Operations Research, Systems Engineering and Industrial Engineering Commons^™

Inhibition Of Hiv-1 Infection Of Peripheral Blood Mononuclear Cells By A Monoclonal Antibody That Binds To Phosphoinositides And Induces Secretion Of Β-Chemokines, Gary R. Matyas, Lindsay Wieczorek, Divya Bensal, Agnes-Laurence Chenine, Eric Saunders-Buell, Sodsai Tovanabutra, Jerome H. Kim, Victoria Polonis, Carl R. Alving

United States Army: Publications

A murine IgG mAb, WR321, selected for the ability to bind to phosphatidylinositol-4-phosphate and phosphatidylinositol-4, 5-bisphosphate, but an inability to bind to any of 17 other lipids, including phosphatidylinositol, was examined as a probe for studying interactions of HIV-1 with primary human peripheral blood mononuclear cells. The WR321 mAb broadly neutralized CCR5-tropic strains of HIV-1 to prevent infection of the cells. The mAb also exhibited direct interaction with cells in the culture, resulting in secretion of chemokines that interfered with the interaction of HIV-1 virions with CCR5, the coreceptor for HIV-1 on the susceptible cells, leading to inhibition of infection …

Multiscale Modeling Of The Impact Of Textile Fabrics Based On Hybrid Element Analysis, Gaurav Nilakantan, Michael Keefe, Travis A. Bogetti, John W. Gillespie Jr.

United States Army: Publications

In this work, a multi scale modeling approach has been developed to simulate the impact of woven fabrics using a finite element (FE) analysis. A yarn level of resolution is used in the model. This approach, referred to as the hybrid element analysis (HEA) is based on decreasing the complexity of the finite element model with distance away from the impact zone based on the multiscale nature of the fabric architecture and the physics of the impact event. Solid elements are used to discretize the yarns around the impact region, which transition to shell elements in the surrounding region. A …

Shrapnel-Induced Mandibular Hypomobility, David E. Palo, Paul J. Warden

United States Army: Publications

Mandibular hypomobility can develop from direct injury to, or as a result of disorders affecting, the supporting structures of the temporomandibular joint. This can be subdivided into intra-articular and extraarticular processes. Ankylosis is commonly associated with trauma (31% to 98%), followed by infections (10% to 49%) and systemic disease (10%). Temporomandibular joint ankylosis is an intra-articular process characterized by fibrous, fibro-osseous, or osseous obliteration of the joint space. Pseudoankylosis involves extracapsular causes of restricted jaw motion that include, but are not limited to, coronoid-zygomatic fusion, coronoid hypertrophy, and muscular fibrosis. Shrapnel injuries can be as devastating as high-velocity gunshot wounds, …

Biological Transformation Pathways Of 2,4-Dinitro Anisole And N-Methyl Paranitro Aniline In Anaerobic Fluidized-Bed Bioreactors, William E. Platten Iii, David Bailey, Makram T. Suidan, Stephen W. Maloney

United States Army: Publications

The US Army is evaluating new, insensitive explosives to produce safer munitions. Two potential new components are 2,4-dinitro anisole (DNAN) and N-methyl paranitro aniline (MNA), which would eventually make their way to waste streams generated in the production and handling of new munitions. The effectiveness of anaerobic fluidized-bed bioreactors (AFBB) was studied for treatment and transformation of these two new chemical components in munitions. Each compound was fed into a separate reactor and monitored for removal and transformation, using ethanol as the electron donor. The results show that both were degradable using the AFBB system. DNAN was found to transform …

Characterization Of Silver Nanoparticles Using Flow-Field Flow Fractionation Interfaced To Inductively Coupled Plasma Mass Spectrometry, A. R. Poda, A. J. Bednar, A. Harmon, M. Hull, D. M. Mitrano, J. F. Ranville, J. Steevens

United States Army: Publications

The ability to detect and identify the physiochemical form of contaminants in the environment is important for degradation, fate and transport, and toxicity studies. This is particularly true of nanomaterials that exist as discrete particles rather than dissolved or sorbed contaminant molecules in the environment. Nanoparticles will tend to agglomerate or dissolve, based on solution chemistry, which will drastically affect their environmental properties. The current study investigates the use of field flow fractionation (FFF) interfaced to inductively coupled plasma-mass spectrometry(ICPMS) as a sensitive and selective method for detection and characterization of silver nanoparticles. Transmission electron microscopy (TEM) is used to …

Current Us Military Operations And Implications For Military Surgical Training, Joshua A. Tyler, Kevin S. Clive, Christopher E. White, Alec C. Beekley, Lorne H. Blackbourne

United States Army: Publications

BACKGROUND:

Since 2001, US military surgeons have deployed frequently, with many surgeons deploying within 1 year of graduating residency. The purpose of this study was to evaluate readiness of recent graduates to manage combat-related injuries and to make recommendations for improvements in training military surgeons.

