Operations Research, Systems Engineering and Industrial Engineering Commons^™

Immobilization Of A Catalytic Dna Molecular Beacon On Au For Pb(Ii) Detection, Carla B. Swearingen, Daryl P. Wernette, Donald M. Cropek, Yi Lu, Jonathan V. Sweedler, Paul W. Bohn

United States Army: Publications

A Pb(II)-specific DNAzyme fluorescent sensor has been modified with a thiol moiety in order to immobilize it on a Au surface. Self-assembly of the DNAzyme is accomplished by first adsorbing the single-thiolated enzyme strand (HS-17E-Dy) followed by adsorption of mercaptohexanol, which serves to displace any Au-N interactions and ensure that DNA is bound only through the Sheadgroup. The preformed self-assembled monolayer is then hybridized with the complementary fluorophorecontaining substrate strand (17DS-Fl). Upon reaction with Pb(II), the substrate strand is cleaved, releasing a fluorescent fragment for detection. Fluorescence intensity may be correlated with original Pb(II) concentration, and a linear calibration was …

Conformational Sampling Of The Botulinum Neurotoxin Serotype A Light Chain: Implications For Inhibitor Binding, James C. Burnett, James J. Schmidt, Connor F. Mcgrath, Tam L. Nguyen, Ann R. Hermone, Rekha G. Panchal, Jonathan L. Vennerstrom, Krishna Kodukula, Daniel W. Zaharevitz, Rick Gussio, Sina Bavari

United States Army: Publications

Botulinum neurotoxins (BoNTs) are the most potent of the known biological toxins, and consequently are listed as category A biowarfare agents. Currently, the only treatments against BoNTs include preventative antitoxins and long-term supportive care. Consequently, there is an urgent need for therapeutics to counter these enzymes––post exposure. In a previous study, we identified a number of small, nonpeptidic lead inhibitors of BoNT serotype A light chain (BoNT/A LC) metalloprotease activity, and we identified a common pharmacophore for these molecules. In this study, we have focused on how the dynamic movement of amino acid residues in and surrounding the substrate binding …

Miniaturized Lead Sensor Based On Lead-Specific Dnazyme In A Nanocapillary Interconnected Microfluidic Device, In-Hyoung Chang, Joseph J. Tulock, Juewen Liu, Won-Suk Kim, Donald M. Cannon, Jr., Yi Lu, Paul W. Bohn, Jonathan V. Sweedler, Donald M. Cropek

United States Army: Publications

A miniaturized lead sensor has been developed by combining a lead-specific DNAzyme with a microfabricated device containing a network of microfluidic channels that are fluidically coupled via a nanocapillary array interconnect. A DNAzyme construct, selective for cleavage in the presence of Pb²⁺ and derivatized with fluorophore (quencher) at the 5’ (3’) end of the substrate and enzyme strands, respectively, forms a molecular beacon that is used as the recognition element. The nanocapillary array membrane interconnect is used to manipulate fluid flows and deliver the small-volume sample to the beacon in a spatially confined detection window where the DNAzyme is …

Food Acceptability In Field Studies With Us Army Men And Women: Relationship With Food Intake And Food Choice After Repeated Exposures, Cees De Graaf, F. Matthew Kramer, Herbert L. Meiselman, Larry L. Lesher, Carol Baker-Fulco, Edward S. Hirsch, John Warber

United States Army: Publications

Laboratory data with single exposures showed that palatability has a positive relationship with food intake. The question addressed in this study is whether this relationship also holds over repeated exposures in non-laboratory contexts in more natural environments. The data were collected in four field studies, lasting 4–11 days with 307 US Army men and 119 Army women, and comprised 5791 main meals and 8831 snacks in total. Acceptability was rated on the nine point hedonic scale, and intake was registered in units of 1/4, 1/2, 3/4, or 1 or more times of the provided portion size. Correlation coefficients between individual …

Brown Recluse Spider Bite To The Face, Daniel C. Madion, Melanie K. Marshall, Christopher D. Jenkins, George M. Kushner

United States Army: Publications

Oral and maxillofacial surgeons must be prepared to manage a variety of maxillofacial infections, both odontogenic and non-odontogenic in nature. While odontogenic infections are quite common, non-odontogenic infections can present with diagnostic and therapeutic challenges. An uncommon non-odontogenic infection is the cellulitis secondary to a spider bite.
Few spider species have the ability to bite through human skin. Most of these insults result in only a small, red nodule centered within a larger, erythematous plaque. Symptoms are usually limited to pruritus and perhaps mild tenderness. The brown recluse and the black widow are 2 types of spiders that inhabit the …

Coronary Calcium Independently Predicts Incident Premature Coronary Heart Disease Over Measured Cardiovascular Risk Factors, Allen J. Taylor, Jody Bindeman, Irwin Feuerstein, Felix Cao, Michael Brazaitis, Patrick G. O'Malley

United States Army: Publications

OBJECTIVES - We sought to examine the independent predictive value of coronary artery calcium detection for coronary outcomes in a non-referred cohort of healthy men and women ages 40 to 50 years.

