Electrical and Computer Engineering Commons^™

Integrated Multi-Omics Analysis Of Cerebrospinal Fluid In Postoperative Delirium, Bridget A. Tripp, Simon T. Dillon, Min Yuan, John M. Asara, Sarinnapha M. Vasunilashorn, Tamara G. Fong, Sharon K. Inouye, Long H. Ngo, Edward R. Marcantonio, Zhongcong Xie, Towia A. Libermann, Hasan H. Otu

Department of Electrical and Computer Engineering: Faculty Publications

Preoperative risk biomarkers for delirium may aid in identifying high-risk patients and developing intervention therapies, which would minimize the health and economic burden of postoperative delirium. Previous studies have typically used single omics approaches to identify such biomarkers. Preoperative cerebrospinal fluid (CSF) from the Healthier Postoperative Recovery study of adults ≥ 63 years old undergoing elective major orthopedic surgery was used in a matched pair delirium case–no delirium control design. We performed metabolomics and lipidomics, which were combined with our previously reported proteomics results on the same samples. Differential expression, clustering, classification, and systems biology analyses were applied to individual …

Development And Evaluation Of An Expedited System For Creation Of Single Walled Carbon Nanotube Platforms, Ivon Acosta Ramirez, Omer Sadak, Wali Sohail, Xi Huang, Yongfeng Lu, Nicole M. Iverson

Department of Electrical and Computer Engineering: Faculty Publications

Single-walled carbon nanotubes (SWNT) have a strong and stable near-infrared (nIR) fluorescence that can be used to selectively detect target analytes, even at the single molecule level, through changes in either their fluorescence intensity or emission peak wavelength. SWNTs have been employed as NIR optical sensors for detecting a variety of analytes. However, high costs, long fabrication times, and poor distributions limit the current methods for immobilizing SWNT sensors on solid substrates. Recently, our group reported a protocol for SWNT immobilization with high fluorescence yield, longevity, fluorescence distribution, and sensor response, unfortunately this process takes 5 days to complete. Herein …

Electronic Properties Of Group-Iii Nitride Semiconductors And Device Structures Probed By Thz Optical Hall, Nerijus Armakavicius, Philipp Kühne, Alexis Papamichail, Hengfang Zhang, Sean Knight, Axel Persson, Vallery Stanishev, Jr-Tai Chen, Plamen Paskov, Mathias Schubert, Vanya Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

Group-III nitrides have transformed solid-state lighting and are strategically positioned to revolutionize high-power and high-frequency electronics. To drive this development forward, a deep understanding of fundamental material properties, such as charge carrier behavior, is essential and can also unveil new and unforeseen applications. This underscores the necessity for novel characterization tools to study group-III nitride materials and devices. The optical Hall effect (OHE) emerges as a contactless method for exploring the transport and electronic properties of semiconductor materials, simultaneously offering insights into their dielectric function. This nondestructive technique employs spectroscopic ellipsometry at long wavelengths in the presence of a magnetic …

Chiroptical Second-Harmonic Tyndall Scattering From Silicon Nanohelices, Ben J. Olohan, Emilija Petronijevic, Ufuk Kilic, Shawn Wimer, Matthew Hilfiker, Mathias Schubert, Christos Argyropoulos, Eva Schubert, Samuel R. Clowes, G. Dan Pantoş, David L. Andrews, Ventsislav K. Valev

Department of Electrical and Computer Engineering: Faculty Publications

Chirality is omnipresent in the living world. As biomimetic nanotechnology and self-assembly advance, they too need chirality. Accordingly, there is a pressing need to develop general methods to characterize chiral building blocks at the nanoscale in liquids such as water-the medium of life. Here, we demonstrate the chiroptical second-harmonic Tyndall scattering effect. The effect was observed in Si nanohelices, an example of a high-refractive-index dielectric nanomaterial. For three wavelengths of illumination, we observe a clear difference in the second-harmonic scattered light that depends on the chirality of the nanohelices and the handedness of circularly polarized light. Importantly, we provide a …