STUDY DESIGN:

We reviewed casualties treated at the 31^st Combat Support Hospital in Baghdad from December 2003 to November 2004.We identified 3,426 wounded patients; of these, 2,648 (77.3%) required an operative procedure. There were 2,788 patients (81.4%) who sustained penetrating injuries. The most common procedures performed were debridement of wounds (39%), skeletal fixation (14.7%), …

Monotonic And Cyclic Short Beam Shear Response Of 3d Woven Composites, T. R. Walter, G. Subhash, University Of Florida, C. F. Yen

United States Army: Publications

Monotonic, multi-step and cyclic short beam shear tests were conducted on 2D and 3D woven composites. The test results were used to determine the effect of z-yarns on the inter-laminar shear strength as well as the multi-loading behavior. The presence of z-yarns was found to affect not only the inter-laminar shear strength of the composite but also the behavior of the composite beyond the elastic limit. Microscopic examination of the damaged specimens revealed large delamination cracks in 2D woven composites while delamination cracks were hindered by z-yarns in 3D composites. This crack arrest phenomena resulted in a reduction in inter-laminar …

Task Analysis, Modeling, And Automatic Identification Of Elemental Tasks In Robot-Assisted Laparoscopic Surgery, Lavie Pinchas Golenberg

Wayne State University Dissertations

Robotic microsurgery provides many advantages for surgical operations, including tremor filtration, an increase in dexterity, and smaller incisions. There is a growing need for a task analyses on robotic laparoscopic operations to understand better the tasks involved in robotic microsurgery cases. A few research groups have conducted task observations to help systems automatically identify surgeon skill based on task execution. Their gesture analyses, however, lacked depth and their class libraries were composed of ambiguous groupings of gestures that did not share contextual similarities.

A Hierarchical Task Analysis was performed on a four-throw suturing task using a robotic microsurgical platform. Three …

Causal Product Knowledge Management, Yun Seon Kim

Wayne State University Dissertations

The US engineering industry base is facing a significant loss of knowledge due to large numbers of employees retiring in the next decade. Problems in various product developments including product design may arise when the expertise is no longer available or the knowledge is forgotten. Also, most of product design knowledge is not reusable, because product design knowledge in an organization remains un-codified. Generally, knowledge-based system can solve or infer these problems. However, knowledge-based systems have been developed solely through the use of rule-based approach, which allows for easy modeling of expert reasoning, but such an approach is not general …

A Hybrid Problem-Based And Just-In-Time Inductive Teaching Method For Failure Analysis Instruction, Ryan Michael Arlitt

Masters Theses

"When engineers retire, they take their expert knowledge with them. Preservation of this expert knowledge in a usable form is beneficial for the advancement of any engineering field. Risk in Early Design (RED) is one method for preserving expert risk analysis knowledge. The first purpose of this paper is to examine the usability of RED when incorporated with a hybrid problem-based and just-in-time inductive teaching method for failure analysis instruction. The second purpose of this paper is to propose and perform steps toward verification and validation of the RED methodology and implementation. Evaluation metrics were developed, and several of these …

Risk And System-Of-Systems: Toward A Unified Concept, C. Ariel Pinto, Michael K. Mcshane, Rani Kady

Engineering Management & Systems Engineering Faculty Publications

The scope of this paper is the survey of both fundamental and most recent publications in system-of-systems, business and insurance, as well as risk analysis, modeling, and management for the purpose of better describing the concept of risk in recognition of emergence and complexity which characterizes many systems within the concern of engineering and business managers. The ultimate goal is to provide engineering and business managers the necessary perspective on the concept of risk and in its management for the next generation of sustainable systems - including various descriptions of risk and discussion of the relevance of properties of system-of-systems …

