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Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander 2024 CUNY Bernard M Baruch College

Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander

Student Theses and Dissertations

Aerobic metabolism is known to generate damaging ROS, particularly hydrogen peroxide. Reactive oxygen species (ROS) are highly reactive molecules containing oxygen that have the potential to cause damage to cells and tissues in the body. ROS are highly reactive atoms or molecules that rapidly interact with other molecules within a cell. Intracellular accumulation can result in oxidative damage, dysfunction, and cell death. Due to the limitations of H2O2 (hydrogen peroxide) detectors, other impacts of ROS exposure may have been missed. HyPer7, a genetically encoded sensor, measures hydrogen peroxide emissions precisely and sensitively, even at sublethal levels, during …


The Quantitative Analysis And Visualization Of Nfl Passing Routes, Sandeep Chitturi 2024 University of Arkansas, Fayetteville

The Quantitative Analysis And Visualization Of Nfl Passing Routes, Sandeep Chitturi

Computer Science and Computer Engineering Undergraduate Honors Theses

The strategic planning of offensive passing plays in the NFL incorporates numerous variables, including defensive coverages, player positioning, historical data, etc. This project develops an application using an analytical framework and an interactive model to simulate and visualize an NFL offense's passing strategy under varying conditions. Using R-programming and data management, the model dynamically represents potential passing routes in response to different defensive schemes. The system architecture integrates data from historical NFL league years to generate quantified route scores through designed mathematical equations. This allows for the prediction of potential passing routes for offensive skill players in response to the …


Artificial Intelligence Could Probably Write This Essay Better Than Me, Claire Martino 2024 Augustana College, Rock Island Illinois

Artificial Intelligence Could Probably Write This Essay Better Than Me, Claire Martino

Augustana Center for the Study of Ethics Essay Contest

No abstract provided.


On Generative Models And Joint Architectures For Document-Level Relation Extraction, Aviv Brokman 2024 University of Kentucky

On Generative Models And Joint Architectures For Document-Level Relation Extraction, Aviv Brokman

Theses and Dissertations--Statistics

Biomedical text is being generated at a high rate in scientific literature publications and electronic health records. Within these documents lies a wealth of potentially useful information in biomedicine. Relation extraction (RE), the process of automating the identification of structured relationships between entities within text, represents a highly sought-after goal in biomedical informatics, offering the potential to unlock deeper insights and connections from this vast corpus of data. In this dissertation, we tackle this problem with a variety of approaches.

We review the recent history of the field of document-level RE. Several themes emerge. First, graph neural networks dominate the …


Imputation Strategies For Different Categories Of Missing Data, Karthik Chalumuri 2024 University of New Hampshire, Durham

Imputation Strategies For Different Categories Of Missing Data, Karthik Chalumuri

Honors Theses and Capstones

Addressing missing data in research is crucial for ensuring the reliability and validity of study findings, yet it remains a significant challenge. This study investigates the impact of missing data on research outcomes and explores the underutilization of existing tools for managing missingness, potentially leading to gaps in critical information with tangible implications for decision-making processes (Dziura et al.).

Focusing on the different categories of missing data—Missing Completely At Random (MCAR), Missing At Random (MAR), and Missing Not At Random (MNAR)—this research examines various imputation strategies tailored to each category. Specifically, we compare the efficacy of several model-based imputation methods, …


Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia 2023 Brigham Young University

Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia

Journal of Nonprofit Innovation

Urban farming can enhance the lives of communities and help reduce food scarcity. This paper presents a conceptual prototype of an efficient urban farming community that can be scaled for a single apartment building or an entire community across all global geoeconomics regions, including densely populated cities and rural, developing towns and communities. When deployed in coordination with smart crop choices, local farm support, and efficient transportation then the result isn’t just sustainability, but also increasing fresh produce accessibility, optimizing nutritional value, eliminating the use of ‘forever chemicals’, reducing transportation costs, and fostering global environmental benefits.

