Pharmacology, Toxicology and Environmental Health Commons^™

Development Of Gene Delivery Methods(การพัฒนาวิธีนำส่งยีน), Praneet Opanasopit

The Thai Journal of Pharmaceutical Sciences

Development of an efficient method of gene introduction to target cells is the key issue in treating genetic and acquired diseases by in vivo gene therapy. Many transfection techniques have been developed and can be classified into physical, chemical and...

Chemical Constituents Of Cleidion Spiciflorum Leaves(องค์ประกอบทางพฤกษเคมีของใบดีหมี), Supotchana Menkham, Rutt Suttisri

The Thai Journal of Pharmaceutical Sciences

Two flavone glycosides, acacetin-7-(VP-D-glucopyranoside and diosmetin-7-O-P-D glucopyranoside, a phenylpropanoid glycoside, p-propenylphenoipD -glucopyranoside, a linear diterpene, Érans-phytol, and a lanostane triterpene, (24$-24-methyl-5a-lanosta-9(1...

A High Pressure Liquid Chromatographic Method For The Determination Of Arecoline In Areca Nuts(การหาปริมาณอะรีโคลีนในผลหมากโดยวิธีโครมาโทกราฟีสมรรถน..., Chantana Aromdee, Sirinart Panuwongse, Rutchayaporn Anorach, Suwanna Vorarat

The Thai Journal of Pharmaceutical Sciences

A reversed phase high pressure liquid chromatography was developed to determine arecoline in areca nut. The column was 018, the mobile phase was a phosphate buffer pH 5.5, and the UVdetector was set at 216 nm. The method was used to determine the content...

Association Between Skin Tattoos And Hepatitis B Of 1/2001 Privates At Adisorn Fort Hospital In Saraburi(ความสัมพันธ์ระหว่างรอยสักบนผิวหนังกับไวรัสตับอักเ..., Titinun Auamnoy, Somchai Mekaroonreung, Titipoom Auamnoy, Pagorn Taweechotipatr

The Thai Journal of Pharmaceutical Sciences

The objectives of this study were (1) to determine whether there is association between skin tattoos, hepatitis-B and prisons, (2 ) to investigate risk behaviors for hepatitis-B and (3) to describe characteristics of person who have tattoos. Methods: Thi...

Association Among Pharmacy Student’S Personality Traits And Career Preferences(ความสัมพันธ์ระหว่างบุคลิกลักษณะของนิสิตเภสัชศาสตร์,กับความ..., Tanattha Kittisopee

The Thai Journal of Pharmaceutical Sciences

A person tends to choose career with the characteristics that are compatible with his personality. The match between their personality and career characteristic can bring motivation, job satisfaction and increase productivity. The purpose of this study w...

Hepatotoxic Effects Of Xanthones Extracted From Rind Of Garcinia Mangostana In Isolated Rat Hepatocytes(ผลพิษต่อตับของแซนโธน ที่สกัดจากเปลือกมังคุดในเซลล์..., Pompen Pramyothin, Suwimol Sapwarobol, Nijsiri Ruangrungsi

The Thai Journal of Pharmaceutical Sciences

Hepatotoxic effects of xanthones extracted from rind of mangosteen (Garcinia mangostana) were studied in isolated rat hepatocytes using the release of cellular transaminases (AST, ALT) as the criteria for loss of cell membrane integrity. Malondialdehyde ...

Key Word Index, Author Index(ดรรชนีกุญแจคำ, ดรรชนีผู้แต่ง), N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Manganese Distribution Across The Blood-Brain Barrier. I. Evidence For Carrier-Mediated Influx Of Managanese Citrate As Well As Manganese And Manganese Transferrin, Janelle S. Crossgrove, David D. Allen, Bonny L. Bukaveckas, Susan S. Rhineheimer, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

Manganese (Mn) is an essential element and a neurotoxicant. Regulation of Mn movement across the blood–brain barrier (BBB) contributes to whether the brain Mn concentration is functional or toxic. In plasma, Mn associates with water, small molecular weight ligands and proteins. Mn speciation may influence the kinetics of its movement through the BBB. In the present work, the brain influx rates of ⁵⁴Mn²⁺, ⁵⁴Mn citrate and ⁵⁴Mn transferrin (⁵⁴Mn Tf) were determined using the in situ brain perfusion technique. The influx rates were compared to their predicted diffusion rates, which were determined from …

Oral Peptide And Protein Drug Delivery(การนำส่งเปปไทด์และโปรตีนโดยการรับประทาน), Wiwat Pichayakom, Chirasak Kusonwiriyawong, Gampimol C. Ritthidej

The Thai Journal of Pharmaceutical Sciences

Recent advances in biotechnology and biochemistry have profoundly led to the discovery of numerous biologically active peptides and proteins. Their therapeutic applications have also been extensively investigated. Oral administration has major advantages...