A Methodology To Stabilize The Supply Chain, Alfonso Sarmiento

Electronic Theses and Dissertations

In today's world, supply chains are facing market dynamics dominated by strong global competition, high labor costs, shorter product life cycles, and environmental regulations. Supply chains have evolved to keep pace with the rapid growth in these business dynamics, becoming longer and more complex. As a result, supply chains are systems with a great number of network connections among their multiple components. The interactions of the network components with respect to each other and the environment cause these systems to behave in a highly nonlinear dynamic manner. Ripple effects that have a huge, negative impact on the behavior of the …

An Interval Based Approach To Model Input Uncertainty In Discrete-Event Simulation, Ola Batarseh

Electronic Theses and Dissertations

The objective of this research is to increase the robustness of discrete-event simulation (DES) when input uncertainties associated models and parameters are present. Input uncertainties in simulation have different sources, including lack of data, conflicting information and beliefs, lack of introspection, measurement errors, and lack of information about dependency. A reliable solution is obtained from a simulation mechanism that accounts for these uncertainty components in simulation. An interval-based simulation (IBS) mechanism based on imprecise probabilities is proposed, where the statistical distribution parameters in simulation are intervals instead of precise real numbers. This approach incorporates variability and uncertainty in systems. In …

Adaptive Pain Management Decision Support System, Ching-Feng Lin

Industrial, Manufacturing, and Systems Engineering Dissertations - Archive

Pain management is an international health issue. The Eugene McDermott Center for Pain Management at the University of Texas Southwestern MedicalCenter at Dallas conducts a two-stage interdisciplinary pain management program that considers a wide variety of treatments. Prior to treatment (stage 1), an evaluation records the patient's pain characteristics, medical history and related health parameters. A treatment regime is then determined. At the midpoint of their program (stage 2), an evaluation is conducted to determine if an adjustment in the treatment should be made. A final evaluation is conducted at the end of the program to assess final outcomes. The …

Corporate Environmental Performance Rating Methodology, Arunapprakasini Sankaranarayanan

Industrial, Manufacturing, and Systems Engineering Dissertations - Archive

Environmental issues are becoming increasingly important to all kinds of stakeholders and companies themselves, not only for cost avoidance due to regulations, laws, cleanup costs, litigations, controversies, etc, but to improve their intrinsic ethical worth as a company for better environmental sustainability. Off late, companies are increasingly investing in environmental initiatives for cost savings and to generate profits as well. However, since no clear definition of greenness exists, companies are finding it difficult to measure environmental performance as an internal and external benchmark and hence a sound performance measurement system with formal guidelines is yet to be in place. What …

Goal Approach To Risk Scenario Identification In Systems Development, Cesar Ariel Pinto, Andreas Tolk, Rafael Landaeta

Engineering Management & Systems Engineering Faculty Publications

The scope of this paper is the exploration of fundamental issues in identifying risk scenarios during systems development. Systems development refers to a series of processes which span conceptualization, designing the architecture, obtaining the elements, and eventually integrating all these elements into the fully developed final system. For truly sustainable and green systems, identifying risk scenarios early and continuously over the system development processes is vital. This paper contains various descriptions of risk from the project (i.e. programmatic) and technical perspectives, an exploration of the generally accepted risk management process, and how these relate to systems development through system goals. …

T-6a Texan Ii Systems Engineering Case Study, Air Force Center For Systems Engineering, Bill Kinzig, Dave Bailey

AFIT Documents

No abstract provided.

Towards A Center For Modeling And Simulation: The Case For Jordan, Ghaith Rabadi, Hazem Kaylani, Joseph Barjis (Ed.), Murali Mohan Narasipuram (Ed.), Ghaith Rabadi (Ed.), Jolita Ralyt (Ed.), Pierluigi Plebani (Ed.)

