observed 6, 30, and 54 h after captan treatment among 300, 300, and 101 metaphase spreads respectively, whereas none appeared in 1495 control spreads.

Progress In Mastitis Control : A Simple Control Programme That Works, G R. Olney, R. K. Mitchell

Journal of the Department of Agriculture, Western Australia, Series 4

Intensive Department of Agriculture work on the mastitis problem has resulted in development of a simple control programme that works in W.A. dairy herds.

Farmern receive regular advice on their herd mastitis levels, and advice is available on overcoming specific problems.

Federal Toxic Substances Act

William & Mary Environmental Law and Policy Review

No abstract provided.

Cotton Fireweed : Potential Poison : Research Roundup, J Dickson, R. Hill

Journal of the Department of Agriculture, Western Australia, Series 4

Although long known as a potential toxic species because of its content, and although it is widely distribuited in all Australian States, cotton fireweed has not generally been consdidered toxic because it is unpalatable and not usually eaten by stock.

In 1973 cattle deaths occured near Ravensthorpe which led to research into Senecio quadridentatus (cotton fireweed).

The plant must be seen as a potential toxic species in situations where the lack of other feed forces cattle to eat the normally unpalatable cotton fireweed.

การศึกษาความเป็นพิษในลูกเนียง Pithecolobium Lobatum, Benth. และพยาธิสภาพที่เกิดขึ้นในสัตว์ทดลอง, พิมพรรณ เกิดอุดม

The Thai Journal of Pharmaceutical Sciences

Pimpun Kirdudom (1977). Studies on the toxicity of niang bean and the pathology in experimental animals. The chemical components and the toxic substance were analyzed from niang beans. The results showed that they contained high protein and carbohydrate ...

ประมวลบทคัดย่อ, มยุรี หาญตระกูล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

El Spray Nos Aniquilará, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

ยาและอาการตาย, ประโชติ เปล่งวิทยา

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Air Suspension Coating, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ประมวลบทคัดย่อ, มยุรี หาญตระกูล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

การเจ็บป่วยเนื่องจากยา ตอนที่ 4 พิษของยาต่อไต (Drug Induced Nephrotoxicity), ประโชติ เปล่งวิทยา

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

บทบรรณาธิการ : วิชาการคือความอยู่รอดของเภสัชกรยาสีฟัน, สอาด รักตัวัต

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Masking Moieties, อนัญญา โพธิศิริ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Spray Drying And Its Application In Tablet Manufacture Spray Drying Process กับการผลิตยาเม็ด, ศศิบุษบา ชลวิจารณ์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

โภชนาการและการบำบัดโรค, นุชรี เบญจานุวัตรา

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

แผลในกระเพาะอาหารและลำไส้กับ Carbenoxolone, มยุรี หาญตระกูล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

บทบรรณาธิการ : การบริหารโรงพยาบาล และเภสัชกรรมโรงพยาบาล, ทวี ธนตระกูล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Air Suspension Coating Ii, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

การเจ็บป่วยเนื่องจากยา ตอนที่ 3 พิษของยาต่อหู(Drug Induced Ototoxicity), ประดชติ เปล่งวิทยา

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Beclomethasone Dipropionate Aerosol กับโรคหืด, วิทยา จันทรสูตร

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

โฉมหน้าใหม่ของเพพไทด์, สุรางค์ อัศวมมั่นคง

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

The In Vitro Effects Of Griseofulvin On Morphological Changes Of Dermatophytes, Yupin Charoenvit

The Thai Journal of Pharmaceutical Sciences

Griseofulvin , the antifungal antibiotic caused morphological changes in 13 selected derma· tophytes isolated in Thailand, especially on the microscopic struct ures of the myce lium . Discernib le effects occurred at every concentration used in this stu...

Azapropazone, วิไลลักษณ์ อิ่มอุดม

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

วัคซีนป้องกันมาเลเรีย?, จิราพร ลิ้มปานานนท์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

บทสัมภาษณ์ : เภสัชกร ป่วน เจริญพานิช, บุญยงค์ ตันติสิระ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

บทบรรณาธิการ : การพัฒนาบริการสาธารณสุข และวิชาชีพเภสัชกรรม ตอนที่ 2 บริการสาธารณสุขภาคเอกช..., ประโชติ เปล่งวิทยา

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

การบำบัดภาวะไขมันในเลือดสูง ซึ่งเกิดจากกรรมพันธุ์ ร่วมกับการป่วยเป็นโรคเบาหวาน การดื่ม..., ชูจิตร เปล่งวิทยา

The Thai Journal of Pharmaceutical Sciences

A 35-year-old Thai male patient coming in with disseminated xantho matosis charaderized of primary type III hyperlipoproteinemia. He consumed half a bottle of whiskey and fatty food almost everyday for 10 years. He began to have attacks of abdominal pain...