The Mutagenicity Of Nitrite Treated Extracts From Some Edible Fried Insects, Using Ames Test(ฤทธิ์ก่อกลายพันธุ์ของสารสกัดจากแมลงทอดที่รับประทานได้..., Linna Tongyonk, Kaew Kangsadalampai, Rujirek Chanavirat

The Thai Journal of Pharmaceutical Sciences

The extracts from true water beetle, short tailed cricket, silk worm pupae, house cricket, longhorned grasshopper, scarab beetle, bombay locust, red ant, giant water bug, and mole cricket did not have mutagenicity when they were tested by using Salmonell...

Antimutagenicity On Urethane Of Various Soybean Products Using In Vivo Somatic Mutation And Recombination Test(การต้านฤทธิ์ก่อกลายพันธุ์ของยูรีเทนโดยผลิตภัณฑ์..., Kaew Kangsadalampai, Piyanart Sommani

The Thai Journal of Pharmaceutical Sciences

Different soy bean products, namely fermented products (soy paste, red sufu, yellow sufu and Tooa Nao and nonfermented products (Textured Vegetable Protein or TVP and dried-soybean curd or yuba), were evaluated for their antimutagenicity against urethane...

Determination Of Flavonoids In Kaempferia Parviflora By Gas Chromatographie Method(การวิเคราะห์หาปริมาณฟลาโวนอยด์ในกระชายดำโดยวิธีแก็ส โครมา..., Supawadee Daodee, Chavi Yenjai, Cattareya Suttanut, Suganya Supattanapong

The Thai Journal of Pharmaceutical Sciences

Kaempferia parviflora is a herbal plant which is commercially popular at the present time. These products are available in several dosage forms, e.g. capsule and powder for decoction. This study aimed to determine the constituents in 17 samples of Kaempf...

Pharmaceutical Care Scales And Thai Hospital Pharmacists’ Attitude Toward Pharmaceutical Care(แบบวัดการบริบาลเภสัชกรรมและทัศนคติต่องานบริบาลเภสัชก..., Ratanaporn Awiphan, Unchalee Thadapark

The Thai Journal of Pharmaceutical Sciences

Pharmaceutical care is the concept expanding pharmacists’ role in health care, which urges their increasing responsibility in collaboration with other health professionals in taking care of patients. The objectives of this study were to l) develop the ...

Consumers’ Perceptions Of General Pharmacy Patronage And Pharmacist Consultation Service Activities Offered By Community Pharmacy Laboratory, Chulalongkorn University (Osotsala)(ความคิดเห็นของผู้มารับบร..., Burin T. Sriwong

The Thai Journal of Pharmaceutical Sciences

The objectives of this study were to determine consumers’ perceptions of general pharmacy patronage and pharmacist consultation service activities offered by the Community Pharmacy Laboratory, Chulalongkorn University (Osotsala). This study is explorat...

Stock Management Of Drug Inventory Control In The Community Pharmacy Laboratory, Faculty Of Pharmacy, Chiang Mai University(การจัดการเวชภัณฑ์คงคลังของห้องปฏิบัติการเภส..., Chupen Viboonsunti, Usanee Kumprakorb, Panee Sirisa-Ard

The Thai Journal of Pharmaceutical Sciences

The objective of this study is to analyze and determine the most economic order quantity and the appropriate time of reordering drugs to keep as an inventory control. The data of the drugs sold was collected from the Community Pharmacy Laboratory, Facult...

Analysis Of Phycotoxin And Mycotoxin, Contaminants In Foods, Using Liquid Chromatography - Mass Spectrometry Techniques, Ana Brana Magdalena

Theses

The impact of phycotoxins and mycotoxins on human and animal health are of important concern for worldwide authorities and the scientific community. Liquid chromatography-mass spectrometry (LC-MS) techniques have been developed, optimised and validated for the analysis of these toxins.

Phycotoxins are potentially toxic substances, which are produced by marine phytoplankton and which may accumulate in shellfish or finfish. Azaspiracid poisoning (AZP) is a recently discovered syndrome that has been implicated in several incidents of human intoxications. A study was undertaken to examine the distribution of azaspiracids (AZA) in scallops {Pecten maximiis) and mussels {Mytiliis edulis). Domoic acid (DA) is an …

Embryo And Gamete Development Upon Exposure To Cca Components: Cro3, Cuo, And As2o5, Nerbana Talaat-Elsebaei Mahmoud

Theses and Dissertations in Biomedical Sciences

Production of functional gametes and healthy embryos is essential for proliferation of all vertebrates, especially humans. Many compounds have toxic effects on developing gametes and embryos among which are chromium trioxide (CrO₃), cupric oxide (CuO) and arsenic pentaoxide (As₂O₅) as a mixture (CCA) or individually. Controversy surrounding the safety of CCA-treated wood centers primarily on the toxicity of its components and the potential for these metals to be released from the wood.