Engineering Management & Systems Engineering Faculty Publications

Modeling and Simulation (M&S) has recently become an important area that is pursued by many researchers and practitioners due to the role it plays in understanding complex systems and problems. We have therefore witnessed the establishment of many M&S organizations in the last two decades especially in the more developed world. Less developed countries are starting to recognize the need for such capability especially that the problems they face are not less complex. In this paper, we present a preliminary study towards a business plan for establishing a scientific center for Modeling, Analysis, Simulation and Animation in Jordan (JoSAMA) and …

Environmentally-Conscious Supply Chain Design In Support Of Food Security, Caroline C. Krejci, Benita M. Beamon

Industrial, Manufacturing, and Systems Engineering Faculty Publications - Archive

This paper seeks to design food supply chain structures that can provide food security for every person in the world while supporting long-term environmental sustainability. In particular, we provide alternatives to the current food supply chain structure and analyze their potential for providing food security, in terms of productive capacity and long-term environmental sustainability. Given the current world population and expected continued growth, our analysis suggests that environmentally-sustainable food supply chains would be most effectively supported by local and organic agriculture, while maintaining a parallel industrial agricultural system. This hybrid system would adopt environmentally-sustainable principles whenever possible, seeking to increase …

Effect Of Different Detrending Approaches On Computational Intelligence Models Of Time Series, Federico Montesino Pouzols, Amaury Lendasse

Engineering Management and Systems Engineering Faculty Research & Creative Works

This Paper Analyzes the Impact of Different Detrending Approaches on the Performance of a Variety of Computational Intelligence (Ci) Models. Three Approaches Are Compared: Linear, Nonlinear Detrending (based on Empirical Mode Decomposition) and First-Differencing. Five Representative Ci Methods Are Evaluated: Dynamic Evolving Neural-Fuzzy Inference System (DENFIS), Gaussian Process (GP), Multilayer Perceptron (MP), Optimally Pruned Extreme Learning Machine (Op-Elm) and Support Vector Machines (SVM). Four Major Conclusions Are Drawn from Experiments Performed on Six Time Series Benchmarks: 1) Qualitatively, the Effect of Detrending is Remarkably Uniform for All the Ci Methods Considered, 2) Extraction of the overall Trend Does Not Improve …

Op-Elm: Optimally Pruned Extreme Learning Machine, Yoan Miche, Antti Sorjamaa, Patrick Bas, Olli Simula, Christian Jutten, Amaury Lendasse

Engineering Management and Systems Engineering Faculty Research & Creative Works

In This Brief, the Optimally Pruned Extreme Learning Machine (Op-Elm) Methodology is Presented. It is based on the Original Extreme Learning Machine (Elm) Algorithm with Additional Steps to Make It More Robust and Generic. the Whole Methodology is Presented in Detail and Then Applied to Several Regression and Classification Problems. Results for Both Computational Time and Accuracy (Mean Square Error) Are Compared to the Original Elm and to Three Other Widely Used Methodologies: Multilayer Perceptron (MLP), Support Vector Machine (SVM), and Gaussian Process (GP). as the Experiments for Both Regression and Classification Illustrate, the Proposed Op-Elm Methodology Performs Several Orders …

Accidents Will Happen. Do Safety Systems Improve Warehouse Safety Performance?, Rene B. M. De Koster, B. M. Balk, I Davelaar, M. Martens

11th IMHRC Proceedings (Milwaukee, Wisconsin. USA – 2010)

Safety is becoming more and more an issue in warehouses. In the literature, effective measures leading to increased occupational health and safety have hardly been researched. Most research focuses on the impact of perceived safety-related leadership of managers and worker safety consciousness on ‘safety climate’ and workers’ safe behavior. We have carried out exploratory research into which measures really improve the safety performance of a warehouse. We particularly focus on the effects of (1) safety-related work procedures, (2) safety leadership, and (3) workers’ safety consciousness. Based on a survey we show that safety leadership and safety-related work procedures significantly drive …

Optimizing The Rearrangement Process In A Dedicated Warehouse, Hector J. Carlo, German E. Giraldo

11th IMHRC Proceedings (Milwaukee, Wisconsin. USA – 2010)

Determining the optimal storage assignment for products in a dedicated warehouse has been addressed extensively in the Facility Logistics literature. However, the process of implementing a particular storage assignment given the current location of products has not received much attention in the existing literature. Typically, warehouses use downtime or overtime to remove products from their current location and move them to the suggested location. This work presents the Rearrange-While-Working (RWW) policy to optimize the process of rearranging a dedicated warehouse. The RWW policy seeks to relocate products in a warehouse from the initial arrangement to the optimal arrangement while serving …

A New Milp Approach For The Facility Layout Design Problem With Rectangular And L/T Shaped Departments, Yossi Bukchin, Michal Tzur

11th IMHRC Proceedings (Milwaukee, Wisconsin. USA – 2010)

In this paper we propose a new approach for the facility layout problem (FLP) and suggest new mixed-integer linear programming (MILP) formulations. The proposed approach considers simultaneously the location of the departments within the facility and the internal arrangement of the machines. Two models are suggested, where the first addresses the rectangular department case and the second allows nonrectangular departments defined by an L/T shape. New regularity constraints are developed to avoid irregular department shapes.

