Study Of The Visual Adaptation Mechanism In Marine Species With The Change Of Habitation Depth., 2018 Physical-Technical High School
Study Of The Visual Adaptation Mechanism In Marine Species With The Change Of Habitation Depth., Demid Osipov, Daniil Moshnikov
The International Student Science Fair 2018
The goal of our work was to determine the principal mechanisms that provide the difference in visual perception of two marine species that live on different depths: T. Pacificus and O. Vulgaris. In nature, visual perception of species that live deeper is shifted towards the blue region. This is related to the fact that red, orange and yellow light is absorbed more strongly by water than the blue light. On the other hand, the visual perception spectrum of an animal is determined by the absorption spectrum of the "light sensor" located in rods and cones of its eye retina. These ...
Statistical Biophysics Blog: Recovering From Bootstrap Intoxication, 2018 Oregon Health & Science University
Statistical Biophysics Blog: Recovering From Bootstrap Intoxication, Daniel M. Zuckerman
When analyzing statistical uncertainty for large-variance data sets with small sample sizes, the 'bootstrap' method must viewed with great caution.
Multicomponent Analysis Using A Confocal Raman Microscope, 2018 NUI Maynooth
Multicomponent Analysis Using A Confocal Raman Microscope, Zhengyuan Tang, Sinead J. Barton, Thomas E. Ward, John P. Lowry, Michelle M. Doran, Hugh Byrne, Bryan M. Hennelly
Measuring the concentration of multiple chemical components in a low volume aqueous mixture by Raman spectroscopy has received significant interest in the literature. All of the contributions to date focus on the design of optical systems that facilitate the recording of spectra with high signal-to-noise ratio, by collecting as many Raman scattered photons as possible. In this study, the confocal Raman microscope set-up is investigated for multicomponent analysis. Partial Least Squares Regression is used to quantify physiologically relevant aqueous mixtures of glucose, lactic acid, and urea. The predicted error is 17.81 mg/dL for glucose, 10.6 mg/dL ...
Advancing Raman Microspectroscopy For Cellular And Subcellular Analysis: Towards In Vitro High Content Spectralomic Analysis, 2018 Dublin Institute of Technology
Advancing Raman Microspectroscopy For Cellular And Subcellular Analysis: Towards In Vitro High Content Spectralomic Analysis, Hugh Byrne, Franck Bonnier, Alan Casey, Marcus Maher, Jennifer Mcintyre, Esen Efeoglu, Zeineb Farhane
In the confocal mode, Raman microspectroscopy can profile the biochemical content of biological cells at a subcellular level, and any changes to it by exogenous agents, such as therapeutic drugs or toxicants. As an exploration of the potential of the technique as a high content, label free analysis technique, this report reviews work to monitor the spectroscopic signatures associated with the uptake and response pathways of commercial chemotherapeutic agents and polymeric nanoparticles by human lung cells. It is demonstrated that the signatures are reproducible and characteristic of the cellular event, and can be used, for example, to identify the mode ...
Elucidating The Action Of A Regulatory Lipid Ligand Via Molecular Simulation: Cholesterol Swarms And The Inwardly Rectifying Potassium Channel, 2018 North Carolina State University
Elucidating The Action Of A Regulatory Lipid Ligand Via Molecular Simulation: Cholesterol Swarms And The Inwardly Rectifying Potassium Channel, Belinda Akpa, Nicolas Barbera, Irena Levitan
Biology and Medicine Through Mathematics Conference
No abstract provided.
Collective Gradient Sensing In Fish Schools, 2018 Gettysburg College
Collective Gradient Sensing In Fish Schools, James G. Puckett, Aawaz R. Pokhrel, Julia A. Giannini
Physics and Astronomy Faculty Publications
Throughout the animal kingdom, animals frequently benefit from living in groups. Models of collective behaviour show that simple local interactions are sufficient to generate group morphologies found in nature (swarms, flocks and mills). However, individuals also interact with the complex noisy environment in which they live. In this work, we experimentally investigate the group performance in navigating a noisy light gradient of two unrelated freshwater species: golden shiners (Notemigonuscrysoleucas) and rummy nose tetra (Hemigrammus bleheri). We find that tetras outperform shiners due to their innate individual ability to sense the environmental gradient. Using numerical simulations, we examine how group performance ...
Computational Analysis Of Poliovirus Structural Dynamics Using A Coarse-Grained Model, 2018 University of Connecticut
Computational Analysis Of Poliovirus Structural Dynamics Using A Coarse-Grained Model, Maneesh Koneru
University Scholar Projects
Though eradicated in most of the world, poliovirus remains a common model virus for a family of mammalian viruses known as Picornaviruses. Despite the development of a vaccination, little is understood about the infection process, particularly the mechanism of cell entry. Experimental studies have attempted to elucidate the dynamics of this process and have proposed pathways focused on VP4, the smallest of the four peptides which makes up the viral capsid, and its interaction with the pentameric interfaces of the five fold axes. This study utilizes coarse-grained molecular dynamics to supplement these proposed mechanisms with simplified simulations which reduce the ...