BACKGROUND - Existing studies have suggested that coronary calcium might have incremental predictive value for coronary outcomes above standard coronary risk factors. However, additional data from non-referred and younger populations are needed.

METHODS - Participants (n = 2,000; mean age 43 years) were evaluated with measured coronary risk variables and coronary calcium detected with electron beam tomography. Incident acute coronary syndromes and sudden cardiac death were ascertained via …

Enhancing Erp System’S Functionality With Discrete Event Simulation, Young Moon, Dinar Phatak

Mechanical and Aerospace Engineering - All Scholarship

Purpose – To develop a methodology to augment enterprise resource planning (ERP) systems with the discrete event simulation’s inherent ability to handle the uncertainties.

Design/methodology/approach – The ERP system still contains and uses the material requirements planning (MRP) logic as its central planning function. As a result, the ERP system inherits a number of shortcomings associated with the MRP system, including unrealistic lead-time determination. The developed methodology employs bi-directional feedback between the non-stochastic ERP system and the discrete event simulation model until a set of converged lead times is determined.

Findings – An example of determining realistic production lead-time data …

Modeling Of Commercial Maritime Port Recoverability From Security Disruptions: Work-In-Progress, C. Ariel Pinto, Wayne K. Talley

Engineering Management & Systems Engineering Faculty Publications

This article describes active research in commercial maritime port's recovery from security disruptions which explores the synergy of economic and simulation models in investigating the recoverability of ports after security incidents. Previous study has identified decision variables and throughput simulation models of port operation. However, none of these models have been utilized to investigate port's recovery from a security disruption and in evaluating recoverability investments. The method of research includes analysis of recorded disruptions, identification of impediments to recovery and investment criteria for recoverability. This article provides managers insight into including security and continuity of operation in managing various types …

Software Development Project Risk Management: A Literature Review, Kevin Macg. Adams, C. Ariel Pinto

Engineering Management & Systems Engineering Faculty Publications

The rapid and unprecedented growth in software has brought with it some of the most spectacular and costly project failures in modern history. How risk management is presented in the scholarly journals may give insight into the risk management methods and techniques in use on software development projects. This paper provides a glimpse into the risk management methods, methodologies and techniques available to those who are responsible for software development projects by conducting a non-experimental content analysis. The findings reveal that risk management has not received sufficient attention and does not appear to be widely accepted within the software engineering …

Managing The Transformation Of System Of Systems Engineering, Samuel F. Kovacic, Andres Sousa-Poza

Engineering Management & Systems Engineering Faculty Publications

SOSE methodologies exist that support engineering difficult and disparate systems with a technical solution. However, from literature it is apparent that there is a need for a formal methodology and methods that govern engineering of System of Systems (SOS) beyond the technical solution. This paper presents some of the current thinking being undertaken at NCSOSE (National Centers for Systems of Systems Engineering), on what is driving the development of SOSE, and a hypothesized solution to this problem. The purpose is to offer a different approach for resolving complexity within a situation. The paper concludes with an initial derivative of a …

Using Multi-Stack And Variable-Speed-Drive Systems To Reduce Laboratory Exhaust Fan Energy, Gang Wang, Mingsheng Liu

Durham School of Architectural Engineering and Construction: Faculty Publications

In buildings that contain laboratories, fume hoods are normally used to control contaminant concentrations. Exhaust stacks with a constant exit velocity are required to make sure that dangerous concentrations do not occur in occupied areas near the building or on the roof top. To achieve constant velocity when exhaust flow rates are less than design, makeup air is introduced to the system at the inlet of the exhaust fan. Since laboratory exhaust airflow is often significantly less than the design airflow, exhaust fans consume significantly more energy than is necessary. To reduce exhaust fan energy, techniques involving multiple exhaust stacks …

Development Of A System Of Systems Engineering Method, Ji Hyon Mun, Morgan Henrie, Yaneth Correa, Charles Keating, Andres Sousa-Poza

Engineering Management & Systems Engineering Faculty Publications

Systems engineers have been facing challenges with the design and analysis of multiple complex systems. System of Systems Engineering has emerged to assist in this challenge with the systemic analysis, design, and transformation of complex metasystems. This paper outlines a proposed method to overcome these challenges, which is grounded in System of Systems Engineering principles and methodology. An overview of System of Systems Engineering will be provided for understanding of its significance and the attempt to complement Systems Engineering efforts in dealing with the aforementioned challenges. Finally, discussion on the proposed method, with respect to complex system analysis, is provided.

