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Full-Text Articles in Electrical and Computer Engineering

Development And Processing Of Shape Memory Polymer Composites (Smpcs) For Application In Structural Robotics And Robotic Sensors., Kavish Sudan Aug 2024

Development And Processing Of Shape Memory Polymer Composites (Smpcs) For Application In Structural Robotics And Robotic Sensors., Kavish Sudan

Electronic Theses and Dissertations

Shape Memory Polymers (SMPs) have attracted significant attention since their introduction in the 1980s due to their remarkable ability to regain their original shape from a temporarily deformed state when exposed to an external stimulus, typically heat. This shape memory effect, driven by thermal transitions such as the glass transition temperature (Tg) or melting temperature (Tm), has made SMPs highly attractive for applications in soft robotics, aerospace, and biomedical devices. However, SMPs face challenges such as limited mechanical strength, thermal stability, and electrical conductivity, which hinder their broader adoption in advanced applications. To address these challenges, …


Magnetic Sensor Compensation Utilizing Factor Graph Estimation, Frederic W. Lathrop, Clark N. Taylor, Aaron Nielsen Aug 2024

Magnetic Sensor Compensation Utilizing Factor Graph Estimation, Frederic W. Lathrop, Clark N. Taylor, Aaron Nielsen

Faculty Publications

Recently, there has been significant interest in the ability to navigate without GPS using the magnetic anomaly field of the Earth (magnav). One of the key technical bottlenecks to achieving magnav is obtaining an accurate magnetic sensor calibration, taking into account own-ship and sensor effects. The Tolles-Lawson magnetic calibration method continues to be the industry standard and was developed when airborne magnetic survey aircraft were first employed over 70 years ago. In this paper, we present a magnetic calibration algorithm based on a factor graph optimization using inertial measurements as well as inputs from both a vector and scalar magnetometer. …


Evaluation Of The Alveolar Crest And Cemento-Enamel Junction In Periodontitis Using Object Detection On Periapical Radiographs, Tai Jung Lin, Yi Cheng Mao, Yuan Jin Lin, Chin Hao Liang, Yi Qing He, Yun Chen Hsu, Shih Lun Chen, Tsung Yi Chen, Chiung An Chen, Kuo Chen Li, Patricia Angela R. Abu Aug 2024

Evaluation Of The Alveolar Crest And Cemento-Enamel Junction In Periodontitis Using Object Detection On Periapical Radiographs, Tai Jung Lin, Yi Cheng Mao, Yuan Jin Lin, Chin Hao Liang, Yi Qing He, Yun Chen Hsu, Shih Lun Chen, Tsung Yi Chen, Chiung An Chen, Kuo Chen Li, Patricia Angela R. Abu

Ateneo Laboratory for Intelligent Visual Environments

The severity of periodontitis can be analyzed by calculating the loss of alveolar crest (ALC) level and the level of bone loss between the tooth’s bone and the cemento-enamel junction (CEJ). However, dentists need to manually mark symptoms on periapical radiographs (PAs) to assess bone loss, a process that is both time-consuming and prone to errors. This study proposes the following new method that contributes to the evaluation of disease and reduces errors. Firstly, innovative periodontitis image enhancement methods are employed to improve PA image quality. Subsequently, single teeth can be accurately extracted from PA images by object detection with …


Impacts Of High-Frequency Operation On Magnetics And Performance On Isolated Power Electronic Converter Design, David Arturo Porras Fernandez Aug 2024

Impacts Of High-Frequency Operation On Magnetics And Performance On Isolated Power Electronic Converter Design, David Arturo Porras Fernandez

Graduate Theses and Dissertations

The pursuit of high-power density and high switching frequency is a central theme in the advancement of power electronic converters. While these parameters offer significant benefits in terms of compactness and performance, they also introduce challenges related to efficiency and thermal management. This doctoral dissertation aims to provides a design framework to analyze the implications of high-frequency operation (> 100 kHz) on magnetics design and performance in power electronic converters, particularly when integrating silicon carbide (SiC) power modules. It examines the advantages and disadvantages of high-frequency operation and delves into its effects on the performance of the converter, focusing on …


High-Power Power Conditioning Systems For Medium-Voltage Applications, Ahmed Rahouma Fares Rahouma Aug 2024

High-Power Power Conditioning Systems For Medium-Voltage Applications, Ahmed Rahouma Fares Rahouma