The Computational Study Of Fly Swarms & Complexity, 2018 Linfield College
The Computational Study Of Fly Swarms & Complexity, Austin Bebee
A system is considered complex if it is composed of individual parts that abide by their own set of rules, while the system, as a whole, will produce non-deterministic properties. This prevents the behavior of such systems from being accurately predicted. The motivation for studying complexity spurs from the fact that it is a fundamental aspect of innumerable systems. Among complex systems, fly swarms are relatively simple, but even so they are still not well understood. In this research, several computational models were developed to assist with the understanding of fly swarms. These models were primarily analyzed by using the ...
Raman Spectral Analysis For Rapid Screening Of Dengue Infection, 2018 Department of Chemistry, University of Agriculture, Faisalabad, Pakistan.
Raman Spectral Analysis For Rapid Screening Of Dengue Infection, Tahir Mahmood, Haq Nawaz, A. Ditta, M.I. Majeed, M.A. Hanif, N. Rashid, H.N. Bhatti, H.F. Nargis, M. Saleem, Franck Bonnier, Hugh Byrne
Infection with the dengue virus is currently clinically detected according to different biomarkers in human blood plasma, commonly measured by enzyme linked immunosorbent assays, including non-structural proteins (Ns1), immunoglobulin M (IgM) and immunoglobulin G (IgG). However, there is little or no mutual correlation between the biomarkers, as demonstrated in this study by a comparison of their levels in samples from 17 patients. As an alternative, the label free, rapid screening technique, Raman spectroscopy has been used for the characterisation/diagnosis of healthy and dengue infected human blood plasma samples. In dengue positive samples, changes in specific Raman spectral bands associated ...
Photonic Tools For Advanced Sensing And Imaging At The Nanoscale., 2018 University of Louisville
Photonic Tools For Advanced Sensing And Imaging At The Nanoscale., Jafar Hamed Ghithan
Electronic Theses and Dissertations
This dissertation reports a novel bio-sensing strategy based on single-mode, electro-active, integrated optical waveguide (SM-EA-IOW) platforms. It also reports the development of a super-resolved far-field optical imaging tool to enable optical, electronic, and spectroelectrochemical investigations at the nanoscale. SM-EA-IOW platforms with its outstanding sensitivity for spectroelectrochemical interrogation was combined with a sandwich bioassay for the development of a novel immunosensing based strategy for label-free detection of infectious pathogens. The strategy begins with the functionalization of the electroactive waveguide surface with a capturing antibody aimed at a specific target analyte. Once the target analyte is bound to the photonic interface, it ...
Sex Differences In Lower Limb Biomechanics During A Single-Leg Cut With Body Borne Load, 2018 Boise State University
Sex Differences In Lower Limb Biomechanics During A Single-Leg Cut With Body Borne Load, Auralea Carylon Fain
Boise State University Theses and Dissertations
Introduction: Musculoskeletal injuries are ever-increasing in military personnel, particularly females. These musculoskeletal injuries are attributed to adaptations in lower limb biomechanics while performing routine military tasks, such as a single-leg cut, with the addition of body borne load. However, it is unknown if females and males exhibit similar lower limb biomechanics with the addition of body borne load during these tasks. This study sought to compare the lower limb biomechanical adaptations exhibited by females and males performing a single-leg cut with body borne load. Methods: Eleven females and 17 males had lower limb biomechanics quantified during a single-leg cut with ...
Pregnancy Induced Alterations Of Reproductive Tract Collagen And Elastin In A Murine Model, 2018 The Graduate Center, City University of New York
Pregnancy Induced Alterations Of Reproductive Tract Collagen And Elastin In A Murine Model, Basant K. Dhital
All Dissertations, Theses, and Capstone Projects
This thesis reports on structural and dynamical modifications of reproductive tract elastin and collagen as a function of parity. Pelvic floor dysfunction, including pelvic organ prolapse (POP) is a major concern affecting female health worldwide, leading to surgeries costing billions of dollars annually. Collagen, elastic fibers, and proteoglycans are major extracellular matrix (ECM) components found in connective tissues. Vaginal child birth, advancing age, and disruption or dysfunction of connective tissue are major risk factors of POP. In the female reproductive tract, the assembly of elastic fibers is crucial for the pelvic floor support. Any disturbance in the synthesis, assembly, and ...
The Incorporation Of Graphene To Lithium Cobalt Oxide As A Cathode To Improve The Performance Of Lithium Ion Batteries, 2018 University of Arkansas, Fayetteville
The Incorporation Of Graphene To Lithium Cobalt Oxide As A Cathode To Improve The Performance Of Lithium Ion Batteries, Kenan Wang
Theses and Dissertations
One of the objectives of this thesis work was to investigate the cathode performance of lithium cobalt oxide (LiCoO2) incorporated with graphene powder in lithium ion batteries (LIBs). Graphene powder was incorporated into cathode materials to enhance the performance of LIBs. The other objective was to impede the construction of a solid electrolyte interphase (SEI) sheet using graphene sheet coating on its cathode.
