Pharmacology, Toxicology and Environmental Health Commons^™

Writing On Water: Resources, Discourses, Reflections, Justin Scott-Coe, W. Scott Howard

Reconstruction: Studies in Contemporary Culture

[First paragraph]

We started this project in the shadow of the Great Tsunami of 2004, witnessed Katrina destroy New Orleans as submissions were coming in, and now publish during a record-breaking, nationwide—some say worldwide—heat wave. Is it any wonder the release of our journal issue on water appears as suspiciously timed as Al Gore's droning tome on global warming?

The Land Is In Your Hands : A Practical Guide For Owners Of Small Rural Landholdings In Western Australia, Department Of Agriculture And Food, Wa

Bulletins 4000 -

This Bulletin discusses various aspects of managing a small farm or property in Western Australia, including soil and land care, vegetation and plant control on farm holdings, water resource management, biosecurity, plant, animal and insect pest control and livestock management.

Previous Spatial Memory Training And Nicotine Administration Alleviates Cognitive Deficits Produced By Medial Frontal Cortex Lesions In Rats., Rachel L. Norris

Electronic Theses and Dissertations

Rats were administered nicotine (0.3 mg/kg) for 11 consecutive days before and after an electrolytic medial frontal cortex lesion. Behavioral testing was arranged so that the rats were tested on the RAM 1 day after drug administration followed by behavioral testing on the MWT 19 days after drug treatment, or tested on the MWT 1 day after drug administration followed by testing on the RAM4 days after drug treatment. Results of MWT testing showed that regardless of the drug/behavioral testing interval, lesioned rats given nicotine demonstrated enhancement relative to saline-treated animals. Results of RAM testing showed that nicotine improved performance …

In Vitro Expression And Purification Of Class I Mhc Molecules, Loi Cheng

Honors Scholar Theses

The major histocompatibility complex (MHC) is a gene family responsible for many critical functions of the immune system in most vertebrates. The MHC consists of three classes differentiated by their structure and function, and MHC class I encodes antigen binding proteins as well as chaperone and accessory proteins such as tapasin. The purpose of this project is to reconstitute several human MHC class I molecules in their peptide-filled and peptide-deficient forms, and to purify these proteins for biochemical study. The expressed proteins include wild type and mutant variants of the fusion protein human leukocyte antigen HLA-B*0801-fos, and human beta-2-microglobulin (β2m). …

Anticonvulsant And Neuroprotective Effects Of Ginsenosides In Rats (Abstract), Xiao-Yuan Lian, Zhizhen Zhang, Janet L. Stringer

NCPC Publications and Patents

No abstract provided.

Smoking, Anemia, And Risk Of Oral Clefts In Utah, Melinda Michelle Moss

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Cigarette smoke contains sufficient carbon monoxide to induce maternal and fetal hypoxia. Hypoxia is a known teratogen, and consequently maternal smoking has been the focus of many studies on adverse birth outcomes, including cleft lip and palate. Current literature of epidemiological studies on smoking and clefts suggests a modest but statistically significant increase in risk of clefting associated with maternal smoking. A biological condition that may also contribute to hypoxia is anemia. Data from the Utah Child and Family Health Study was used to assess the effects of hypoxia-inducing conditions, maternal smoking, anemia, and their interaction, on the risk of …

Comparative Analysis Of Airborne Chemical Exposure To Air Force Small Arms Range Instructors, Eric J. Cameron

Theses and Dissertations

This study examines airborne chemical exposure to Air Force small arms range instructors during M16 firing of lead and lead-free bullets. Historical range information collected from 63 active duty Air Force bases identified that two thirds of the Air Force military ranges within the Continental United States are currently firing lead-free ammunition. Average 8-hr TWA exposures for lead during M16 firing of leaded ammunition were 17% of the Occupational Exposure Limit (OEL). Task exposures, representing worst case conditions, were found to be 1.2 time the OEL. Two indoor and four outdoor firing ranges currently firing frangible lead-free ammunition were evaluated …