Controlling The Broadband Enhanced Light Chirality With L-Shaped Dielectric Metamaterials, Ufuk Kilic, Matthew Hilfiker, Shawn Wimer, Alexander Ruder, Eva Schubert, Mathias Schubert, Christos Argyropoulos

Department of Electrical and Computer Engineering: Faculty Publications

The inherently weak chiroptical responses of natural materials limit their usage for controlling and enhancing chiral light-matter interactions. Recently, several nanostructures with subwavelength scale dimensions were demonstrated, mainly due to the advent of nanofabrication technologies, as a potential alternative to efficiently enhance chirality. However, the intrinsic lossy nature of metals and the inherent narrowband response of dielectric planar thin films or metasurface structures pose severe limitations toward the practical realization of broadband and tailorable chiral systems. Here, we tackle these problems by designing all-dielectric silicon-based L-shaped optical metamaterials based on tilted nanopillars that exhibit broadband and enhanced chiroptical response in …

Spatiotemporal Reaction Dynamics Control In Two-Photon Polymerization For Enhancing Writing Characteristics, Aofei Mao, Sarah Fess, Nada Kraiem, P. Li, Zhipeng P. Wu, Qiuchi Zhu, Xi Huang, Peixun Fan, Bai Cui, Jean-Francois Silvain, Suxing Hu, Mitchell Anthamatten, Sean P. Regan, David Harding, Yongfeng Lu

Department of Electrical and Computer Engineering: Faculty Publications

Since 2001, 3D microfabrication based on two-photon polymerization (TPP) has drawn extensive attention and interest in biology, optics, photonics, material science, and high-energy physics. The in-volume fabrication capability due to the threshold behavior of two-photon absorption enables TPP higher flexibility compared with other nanofabrication techniques. However, as determined by the in-volume fabrication feature as well as various reaction dynamics, the writing characteristics of TPP, such as throughput, accuracy, surface quality, and fabrication capability, are still limited. Herein, a comprehensive study is performed on the spatiotemporal behavior of reaction dynamics during TPP fabrication, mainly focusing on spatiotemporal characteristics of radical diffusion, …

A Deep Learning Convolutional Neural Network For Antenna Near-Field Prediction And Surrogate Modeling, Md Rayhan Khan, Constantinos L. Zekios, Shubhendu Bhardwaj, Stavros V. Georgakopoulos

Department of Electrical and Computer Engineering: Faculty Publications

This study investigates the use of deep learning techniques for building a generalized surrogate model that can accurately and very efficiently predict antenna performance parameters. Notably, we focus on applications where a substantial amount of simulation time is required and prior data is available for deep learning use. Specifically, for these applications, we introduce deep learning models that efficiently and reliably model the near-field of the antenna. These models, in turn, accurately predict far-field properties and essential antenna metrics, such as the reflection coefficient. To demonstrate the efficiency of our method, the widely used rectangular patch antenna is considered, encompassing …

A Systematic Survey On 5g And 6g Security Considerations, Challenges, Trends, And Research Areas, Paul Scalise, Matthew Boeding, Hamid Sharif, Joseph Delloiacovo, John Reed

Department of Electrical and Computer Engineering: Faculty Publications

With the rapid rollout and growing adoption of 3GPP 5thGeneration (5G) cellular services, including in critical infrastructure sectors, it is important to review security mechanisms, risks, and potential vulnerabilities within this vital technology. Numerous security capabilities need to work together to ensure and maintain a sufficiently secure 5G environment that places user privacy and security at the forefront. Confidentiality, integrity, and availability are all pillars of a privacy and security framework that define major aspects of 5G operations. They are incorporated and considered in the design of the 5G standard by the 3rd Generation Partnership Project (3GPP) with the goal …

Room Temperature Polaritonic Soft-Spin Xy Hamiltonian In Organic–Inorganic Halide Perovskites, Kai Peng, Wei Li, Natalia G. Berloff, Xiang Zhang, Wei Bao