The results of this work show that adding graphene powder improved the performance of LiCoO¬2 as a cathode material. With the incorporation of different weight percentages of graphene powder, the LiBs showed distinct changes in their ...
Combining Microdialysis And Electrophysiology In Cerebral Cortex To Delineate Functional Implications Of Acetylcholine Gradients, 2018 University of Arkansas, Fayetteville
Combining Microdialysis And Electrophysiology In Cerebral Cortex To Delineate Functional Implications Of Acetylcholine Gradients, Tazima Nur
Theses and Dissertations
The neuronal network in cerebral cortex is a dynamic system that can undergo changes in collective neural activity as the organism changes its behavior. For example, during sleep and quiet restful awake state, many neurons tend to fire together in synchrony. In contrast, during alert awake states, firing patterns of neurons tend to be more asynchronous, firing more independently. These changes in population-level synchrony are defined as changes in cortical state. Response to sensory input is state-dependent, i.e., change in cortical state can impact the sensory information processing in cortex and introduce trial-to-trial variability in response to the same ...
Physics 516: Electromagnetic Phenomena (Spring 2018), 2018 University of Pennsylvania
Physics 516: Electromagnetic Phenomena (Spring 2018), Philip C. Nelson
Department of Physics Papers
These course notes are made publicly available in the hope that they will be useful. All reports of errata will be gratefully received. I will also be glad to hear from anyone who reads them, whether or not you find errors: email@example.com.
The Association Of Size Variation In The Dental Arch To Third Molar Agenesis For A Modern Population, 2018 University of South Florida
The Association Of Size Variation In The Dental Arch To Third Molar Agenesis For A Modern Population, Devin N. Williams
Graduate Theses and Dissertations
The frequency with which individuals do not develop their third molars, or wisdom teeth, is increasing worldwide. This current topic of human evolution is relevant to the research of anthropologists, geneticists, dentists, and other researchers involved in the study of human dentition. Many explanations have been offered to account for the prevalence of molar agenesis including, evolutionary, environmental, and genetic theories. The purpose of this research project is to determine the frequency of third molar agenesis and investigate the relationship between third molar agenesis and maxillomandibular jaw dimensions in a sample of orthodontic patients. This research tests the hypotheses that ...
Vibration Response: Mapping The Behavioral Response Of Fruit Fly Larvae To Mechanical Stimuli, 2018 University of Miami
Vibration Response: Mapping The Behavioral Response Of Fruit Fly Larvae To Mechanical Stimuli, Alexander Berne
Drosophila larvae are capable of a wide array of simple, quantifiable behavioral responses to stimuli, which makes the organism a useful tool for deconstructing biotic behavior for wider application. To this end, an understanding of the response to mechanical stimulation remains relatively unexplored in this organism, and warrants investigation. This research aims to map the fruit fly’s behavior as a function of a generalized mechanical stimulus, namely, vibration.
Fruit fly larvae are placed in a light and temperature controlled environment, and observed crawling on vibrating agar plates with CCD cameras controlled through LabVIEW. Larvae are monitored for their instantaneous ...
Using The I-Motif As A Ph Sensor In Single-Molecule Fluorescence Microscopy Imaging, 2018 Kent State University
Using The I-Motif As A Ph Sensor In Single-Molecule Fluorescence Microscopy Imaging, Jacob Taylor
Undergraduate Research Symposium
We used biophysics techniques to study the behavior of the single molecule human i-motif DNA structure as a function of the pH of its surroundings. We found that the molecule folds into a compact state around pH 6.0. We used FRET trace to observing the behavior of the molecule as it folds in a common imaging buffer of time-variant pH.
Evolving Specialization In An Agent-Based Model Without Task-Switching Costs, 2018 University of Missouri, St. Louis
Evolving Specialization In An Agent-Based Model Without Task-Switching Costs, Shane Meyer
This work examines the possibility of evolving the phenotypic specialization associated with division of labor in an agent-based model without task-switching costs. The model examines two groups competing for vital resources, where members of one group are capable of sharing resources with other agents in their group. Agents attempt to collect resources which allow them to reproduce, with more resources leading to a greater number of offspring by asexual reproduction. Four variants of the model are examined, with combinations of one or two resources and the presence of a foraging risk. The presence of the foraging risk can lead to ...
Nadph-Cytochrome P450 Oxidoreductase: Extraction Of The Full-Length Protein And Methyl-Trosy Nmr Of The Soluble Mutants, Sara Ali Jamal Arafeh
Master's Theses (2009 -)
NADPH-cytochrome p450 oxidoreductase (CYPOR) is a membrane-bound protein in living cells. CYPOR delivers electrons to cytochrome p450 proteins (CYPs) to catalyze metabolism of drugs and synthesis of steroids. Extraction and solubilization of CYPOR from the membrane is typically done with the TritonX-100 detergent. The amount of the solubilized protein by this detergent, however, remains relatively low to structurally analyze CYPOR with NMR spectroscopy. The goal of the first project in this thesis was to optimize the amount of the extracted CYPOR from the E. coli membrane using various detergents and additives. To this aim, non-ionic detergents with variable hydrophobicity (TritonX-100 ...