A Comparison Of The Canons Of Science Used In Positivistic Research And Constructivist/Naturalistic Research, Ipek Bozkurt, Andres Sousa-Poza

Engineering Management & Systems Engineering Faculty Publications

In this paper, the canons of science which are crucial for positivistic, empirical research and constructivist/naturalistic research will be identified, described, compared and discussed. Although there are common canons which are often used in papers throughout literature, it would be beneficial to set a common ground for the identification and use of the canons. The canons used in positivistic research will differ from the canons used in constructivist/ naturalistic research. This paper will analyze major publications (papers, books, etc.) exploring the canons either directly or indirectly, and will provide a link between major characteristics of two different research philosophies and …

Evaluating The Impact Of Production Scheduling On Tool Performance, Amr Arisha, Paul Young

Conference papers

Scheduling of a semiconductor manufacturing facility is one of the most complex tasks encountered. Confronted with a high technology product market, semiconductor manufacturing is increasingly more dynamic and competitive in the introduction of new products in shorter time intervals. Simulation provides an effective decision support tool in scheduling of semiconductor manufacturing. Simulation model was developed as a risk assessment tool for one of the implant process area. The model examines the impact of production schedule on tool performance by testing different production scenarios. Production ramping, local buffer capacity, product sequence and product mix seem to be influential factors of the …

Design Stability, K. M. Ragsdell

Engineering Management and Systems Engineering Faculty Research & Creative Works

Design for Six Sigma (DFSS) is a quality management strategy, which shows promise for manufacturing organizations, which seek to rapidly develop and market high-quality, low-cost products for hyper-competitive markets. This paper introduces and discusses the concept of design stability, and its relationship to reliability, durability and warranty cost. the use of this concept at very early stages of product development, even before knowledge of customer preferences, is discussed. the use of the design stability concept as a part of DFSS is suggested as an effective supply chain management strategy. Copyright © 2005 SAE International.

Production Research In China, S. Chaudhry, S. Feng, H. Li, H. Sui, J. L. Zhang, Z Zhang, Li Xu

Information Technology & Decision Sciences Faculty Publications

(First paragraph) China is the world’s largest emerging economy. In recent years, China has moved to an increasingly market-oriented economy that opens to international trade and investment. At the same time, the popularity of China as a manufacturing base, assembling goods for sale worldwide is growing. In addition to global manufacturers who have built their own plants in China, many manufacturing companies are outsourcing production to Chinese subcontractors and branding the products with their own logos. In today’s China, production research is becoming more and more important; advanced production research becomes an important enabler to make its manufacturing industry competitive. …

Development Of A Systems Engineering Model Of The Chemical Separations Process, Yitung Chen, Darrell Pepper, Sean Hsieh

Separations Campaign (TRP)

The chemical processing of used nuclear fuel is an integral component of any strategy for the transmutation of nuclear waste. Due to the large volume of material that must be handled in this first step of the transmutation process, the efficiency of the separations process is a key factor in the potential economic viability of transmutation strategies. The ability to optimize the chemical separation systems is vital to ensure the feasibility of the transmutation program.

Systems analysis, or total systems modeling, is one of the strongest tools available to researchers for understanding and optimizing complex systems such as chemical separations …

Development Of Integrated Process Simulation System Model For Spent Fuel Treatment Facility (Sftf) Design, Yitung Chen, Sean Hsieh

Separations Campaign (TRP)

The major objective is to create a framework that combines all the strengths of AMUSE’s complicated calculations, well established commercial system process package such as ASPENPLUS, HYSYS and PRO/II and TRPSEMPro’s flexible parameter optimization modules. Development of the process simulation code can be done using the solvent extraction process experience at Argonne National Laboratory and in collaboration with the NCACM.