Department of Electrical and Computer Engineering: Faculty Publications

Exciton–polariton condensates, due to their nonlinear and coherent characteristics, have been employed to construct spin Hamiltonian lattices for potentially studying spin glass, critical dephasing, and even solving optimization problems. Here, we report the room-temperature polariton condensation and polaritonic soft-spin XY Hamiltonian lattices in an organic–inorganic halide perovskite microcavity. This is achieved through the direct integration of highquality single-crystal samples within the cavity. The ferromagnetic and antiferromagnetic couplings in both one- and two-dimensional condensate lattices have been observed clearly. Our work shows a nonlinear organic–inorganic hybrid perovskite platform for future investigations as polariton simulators.

Editorial: Frontiers In Lasers And Applications, John T. Fourkas, Koji Sugioka, Yongfeng Lu

Department of Electrical and Computer Engineering: Faculty Publications

When the laser was invented in 1960 by Theodore H.Maiman, the potential applications of this apparatus were far from clear. Indeed, even 4 years later, Maiman himself, in an interview with The New York Times, called the laser “a solution seeking a problem.”

Nearly 64 years later, it is safe to say that the laser’s influence on our everyday lives has been nearly beyond measure. Lasers are integral to CD and DVD readers, barcode readers, many computer printers, speed and distance sensors, and in various entertainment systems used in concerts and other events.

High Crystalline Quality Homoepitaxial Si-Doped Β-Ga2O3(010) Layers With Reduced Structural Anisotropy Grown By Hot-Wall Mocvd, D. Gogova, D. Q. Tran, V. Jokubavicius, L. Vines, M. Schubert, R. Yakimova, P. P. Paskov, V. Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

A new growth approach, based on the hot-wall metalorganic chemical vapor deposition concept, is developed for high-quality homoepitaxial growth of Si-doped single-crystalline β-Ga₂O₃ layers on (010)-oriented native substrates. Substrate annealing in argon atmosphere for 1 min at temperatures below 600 ^oC is proposed for the formation of epi-ready surfaces as a cost-effective alternative to the traditionally employed annealing process in oxygen-containing atmosphere with a time duration of 1 h at about 1000 ^oC. It is shown that the on-axis rocking curve widths exhibit anisotropic dependence on the azimuth angle with minima for in-plane direction …

Electron Effective Mass In Gan Revisited: New Insights From Terahertz And Mid-Infrared Optical Hall Effect, Nerijus Armakavicius, Sean Knight, Philipp Kühne, Vallery Stanishev, Dat Q. Tran, Steffen Richter, Alexis Papamichail, Megan Stokey, Preston Sorensen, Ufuk Kilic, Mathias Schubert, Plamen P. Paskov, Vanya Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

Electron effective mass is a fundamental material parameter defining the free charge carrier transport properties, but it is very challenging to be experimentally determined at high temperatures relevant to device operation. In this work, we obtain the electron effective mass parameters in a Si-doped GaN bulk substrate and epitaxial layers from terahertz (THz) and mid-infrared (MIR) optical Hall effect (OHE) measurements in the temperature range of 38–340 K. The OHE data are analyzed using the well-accepted Drude model to account for the free charge carrier contributions. A strong temperature dependence of the electron effective mass parameter in both bulk and …

Terahertz Permittivity Parameters Of Monoclinic Single Crystal Lutetium Oxyorthosilicate, Sean Knight, Steffen Richter, Alexis Papamichail, Megan Stokey, Rafał Korlacki, Vallery Stanishev, Philipp Kühne, Mathias Schubert, Vanya Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

The anisotropic permittivity parameters of monoclinic single crystal lutetium oxyorthosilicate, Lu₂SiO₅ (LSO), have been determined in the terahertz spectral range. Using terahertz generalized spectroscopic ellipsometry (THz-GSE), we obtained the THz permittivities along the a, b, and c^⋆ crystal directions, which correspond to the ε_a; ε_b, and ε_c? on-diagonal tensor elements. The associated off diagonal tensor element ε_ac? was also determined experimentally, which is required to describe LSO’s optical response in the monoclinic a–c crystallographic plane. From the four tensor elements obtained in the model fit, we calculate the …