The aim of this research is to test the hypothesis that CCA components have deleterious effects on embryo development, oocyte maturation and …

Recognizing Toxic Species In Aquatic Habitats: A Potential Concern In Lake Management, Mikolaj Kokocinski, Harold G. Marshall

Biological Sciences Faculty Publications

The importance of distinguishing toxic and non-toxic algal species is becoming a more common problem for management decisions associated with various freshwater and estuarine habitats. An example is given where two dinoflagellates, originally unidentified as closely resembling the toxin producing Pfiesteria spp., have been compared to these species. In order to clarify any relationship to Pfiesteria spp., scanning electron microscopy was used to determine the plate tabulation patterns of these dinoflagellates and make comparisons to the tabulation present in Pfiesteria spp. The results indicated significant differences in the plate tabulations of these taxa to distinguish them from Pfiesteria …

Enhancement Of Disease And Pathology By Synergy Of Trichuris Suis And Campylobacter Jejuni In The Colon Of Immunologically Naive Swine, Linda S. Mansfield, David T. Gauthier, Sheila R. Abner, Kathryn M. Jones, Stacey R. Wilder, Joseph F. Urban

Biological Sciences Faculty Publications

Campylobacter jejuni, a leading cause of bacterial gastroenteritis, has different age distribution and disease expression in developing and developed countries, which may be due to the endemnicity of infection and the age of acquisition of immunity. Differences in disease expression are not solely dependent on the C jejuni strain or virulence attributes. Another modulating factor in developing countries may be endemic nematode infections such as Trichuris, which drive type 2 cytokine responses and down-regulate type I immune responses. In this study, three-day-old germfree pigs given dual infections with Trichuris suis and C jejuni had more frequent, more severe …

Introduction To Special Issue On Radiation Effects, P. Andrew Karam

The University of New Hampshire Law Review

[Excerpt] "How dangerous is radiation? How much radiation does it take to give us cancer? Are we wasting money on overly restrictive regulations, or are we not being sufficiently protective of our radiation workers and the public? How much clean-up is necessary on our Department of Energy facilities? What about Yucca Mountain and nuclear reactor plants – can they be made safe?

These are only a few of the questions that have been asked, and will continue to be asked, about radiation. Unfortunately, these all come down, in part or in whole, to the question “What is the shape of …

Effects Of The Shape Of The Radiation Dose-Response Curve On Public Acceptance Of Radiation And Nuclear Energy, Audeen W. Fentiman

The University of New Hampshire Law Review

[Excerpt] “The public generally accepts the premise that exposure to radiation can have an undesirable effect. Furthermore, it believes that as the radiation dose increases, the magnitude of the effect will increase. On the other hand, while the background radiation dose varies from a few hundred millirem/year (a few millisieverts/yr) in some places to a few thousand millirem/yr (tens of millisieverts/yr) in others, researchers have been unable to find a correlation between the level of background radiation and incidence of cancer or other maladies attributable to radiation.

…

Because there is considerable controversy about the relationship between radiation dose and …

The Debate On The Health Effects Attributable To Low Radiation Exposure, Abel J. Gonzalez

The University of New Hampshire Law Review

[Excerpt] "Few scientific issues have aroused passions more than the dispute about the health effects attributable to low levels of exposure to ionizing radiation (or radiation in short) and the currently authoritative dose response hypothesis, termed “linear non-threshold,” or LNT. Finding out whether health effects are induced by low-level radiation exposures, and if so, what they are, has become a kind of contest rather than a serious scientific inquiry. Sometimes it seems that rationality, or a methodical examination of the unknown, has disappeared from this debate. While the confrontation of different hypotheses is typical in academic discussions – at least …

Historical Development Of The Linear Nonthreshold Dose-Response Model As Applied To Radiation, Ronald L. Kathren

The University of New Hampshire Law Review

[Excerpt] "Despite the nearly universal adoption of the linear nonthreshold dose response model (LNT) as the primary basis for radiation protection standards for the past half century, the LNT remains highly controversial and a contentious topic of discussion among health physicists, radiation biologists, and other radiological scientists. Indeed, it has been pointed out that the LNT has assumed the status of a paradigm, synonymous with an ideal, standard, or paragon or perhaps to some, a sacred cow. Reduced to its very basics, the LNT postulates that every increment of ionizing radiation dose, however small, carries with it a commensurate increase …

Optimization Of Edxrf For The Study Of Heavy Metal Pollution Of Lake Victoria, Nk Mahommed, In Makundi

