Pharmacology, Toxicology and Environmental Health Commons^™

Analysis Of C2 And C3 Hydrocarbons In Ambient Air. Section I ; Identification And Quantification Of Volatile Organics Emitted From A Landfill. Section Ii, Tsong-Sheng Chang

Theses

SECTION I

A method was developed to analyze Acetylene, Ethylene, Ethane, Propylene and Propane levels in the ambient air. Chlorinated compounds within the operation retention time, Methyl chloride, Methylene chloride and Vinyl chloride, were monitored also.

Four sampling sites are located at Carteret, Elizabeth, Newark and Montville in New Jersey. Samples were taken during the summer of 1988. Two sample duration periods utilizing 12 and 6 liter stainless steel canisters were set up to take 24 hour air samples and instantaneous air samples (5 minutes collection period).

The average levels of Acetylene, Ethylene, Ethane, Propylene and Propane at the four …

A Study Of Human Exposure To Benzo(A)Pyrene (Bap) Through Different Pathways. Part A ; Assessment Of Benzo(A)Pyrene (Bap) Exposure Through Urine Analysis With The Hydriodic Acid Reduction Reaction. Part B, Shao-Keng Liang

Theses

PART A: An investigation of total human exposure to an environmental pollutant is described. The study is being conducted in a community impacted by a foundry suspected to be a dominant local source of benzo(a)pyrene (BaP). The research aims to assess the relative contributions of indoor and outdoor sources and to measure BaP in media including indoor air, outdoor air, food and water.

PART B: A method for biological monitoring of exposure to benzo(a)pyrene, a representative polycyclic aromatic hydrocarbon (PAH), has been developed. The analytical procedure includes extraction of PAH and PAH metabolites from urine using commercial cartridges containing c …

Are Rats Relevant?, Edward J. Calabrese

Bridgewater Review

No abstract provided.

Anion-Exchange Chromatography Of The Murine Estrogen Receptor: Ionic Forms Of Receptor Under Different States Of Activation, Gregory Craft

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Arts and Sciences at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Science by Gregory Craft on August 5, 1988.

The Effect Of 48 Hr Glucose Administration On The Hepatic P-450 System, John N. Buchholz

Loma Linda University Electronic Theses, Dissertations & Projects

The administration of glucose for 48 hrs to mice resulted in a shift of the dose response curve of phenobarbital, an indication that glucose administration significantly sensitized the animals to the effects of the drug. Glucose administration produced a reduction in the catalytic activity of hepatic microscopical P-450 as measured by the in vitro conversion of p-Nitrocellulose to p-Nitrophenol.

The administration of glucose to rats for 48 hrs resulted in prolonged anesthesia after the administration of pentobarbital. The spectral binding of hexobarbital and methadone to hepatic microsomal P-450 was found to be significantly reduced following glucose administration. The changes in …

A New Hazardous Waste Treatment Technology Utilizing Low Power Density Microwave Energy, Gabriele Else Windgasse

Theses

Two major applications of a new hazardous waste treatment technology using low power density microwave energy have been characterized: 1) Desorption of organic materials such as: trichloro-ethylene, para-xylene, naphthalene and gasoline hydrocarbons from substrates such as: sand and granulated activated carbon was achieved by microwave induced steam distillation and the application of a new phenomenon: arcing between GAC particles when they are exposed to microwave radiation. All contaminants could be removed to 100% (non-detectable with GC and GC-MS). 2) Decomposition of organic contaminants such as: trichloro-ethylene and trichloro-ethane in arcing/heating GAC beds. A new fluidized bed reactor ("RDW-reactor", after Ray, …

Microbial Phenol Degradation Utilizing A Complete-Mix Biological Reactor : The Effects Of Dissolved Oxygen Content, Keith Kollar

Theses

Experiments were conducted using phenol as a sole carbon source in a series of completely mixed biological reactors with solids recycle (CMBR). The reactor working volume was 4 liters, and solids were recycled from 3 liter clarifiers. Dissolved oxygen concentration (DO) was varied in order to determine the impact of this important variable on system operability.

Phenol was removed at better than 99 percent efficiency during most of the runs. Filamentous growth was not observed during any run. However, bulking did occur at higher DO levels, which was the result of microbial slime production.

A Field Perspective On Groundwater Contamination, John A. Cherry

Maine Collection

A Field Perspective on Groundwater Contamination

Geological Society of Maine Distinguished Lecturer John Cherry, University of Waterloo, Ontario, sponsored by the Department of Geosciences, University of Southern Maine, 19th May 1988.