Graduate Theses and Dissertations

The purpose of this dissertation is to address the background, theoretical analyses, design methodologies, and evaluation techniques relevant to high-power power conditioning systems (PCSs) tailored for medium-voltage (MV) applications. Conventional PCSs, reliant on line-frequency transformers (LFTs), suffer from many problems including low power densities, inflexible designs, and scalability constraints. Employing multilevel converters (MLCs), particularly cascaded H-bridge topology, eliminates the need for these LFTs. A key focus lies in minimizing the number of cascaded building blocks by harnessing MV power switching modules. The dissertation makes two primary contributions: firstly, it offers a design methodology for MV-PCS, facilitating the selection of the …


Evaluation, Modeling And Application Of Gallium Nitride Field Effect Transistor, Geno Guillaume Aug 2024

Evaluation, Modeling And Application Of Gallium Nitride Field Effect Transistor, Geno Guillaume

Graduate Theses and Dissertations

Gallium Nitride (GaN) has emerged as one of the leading materials for power devices due to its wide band gap and high electron mobility. The band gap is the minimum energy required to excite an electron up to a state in the conduction band where it can participate in conduction. Because of this, wide band gap (WBG) materials are favorable for various electrical applications. The market for GaN high-electron-mobility transistor (HEMT) is projected to exceed $1.25 billion by 2027. With the increase of market interest, modern technologies emerge that aim to push the boundaries of efficiency for GaN power devices. …


Modification Of Time-Domain Terahertz Spectroscopy System To Polarimetry Imaging System With Application To Human Breast Cancer Surgical Specimen, Nikita Gurjar Aug 2024

Modification Of Time-Domain Terahertz Spectroscopy System To Polarimetry Imaging System With Application To Human Breast Cancer Surgical Specimen, Nikita Gurjar

Graduate Theses and Dissertations

Breast-conserving therapy (lumpectomy) is one of the most performed breast cancer surgeries in the United States. The best outcome of lumpectomy surgery is achieved when the surgical margins are free of cancer. When remnants of cancer are detected at the surgical margins after the initial operation, a second operation will be required to remove the cancer. Unfortunately, a significant number of patients undergo breast conserving surgery (BCS) at local hospitals that do not have access to immediate on-site pathology leading to high rates of re-excision or reoperation (greater than 30%). Therefore, there is a significant need for new intraoperative technology …


Synthesis Of Nanoparticles And Their Applications In Power Module Packaging And Organic Electronics, Xinsong Zhang Aug 2024

Synthesis Of Nanoparticles And Their Applications In Power Module Packaging And Organic Electronics, Xinsong Zhang

Graduate Theses and Dissertations

Nanoparticles can greatly change the properties of regular materials due to their special structures. In this research nanoparticles, such as silver nanowires, silver nanospheres and expanded graphite, are used in interconnection materials for power module packaging, and in conductive films for organic electronics. Silver nanowires synthesized by polyol synthesis, are used as fillers in micron silver paste. The electrical and mechanical properties of the sintered hybrid silver paste are investigated and compared with those of micron silver paste. The composites of silver nanospheres and expanded graphite are mixed with PEDOT:PSS solutions in 5 different weight ratio. The electrical and optical …


Esd-Robust 4h-Sic Low-Voltage Cmos Technology Development For High Temperature, Hui Wang Aug 2024

Esd-Robust 4h-Sic Low-Voltage Cmos Technology Development For High Temperature, Hui Wang

Graduate Theses and Dissertations

This dissertation explores the development and optimization of electrostatic discharge (ESD)-robust, low-voltage CMOS technology using 4H-silicon carbide (SiC) tailored for high-temperature applications, addressing the critical need for reliable semiconductor devices in harsh environmental conditions. The advent of SiC as a semiconductor material offers significant advantages over traditional silicon (Si) in harsh environments, including higher thermal conductivity, greater electron mobility, and improved electrical characteristics at elevated temperatures. This research explores the integration of 4H-SiC into CMOS technology to enhance device reliability and performance in extreme conditions such as those found in aerospace, automotive, and energy sectors. The study begins with a …


Ω-Shaped Rogowski Coil Current Sensor Optimization Design In Power Electronics Applications, Xia Du Aug 2024

Ω-Shaped Rogowski Coil Current Sensor Optimization Design In Power Electronics Applications, Xia Du

Graduate Theses and Dissertations

Accurate switching current measurement plays a pivotal role in characterization of power devices, overcurrent protection, and real-time control of system-level operations in power electronics applications. However, the ongoing revolution in power electronics, driven by the emergence of wide bandgap power devices operating at megahertz (MHz) switching frequencies, introduces challenges for current sensor design. The urgent issue now is the need to increase current sensor bandwidth significantly to adeptly capture the rapid switching speed current. Additionally, the trend towards high power density and compact power converters in various applications demands current sensors that are not only compact and nonintrusive but can …