In Vitro Toxicity Of Aluminum Nanoparticles In Rat Alveolar Macrophages, Andrew J. Wagner

Theses and Dissertations

Nanomaterials, which are by definition in the 1 - 100 nanometer range, have numerous possible benefits to society, but currently there is a lack of data that characterizes these materials effects on human health and environment. In general nanomaterials are of interest to the Air Force because of their applications in electronics, sensors, munitions and energetic/reactive systems. Nanoparticles such as aluminum have been considered for enhancing propulsion in solid rocket fuel. To date, only a few studies have looked at the toxicological effects of direct exposure to nanoparticles, none with aluminum. It is important to increase the understanding of the …

Antibiotic Resistant And Coliform Bacteria In The Ohio River; 2002 To 2004, Lisa Marie Smith

Theses, Dissertations and Capstones

During 2002 and 2003 samples, collected every five miles along the Ohio River, were analyzed for total cultivable bacteria, ciprofloxacin resistant bacteria, erythromycin resistant bacteria, tetracycline resistant bacteria, and fecal coliforms. During 2004 samples were analyzed for total cultivable bacteria, ciprofloxacin resistant bacteria, sulfamethizole resistant bacteria, tetracycline resistant bacteria, Virginiamycin resistant bacteria, total coliforms, and Escherichia coli. The objectives of this study were to systematically collect data on fecal coliforms, E. coli, and antibiotic resistant bacteria in the Ohio River and its major tributaries; to determine if antibiotic resistance populations are correlated to each other or to coliforms; and …

Science-Based Organic Farming 2006: Toward Local And Secure Food Systems, Charles A. Francis, Katja Koehler-Cole, Twyla Hansen, Peter Skelton

Publications from the Center for Applied Rural Innovation (CARI)

Organic farming includes growing food and fiber—animals, agronomic crops, horticultural fruits and vegetables, related products—as one dynamic and rapidly evolving component of our complex U.S. food system. Even as more farmers are moving toward organic certification and participation in an environmentally sound and economically lucrative market, questions arise about the long-term social impacts and sustainability of a set of practices that has gone from a movement to an industry. Consolidations in the organic trade have brought multinational corporations to the table, as they have observed a grassroots activity that has grown by 20% per year for the past two decades, …

Differential Expression Of Immune Response Genes In Steller Sea Lions (Eumetopias Jubatus): An Indicator Of Ecosystem Health?, Lizabeth Bowen, Brian Aldridge, Kimberlee Beckmen, Tom Gelatt, Lorrie Rea, Kathy Burek, Ken Pitcher, Jeffrey L. Stott

United States Department of Commerce: Staff Publications

Characterization of the polygenic and polymorphic features of the Steller sea lion major histocompatibility complex (MHC) provides an ideal window for evaluating immunologic vigor of the population and identifying emergence of new genotypes that reflect ecosystem pressures. MHC genotyping can be used to measure the potential immunologic vigor of a population. However, since ecosystem-induced changes to MHC genotype can be slow to emerge, measurement of differential expression of these genes can potentially provide real-time evidence of immunologic perturbations. MHC DRB genes were cloned and sequenced using peripheral blood mononuclear leukocytes derived from 10 Steller sea lions from southeast Alaska, Prince …

Effects On The Function Of Three Trophic Levels In Marine Plankton Communities Under Stress From The Antifouling Compound Zinc Pyrithione, M. Hjorth, I. Dahllöf, Valery E. Forbes

Valery Forbes Publications

This study aimed to investigate functional responses of natural marine planktonic communities to stress from the antifouling compound zinc pyrithione (ZPT). Isotope labelling techniques (¹⁴C) were applied to study bacterial incorporation of leucine, photosynthetic activity of phytoplankton and grazing of labelled prey by zooplankton communities for 6 days after exposures to nominal concentrations of 0, 5, 25, 50 nM ZPT in a mesocosm experiment in Isefjord, Denmark.