Imagine Doris, who is …


Is The Declining Birthrate Really An Issue For The Economy?, Harsh Ramesh Pednekar, Theodore Lee, Darrion Chin 2023 Embry-Riddle Aeronautical University

Is The Declining Birthrate Really An Issue For The Economy?, Harsh Ramesh Pednekar, Theodore Lee, Darrion Chin

Introduction to Research Methods RSCH 202

This study aims to explore the complex implications of declining birth rates on the economy, focusing on GDP per capita as a crucial metric, and aims to uncover both potential opportunities and challenges stemming from this demographic transformation using regression analysis. Using a quantitative methodology and secondary data from OECD.stat, World Population Review, and World Bank, the study explores the relationship between declining birth rates and economic impacts. GDP per capita serves as an essential dependent variable, and it accounts for control variables such as labour force participation, literacy, and education levels, child dependence ratio, and physical capital. Past studies …


Random Variable Spaces: Mathematical Properties And An Extension To Programming Computable Functions, Mohammed Kurd-Misto 2023 Chapman University

Random Variable Spaces: Mathematical Properties And An Extension To Programming Computable Functions, Mohammed Kurd-Misto

Computational and Data Sciences (PhD) Dissertations

This dissertation aims to extend the boundaries of Programming Computable Functions (PCF) by introducing a novel collection of categories referred to as Random Variable Spaces. Originating as a generalization of Quasi-Borel Spaces, Random Variable Spaces are rigorously defined as categories where objects are sets paired with a collection of random variables from an underlying measurable space. These spaces offer a theoretical foundation for extending PCF to natively handle stochastic elements.

The dissertation is structured into seven chapters that provide a multi-disciplinary background, from PCF and Measure Theory to Category Theory with special attention to Monads and the Giry Monad. The …


Static And Dynamic State Estimation Applications In Power Systems Protection And Control Engineering, Ibukunoluwa Olayemi Korede 2023 University of Tennessee, Knoxville

Static And Dynamic State Estimation Applications In Power Systems Protection And Control Engineering, Ibukunoluwa Olayemi Korede

Doctoral Dissertations

The developed methodologies are proposed to serve as support for control centers and fault analysis engineers. These approaches provide a dependable and effective means of pinpointing and resolving faults, which ultimately enhances power grid reliability. The algorithm uses the Least Absolute Value (LAV) method to estimate the augmented states of the PCB, enabling supervisory monitoring of the system. In addition, the application of statistical analysis based on projection statistics of the system Jacobian as a virtual sensor to detect faults on transmission lines. This approach is particularly valuable for detecting anomalies in transmission line data, such as bad data or …


Wavelet Compression As An Observational Operator In Data Assimilation Systems For Sea Surface Temperature, Bradley J. Sciacca 2023 University of New Orleans, New Orleans

Wavelet Compression As An Observational Operator In Data Assimilation Systems For Sea Surface Temperature, Bradley J. Sciacca

University of New Orleans Theses and Dissertations

The ocean remains severely under-observed, in part due to its sheer size. Containing nearly billion of water with most of the subsurface being invisible because water is extremely difficult to penetrate using electromagnetic radiation, as is typically used by satellite measuring instruments. For this reason, most observations of the ocean have very low spatial-temporal coverage to get a broad capture of the ocean’s features. However, recent “dense but patchy” data have increased the availability of high-resolution – low spatial coverage observations. These novel data sets have motivated research into multi-scale data assimilation methods. Here, we demonstrate a new assimilation approach …


Good Practices And Common Pitfalls In Climate Time Series Changepoint Techniques: A Review, ROBERT B. LUND, CLAUDIE BEAULIEU, REBECCA KILLICK, QIQI LU, XUEHENG SHI 2023 University of California, Santa Cruz

Good Practices And Common Pitfalls In Climate Time Series Changepoint Techniques: A Review, Robert B. Lund, Claudie Beaulieu, Rebecca Killick, Qiqi Lu, Xueheng Shi

Department of Statistics: Faculty Publications

Climate changepoint (homogenization) methods abound today, with a myriad of techniques existing in both the climate and statistics literature. Unfortunately, the appropriate changepoint technique to use remains unclear to many. Further complicating issues, changepoint conclusions are not robust to perturbations in assumptions; for example, allowing for a trend or correlation in the series can drastically change changepoint conclusions. This paper is a review of the topic, with an emphasis on illuminating the models and techniques that allow the scientist to make reliable conclusions. Pitfalls to avoid are demonstrated via actual applications. The discourse begins by narrating the salient statistical features …


The Use Of Regularization To Detect Racial Inequities In Pay Equity Studies: An Empirical Study And Reflections On Regulation Methods, Christopher M. Peña 2023 University of Denver

The Use Of Regularization To Detect Racial Inequities In Pay Equity Studies: An Empirical Study And Reflections On Regulation Methods, Christopher M. Peña