Patterning Synthesis Of Lead Halide Perovskites Toward Photonic Application, S. M. Nayeem Arefin Aug 2024

Patterning Synthesis Of Lead Halide Perovskites Toward Photonic Application, S. M. Nayeem Arefin

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

Lead halide perovskites (LHPs) are a fascinating class of photonic materials with the potential to revolutionize various optoelectronic applications. Their diverse crystal structures, ranging from 0D to 3D configurations, offer a unique combination of properties, including high tunability and ease of synthesis. However, their inherent instability and the difficulty of patterning them into sophisticated photonic structures using conventional methods present a significant hurdle to their widespread applications. This thesis addresses these challenges by proposing a novel synthesis method that combines soft lithography and self-assembly. By utilizing a patterned template with controlled wettability, precise manipulation of LHP crystal formation is achieved, …


Ultrashort Pulsed Laser Treatment Is Effective At Sterilizing Metal Surfaces For Planetary Protection, Kaleb Mcquillan Aug 2024

Ultrashort Pulsed Laser Treatment Is Effective At Sterilizing Metal Surfaces For Planetary Protection, Kaleb Mcquillan

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

To prevent forward contamination from microbes aboard spacecraft intended for exploration of solar system bodies there is a need for effective sterilization methods. However, current techniques are both time-consuming and expensive. For example, dry heat sterilization requires removal from the assembly site and several days of treatment. Furthermore, some components such as optics and electronics are not compatible with current sterilization techniques. In this thesis, a novel femtosecond laser surface processing technique for the rapid sterilization of spacecraft hardware is reported. Femtosecond lasers produce extremely high photon fluxes (1029 photons/s*cm2, ~0.03 J/cm2) in extremely short …


Gps-Denied Navigation Using Location Estimation And Texel Image Correction, Nikolas I. Jensen Aug 2024

Gps-Denied Navigation Using Location Estimation And Texel Image Correction, Nikolas I. Jensen

All Graduate Theses and Dissertations, Fall 2023 to Present

In recent years, the use of small drones, also categorized as small Unmanned Aerial Vehicles (sUAV), has surged. They are used for tasks like surveying land, collecting data from a distance, and performing maneuvers for military operations. These drones are popular because they are affordable, small, easy to use, and can navigate well in complex areas. These factors make them a cheap and quick option for tasks like surveying and surveillance when compared to traditional methods.

This thesis introduces a system that uses algorithms to figure out where the drone is. Typically, this relies on sensors and GPS, but GPS …


Federated Learning In Wireless Networks, Xiang Ma Aug 2024

Federated Learning In Wireless Networks, Xiang Ma

All Graduate Theses and Dissertations, Fall 2023 to Present

Artificial intelligence (AI) is transitioning from a long development period into reality. Notable instances like AlphaGo, Tesla’s self-driving cars, and the recent innovation of ChatGPT stand as widely recognized exemplars of AI applications. These examples collectively enhance the quality of human life. An increasing number of AI applications are expected to integrate seamlessly into our daily lives, further enriching our experiences.

Although AI has demonstrated remarkable performance, it is accompanied by numerous challenges. At the forefront of AI’s advancement lies machine learning (ML), a cutting-edge technique that acquires knowledge by emulating the human brain’s cognitive processes. Like humans, ML requires …


Ensemble Machine Learning At The Edge Using The Codec Classifier Structure And Weak Learners Guided By Mutual Information, Aj Beckwith Aug 2024

Ensemble Machine Learning At The Edge Using The Codec Classifier Structure And Weak Learners Guided By Mutual Information, Aj Beckwith

All Graduate Theses and Dissertations, Fall 2023 to Present

The Codec Classifier is a low-computation, low-memory tree ensemble method that dramatically improves feasibility of image classification on resource-constrained edge devices. It achieves advantages over other tree ensemble methods due the separation of encoder and decoder tasks in the classifier. The encoder partitions feature space, and the decoder labels the regions in the partition. This functional separation of tasks enables the encoder design (partitioning) to be guided by maximizing the mutual information (MI) between class labels and the features (i.e. the encoded representation of the data) without regard to the error performance of the classifier. Experiments show maximizing MI leads …


A Position Allocation Approach To The Battery Electric Bus Charging Problem, Alexander Brown Aug 2024