Significant direct effects were visible on chlorophyll α concentrations, which decreased in all exposed communities, to between 48 and 36% of control concentrations on Day 3, 1 day after the last …

Influence Of Biotransformation On Trophic Transfer Of The Pah, Fluoranthene, Annemette Palmqvist, Lene Juel Rasmussen, Valery E. Forbes

Valery Forbes Publications

The persistence of polycyclic aromatic hydrocarbons (PAHs) in marine sediments may be influenced by benthic invertebrate bioturbation. Through processes such as deposit-feeding and enhancement of microbial metabolic activity PAHs may be remobilized from the sediment compartment, and either transferred to organisms at higher trophic levels or to the overlying water column, both processes inevitably changing the bioavailability of the PAH. Accumulation of contaminants from one level in the food chain to the next depends on feeding rate and assimilation efficiency, two factors that basically vary with food quality and contaminant type. Though it is generally believed that pre-consumptive biotransformation will …

Effects Of Food Type, Feeding Frequency, And Temperature On Juvenile Survival And Growth Of Marisa Cornuarietis (Mollusca: Gastropoda), Henriette Selck, John Aufderheide, Nadine Pounds, Charles Staples, Norbert Caspers, Valery E. Forbes

Valery Forbes Publications

The present experiments are part of a larger study designed to investigate the influence of husbandry parameters on the life history of the ramshorn snail, Marisa cornuarietis, in order to identify suitable husbandry conditions for maintaining multi-generation populations in the laboratory for use in ecotoxicological testing. In this paper we focus on the effects of a combination of food types and feeding frequencies (i.e., the frequency with which the snails were offered food) on juvenile growth and survival at different temperatures. Offspring produced in the laboratory by wild specimens of M. cornuarietis, from Puerto Rico, were used to …

Effects Of Husbandry Parameters On The Life-History Traits Of The Apple Snail, Marisa Cornuarietis: Effects Of Temperature, Photoperiod, And Population Density, John Aufderheide, Ryan Warbritton, Nadine Pounds, Sharon File-Emperador, Charles Staples, Norbert Caspers, Valery E. Forbes

Valery Forbes Publications

These experiments are part of a larger study designed to investigate the influence of husbandry parameters on the life history of the apple snail, Marisa cornuarietis. The overall objective of the program is to identify suitable husbandry conditions for maintaining multigeneration populations of this species in the laboratory for use in ecotoxicological testing. In this article, we focus on the effects of photoperiod, temperature, and population density on adult fecundity and juvenile growth. Increasing photoperiod from 12 to 16 h of light per day had no effect on adult fecundity or egg hatching and relatively minor effects on juvenile growth …

Ecology In A Cost-Benefit Society: The Issues, Valery E. Forbes, Peter Calow

Valery Forbes Publications

Is there a role for ecology in a cost-benefit society? As a prelude to a collection of papers arising from a conference on this theme held at Roskilde University in June 2004, this paper summarizes divergent approaches to public policy decision making. Whether based on strict cost-benefit analysis or wide-ranging discussion, we make the point that decisions need to be informed by an understanding of the causes behind environmental problems and their consequences, through impaired ecosystem services, on the economy. Taking this forward will require forums that bring ecologists, economists, and regulators into active and constructive dialogue.

Influence Of Biotransformation On Trophic Transfer Of The Pah, Fluoranthene, Annemette Palmqvist, Lene Juel Rasmussen, Valery E. Forbes

Valery Forbes Publications

The persistence of polycyclic aromatic hydrocarbons (PAHs) in marine sediments may be influenced by benthic invertebrate bioturbation. Through processes such as deposit-feeding and enhancement of microbial metabolic activity PAHs may be remobilized from the sediment compartment, and either transferred to organisms at higher trophic levels or to the overlying water column, both processes inevitably changing the bioavailability of the PAH. Accumulation of contaminants from one level in the food chain to the next depends on feeding rate and assimilation efficiency, two factors that basically vary with food quality and contaminant type. Though it is generally believed that pre-consumptive biotransformation will …