Electronic Theses and Dissertations

Since the late 1970s, multiple linear regression has been the preferred method for identifying discrimination in pay. An empirical study on this topic was conducted using quantitative critical methods. A literature review first examined conflicting views on using multiple linear regression in pay equity studies. The review found that multiple linear regression is used so prevalently in pay equity studies because the courts and practitioners have widely accepted it and because of its simplicity and ability to parse multiple sources of variance simultaneously. Commentaries in the literature cautioned about errors in model specification, the use of tainted variables, and the …


Data Sharing And Ontology Use Among Agricultural Genetics, Genomics, And Breeding Databases And Resources Of The Agbiodata Consortium, Jennifer L. Clarke, Laurel D. Cooper, Monica F. Poelchau, Tanya Z. Berardini, Justin Elser, Andrew D. Farmer, Stephen Ficklin, Sunita Kumari, Marie-Angélique Laporte, Rex T. Nelson, Rie Sadohara, Peter Selby, Anne E. Thessen, Brandon Whitehead, Taner Z. Sen 2023 University of Nebraska–Lincoln

Data Sharing And Ontology Use Among Agricultural Genetics, Genomics, And Breeding Databases And Resources Of The Agbiodata Consortium, Jennifer L. Clarke, Laurel D. Cooper, Monica F. Poelchau, Tanya Z. Berardini, Justin Elser, Andrew D. Farmer, Stephen Ficklin, Sunita Kumari, Marie-Angélique Laporte, Rex T. Nelson, Rie Sadohara, Peter Selby, Anne E. Thessen, Brandon Whitehead, Taner Z. Sen

Department of Statistics: Faculty Publications

Over the last couple of decades, there has been a rapid growth in the number and scope of agricultural genetics, genomics and breeding databases and resources. The AgBioData Consortium (https://www.agbiodata.org/) currently represents 44 databases and resources (https://www.agbiodata.org/databases) covering model or crop plant and animal GGB data, ontologies, pathways, genetic variation and breeding platforms (referred to as ‘databases’ throughout). One of the goals of the Consortium is to facilitate FAIR (Findable, Accessible, Interoperable, and Reusable) data management and the integration of datasets which requires data sharing, along with structured vocabularies and/or ontologies. Two AgBioData working groups, focused on Data Sharing and …


A Data-Driven Multi-Regime Approach For Predicting Real-Time Energy Consumption Of Industrial Machines., Abdulgani Kahraman 2023 University of Louisville

A Data-Driven Multi-Regime Approach For Predicting Real-Time Energy Consumption Of Industrial Machines., Abdulgani Kahraman

Electronic Theses and Dissertations

This thesis focuses on methods for improving energy consumption prediction performance in complex industrial machines. Working with real-world industrial machines brings several challenges, including data access, algorithmic bias, data privacy, and the interpretation of machine learning algorithms. To effectively manage energy consumption in the industrial sector, it is essential to develop a framework that enhances prediction performance, reduces energy costs, and mitigates air pollution in heavy industrial machine operations. This study aims to assist managers in making informed decisions and driving the transition towards green manufacturing. The energy consumption of industrial machinery is substantial, and the recent increase in CO2 …


Penalized Bayesian Exponential Random Graph Models., Vicki Modisette 2023 University of Louisville

Penalized Bayesian Exponential Random Graph Models., Vicki Modisette

Electronic Theses and Dissertations

Networks have the critical ability to represent the complex interconnectedness of social relationships, biological processes, and the spread of diseases and information. Exponential random graph models (ERGM) are one of the popular statistical methods for analyzing network data. ERGM, however, struggle with computational challenges and degeneracy issues, further exacerbated by their inability to handle high-dimensional network data. Bayesian techniques provide a promising avenue to overcome these two problems. This paper considers penalized Bayesian exponential random graph models with adaptive lasso and adaptive ridge penalties to perform variable selection and reduce multicollinearity on a variety of networks. The experimental results demonstrate …


A Multivariate Investigation Of The Motivational, Academic, And Well-Being Characteristics Of First-Generation And Continuing-Generation College Students, Christopher L. Thomas, Staci Zolkoski 2023 The University of Texas at Tyler

A Multivariate Investigation Of The Motivational, Academic, And Well-Being Characteristics Of First-Generation And Continuing-Generation College Students, Christopher L. Thomas, Staci Zolkoski

Journal of Research Initiatives

Prior research has noted differences in motivational, academic, and well-being factors between first-generation and continuing-education students. However, past investigations have primarily overlooked the interactive influence of protective and risk factors when comparing the characteristics of first-generation and continuing-education students. Thus, the current study adopted a multivariate approach to gain a more nuanced understanding of the influence of generational status on students' self-regulated learning capabilities, academic anxiety, sense of belonging, academic barriers, mental health concerns, and satisfaction with life. University students (N = 432, 67.46% Caucasian, 87.55% female, Age = 28.10 ± 9.46) completed the Cognitive Test Anxiety Scale-2nd …