A Position Allocation Approach To The Battery Electric Bus Charging Problem, Alexander Brown

All Graduate Theses and Dissertations, Fall 2023 to Present

With an increasing adoption of Battery Electric Bus (BEB) fleets, developing a reliable charging schedule is vital to a successful migration from their fossil fuel counterparts. In this work, a BEB charging scheduling framework that considers fixed route schedules, multiple charger types, and battery dynamics is modeled as a Mixed Integer Linear Program (MILP). The MILP is modeled after the Berth Allocation Problem (BAP) in a modified form known as the Position Allocation Problem (PAP). The optimization coordinates BEB charging to ensure that each vehicle remains above a specified charge percentage. The model also minimizes the total number of chargers …


Anomaly Detection On Wind Turbine Blades Using Aerial Imaging, Image Processing, And Deep Learning, Bridger Kohl Altice Aug 2024

Anomaly Detection On Wind Turbine Blades Using Aerial Imaging, Image Processing, And Deep Learning, Bridger Kohl Altice

All Graduate Theses and Dissertations, Fall 2023 to Present

In reaction to rising global temperatures and carbon dioxide emissions, many countries are looking to use energy sources other than fossil fuels. One such source of energy is wind energy, which can be harvested by wind turbines. By rotating at high speeds, the blades of these large turbines are able to convert wind energy to kinetic energy, which is then converted to electricity usable by the power grid. Traditional methods for inspecting these turbines for damages are expensive, unsafe, and susceptible to human error. These turbines are so tall and so large that inspectors run the risk of falling from …


Filter Incidence Narrowband Infrared Spectrometer For Space-Based Methane Measurement And Plume Detection, Bruno Mattos Aug 2024

Filter Incidence Narrowband Infrared Spectrometer For Space-Based Methane Measurement And Plume Detection, Bruno Mattos

All Graduate Theses and Dissertations, Fall 2023 to Present

Monitoring methane emissions from space is essential for reducing global warming. This dissertation introduces the Filter Incidence Narrowband Infrared Spectrometer (FINIS), a compact, lightweight instrument designed for nanosatellites to accurately measure methane emissions. FINIS uses two innovative imaging spectrometers to capture the Earth's reflected light, focusing on the strongest methane absorption feature at 1666 nm. By using tiled interference filters, each imager collects detailed spectral data, allowing precise methane detection. FINIS has been significantly improved from its prototype to its space-ready version, set to launch on the ACMES CubeSat in late 2025. The new design includes a binocular optical system …


Thermal Management Of Roadway-Embedded Power Electronics For Electric Vehicle Dynamic Wireless Charging Systems, Conner R. Sabin Aug 2024

Thermal Management Of Roadway-Embedded Power Electronics For Electric Vehicle Dynamic Wireless Charging Systems, Conner R. Sabin

All Graduate Theses and Dissertations, Fall 2023 to Present

Electric vehicles (EVs) are gaining popularity worldwide. However, concerns raised by the public about purchasing EVs include the limited availability of charging infrastructure, high costs, and the inconvenience of current charging methods. Dynamic wireless charging systems enable electric vehicles to charge while driving, thereby extending the range of EVs and reducing the necessity for large, expensive batteries. Moreover, these systems can initiate charging automatically without user interaction, enhancing charging convenience.

The ground assembly of existing dynamic wireless charging systems consists of an electromagnetic assembly, power electronics for the transmitter pad, and power electronics for grid connection. Installation of these systems …


Mmwave Tx-Rx Self-Interference Suppression Through A High Impedance Surface Stacked Ebg, Adewale K. Oladeinde, Ehsan Aryafar, Branimir Pejcinovic Aug 2024

Mmwave Tx-Rx Self-Interference Suppression Through A High Impedance Surface Stacked Ebg, Adewale K. Oladeinde, Ehsan Aryafar, Branimir Pejcinovic

Electrical and Computer Engineering Faculty Publications and Presentations

This paper proposes a full-duplex (FD) antenna design with passive self-interference (SI) suppression for the 28 GHz mmWave band. The reduction in SI is achieved through the design of a novel configuration of stacked Electromagnetic Band Gap structures (EBGs), which create a high impedance path to travelling electromagnetic waves between the transmit and receive antenna elements. The EBG is composed of stacked patches on layers 1 and 2 of a four-layer stack-up configuration. We present the design, optimization, and prototyping of unit antenna elements, stacked EBGs, and integration of stacked EBGs with antenna elements. We also evaluate the design through …