Strategic Design Of A Robust Supply Chain, Marc Goetschalckx, Edward Huang

11th IMHRC Proceedings (Milwaukee, Wisconsin. USA – 2010)

The strategic design of a robust supply chain has as goal the configuration of the supply chain structure so that the performance of the supply chain remains of a consistently high quality for all possible future scenarios. We model this goal with an objective function that trades off the central tendency of the supply chain profit with the dispersion of the profit as measured by the standard deviation for any value of the weights assigned to the two components. However, the standard deviation, used as the dispersion penalty for profit maximization, has a square root expression which makes standard maximization …

Evaluating The Effect Of Operational Conditions And Practices On Warehouse Performance, Andrew L. Johnson

11th IMHRC Proceedings (Milwaukee, Wisconsin. USA – 2010)

Analyzing warehouse performance across different environments is critical to improving overall productivity and reducing costs. Although two-stage DEA estimators have been shown to be statistically consistent, the finite sample bias of DEA in the first stage carries over to the secondstage regression, which causes bias in the estimated coefficients of the contextual variables. The bias is particularly severe when the contextual variables are correlated with inputs. To address this shortcoming, we apply insights from Johnson and Kuosmanen (2010), who demonstrate that DEA can be formulated as a constrained special case of the Convex Nonparametric Least Squares (CNLS) regression to develop …

Comparing Transport Policies In A Full-Scale 300mm Wafer Manufacturing Facility, J. E. Kiba, S. Dauz`Ere-P´Er`Es, C. Yugma, G. Lamiable

11th IMHRC Proceedings (Milwaukee, Wisconsin. USA – 2010)

Research in semiconductor manufacturing ideally wants to determine the “best” transport policy to ensure continuous production. Determining such a policy is difficult because it depends on many factors such as the layout, the product types, the equipment, etc. Most of the transport policies found in the literature combine dispatching policies (scheduling of transport requests) and routing policies (selection of the path to move from one point to another). This paper investigates a policy called "minimum service" which consists in keeping a minimum number of available vehicles in bays, so that they can quickly answer transport requests and empty travel times …

The Human-Centric Warehouse, Kevin R. Gue

11th IMHRC Proceedings (Milwaukee, Wisconsin. USA – 2010)

In theory and in practice, the objective of warehouse design has long been to meet operational requirements of throughput and service performance at minimum cost. A natural product of this “bottom line” approach has been warehouse buildings and operations ill-suited to the humans who spend their working lives interacting with them. We offer an explanation for the current approach, and argue that a new approach— a new paradigm —is needed. We then describe a comprehensive approach to warehouse design that includes human well-being as a primary goal.

Forklift Routing In Warehouses Using Dual-Commands And Stackable Pallets, Ahmed Hassan, Bill Ferrell

11th IMHRC Proceedings (Milwaukee, Wisconsin. USA – 2010)

This research determines time optimal routes for loading and picking pallets that can be stacked on top of each other during transport in a manual warehouse that only contains full pallets and utilizes single deep storage. This research was motivated by the fact that we are seeing this situation on an ever increasing basis, particularly in warehouses that supply parts to automotive assembly. In practice, forklift drivers have developed strategies to take advantage of this opportunity but to our knowledge there is no literature that addresses this problem rigorously. The important features of this work are that a time based …

Plug-And-Work Material Handling Systems, Kai Furmans, Frank Schonung, Kevin R. Gue

11th IMHRC Proceedings (Milwaukee, Wisconsin. USA – 2010)

One disadvantage of automated material handling systems is their relative Inflexibility: once racks are installed and conveyors are laid, making even mi-nor changes to a system can be cumbersome and expensive. However, recent progress in the capabilities and cost of basic system components, such as controllers, drives, and sensors, has made possible a new class of material handling systems having a much higher degree of flexibility. We propose underlying de- sign principles for such systems and describe several prototype plug-and-work" systems, which feature decentralized control and ease of reconfiguration.