The major activities of the task are the following:

• Develop a framework for simulating the SFTF process using AMUSE code, commercial process package, such as ASPEN- PLUS, and system engineering model.
• Develop a middleware package that can communicate between the …

Development Of A Flying Eye: A Project-Based Learning Experience, Sema E. Alptekin, Dianne Deturris, Daniel J. Macy, Jon E. Ervin

Industrial and Manufacturing Engineering

The paper describes the design for manufacturability of a prototype product as part of a manufacturing engineering capstone course. The product chosen was a vertically launched unmanned aerial vehicle (UAV)—the “Flying Eye.” The Flying Eye is an autonomous parafoil surveillance platform quipped with sensors, controllers, mechanical components, and software. Once the autonomous UAV is deployed, it is designed to follow a predetermined flight path down to the ground. The design effort of the prototype device took place over a three-year period as a collaborative effort between the Aerospace Engineering and Industrial and Manufacturing Engineering departments at California Polytechnic State University. …

Simulation In Semiconductor Manufacturing Facilities, Amr Arisha, Paul Young

Conference papers

Semiconductor manufacturing is one of the most complex industries in terms of technology and manufacturing procedure. The life cycle of a semiconductor facility (FAB) has many phases, in their life cycle including capacity planning, new products introduction, variation of products/technologies, and decline phase. The complexity of the manufacturing and the external forces from markets and technology growth make predicting the effects of changes in the manufacturing system problematic. Simulation, if used correctly, is a powerful hands-on tool which may be used to give a better insight of the effect of engineering/management decisions on the performance of the manufacturing system. While …

Perchlorate: Sources, Uses, And Occurrences In The Environment, Clayton W. Trumpolt, Michael Crain, Geoffrey D. Cullison, Susan J. P. Flanagan, Lenny Siegel, Stephen Lathrop

United States Navy: Publications

Perchlorate contamination of groundwater and soil continues to be a hot topic in many sectors, including industry, the federal Departments of Defense and Energy, regulators, and the general public. This article presents information on what is currently known regarding perchlorate uses, known and suspected naturally occurring versus anthropogenic perchlorate sources, and past and present manufacturing locations. It provides the reader with a baseline as well as background information to facilitate an understanding of perchlorate in the environment for the ultimate purpose of remediation. The article is based on research conducted by the Interstate Technology Regulatory Council for a forthcoming, more …

Towards An Rts,S-Based, Multi-Stage, Multi-Antigen Vaccine Against Falciparum Malaria: Progress At The Walter Reed Army Institute Of Research, D. Gray Heppner Jr., Kent E. Kester, Christian F. Ockenhouse, Nadia Tornieporth, Opokua Ofori, Jeffrey A. Lyon, V. Ann Stewart, Patrice Dubois, David E. Lanar, Urszula Krzych, Philippe Moris, Evelina Angov, James F. Cummings, Amanda Leach, B. Ted Hall, Sheetij Dutta, Robert Schwenk, Collette Hillier, Arnoldo Barbosa, Lisa A. Ware, Lalitha Nair, Christian A. Darko, Mark R. Withers, Bernhards Ogutu, Mark E. Polhemus, Mark Fukuda, Sathit Pichyangkul, Montip Gettyacamin, Carter Diggs, Lorraine Soisson, Jessica Milman, Marie-Claude Dubois, Nathalie Garcon, Kathryn Tucker, Janet Wittes, Christopher V. Plowe, Mahamadou A. Thera, Ogobara K. Duombo, Maria G. Pau, Jaap Goudsmit, W. Ripley Ballou, Joe Cohen

United States Army: Publications

The goal of the Malaria Vaccine Program at the Walter Reed Army Institute of Research (WRAIR) is to develop a licensed multi-antigen, multi-stage vaccine against Plasmodium falciparum able to prevent all symptomatic manifestations of malaria by preventing parasitemia. A secondary goal is to limit disease in vaccinees that do develop malaria. Malaria prevention will be achieved by inducing humoral and cellular immunity against the pre-erythrocytic circumsporozoite protein (CSP) and the liver stage antigen-1 (LSA-1). The strategy to limit disease will target immune responses against one or more blood stage antigens, merozoite surface protein-1 (MSP-1) and apical merozoite antigen-1 (AMA-1). The …

Management Of Extremes In The Configuration Of Interoffice Telephone Switch & Priority Systems, C. Ariel Pinto

Engineering Management & Systems Engineering Faculty Publications

This paper describes how to enable diverse enterprise customers for voice-data switch to achieve in configuration a balance among users, features, and perceived reliability subject to extremes of traffic. The analysis entailed the simulation of the voice-data switch with embedded priority system, generation of latency times for various configurations and transaction traffic rates, and the development of a framework and theoretical propositions for configuration of super-saturated systems. It was shown that the concept of tolerance levels defined in the risk of extreme events can be applied for embedded priority systems and was the basis for the application of the zone-configuration …