Contents: Lecture 1 : Contaminant Migration Processes Illustrated by Field Experiments / Lecture 2 : Behavior of Dense Non-Aqueous Phase Liquids, Illustrated by Lab Experiments and Conceptual Examples / Lecture 3 : Field Case Histories on Groundwater Contamination / Lecture 4 : Hydrogeological Concepts and Criteria for Waste Disposal / Waterloo Center for Groundwater Research Publications List

The Immunological And Neurochemical Toxicity Of Benzene And Its Interaction With Toluene In Mice, Gin-Chang Hsieh

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Benzene and toluene are known groundwater contaminants . Male CD-I mice were continuously exposed to 0, 31, 166, and 790 mg/ L benzene and 0, 17, 80, and 405 mg/L toluene, respectively, in drinking water for four weeks. Benzene caused a reduction of leukocytes, lymphocytes and erythrocytes, and resulted in a macrocytic anemia. Lymphocyte response to both B- and T-cell mitogens, mixed lymphocyte response to alloantigens, and the ability of cytotoxic lymphocytes to lyse tumor cells were enhanced at the lowest dose of benzene and depressed in the higher dosage animals. Benzene at doses of 166 and 790 mg/L decreased …

Attenuation Of Antagonist-Induced Impairment Of Dopamine Receptors By L-Prolyl - L-Leucyl-Glycinamide, Mohamad I. Saleh

Electronic Theses and Dissertations

It has been shown by others that the prenatal treatment of rats with haloperidol, a dopamine D2 receptor antagonist, leads to a permanent reduction in the number of striatal dopamine D2 receptors in adulthood. Conversely, postnatal treatment of lactating dams with haloperidol from birth for 21 days, leads to an increase in the number of striatal dopamine D2 receptors in the litters, when assessed as adults. The present study was undertaken in order to determine whether chronic, long-term postnatal challenge of rat pups per se, with specific dopamine D1 and D2 receptor antagonists, would modify the ontogeny of the respective …

Policy For Identifying And Assessing The Health Risks Of Toxic Substances, Maine Bureau Of Health

Maine Collection

Policy for Identifying and Assessing the Health Risks of Toxic Substances

by Norman T. Anderson, Environmental Toxicology Program, Division of Disease Control, Bureau of Health (February, 1988).

Contents: Section I: Introduction / Section II: Methods / Section III: Exposure Assessment / Section IV: Hazard Identification / Section V: Hazard Assessment / Section VI: Risk Characterization / List of Figures / List of Tables

Comparative Adsorption Studies On Clay Soils, Prasanna R. Mysore

Theses

An investigation has been made to study clay as sorbent in the treatment of the hazardous contaminants of potential sludge leachate emanating from industrial landfills.

Experimentally was studied six highly toxic and hazardous chemicals, which include: phenol, aniline, cyclohexanol, cyclohexanone, cresol and monochlorophenol. Vermiculate, Kaolinite, Attacote and Hectorite clays were studied as the sorbent material. Removal of organic pollutants were measured using a total organic carbon analyzer (TOC).

Results indicate that these clays can be used for some treatment of the above mentioned organic compounds. The study shows that removal of organic pollutants by clay depends on several factors, such …

Thermal Desorption Of Hazardous And Toxic Organic Compounds From Soil Matrices : Dichloromethane, Chloroform, Benzene, Toluene, 1-Chloronaphthalene, 1, 2, 4-Trichlorobenzene, Arun S. Chemburkar

Theses

This research project was undertaken to understand the process of desorption/removal of organic compounds from soil matrices under the influence of temperature and gas purging. The project was divided in two parts :

A. Plug deposition experiments: Columns packed with soil matrices were purged with an inert gas under isothermal conditions. Organic compounds were then introduced as a plug on the front of the column by on-line injection. The rate of passage (due to sequential adsorption/desorption) of the plug through the various soil matrices was measured by a gas chromatograph equipped with a flame ionization detector (FID). The compounds studied …

An Inventory And Condition Survey Of Rangelands In The Ashburton River Catchment, Western Australia, A A. Mitchell, A L. Payne, W F. Holman

Technical Bulletins

The inventory and condition survey of rangelands in the Ashburton River catchment, undertaken by the Department of Agriculture and Food, Western Australia (DAFWA) between 1976 and 1978, describes and maps the natural resources of the region’s pastoral leasehold land. This survey report provides a baseline record of the existence and condition of the natural area’s resources, to assist with the planning and implementation of land management practices. The report identified and described the condition of soils, landforms, vegetation, habitat, ecosystems, and declared plants and animals. It also assessed the impact of pastoralism and made land management recommendations. The area surveyed …

Inhibitor(S) Of Prostaglandin Endoperoxide Synthase And Lipoxygenase Activity In Extracts Of Barley, S Salam