Periodic Information Leakage Fault Detection On A Risc-V Microprocessor, Idris Somoye Jul 2024

Periodic Information Leakage Fault Detection On A Risc-V Microprocessor, Idris Somoye

Electrical and Computer Engineering ETDs

The execution behavior of a Microprocessor (μP) in the presence of a fault is difficult to predict because of the complex interactions across pipeline stages and between functional units within the architecture. Fault effects are known to not introduce any type of anomaly in the input-output behavior for 10s of thousands to millions of clock cycles. These characteristics increase the difficulty of evaluating μP architectures for resilience to information leakage events, i.e., scenarios where a fault causes sensitive data such as an encryption key to be inadvertently diverted to a primary output channel. This dissertation explores two promising strategies for …


Secondary Electron Yield Of Metals, Alloys, And Metal Oxides From First Principles Based Monte Carlo Simulations, Raul E. Gutierrez Jul 2024

Secondary Electron Yield Of Metals, Alloys, And Metal Oxides From First Principles Based Monte Carlo Simulations, Raul E. Gutierrez

Electrical and Computer Engineering ETDs

Density Functional Theory (DFT) based Monte Carlo (MC) simulations of the Sec-
ondary Electron Yield (SEY) of metals, alloys, and metal oxides are performed to
find material properties that could help reduce or influence the multipactor effect.
In order to accurately model the SEY of materials, knowledge of the frequency- and
momentum-dependent Energy Loss Function (qDepELF) is required. The qDepELF
is difficult to determine from experiment; however, it can be calculated from first
principles. The DFT-MC approach for simulating the secondary electron genera-
tion, propagation, and emission processes is described herein. Material properties,
which are calculated using DFT and used …


Fabrication And Characterization Of A Monolithic Photonic Integrated Circuit With High-Aspect Ratio Photonic Device Structures, Sami A. Nazib Jul 2024

Fabrication And Characterization Of A Monolithic Photonic Integrated Circuit With High-Aspect Ratio Photonic Device Structures, Sami A. Nazib

Optical Science and Engineering ETDs

The focus of this work was to create a process to fabricate an InP-based Photonic Integrated Circuit (PIC). The design of the PIC required the photonic components of this device to be created by deep etching of an epitaxially-grown multilayer structure. Therefore, a novel dry etching process was developed to produce very high aspect- ratio (HAR) features. This process not only involved the development of dry etch chemistry but also the engineering of a metal mask structure. The next step of the challenge was to use a polymer-based material that would have two functions: cladding for the etched photonic components …


Series Reports From Professor Wei’S Group Of Chongqing University: Advancements In Electrochemical Energy Conversions (1/4): Report 1: High-Performance Oxygen Reduction Catalysts For Fuel Cells, Fa-Dong Chen, Zhuo-Yang Xie, Meng-Ting Li, Si-Guo Chen, Wei Ding, Li Li, Jing Li, Zi-Dong Wei Jul 2024

Series Reports From Professor Wei’S Group Of Chongqing University: Advancements In Electrochemical Energy Conversions (1/4): Report 1: High-Performance Oxygen Reduction Catalysts For Fuel Cells, Fa-Dong Chen, Zhuo-Yang Xie, Meng-Ting Li, Si-Guo Chen, Wei Ding, Li Li, Jing Li, Zi-Dong Wei

Journal of Electrochemistry

Two major challenges, high cost and short lifespan, have been hindering the commercialization process of low-temperature fuel cells. Professor Wei’s group has been focusing on decreasing cathode Pt loadings without losses of activity and durability, and their research advances in this area over the past three decades are briefly reviewed herein. Regarding the Pt-based catalysts and the low Pt usage, they have firstly tried to clarify the degradation mechanism of Pt/C catalysts, and then demonstrated that the activity and stability could be improved by three strategies: regulating the nanostructures of the active sites, enhancing the effects of support materials, and …


Kai Wu, The Editorial Board Member Of Journal Of Electrochemistry And Chief Scientist Of Catl, Receives The National Science And Technology Progress Award, Editorial Office Of J.Electrochem. Jul 2024

Kai Wu, The Editorial Board Member Of Journal Of Electrochemistry And Chief Scientist Of Catl, Receives The National Science And Technology Progress Award, Editorial Office Of J.Electrochem.

Journal of Electrochemistry

No abstract provided.