Complex System Transformation: A System Of Systems Engineering (Sose) Perspective, Charles B. Keating, Andres Sousa-Poza, Samuel Kovacic

Engineering Management & Systems Engineering Faculty Publications

The purpose of this paper is to develop a perspective for complex system transformation from a System of Systems Engineering (SoSE) viewpoint. This is a first attempt to make explicit a SoSE viewpoint on complex system transformation. As such, the formulation is intended to escalate the dialog and integrate the current state of understanding with respect to the nature, utility, and implications of complex system transformation in SoSE terms. To achieve our purpose we will: (1) present a short introduction that provides an essential background for SoSE, (2) provide five fundamental systems concepts that underlie a SoSE perspective of complex …

Managing The Transformation Of System Of Systems Engineering, Samuel F. Kovacic, Andres Sousa-Poza

Engineering Management & Systems Engineering Faculty Publications

SOSE methodologies exist that support engineering difficult and disparate systems with a technical solution. However, from literature it is apparent that there is a need for a formal methodology and methods that govern engineering of System of Systems (SOS) beyond the technical solution. This paper presents some of the current thinking being undertaken at NCSOSE (National Centers for Systems of Systems Engineering), on what is driving the development of SOSE, and a hypothesized solution to this problem. The purpose is to offer a different approach for resolving complexity within a situation. The paper concludes with an initial derivative of a …

Hierarchical Indexing For Region Based Image Retrieval, Eka Aulia

LSU Master's Theses

Region-based image retrieval system has been an active research area. In this study we developed an improved region-based image retrieval system. The system applies image segmentation to divide an image into discrete regions, which if the segmentation is ideal, correspond to objects. The focus of this research is to improve the capture of regions so as to enhance indexing and retrieval performance and also to provide a better similarity distance computation. During image segmentation, we developed a modified k-means clustering algorithm for image retrieval where hierarchical clustering algorithm is used to generate the initial number of clusters and the cluster …

Usability Of Home Cholesterol Test Kits And Their Impact On Patients' Decision, Deepti Surabattula

LSU Master's Theses

Release of home health testing kits into the market has enabled people to take care of their own health. Misinterpretation of results and delays in treatments are the major concerns of the doctors. In the present study, two cholesterol test kits, AccuchekÒ Instant plusÒ and Home Access® Instant Cholesterol Test, were compared on the basis of user performance, accuracy, and the patient’s future medical decisions based on the test results. The study was conducted with 30 participants, 15 men and 15 women. Participants tested their overall cholesterol level with both kits. In addition, a clinical cholesterol evaluation, the medical gold …

Predictive Congestion Control Mac Protocol For Wireless Sensor Networks, Maciej Jan Zawodniok, Jagannathan Sarangapani

Electrical and Computer Engineering Faculty Research & Creative Works

Available congestion control schemes, for example transport control protocol (TCP), when applied to wireless networks results in a large number of packet drops, unfairness with a significant amount of wasted energy due to retransmissions. To fully utilize the hop by hop feedback information, a suite of novel, decentralized, predictive congestion control schemes are proposed for wireless sensor networks in concert with distributed power control (DPC). Besides providing energy efficient solution, embedded channel estimator in DPC predicts the channel quality. By using the channel quality and node queue utilizations, the onset of network congestion is predicted and congestion control is initiated. …

Complex System Contextual Framework (Cscf): A Grounded-Theory Construction For The Articulation Of System Context In Addressing Complex Systems Problems, W. B. Max Crownover

Engineering Management & Systems Engineering Theses & Dissertations

The complexity of problems facing society continues to grow, and decision-makers and problem-solvers are finding many of today's emerging problems to be beyond their capability to adequately address. There is agreement in the literature that problems of this nature are complex system problems, inextricably linked to some highly complex system of systems. Establishing a clear understanding of the specific complex system context is fundamental to the process of understanding and analyzing complex systems and complex system problems across all of the different systems-based disciplines. While complex system context is widely referred to in systems literature, there is no clear characterization …

Semantic Classification Of Rural And Urban Images Using Learning Vector Quantization, Prakash Thulasiraman

LSU Master's Theses

One of the major hurdles in semantic image classification is that only low-level features can be reliably extracted from images as opposed to higher level features (objects present in the scene and their inter-relationships). The main challenge lies in grouping images into semantically meaningful categories based on the available low-level visual features of the images. It is important that we have a classification method that will handle a complex image dataset with not so well defined boundaries between clusters. Learning Vector Quantization (LVQ) neural networks offer a great deal of robustness in clustering complex datasets. This study presents a semantic …