Department of Biological & Biomedical Sciences

Aqueous extract of barley was found to inhibit PG endoperoxide synthase and lipoxygenase enzymes responsible for arachidonic acid metabolism. Only 6% (v/v) of aqueous extract produced 50% inhibition of PG endoperoxide synthase while five times more extract was required to produce 50% inhibition of lipoxygenase. Boiling barley extract did not destroy the ability of the extract to inhibit the enzymes. Fractionation of barley with organic solvents, petroleum ether, chloroform, ethylacetate and acetone exhibited selectivity in its action in that foamy layer formed during petroleum ether and ethyl acetate extraction inhibited PG endoperoxide synthase completely whereas lipoxygenase activity was only partially …

Can We Guarantee The Safety Of Genetically Engineered Organisms In The Environment?, Kathleen H. Keeler, Frances E. Sharples

School of Biological Sciences: Faculty Publications

Can we guarantee the safety of genetically engineered organisms in the environment? To anticipate my remarks, the answer to the title question is “No, we cannot guarantee the safety of genetically engineered organisms released into the environment.” Indeed, it is a tenet of the scientific method that nothing can be proved, only disproved. Thus, we can never show that a release will be safe. We could only show that it would be unsafe, if that were the case. However, if the question is posed differently, for example, can we safely release genetically engineered organisms into the environment?, the answer is …

นมผง หรือ รอยัลเยลลี่, อุบลทิพย์ นิมมานนิตย์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ลับสมอง, วราภรณ์ สุวกูล

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

การใช้ยาสำหรับทางเดินอาหารในสตรีที่ตั้งครรภ์และระหว่างให้นมบุตร, สุกัญา เจษฏานนท์, อุมา กิติยานี

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Gentamicin Dosage Regimens In Thai Cancer Patients(ขนาดและความถี่ในการให้ยา Gentamicin ในผู้ป่วยมะเร็งชาวไทย), Thomayant Prueksaritanont, Churdsak Prueksaritanont, Wirarat Kammuang

The Thai Journal of Pharmaceutical Sciences

Three dosing nomograms for the estimation of gentamicin dosage were evaluated in 35 patients admitted in the National Cancer Institute of Thailand. The pharmacokinetic parameters of gentamicin were also determined following multiple intramuscular or intr...

ข่าว, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Stability Of Penicillins For Oral Suspension(เสถียรภาพของยากลุ่มเพนิชิลลินใน Dry Syrup), สุทธาทิพย์ จันทรสกุล, ดาราวัลย์ ธัญญะวุฒิ, สมพล ประคองพันธ์

The Thai Journal of Pharmaceutical Sciences

The chemical stability of penicillins marketed in Thailand, i.e., penicillin V, ampicillin and amoxicillin, both in dry syrup and reconstituted forms were studied. For reconstituted penicillins, it was found that their degradation followed a first order ...

สารเคมีในพืชสกุล Piper, กิตติศักดิ์ ลิขิตวิทยาวุฒิ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ยาปฏิชีวนะใช้ระหว่างตั้งครรภ์และให้นมบุตร, สุกัญญา เจนฎานนท์, ศิริพร ฟุ้งวิทยา

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

ประมวลบทคัดย่อ, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

การประเมินความเท่าเทียมกันของประสิทธิภาพยา (Therapeutic Equivalence Evaluations), ทมยันต์ พฤกษะริตานนท์

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Stability Of Amoxicillin For Oral Suspension Marketed In Thailand. I : Physical Stability(ความคงตัวของยาแขวนตะกอนอะมอกซิซิลลินที่จำหน่ายในประเทศ..., สุชาดา ประเสริฐวิทยาการ, วราภรณ์ สุวกูล

The Thai Journal of Pharmaceutical Sciences

Physical stability of 12 amoxicillin for oral suspensions commercially available in Thailand after reconstitution was studied. It was designed to assess the sedimentation volume, dense of sediment and redispersibility of suspensions under the refrigerate...

The Disintegration Behaviors Of Insoluble Tablets Containing Different Disintegrants.(พฤติกรรมการแตกตัวของยาเม็ดไม่ละลายน้ำที่ประกอบด้วยสารช่ว..., G.C. Ritthidej, C. Thongplengsri, S. Dumrongpisudthikul

The Thai Journal of Pharmaceutical Sciences

Dibasiccalcium phosphate dihydrate with different types and varying percentages of disintegrants were directly compressed into tablets. The mechanisms of action from moisture sorption and water penetration were investigated to elucidate the disintegratio...

สารเคมีในพืชสกุล Piper, กิตติศักดิ์ ลิขิตวิทยาวุฒิ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Solid Dispersions, เพียรกิจ แดงประเสริฐ

The Thai Journal of Pharmaceutical Sciences

No abstract provided.