Critical Evaluation Of The Claims Made By Pharmaceutical Companies In Drug Promotional Material In Pakistan, Dileep Kumar Rohra, Anwarul Hassan Gilani, Ismail Kamal Memon, Ghazala Perven, Muhammad Talha Khan, Hina Zafar, Rakesh Kumar

Department of Biological & Biomedical Sciences

Background: In Pakistan, there is no mechanism to monitor the drug promotional campaign by pharmaceutical industry despite the fact that there is enough evidence that irrational pharmacotherapy is increasingly encountered even in the developed countries due to unethical practices of pharmaceutical promotion. Objectives. To audit the drug promotional claims made by the pharmaceutical companies in Pakistan.
Methods: Drug promotional pamphlets and brochures containing claims for the drugs, which were circulated by the pharmaceuticalrepresentatives were collected from 122 general practitioners (GPs) from Karachi and Larkana cities of the Sindh Province. The claims were critically analyzed and audited with the help of …

Cytotoxicity And Inhibitory Activity On Hepatitis B Surface Antigen Secretion From Plc/Prf/5 Cells Of Medicinal Plant Extracts, Thaveechai Prommetta, Sattaporn Sirotamarat, Kruavon Balachandra, Ekarin Saifah

The Thai Journal of Pharmaceutical Sciences

Ethanolic extracts of three medicinal plants including Derris scandens, Rhinacanthus nasutus and Santalum album were investb'ated for cytotoxicity by MTT assay and inhibition of hepatitis B surface antigen secretion from PLC/PRF/5 cells by ELISA. Results...

Aqueous Extract Of The Calyces Of Hibiscus Subdariffa Linn.: Effects On Hepatic Cytochrome P450 And Subacute Toxicity In Rats, Promphorn Wirotesangthong, Laddawal Phivthong-Ngam, Chaiyo Chaichantipyuth, Nuansri Niwattisaiwong, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

Hibiscus sabdariffa Linn, has been reported to have a broad range of therapeutic effects. Subacute effects of the calyces of H. sabdariffa aqueous extract on the activities of cytochrome P450 (CYP), clinical blood chemistry and hematology were investigat...

Antioxidant Activity, Phenolic Compound Contents And Antimutagenic Activity Of Some Water Extract Of Herbs, Kalyarat Mekaroonreung, Kaew Kangsadalampai

The Thai Journal of Pharmaceutical Sciences

Ten water extracts from herbs were prepared by boiling in hot water for 10 min. The herbal extracts were studied for their antioxidant activity and phenolic compound contents. In this study, the extracts of C arthamus tinctorius L, Hibiscus sabdariffa L,...

Effects Of Cassava On Thyroid Gland In Rats, Rubporn N/A

The Thai Journal of Pharmaceutical Sciences

The root of cassava has been consumed as a food in many tropical countries. In pharmaceutical industry, cassava starch can be used as a binder in tablet formulation. Since cassava contains high concentration of linamarin, a cyanogenic glucoside which can...

Detection Of Mycoplasma Contamination In Cell Cultures: Comparison Between Dna Flurorochrom Staining And Pcr Amplification Methods(การตรวจหาการปนเปีอนของเชื้อมัยโคพลาสมาในเ..., Supaporn Phumiamorn, Kornnika Kullabutr, Sukanlayanee Tepbhuthorn, Teeranart Jivapaisarnpong

The Thai Journal of Pharmaceutical Sciences

Mycoplasma contamination of cell cultures is one of the major problems In cell culture technology. Therefore, prevention by continuous surveillance dem ands adequate mycoplasm as testing procedures. In this study, the standard procedures of microbiologic...

Author Index, Key Word Index, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Comparison Of Weight Reduction And Satisfaction Of Orlistat And Sibutramine, Somchai Anansiriwattana, Titinun Auamnoy, Pagorn Taweechotepatr

The Thai Journal of Pharmaceutical Sciences

The study was to compare and evaluate the efficacy and satisfaction of orlistat and sibutramine in Thai overweight females at Adisorn Fort Hospital, Saraburi Province, Thailand. Orlistat is a drug which increases the fecal fat excretion, with gastrointes...