Tanzania Journal of Science

This study reports on the optimisation and calibration of the Energy Dispersive X-ray Fluorescence (EDXRF) spectrometer installed in the Department of Physics, University of Dar es Salaam. The spectrometer was subsequently utilized to determine concentrations of heavy metals in water hyacinth (Eichhornia crassipes (Mart) Solms.) found growing along the shore of Lake Victoria. The optimal conditions and detection limits were determined experimentally by variation of the excitation parameters. The study found that the use of a collimator with two apertures of diameter 4 mm each placed 8 mm apart and made of materials that do not interfere with elements to …

Guidelines For The Management Of Microbial Food Safety In Fruit Packing Houses, Tony Portman, Elizabeth Frankish, Graham Mcalpine

Bulletins 4000 -

The fresh produce industry has undergone significant change in recent years in the application of quality assurance to business operations. The quality assurance schemes implemented such as the SQF^CM programs, have generally served to provide a focus on food quality and operational issues, as well as food safety. Improvements of all aspects of the operations are identified to provide consistent quality, safe produce.

Inhibition Of Amyloid-Β Aggregation And Caspase-3 Activation By The Ginkgo Biloba Extract Egb761, Yuan Luo, Julie V. Smith, Vijaykumar Paramasivam, Adam Burdick, Kenneth J. Curry, Justin P. Buford, Ikhlas Khan, William J. Netzer, Huaxi Xu, Peter Butko

Faculty Publications

Standardized extract from the leaves of the Ginkgo biloba tree, labeled EGb761, has been used in clinical trials for its beneficial effects on brain functions, particularly in connection with age-related dementias and Alzheimer's disease (AD). Substantial experimental evidence indicates that EGb761 protects against neuronal damage from a variety of insults, but its cellular and molecular mechanisms remain unknown. Using a neuroblastoma cell line stably expressing an AD-associated double mutation, we report that EGb761 inhibits formation of amyloid-β (Aβ) fibrils, which are the diagnostic, and possibly causative, feature of AD. The decreased Aβ fibrillogenesis in the presence of EGb761 was observed …

Kalirin Dbl-Homology Guanine Nucleotide Exchange Factor 1 Domain Initiates New Axon Outgrowths Via Rhog-Mediated Mechanisms, Victor May, Martin R. Schiller, Betty A. Eipper, Richard E. Mains

Life Sciences Faculty Research

The large multidomain Kalirin and Trio proteins containing dual Rho GTPase guanine nucleotide exchange factor (GEF) domains have been implicated in the regulation of neuronal fiber extension and pathfinding during evelopment. In mammals, Kalirin is expressed predominantly in the nervous system, whereas Trio, broadly expressed throughout the body, is expressed at a lower level in the nervous system. To evaluate the role of Kalirin in fiber initiation and outgrowth, we microinjected cultured sympathetic neurons with vectors encoding Kalirin or with Kalirin antisense oligonucleotides, and we assessed neuronal fiber growth in a serum-free, satellite cell-free environment. Kalirin antisense oligonucleotides blocked the …

Effects Of Ethanol On The Toxicity And Metabolism Of Acetonitrile And Acrylonitrile, Nancy Ochoa-Garza

Theses and Dissertations - UTB/UTPA

This study examined the effects of ethanol on the toxicities and metabolism of two aliphatic nitriles: acetonitrile and acrylonitrile (one unsaturated and one saturated aliphatic nitrile, respectively) in male Sprague-Dawley rats at four different time intervals. Toxicity signs were apparent in all animals given the nitrile dosage, but those treated with ethanol dosages showed signs of toxicity earlier than those treated with glucose dosages. Both of the nitrites were metabolized to cyanide and thiocyanate. The concentration levels of each metabolite was apparent at 2 and 3 g/kg ethanol dosage for acetonitrile and 3 and 4.5 g/kg ethanol dosage for acrylonitrile …

1080 Summary Information, Department Of Agriculture, Western Australia, Department Of Conservation And Land Management, Western Australia, Department Of Health, Western Australia

Biosecurity research reports

Fluoroacetate, the active ingredient of 1080, occurs naturally in toxic plants in Australia, South Africa, and South America. Manufactured I080 underpins most vertebrate pest control programs in Australia and New Zealand. Fluoroacetate occurs naturally in about 40 plant species in Australia with most of these plants restricted to the south-west of WA.

I080 was introduced to rabbit control programs in the early 1950s and therefore has a long history of proven effectiveness and safety in Australia. There have been few repo1ted problems associated with human safety, environmental persistence, bioaccumulation or impact on populations of non-target species.

In particular, I080 baits …

Five-Hundred Life-Saving Interventions And Their Misuse In The Debate Over Regulatory Reform, Lisa Heinzerling

RISK: Health, Safety & Environment (1990-2002)

The author argues that John D. Graham, administrator of the Office of Information and Regulatory Affairs, holds strong anti-environmental biases and has perpetuated and encouraged a misrepresentation of his own research, which has largely influenced health, safety, and environmental regulation.