Room Temperature Two-Dimensional Electron Gas Scattering Time, Effective Mass, And Mobility Parameters In AlXGa1−XN/Gan Heterostructures (0.07 ≤ X ≤ 0.42), Sean Knight, Steffen Richter, Alexis Papamichail, Philipp Kühne, Nerijus Armakavicius, Shiqi Guo, Axel R. Persson, Vallery Stanishev, Viktor Rindert, Per O. Å. Persson, Plamen P. Paskov, Mathias Schubert, Vanya Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

Al_xGa_1-xN/GaN high-electron-mobility transistor (HEMT) structures are key components in electronic devices operating at gigahertz or higher frequencies. In order to optimize such HEMT structures, understanding their electronic response at high frequencies and room temperature is required. Here, we present a study of the room temperature free charge carrier properties of the two-dimensional electron gas (2DEG) in HEMT structures with varying Al content in the Al_xGa_1-xN barrier layers between x = 0:07 and x = 0:42. We discuss and compare 2DEG sheet density, mobility, effective mass, sheet resistance, and scattering times, …

Study On Debinding And Sintering Conditions In Extrusion-Based Additive Manufacturing Of 316l And 316l + Cu, Jean-François Silvain, Daniel Lincoln Gifford, Sébastien Fourcade, Laurent Cuzacq, Jean-Luc Grosseau-Poussard, Catherine Debiemme-Chouvy, Nicolas Tessier Doyen, Yongfeng Lu

Department of Electrical and Computer Engineering: Faculty Publications

This study investigates the use of a methylcellulose binder in extrusion additive manufacturing of 316L as an alternative to common wax-based binders. Various quantities of copper (Cu) powder were also added in the paste composition to attempt to reduce the sintering temperature by promoting persistent liquid phase sintering. Debinding experiments were conducted under different temperatures and dwell times using argon (Ar), Ar/5%H₂, and Ar/1%O₂ atmospheres. Debinding reduced carbon (C) content to 0.032 wt.% by using a two-step debinding process of Ar/5%H₂ and Ar/1%O₂ thermal treatments. Using this debinding process, sintering was conducted at 1200 ^{o …}

Nitrogen Radiofrequency Plasma Treatment Of Graphene, Antoine Bident, Nathalie Caillault, Florence Delange, Christine Labrugere, Guillaume Aubert, Cyril Aymonier, Etienne Durand, Alain Demourgues, Yongfeng Lu, Jean-François Silvain

Department of Electrical and Computer Engineering: Faculty Publications

The incorporation of nitrogen (N) atoms into a graphitic network such as graphene (Gr) remains a major challenge. However, even if the insertion mechanisms are not yet fully understood, it is certain that the modification of the electrical properties of Gr is possible according to the configuration adopted. Several simulations work, notably using DFT, have shown that the incorporation of N in Gr can induce an increase in the electrical conductivity and N acts as an electron donor; this increase is linked to the amount of N, the sp²/sp³ carbon configuration, and the nature of C-N bonding. …

Detection Of Cancer-Associated Gene Mutations In Urinary Cell-Free Dna Among Prostate Cancer Patients In South Africa, Dada Oluwaseyi Temilola, Martha Wium, Juliano Paccez, Azola Samkele Salukazana, Solomon O. Rotimi, Hasan H. Otu, Giuseppina M. Carbone, Lisa Kaestner, Stefano Cacciatore, Luiz Fernando Zerbini