A Broad-Spectrum Mer Operon In A Multi-Drug Resistant Strain Of The Fish Pathogen, Aeromonas Salmonicida, Erin Parry

Honors Theses

Aeromonas salmonicida AS03, a potential fish pathogen, was isolated from Atlantic salmon, Salmo salar, in 2003. This strain was found to be resistant to ≥1000 mM HgCl2 and ≥32 mM phenylmercuric acetate as well as multiple antimicrobials. Mercury (Hg) and antibiotic resistance genes are often located on the same mobile genetic elements, so the genetic determinants of both resistances and the possibility of horizontal gene transfer were examined. Specific PCR primers were used to amplify and sequence distinctive regions of the mer operon. A. salmonicida AS03 was found to have a pDU1358-like broad-spectrum mer operon, containing merB as well as …

The Speciation Of Metals In Mammals Influences Their Toxicokinetics And Toxicodynamics And Therefore Human Health Risk Assessment, Robert A. Yokel, Stephen M. Lasley, David C. Dorman

Pharmaceutical Sciences Faculty Publications

Chemical form (i.e., species) can influence metal toxicokinetics and toxicodynamics and should be considered to improve human health risk assessment. Factors that influence metal speciation (and examples) include: (1) carrier-mediated processes for specific metal species (arsenic, chromium, lead and manganese), (2) valence state (arsenic, chromium, manganese and mercury), (3) particle size (lead and manganese), (4) the nature of metal binding ligands (aluminum, arsenic, chromium, lead, and manganese), (5) whether the metal is an organic versus inorganic species (arsenic, lead, and mercury), and (6) biotransformation of metal species (aluminum, arsenic, chromium, lead, manganese and mercury). The influence of speciation on metal …

2-Aminoethoxydiphenyl Borate As A Prototype Drug For A Group Of Structurally Related Calcium Channel Blockers In Human Platelets, Yuliya Dobrydneva, Christopher J. Abelt, Beth Dovel, Celina M. Thadigiri, Roy L. Williams, Peter F. Blackmore

Chemistry & Biochemistry Faculty Publications

We have synthesized a series of 2-aminoethoxydiphenyl borate (2-APB, 2,2-diphenyl-1,3,2-oxazaborolidine) analogs and tested their ability to inhibit thrombin-induced Ca²⁺ influx in human platelets. The analogs were either synthesized by adding various substituents to the oxazaborolidine ring (methyl, dimethyl, tert-butyl, phenyl, methyl phenyl, and pyridyl) or increasing the size of the oxazaborolidine ring to seven- and nine-membered rings. NMR analysis of the boron-containing analogs suggests that each of them exist as a ring structure through the formation of an N -> B coordinate bond (except for the hexyl analog). The possibility that these boron-containing compounds formed dimers was also …

Cell Cycle Cyclin Expression Of Atrazine Treated Hepg2 Cells Using Western Blot Analysis, April Dawn Rand

Honors Program Theses

Atrazine is one of the most widely used herbicides in the United States. It is frequently used for general weed control on both industrial and agricultural land. However, atrazine has been associated with many harmful non-target effects in animals and humans. Due to its prevalence in the environment, the United States Environmental Protection Agency (USEP A) has set the maximal contaminant level of atrazine in drinking water at 3 ppb (USEP A, 2003 ). One of the non-target effects of atrazine is slowed growth of both normal and immortalized human cells. Previous work from our lab demonstrated that exposing normal …

Anti-Herpes Simplex Virus Type 2 Activities Of Some Thai Medicinal Plants, Mali Kruawan, Sakulrat Rattanakiat

The Thai Journal of Pharmaceutical Sciences

To explore for plants possessing anti-herpes simplex virus type 2 (anti-HSV-2) activity, 80 extracts prepared from 16 medicinal plants collected in Thailand were investigated in vitro using the plaque reduction assay including the inactivation, pre-treat...