Sorbitol-Electrolyte-Additive Based Reversible Zinc Electrochemistry, Qiong Sun, Hai-Hui Du, Tian-Jiang Sun, Dian-Tao Li, Min Cheng, Jing Liang, Hai-Xia Li, Zhan-Liang Tao Jul 2024

Sorbitol-Electrolyte-Additive Based Reversible Zinc Electrochemistry, Qiong Sun, Hai-Hui Du, Tian-Jiang Sun, Dian-Tao Li, Min Cheng, Jing Liang, Hai-Xia Li, Zhan-Liang Tao

Journal of Electrochemistry

The unstable zinc (Zn)/electrolyte interfaces formed by undesired dendrites and parasitic side reactions greatly hinder the development of aqueous zinc ion batteries. Herein, the hydroxy-rich sorbitol was used as an additive to reshape the solvation structure and modulate the interface chemistry. The strong interactions among sorbitol and both water molecules and Zn electrode can reduce the free water activity, optimize the solvation shell of water and Zn2+ ions, and regulate the formation of local water (H2O)-poor environment on the surface of Zn electrode, which effectively inhibit the decomposition of water molecules, and thus, achieve the thermodynamically stable …


First Announcement Of 76th Annual Meeting Of The International Society Of Electrochemistry, International Society Of Electrochemistry (Ise) Jul 2024

First Announcement Of 76th Annual Meeting Of The International Society Of Electrochemistry, International Society Of Electrochemistry (Ise)

Journal of Electrochemistry

No abstract provided.


Data-Driven Viewpoint For Developing Next-Generation Mg-Ion Solid-State Electrolytes, Fang-Ling Yang, Ryuhei Sato, Eric Jian-Feng Cheng, Kazuaki Kisu, Qian Wang, Xue Jia, Shin-Ichi Orimo, Hao Li Jul 2024

Data-Driven Viewpoint For Developing Next-Generation Mg-Ion Solid-State Electrolytes, Fang-Ling Yang, Ryuhei Sato, Eric Jian-Feng Cheng, Kazuaki Kisu, Qian Wang, Xue Jia, Shin-Ichi Orimo, Hao Li

Journal of Electrochemistry

Magnesium (Mg) is a promising alternative to lithium (Li) in solid-state batteries due to its abundance and high theoretical volumetric capacity. However, the sluggish Mg-ion conduction in the lattice of solid-state electrolytes (SSEs) is one of the key challenges that hamper the development of Mg-ion solid-state batteries. Though various Mg-ion SSEs have been reported in recent years, key insights are hard to be derived from a single literature report. Besides, the structure-performance relationships of Mg-ion SSEs need to be further unraveled to provide a more precise design guideline for SSEs. In this Viewpoints article, we analyze the structural characteristics of …


Professor Yong Yang, The Editorial Board Member Of Journal Of Electrochemistry, Is Elected As A Fellow Of The Electrochemical Society, Editorial Office Of J.Electrochem. Jul 2024

Professor Yong Yang, The Editorial Board Member Of Journal Of Electrochemistry, Is Elected As A Fellow Of The Electrochemical Society, Editorial Office Of J.Electrochem.

Journal of Electrochemistry

No abstract provided.


Integrated Multi-Omics Analysis Of Cerebrospinal Fluid In Postoperative Delirium, Bridget A. Tripp, Simon T. Dillon, Min Yuan, John M. Asara, Sarinnapha M. Vasunilashorn, Tamara G. Fong, Sharon K. Inouye, Long H. Ngo, Edward R. Marcantonio, Zhongcong Xie, Towia A. Libermann, Hasan H. Otu Jul 2024

Integrated Multi-Omics Analysis Of Cerebrospinal Fluid In Postoperative Delirium, Bridget A. Tripp, Simon T. Dillon, Min Yuan, John M. Asara, Sarinnapha M. Vasunilashorn, Tamara G. Fong, Sharon K. Inouye, Long H. Ngo, Edward R. Marcantonio, Zhongcong Xie, Towia A. Libermann, Hasan H. Otu

Department of Electrical and Computer Engineering: Faculty Publications

Preoperative risk biomarkers for delirium may aid in identifying high-risk patients and developing intervention therapies, which would minimize the health and economic burden of postoperative delirium. Previous studies have typically used single omics approaches to identify such biomarkers. Preoperative cerebrospinal fluid (CSF) from the Healthier Postoperative Recovery study of adults ≥ 63 years old undergoing elective major orthopedic surgery was used in a matched pair delirium case–no delirium control design. We performed metabolomics and lipidomics, which were combined with our previously reported proteomics results on the same samples. Differential expression, clustering, classification, and systems biology analyses were applied to individual …