Department of Electrical and Computer Engineering: Faculty Publications

Prostate cancer (PCa) is the most common cause of cancer death among African men. The presence of tumor-specific variations in cell-free DNA (cfDNA), such as mutations, microsatellite instability, and DNA methylation, has been explored as a source of biomarkers for cancer diagnosis. In this study, we investigated the diagnostic role of cfDNA among South African PCa patients. We performed whole exome sequencing (WES) of urinary cfDNA. We identified a novel panel of 31 significantly deregulated somatic mutated genes between PCa and benign prostatic hyperplasia (BPH). Additionally, we performed whole-genome sequencing (WGS) on matching PCa and normal prostate tissue in an …

Laser-Direct-Drive Fusion Target Design With A High-Z Gradient-Density Pusher Shell, S. S. Hu, L. Ceurvorst, J. L. Peebles, A. Mao, P. Li, Yongfeng Lu, A. Shvydky, V. N. Goncharov, R. Epstein, K. A. Nichols, R. M. N. Goshadze, M. Ghosh, J. Hinz, V. V. Karasiev, S. Zhang, N. R. Shaffer, D. I. Mihaylov, J. Cappelletti, D. R. Harding, C. K. Li, E. M. Campbell, R. C. Shah, T. J. B. Collins, S. P. Regan, C. Deeney

Department of Electrical and Computer Engineering: Faculty Publications

Laser-direct-drive fusion target designs with solid deuterium-tritium (DT) fuel, a high-Z gradient-density pusher shell (GDPS), and a Au-coated foam layer have been investigated through both 1D and 2D radiationhydrodynamic simulations. Compared with conventional low-Z ablators and DT-push-on-DT targets, these GDPS targets possess certain advantages of being instability-resistant implosions that can be high adiabat (α ≽ 8) and low hot-spot and pusher-shell convergence (CR_hs ≈22 and CR_PS ≈17), and have a low implosion velocity (v_imp < 3 × 10⁷ cm/s). Using symmetric drive with laser energies of 1.9 to 2.5 MJ, 1D LILAC simulations of these GDPS implosions can result …

Aptamer-Based Proteomics Measuring Preoperative Cerebrospinal Fluid Protein Alterations Associated With Postoperative Delirium, Simon T. Dillon, Sarinnapha M. Vasunilashorn, Hasan H. Otu, Long Ngo, Tamara Fong, Xuesong Gu, Michele Cavallari, Alexandra Touroutoglou, Mouhsin Shafi, Sharon K. Inouye, Zhongcong Xie, Edward R. Marcantonio, Towia A. Libermann

Department of Electrical and Computer Engineering: Faculty Publications

Delirium is a common postoperative complication among older patients with many adverse outcomes. Due to a lack of validated biomarkers, prediction and monitoring of delirium by biological testing is not currently feasible. Circulating proteins in cerebrospinal fluid (CSF) may reflect biological processes causing delirium. Our goal was to discover and investigate candidate protein biomarkers in preoperative CSF that were associated with the development of postoperative delirium in older surgical patients. We employed a nested case–control study design coupled with high multiplex affinity proteomics analysis to measure 1305 proteins in preoperative CSF. Twenty-four matched delirium cases and non-delirium controls were selected …

Integrating Glycolysis, Citric Acid Cycle, Pentose Phosphate Pathway, And Fatty Acid Beta‑Oxidation Into A Single Computational Model, Sylwester M. Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Beata J. Wysocki, Paul H. Davis, Tadeusz A. Wysocki

Department of Electrical and Computer Engineering: Faculty Publications

The metabolic network of a living cell is highly intricate and involves complex interactions between various pathways. In this study, we propose a computational model that integrates glycolysis, the pentose phosphate pathway (PPP), the fatty acids beta-oxidation, and the tricarboxylic acid cycle (TCA cycle) using queueing theory. The model utilizes literature data on metabolite concentrations and enzyme kinetic constants to calculate the probabilities of individual reactions occurring on a microscopic scale, which can be viewed as the reaction rates on a macroscopic scale. However, it should be noted that the model has some limitations, including not accounting for all the …