Addressing The Impact Of Time-Dependent Social Groupings On Animal Survival And Recapture Rates In Mark-Recapture Studies, Alexandru M. Draghici 2023 The University of Western Ontario

Addressing The Impact Of Time-Dependent Social Groupings On Animal Survival And Recapture Rates In Mark-Recapture Studies, Alexandru M. Draghici

Electronic Thesis and Dissertation Repository

Mark-recapture (MR) models typically assume that individuals under study have independent survival and recapture outcomes. One such model of interest is known as the Cormack-Jolly-Seber (CJS) model. In this dissertation, we conduct three major research projects focused on studying the impact of violating the independence assumption in MR models along with presenting extensions which relax the independence assumption. In the first project, we conduct a simulation study to address the impact of failing to account for pair-bonded animals having correlated recapture and survival fates on the CJS model. We examined the impact of correlation on the likelihood ratio test (LRT), …


Pre-Sleep Feeding, Sleep Quality, And Markers Of Recovery In Division I Ncaa Female Soccer Players, Casey E. Greenwalt, Elisa Angeles, Matthew D. Vukovich, Abbie E. Smith-Ryan, Chris W. Bach, Stacy T. Sims, Tucker Zeleny, Kristen E. Holmes, David M. Presby, Katie J. Schiltz, Marine Dupuit, Liliana I. Renteria, Michael J. Ormsbee 2023 Florida State University

Pre-Sleep Feeding, Sleep Quality, And Markers Of Recovery In Division I Ncaa Female Soccer Players, Casey E. Greenwalt, Elisa Angeles, Matthew D. Vukovich, Abbie E. Smith-Ryan, Chris W. Bach, Stacy T. Sims, Tucker Zeleny, Kristen E. Holmes, David M. Presby, Katie J. Schiltz, Marine Dupuit, Liliana I. Renteria, Michael J. Ormsbee

Department of Statistics: Faculty Publications

Pre-sleep nutrition habits in elite female athletes have yet to be evaluated. A retrospective analysis was performed with 14 NCAA Division I female soccer players who wore a WHOOP, Inc. band – a wearable device that quantifies recovery by measuring sleep, activity, and heart rate metrics through actigraphy and photoplethysmography, respectively – 24 h a day for an entire competitive season to measure sleep and recovery. Pre-sleep food consumption data were collected via surveys every 3 days. Average pre-sleep nutritional intake (mean ± sd: kcals 330 ± 284; cho 46.2 ± 40.5 g; pro 7.6 ± 7.3 g; fat 12 …


Utilizing New Technologies To Measure Therapy Effectiveness For Mental And Physical Health, Jonathan Ossie 2023 University of San Diego

Utilizing New Technologies To Measure Therapy Effectiveness For Mental And Physical Health, Jonathan Ossie

Dissertations

Mental health is quickly becoming a major policy concern, with recent data reporting increasing and disproportionately worse mental health outcomes, including anxiety, depression, increased substance abuse, and elevated suicidal ideation. One specific population that is especially high risk for these issues is the military community because military conflict, deployment stressors, and combat exposure contribute to the risk of mental health problems.

Although several pharmacological approaches have been employed to combat this epidemic, their efficacy is mixed at best, which has led to novel nonpharmacological approaches. One such approach is Operation Surf, a nonprofit that provides nature-based programs advocating the restorative …


Increasing Racial Diversity In The North American Plant Phenotyping Network Through Conference Participation Support, David LeBauer, Alexander Bucksch, Jennifer Clarke, Jesse Potts, Sonali Roy 2023 University of Arizona

Increasing Racial Diversity In The North American Plant Phenotyping Network Through Conference Participation Support, David Lebauer, Alexander Bucksch, Jennifer Clarke, Jesse Potts, Sonali Roy

Department of Statistics: Faculty Publications

A key goal of the North American Plant Phenotyping Network (NAPPN) annual conference is to cultivate a new generation of scientists from diverse backgrounds. As part of their effort to diversify the plant phenomics research community, NAPPN acquired funding to cover all attendance costs for participants from historically black colleges and universities (HBCU) for the 2022 annual meeting. Seven award recipients represented the first attendees from HBCUs in the conference’s 6-year history. In this commentary, we report on the impact of the conference awards, including lessons learned, and the future of the award.


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