Potential Of Mirnas In Plasma Extracellular Vesicle For The Stratification Of Prostate Cancer In A South African Population, Dada Oluwaseyi Temilola, Martha Wium, Juliano Paccez, Azola Samkele Salukazana, Hasan H. Otu, Giuseppina M. Carbone, Lisa Kaestner, Stefano Cacciatore, Luiz Fernando Zerbini

Department of Electrical and Computer Engineering: Faculty Publications

Prostate cancer (PCa) is the most common cause of cancer death among African men. The analysis of microRNAs (miRNAs) in plasma extracellular vesicles (EVs) can be utilized as a non-invasive tool for the diagnosis of PCa. In this study, we used small RNA sequencing to profile miRNAs cargo in plasma EVs from South African PCa patients. We evaluated the differential expression of miRNAs between low and high Gleason scores in the plasma EVs of South African patients and in the prostatic tissue from data available in the Cancer Genome Atlas (TCGA) Data Portal. We identified 7 miRNAs differently expressed in …

Integration Of Meta-Multi-Omics Data Using Probabilistic Graphs And External Knowledge, Handan Can, Sree K. Chanumolu, Barbara D. D., Sophie Alvarez, Michael J. Naldrett, Gülhan Ünlü, Hasan H. Otu

Department of Electrical and Computer Engineering: Faculty Publications

Multi-omics has the promise to provide a detailed molecular picture of biological systems. Although obtaining multi-omics data is relatively easy, methods that analyze such data have been lagging. In this paper, we present an algorithm that uses probabilistic graph representations and external knowledge to perform optimal structure learning and deduce a multifarious interaction network for multi-omics data from a bacterial community. Kefir grain, a microbial community that ferments milk and creates kefir, represents a self-renewing, stable, natural microbial community. Kefir has been shown to have a wide range of health benefits. We obtained a controlled bacterial community using the two …

A Unified Switched Nonlinear Dynamic Model Of An Electric Vehicle For Performance Evaluation, Dibyendu Khan, Kuntal Mandal, Anjan Kumar Ray, Abdelali El Aroudi

Department of Electrical and Computer Engineering: Faculty Publications

The advanced modeling and estimation of overall system dynamics play a vital role in electric vehicles (EVs), as the selection of components in the powertrain and prediction of performance are the key market qualifiers. The state-space averaged model and small-signal transfer function model are useful for assessing long-term behavior in system-level analysis and for designing the controller parameters, respectively. Both models take less computation time but ignore the high-frequency switching dynamics. Therefore, these two models could be impractical for the development and testing of EV prototypes. On the other hand, the multi-domain model in available simulation tools gives in-depth information …

An Ai-Based Intervention For Improving Undergraduate Stem Learning, Mohammad Rashedul Hasan, Bilal Khan

Department of Electrical and Computer Engineering: Faculty Publications

We present results from a small-scale randomized controlled trial that evaluates the impact of just-in-time interventions on the academic outcomes of N = 65 undergraduate students in a STEM course. Intervention messaging content was based on machine learning forecasting models of data collected from 537 students in the same course over the preceding 3 years. Trial results show that the intervention produced a statistically significant increase in the proportion of students that achieved a passing grade. The outcomes point to the potential and promise of just-in-time interventions for STEM learning and the need for larger fully-powered randomized controlled trials.

Generation Of Vector Vortex Wave Modes In Cylindrical Waveguides, Md Khadimul Islam, Pawan Gaire, Arjuna Madanayake, Shubhendu Bhardwaj

Department of Electrical and Computer Engineering: Faculty Publications

In this paper, we propose a method to generate Vector Vortex Modes (VVM) inside a metallic cylindrical waveguide at microwave frequencies and demonstrate the experimental validation of the concept. Vector vortex modes of EM waves can carry both spin and orbital angular momentum as they propagate within a tubular medium. The existence of such waves in tubular media can be beneficial to wireless communication in such structures. These waves can carry different orbital angular momentum and spin angular momentum, and therefore, they feature the ability to carry multiple orthogonal modes at the same frequency due to spatial structure of the …

A Flexible Ot Testbed For Evaluating On-Device Implementations Of Iec-61850 Goose, Matthew Boeding, Michael Hempel, Hamid Sharif, Juan Lopez Jr., Kalyan Perumalla

Department of Electrical and Computer Engineering: Faculty Publications

The growing convergence of Information Technology and Operational Technology has enhanced communication and visibility across power grids. This, coupled with the growing use of Distributed Energy Resources in power grids, has enhanced the grid capabilities while also creating a larger attack surface for malicious actors. A common protocol vulnerable to these attacks is the IEC-61850 GOOSE protocol due to its low-latency requirements, multicast packet delivery method, and lack of encryption. In this paper, we evaluate the security implications of different hardware implementations of this protocol by contrasting device response and recovery of two commercial off-the-shelf Intelligent Electronic Devices from separate …

Cometrics: A New Software Tool For Behavior‑Analytic Clinicians And Machine Learning Researchers, Walker S. Arce, Seth G. Walker, Morgan L. Hurtz

Department of Electrical and Computer Engineering: Faculty Publications

Cometrics is a Microsoft Windows compatible clinical tool for the collection and recording of frequency- and duration-based target behaviors, physiological signals, and video data. This software package is designed to record in-vivo observational and physiological data. In addition, we have included features that allow observers to capture video from real-time camera feeds and import saved video for retroactive data collection. By using Microsoft Excel-based spreadsheets, also called keystroke files, assessment and treatment sessions are exported into a single document using the click of a button. Integrated interobserver agreement metrics allow comparisons across primary and reliability observers, with the output exported …

Guest Editorial: Special Issue On Green Iot For Future Space–Air–Ground–Ocean-Integrated Networks And Applications, Bo Rong, Mohamed Cheriet, Jon Montalban, Lei Shu, Yi Qian

Department of Electrical and Computer Engineering: Faculty Publications

The Internet of Things (IoT) plays a critical role in enabling the seamless integration of disparate devices. Future IoT will rapidly expand its coverage to offer future worldwide omnipresent applications and services by merging communications in diverse spatial domains to build the space–air–ground–ocean-integrated network (SAGOI-Net). SAGOI-Net will include a significant number of battery-powered network nodes, such as satellites, unmanned vehicles, and underwater devices, due to the extremely vast geographic reach and dynamics in free space. Given the battery limitations, high-energy-efficiency communications and networking will be critical to the future system. Green SAGOI-Net seeks to not only bring ubiquitous connectivity to …

Anticancer Activities Of Tetra-, Penta-, And Hexacyclic Phenothiazines Modified With Quinoline Moiety., Małgorzata Jel, Beata Morak-Młodawska, Rafał Korlacki

Department of Electrical and Computer Engineering: Faculty Publications

The quinoline molecule is a chemical motif showing a highly promising pharmacological potential. Its numerous derivatives introduced into medicine revolutionized in the treatment of many entities of disease. The presence of the quinoline system in the structure of phenothiazines made it possible to obtain new aza- and diazaphenothiazine derivatives that show promising anticancer potential. The aza-analogs of the phenothiazines are structurally modified phenothiazines by the substitution of one or both benzene rings in the phenothiazine ring system with various azine rings. This approach to the strategy of obtaining new substances with biological potential can be classified as molecular hybridization methods …

Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki

Department of Electrical and Computer Engineering: Faculty Publications

Lipophilicity is one of the key properties of a potential drug that determines the solubility, the ability to penetrate through cell barriers, and transport to the molecular target. It affects pharmacokinetic processes such as adsorption, distribution, metabolism, excretion (ADME). The 10-substituted 1,9-diazaphenothiazines show promising if not impressive in vitro anticancer potential, which is associated with the activation of the mitochondrial apoptosis pathway connected with to induction BAX, forming a channel in MOMP and releasing cytochrome c for the activation of caspases 9 and 3. In this publication, the lipophilicity of previously obtained 1,9-diazaphenothiazines was determined theoretically using various computer programs …